Published in J Psychiatry Neurosci on September 01, 2001
Incorporation of noncanonical amino acids into Rosetta and use in computational protein-peptide interface design. PLoS One (2012) 1.02
Chronic administration of citalopram in olfactory bulbectomy rats restores brain 5-HT synthesis rates: an autoradiographic study. Psychopharmacology (Berl) (2004) 0.83
Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications. Eur J Nucl Med Mol Imaging (2010) 0.80
The lumped constant of α-methyl-l-tryptophan is not influenced by drugs acting through serotonergic system. Neurochem Int (2011) 0.77
Acute effects of combining citalopram and pindolol on regional brain serotonin synthesis in sham operated and olfactory bulbectomized rats. Neurochem Int (2008) 0.77
Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation. Sci Rep (2016) 0.75
[(11)C]5-HTP and microPET are not suitable for pharmacodynamic studies in the rodent brain. J Cereb Blood Flow Metab (2013) 0.75
AGN-2979, an inhibitor of tryptophan hydroxylase activation, does not affect serotonin synthesis in Flinders Sensitive Line rats, a rat model of depression, but produces a significant effect in Flinders Resistant Line rats. Neurochem Int (2009) 0.75
Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and L-tryptophan. J Neurochem (1971) 3.34
An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J Comp Neurol (1978) 2.63
Relapse of depression after rapid depletion of tryptophan. Lancet (1997) 2.61
Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci U S A (1997) 2.50
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain (1992) 2.09
Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology (Berl) (1985) 2.02
Brain serotonin content: physiological dependence on plasma tryptophan levels. Science (1971) 2.00
Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals. Science (1985) 1.88
Autoregulation of serotonin neurons: role in antidepressant drug action. Pharmacol Rev (1999) 1.69
The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proc Natl Acad Sci U S A (1992) 1.68
Tracer kinetic modeling of the 5-HT1A receptor ligand [carbonyl-11C]WAY-100635 for PET. Neuroimage (1998) 1.59
Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. J Neurosci (1998) 1.56
Biochemical and autoradiographic measurements of brain serotonin synthesis rate in the freely moving rat: a reexamination of the alpha-methyl-L-tryptophan method. J Neurochem (1999) 1.52
The suitability of [11C]-alpha-methyl-L-tryptophan as a tracer for serotonin synthesis: studies with dual administration of [11C] and [14C] labeled tracer. J Cereb Blood Flow Metab (2000) 1.48
Effect of acute fluoxetine treatment on the brain serotonin synthesis as measured by the alpha-methyl-L-tryptophan autoradiographic method. J Neurochem (1995) 1.44
Depression: the case for a monoamine deficiency. J Clin Psychiatry (2000) 1.44
Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse (1987) 1.39
5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. Br J Pharmacol (1989) 1.35
Role of norepinephrine in depression. J Clin Psychiatry (2000) 1.34
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. J Pharmacol Exp Ther (1987) 1.33
Monoamine metabolites in lumbar CSF: the question of their origin in relation to clinical studies. Brain Res (1974) 1.29
Imaging epileptogenic tubers in children with tuberous sclerosis complex using alpha-[11C]methyl-L-tryptophan positron emission tomography. Ann Neurol (1998) 1.27
Alpha[C-11]methyl-L-tryptophan PET maps brain serotonin synthesis and kynurenine pathway metabolism. J Cereb Blood Flow Metab (2000) 1.27
Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders. Arch Gen Psychiatry (1994) 1.24
3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy"): pharmacology and toxicology in animals and humans. Addiction (1994) 1.22
A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model. J Cereb Blood Flow Metab (1990) 1.20
Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters. Mol Pharmacol (1993) 1.18
Human brain serotonin synthesis capacity measured in vivo with alpha-[C-11]methyl-L-tryptophan. Synapse (1998) 1.13
Analysis of [C-11]alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate in vivo. J Cereb Blood Flow Metab (1997) 1.09
Mood response to acute tryptophan depletion in healthy volunteers: sex differences and temporal stability. Neuropsychopharmacology (1996) 1.07
Antidepressant action of tryptophan. Lancet (1974) 1.05
Deamination of 5-hydroxytryptamine by both forms of monoamine oxidase in the rat brain. J Neurochem (1982) 1.04
Neurobiological mechanisms involved in antidepressant therapies. Clin Neuropharmacol (1993) 1.00
Serotonin synthesis rate measured in living dog brain by positron emission tomography. J Neurochem (1991) 0.99
Nonhomogeneous distribution of 5-hydroxyindoleacetic acid and homovanillic acid in the lumbar cerebrospinal fluid of man. J Neurol Sci (1977) 0.97
PET imaging of central 5-HT2A receptors with carbon-11-MDL 100,907. J Nucl Med (1998) 0.96
Alpha-methyltryptophan: effects on synthesis and degradation of serotonin in the brain. Neuropharmacology (1972) 0.95
The psychological and physiological effects of MDMA on normal volunteers. J Psychoactive Drugs (1987) 0.95
Determination of the lumped constant for the alpha-methyltryptophan method of estimating the rate of serotonin synthesis. J Neurochem (1995) 0.93
Differences in the central serotonergic effects of methylenedioxymethamphetamine (MDMA) in mice and rats. Neuropharmacology (1987) 0.92
Statistical mapping analysis of serotonin synthesis images generated in healthy volunteers using positron-emission tomography and alpha-[11C]methyl-L-tryptophan. J Psychiatry Neurosci (2000) 0.92
A study of proposed determinants of brain tryptophan concentration in rats after portocaval anastomosis or sham operation. J Neurochem (1978) 0.91
Regulation of serotonin biosynthesis in brain: role of the high affinity uptake of tryptophan into serotonergic neurons. Fed Proc (1977) 0.89
Buspirone: effects on central monoaminergic transmission--possible relevance to animal experimental and clinical findings. Eur J Pharmacol (1982) 0.89
Neurochemical mechanism of action of drugs which modify feeding via the serotoninergic system. Appetite (1986) 0.87
Influence of fluoxetine on regional serotonin synthesis in the rat brain. J Neurochem (1996) 0.87
Rapid steady-state analysis of blood-brain transfer of L-Trp in rat, with special reference to the plasma protein binding. Neurochem Int (1993) 0.87
Anatomic evidence for a neurotoxic effect of (+/-)-fenfluramine upon serotonergic projections in the rat. Brain Res (1990) 0.87
The acute effects of reserpine and NSD-1015 on the brain serotonin synthesis rate measured by an autoradiographic method. Neuropsychopharmacology (1995) 0.86
The involvement of serotonin in psychiatric disorders and behaviour. Br J Psychiatry Suppl (1988) 0.85
Effects of acute and chronic administration of the serotonin1A agonist buspirone on serotonin synthesis in the rat brain. J Neurochem (1999) 0.85
Possible role of free serum tryptophan in the control of brain tryptophan level and serotonin synthesis. Adv Biochem Psychopharmacol (1974) 0.84
How does displacement of albumin-bound tryptophan cause sustained increases in the free tryptophan concentration in plasma and 5-hydroxytryptamine synthesis in brain? Biochem J (1989) 0.83
In vivo-synthesized radioactively labelled alpha-methyl serotonin as a selective tracer for visualization of brain serotonin neurons. Synapse (1995) 0.83
Does brain 5-HIAA indicate serotonin release or monoamine oxidase activity? Eur J Pharmacol (1985) 0.83
Formation of 6-hydroxydopamine in caudate nucleus of the rat brain after a single large dose of methylamphetamine. Pharmacol Biochem Behav (1984) 0.82
Neurochemical analysis of cerebrospinal fluid. Neurology (1980) 0.82
Storage of serotonin and serotonin binding protein in synaptic vesicles. J Neurochem (1979) 0.82
Alpha-methyl-L-tryptophan as a tracer to study brain serotonergic system. Neurochem Res (1995) 0.81
Is alpha-methyl-L-tryptophan a good tracer for brain serotonin synthesis measurements, and does the lumped constant vary in different structures of the rat brain? J Neurochem (1999) 0.81
Inhibition of tryptophan hydroxylase by benserazide and other catechols. Biochem Pharmacol (1991) 0.81
Synthesis of serotonin in traumatized rat brain. J Neurochem (1995) 0.81
Immunohistochemistry of tryptophan hydroxylase in the rat brain. Neuroscience (1987) 0.80
Metabolism of alpha-methyltryptophan. Biochem Pharmacol (1965) 0.80
Release of histamine in rat hypothalamus and corpus striatum in vivo. Brain Res (1990) 0.80
A.E. Bennett Award Paper. A kinetic analysis of 5-hydroxyindoleacetic acid excretion from rat brain and csf. Biol Psychiatry (1976) 0.80
Acute and chronic D-fenfluramine treatments have different effects on serotonin synthesis rates in the rat brain: an autoradiographic study. Neurochem Res (1999) 0.79
Coincidence of blockade of synaptosomal 5-hydroxytryptamine uptake and decrease in tryptophan hydroxylase activity: effects of fenfluramine. J Pharmacol Exp Ther (1976) 0.79
Acute effects of 3,4-methylenedioxymethamphetamine on brain serotonin synthesis in the dog studied by positron emission tomography. Neurochem Int (1999) 0.79
Anorectic effect of fenfluramine isomers and metabolites: relationship between brain levels and in vitro potencies on serotonergic mechanisms. Psychopharmacology (Berl) (1985) 0.79
Amino acid analysis demonstrates that increased plasma free tryptophan causes the increase of brain tryptophan during exercise in the rat. J Neurochem (1986) 0.79
5,6-Dihydroxytryptamine, a serotonergic neurotoxin, is formed endogenously in the rat brain. Brain Res (1987) 0.78
Relationship between central and peripheral serotonin 5-HT2A receptors: a positron emission tomography study in healthy individuals. Neurosci Lett (1999) 0.78
Serotonin synthesis increased in terminals four days after reserpine treatment: an autoradiographic study in rat brain. Neurochem Res (1997) 0.78
Acute and chronic effects of reserpine on biochemical and functional parameters of central and peripheral alpha 2-adrenoceptors. Eur J Pharmacol (1993) 0.78
Measurements of monoamine synthesis and turnover with special reference to 5-hydroxytryptamine. Adv Biochem Psychopharmacol (1974) 0.77
Does labeled alpha-methyl-L-tryptophan image ONLY blood-brain barrier transport of tryptophan? J Cereb Blood Flow Metab (2000) 0.77
Ipsilateral alterations in tryptophan hydroxylase activity in rat brain after hypothalamic 5,7-di-hydroxytryptamine lesion. Brain Res (1996) 0.77
The effect of MDMA (3,4-methylenedioxymethamphetamine) on the 5-HT synthesis rate in the rat brain: an autoradiographic study. Brain Res (1998) 0.77
The effect of L-tryptophan and some psychotropic drugs on the formation of 5-hydroxytryptophan in the mouse brain in vivo. J Neural Transm (1972) 0.77
The use of neurotoxic dihydroxytryptamines as tools for morphological studies and localized lesioning of central indolamine neurons. Z Zellforsch Mikrosk Anat (1973) 0.77
Effect of p-chloroamphetamine on cerebral tryptophan-5-hydroxylase in vivo: a reexamination. Neuropharmacology (1975) 0.76
Hydroxylation of tryptophan and its control in brain. Pavlov J Biol Sci (1975) 0.76
Autoradiographic evaluation of the influence of hypothalamic 5,7-dihydroxytryptamine lesion on brain serotonin synthesis. Biochem Pharmacol (1995) 0.76
Possible explanations for the antagonism by nicotine against reserpine-induced depletion of monoamines in mouse brain. Naunyn Schmiedebergs Arch Pharmacol (1993) 0.75