NCX4016 (NO-Aspirin) has multiple inhibitory effects in LPS-stimulated human monocytes.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 1573016)

Published in Br J Pharmacol on October 01, 2001

Authors

P Minuz1, M Degan, S Gaino, A Meneguzzi, V Zuliani, C L Santonastaso, P D Soldato, A Lechi

Author Affiliations

1: Department of Biomedical and Surgical Sciences, University of Verona, Medicina Interna C, Policlinico G.B. Rossi, Piazzale L.A. Scuro, 10, 37134 Verona, Italy. pietro.minuz@mail.univr.it

Articles cited by this

Atherosclerosis--an inflammatory disease. N Engl J Med (1999) 59.28

Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation (2000) 8.17

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest (1995) 5.09

Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation (2000) 3.66

Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol (1996) 2.27

Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation (2000) 2.22

Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes. J Clin Invest (1994) 1.74

Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids. Br J Pharmacol (1995) 1.63

Regulation of tissue factor expression in human microvascular endothelial cells by nitric oxide. Circulation (2000) 1.56

Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds. J Immunol (1993) 1.53

Tissue factor modulates the thrombogenicity of human atherosclerotic plaques. Circulation (1997) 1.39

Regulation of the tissue factor gene. Thromb Haemost (1997) 1.34

NO-aspirins: a class of new anti-inflammatory and antithrombotic agents. Trends Pharmacol Sci (1999) 1.34

Heme-dependent activation of soluble guanylate cyclase by nitric oxide: regulation of enzyme activity by porphyrins and metalloporphyrins. Semin Hematol (1989) 1.26

Induction of nitric oxide synthase mRNA expression. Suppression by exogenous nitric oxide. J Biol Chem (1995) 1.21

IL-1 beta converting enzyme is a target for nitric oxide-releasing aspirin: new insights in the antiinflammatory mechanism of nitric oxide-releasing nonsteroidal antiinflammatory drugs. J Immunol (2000) 1.14

NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines. Gastroenterology (2000) 1.13

Enhancement of mononuclear procoagulant activity by platelet 12-hydroxyeicosatetraenoic acid. J Clin Invest (1986) 1.10

Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice. Proc Natl Acad Sci U S A (2001) 1.09

Macrophages, smooth muscle cells, and tissue factor in unstable angina. Implications for cell-mediated thrombogenicity in acute coronary syndromes. Circulation (1996) 1.08

NO inhibits cytokine-induced iNOS expression and NF-kappaB activation by interfering with phosphorylation and degradation of IkappaB-alpha. Arterioscler Thromb Vasc Biol (1998) 1.08

In vivo antithrombotic effects of a nitric oxide-releasing aspirin derivative, NCX-4016. Thromb Res (1999) 0.97

Nitric oxide-releasing NSAIDs inhibit interleukin-1beta converting enzyme-like cysteine proteases and protect endothelial cells from apoptosis induced by TNFalpha. Aliment Pharmacol Ther (1999) 0.94

The nitroderivative of aspirin, NCX 4016, reduces infarct size caused by myocardial ischemia-reperfusion in the anesthetized rat. J Pharmacol Exp Ther (2001) 0.90

Acetylsalicylic acid and sodium salicylate inhibit LPS-induced NF-kappa B/c-Rel nuclear translocation, and synthesis of tissue factor (TF) and tumor necrosis factor alfa (TNF-alpha) in human monocytes. Thromb Haemost (1996) 0.88

Pharmacokinetics of a new nitroderivative of acetylsalicylic acid after a single dose in rats. Life Sci (1997) 0.87

Prevention of pulmonary thromboembolism by NCX 4016, a nitric oxide-releasing aspirin. Eur J Pharmacol (2000) 0.87

The antiplatelet effects of a new nitroderivative of acetylsalicylic acid--an in vitro study of inhibition on the early phase of platelet activation and on TXA2 production. Thromb Haemost (1996) 0.85

The role of the tissue factor pathway in initiation of coagulation. Blood Coagul Fibrinolysis (1998) 0.85

Effect of single and repeated doses of a new nitroderivative of acetylsalicylic acid on platelet TXA2 production in rats. Life Sci (1996) 0.81

Modification of tissue factor by peroxynitrite influences its procoagulant activity. FEBS Lett (1998) 0.78

Articles by these authors

Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie. Genes Dev (1994) 2.00

Brain pathology induced by infection with the human immunodeficiency virus (HIV). A histological, immunocytochemical, and electron microscopical study of 100 autopsy cases. Acta Neuropathol (1987) 1.81

Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity. Int J Obes Relat Metab Disord (1999) 1.45

Considerations on a group of 13 patients with Creutzfeldt-Jakob disease in the region of Parma (Italy) Eur J Epidemiol (1990) 1.40

Prevalence of carotid artery kinking in 590 consecutive subjects evaluated by Echocolordoppler. Is there a correlation with arterial hypertension? J Intern Med (2000) 1.36

IL-1 beta converting enzyme is a target for nitric oxide-releasing aspirin: new insights in the antiinflammatory mechanism of nitric oxide-releasing nonsteroidal antiinflammatory drugs. J Immunol (2000) 1.14

ACE inhibitors improve endothelial function in type 1 diabetic patients with normal arterial pressure and microalbuminuria. Diabetes Care (1999) 1.14

Association of Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma with expression of the CD138/syndecan-1 antigen. Blood (1997) 1.13

Study of 2708 heroin-related deaths in north-eastern Italy 1985-98 to establish the main causes of death. Addiction (2001) 1.05

CD30 ligand is frequently expressed in human hematopoietic malignancies of myeloid and lymphoid origin. Blood (1997) 1.05

Neuronal loss in the basal nucleus of Meynert in progressive supranuclear palsy. Acta Neuropathol (1983) 1.00

Human eosinophils express functional CD30 ligand and stimulate proliferation of a Hodgkin's disease cell line. Blood (1996) 0.98

Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines. Blood (1995) 0.96

Growth rate and growth probability of Listeria monocytogenes in dairy, meat and seafood products in suboptimal conditions. J Appl Microbiol (2005) 0.96

The role of eosinophils in the pathobiology of Hodgkin's disease. Ann Oncol (1997) 0.96

The expression of CD26 and CD40 ligand is mutually exclusive in human T-cell non-Hodgkin's lymphomas/leukemias. Blood (1995) 0.95

Nitric oxide-releasing NSAIDs inhibit interleukin-1beta converting enzyme-like cysteine proteases and protect endothelial cells from apoptosis induced by TNFalpha. Aliment Pharmacol Ther (1999) 0.94

Adult metachromatic leucodystrophy: clinicopathological report of two familial cases with slow course. Neuropathol Appl Neurobiol (1979) 0.93

Telomerase expression in B-cell chronic lymphocytic leukemia predicts survival and delineates subgroups of patients with the same igVH mutation status and different outcome. Leukemia (2007) 0.92

Reed-Sternberg cells of classical Hodgkin's disease react with the plasma cell-specific monoclonal antibody B-B4 and express human syndecan-1. Blood (1997) 0.91

The F2-isoprostane 8-epiprostaglandin F2alpha increases platelet adhesion and reduces the antiadhesive and antiaggregatory effects of NO. Arterioscler Thromb Vasc Biol (1998) 0.91

Diagnostic value and biological significance of antibody-coated bacteria in urine. J Clin Pathol (1980) 0.91

Lactic dehydrogenase isoenzymes in urinary tract infections and aminoglycoside nephrotoxicity. Infection (1983) 0.89

CD49d in B-cell chronic lymphocytic leukemia: correlated expression with CD38 and prognostic relevance. Leukemia (2006) 0.88

Isolated presence of antibody to hepatitis B core antigen in injection drug users: do they need to be vaccinated? Clin Infect Dis (2001) 0.88

Noninvasive detection of functional alterations of the arterial wall in IDDM patients with and without microalbuminuria. Diabetes Care (1995) 0.88

Modeling microbial competition in food: application to the behavior of Listeria monocytogenes and lactic acid flora in pork meat products. Food Microbiol (2010) 0.88

Autonomic nervous system dysfunction in sclerodermic and primary Raynaud's phenomenon. Clin Sci (Lond) (1999) 0.86

Accidental poisoning with deadly nightshade berries: a case report. Hum Toxicol (1984) 0.86

Human osteoclasts and preosteoclast cells (FLG 29.1) express functional c-kit receptors and interact with osteoblast and stromal cells via membrane-bound stem cell factor. Cell Growth Differ (1996) 0.86

In vitro and in vivo effects of 2'-deoxycoformycin (Pentostatin) on tumour cells from human gammadelta+ T-cell malignancies. Br J Haematol (2000) 0.86

8-Iso-PGF2 alpha induces beta 2-integrin-mediated rapid adhesion of human polymorphonuclear neutrophils: a link between oxidative stress and ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol (2001) 0.85

The antiplatelet effects of a new nitroderivative of acetylsalicylic acid--an in vitro study of inhibition on the early phase of platelet activation and on TXA2 production. Thromb Haemost (1996) 0.85

Wernicke's encephalopathy: occurrence and pathological aspects in a series of 400 AIDS patients. Acta Biomed Ateneo Parmense (1992) 0.85

The effect of amantadine on arousal and EEG patterns in Creutzfeldt-Jakob disease. Arch Neurol (1983) 0.84

Catecholamine-induced regulation in vitro and ex vivo of intralymphocyte ionized magnesium. J Membr Biol (2004) 0.84

New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma. J Cell Mol Med (2008) 0.84

Urinary kallikrein excretion in Bartter's syndrome. J Clin Endocrinol Metab (1976) 0.84

Antihypertensive activity of enalapril. Effect of ibuprofen and different salt intakes. J Clin Hypertens (1987) 0.84

Mutational status of IgV(H) genes in B-cell chronic lymphocytic leukemia and prognosis: percent mutations or antigen-driven selection? Leukemia (2005) 0.84

Expression of the RET receptor tyrosine kinase and GDNFR-alpha in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment. Blood (1997) 0.84

Urinary kallikrein excretion and plasma renin activity in patients with essential hypertension and primary aldosteronism. Clin Sci Mol Med (1978) 0.84

Levels of F2-isoprostanes in systemic sclerosis: correlation with clinical features. Rheumatology (Oxford) (2005) 0.84

Differential expression of the RET gene in human acute myeloid leukemia. Ann Hematol (1998) 0.83

High plasma levels of a ouabain-like factor in normal pregnancy and in pre-eclampsia. Eur J Clin Invest (1989) 0.83

Penetration of ceftriaxone into human pleural fluid. Antimicrob Agents Chemother (1986) 0.83

Association between depressive mood and cigarette smoking in a large Italian sample of smokers intending to quit: implications for treatment. Intern Emerg Med (2007) 0.83

Non-invasive detection of early endothelial dysfunction in hypercholesterolaemic subjects. Atherosclerosis (1995) 0.82

Prevalence of morphological alterations in cervical vessels: a colour duplex ultrasonographic study in a series of 3300 subjects. Int Angiol (1998) 0.82

[Data on the metabolism of iron in human viral hepatitis. The use of the desferrioxamine test]. G Mal Infett Parassit (1966) 0.82

[Histochemical and functional investigations on the genesis of hypersideremia in acute viral hepatitis]. Policlinico Med (1966) 0.82

ACE genotype and endothelium-dependent vasodilation of conduit arteries and forearm microcirculation in humans. Arterioscler Thromb Vasc Biol (2001) 0.82

Successful treatment of subacute cerebellar degeneration in ovarian carcinoma with plasmapheresis. A case report. Cancer (1985) 0.82

Characterization of anti-CD138 monoclonal antibodies as tools for investigating the molecular polymorphism of syndecan-1 in human lymphoma cells. Br J Haematol (1999) 0.82

The kinetics of cefuroxime in ascitic and pleural fluid. Int J Clin Pharmacol Ther Toxicol (1982) 0.82

Vasodilating properties of a new non-steroidal anti-inflammatory drug, nitroflurbiprofen, on rat aortic rings. Pharmacol Res (1997) 0.81

Thromboxane and prostacyclin biosynthesis in heart failure of ischemic origin: effects of disease severity and aspirin treatment. J Thromb Haemost (2010) 0.81

Evaluation of platelet turnover by flow cytometry. Platelets (2006) 0.81

Erythrocyte Na(+)-H+ exchange activity in essential hypertensive and obese patients: role of excess body weight. J Hypertens (1993) 0.81

Effect of single and repeated doses of a new nitroderivative of acetylsalicylic acid on platelet TXA2 production in rats. Life Sci (1996) 0.81

[The spongy state in the histopathological diagnosis of encephalopathies of presenility]. Acta Neuropathol (1967) 0.81

Effect of losartan on heart rate and blood pressure variability during tilt test and trinitroglycerine vasodilation. J Hypertens (1999) 0.81

Distribution of ceftazidime in ascitic fluid. Antimicrob Agents Chemother (1984) 0.80

Hodgkin's disease: a disorder of dysregulated cellular cross-talk. Biotherapy (1998) 0.79

Study of platelet adhesion in patients with uncomplicated hypertension. J Hypertens (1996) 0.79

Changes in peripheral hemodynamics and vasodilating prostaglandins after high-dose short-term ibuprofen in chronically treated hypertensive patients. Prostaglandins Leukot Essent Fatty Acids (1996) 0.79

Intralymphocyte free magnesium in patients with primary aldosteronism: aldosterone and lymphocyte magnesium homeostasis. Hypertension (2000) 0.79

Meige syndrome: a clinical and EMG study. Eur Neurol (1981) 0.79

[Intracranial and spinal dermo-epidermoid tumours. Anatomoclinical study (author's transl)]. Ateneo Parmense Acta Biomed (1978) 0.79

Fabry's disease with familial lymphedema of the lower limbs. Case report and family study. Eur Neurol (1979) 0.78

Antiaggregating and vasodilatory effects of a new nitroderivative of acetylsalicylic acid. Thromb Res (1995) 0.78

CD30L up-regulates CD30 and IL-4 expression by T cells. FEBS Lett (2001) 0.78

Effects of smoking on cardiopulmonary baroreceptor activation and peripheral vascular resistance. Eur J Clin Invest (2006) 0.78

Meningiomas. A light and electron microscopy study. Acta Neuropathol Suppl (1981) 0.78

Urinary and kidney kallikrein in hypertensive rats. Biomedicine (1976) 0.78

Study on paradoxical effects of NSAIDs on platelet activation. Inflammation (1997) 0.78

Contribution of four markers of tubular proteinuria in detecting upper urinary tract infections. A multivariate analysis. Nephron (1982) 0.78

The RET receptor tyrosine kinase, but not its specific ligand, GDNF, is preferentially expressed by acute leukaemias of monocytic phenotype and is up-regulated upon differentiation. Br J Haematol (1999) 0.78

Neuropathology of AIDS dementia. A review after 205 post mortem examinations. Acta Neurol (Napoli) (1990) 0.78

Frequent expression of the variant CD30 in human malignant myeloid and lymphoid neoplasms. Am J Pathol (1999) 0.78

Orthochromatic leukodystrophy with pigmented glial cells. An adult case with clinical-anatomical study. Acta Neurol Scand (1979) 0.78

Changes in the haemodynamics of large arteries induced by single doses of nicardipine, enalapril, atenolol and urapidil. Eur J Clin Pharmacol (1992) 0.78

Immunological studies in cluster headache and migraine. Headache (1986) 0.78

Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10. Leukemia (2007) 0.78

Serum pancreatic enzyme alterations in acute viral hepatitis. Hepatogastroenterology (1983) 0.78