Published in FASEB J on October 15, 2001
Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med (2010) 3.55
Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do! Ann Rheum Dis (2005) 1.35
A single, mild, transient scrotal heat stress causes hypoxia and oxidative stress in mouse testes, which induces germ cell death. Biol Reprod (2009) 1.26
Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression. J Cell Biochem (2011) 1.10
Metallothionein rescues hypoxia-inducible factor-1 transcriptional activity in cardiomyocytes under diabetic conditions. Biochem Biophys Res Commun (2007) 0.84
Suppression of HIF-1α expression and radiation resistance in acute hypoxic conditions. Exp Ther Med (2011) 0.82
Ηypoxia-inducible factor-1α, von Hippel-Lindau protein, and heat shock protein expression in ophthalmic pterygium and normal conjunctiva. Mol Vis (2014) 0.75
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev (1998) 12.48
Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res (2000) 6.14
Oxygen(es) and the hypoxia-inducible factor-1. Biol Chem (1997) 2.81
HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia. FASEB J (2001) 2.73
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Mol Cell Biol (1996) 2.72
Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3) J Clin Invest (2000) 2.57
Induction of HIF-1alpha in response to hypoxia is instantaneous. FASEB J (2001) 2.51
Biochemical and functional comparison of DNA polymerases alpha, delta, and epsilon from calf thymus. J Biol Chem (1991) 2.08
Embryoid bodies: an in vitro model of mouse embryogenesis. Exp Physiol (2000) 2.02
Erythropoietin gene expression in human, monkey and murine brain. Eur J Neurosci (1996) 1.91
Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature (1997) 1.90
Localization of specific erythropoietin binding sites in defined areas of the mouse brain. Proc Natl Acad Sci U S A (1995) 1.77
Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. J Biol Chem (1997) 1.67
Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system. Cancer Res (1992) 1.51
Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin. Proc Natl Acad Sci U S A (2000) 1.47
Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes. J Exp Med (1997) 1.47
Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells. Proc Natl Acad Sci U S A (1996) 1.46
Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice. Blood (1997) 1.44
The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site. Nucleic Acids Res (1995) 1.43
Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis. Mol Endocrinol (2000) 1.41
Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4. Nat Cell Biol (2000) 1.34
Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase. Eur J Immunol (1992) 1.32
Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha. J Cell Sci (1999) 1.31
Hypoxia, a novel inducer of acute phase gene expression in a human hepatoma cell line. J Biol Chem (1995) 1.29
Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase. Mol Cell Biol (1994) 1.26
Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha. Biochem Biophys Res Commun (1996) 1.23
Increased cerebral infarct volumes in polyglobulic mice overexpressing erythropoietin. J Cereb Blood Flow Metab (2001) 1.22
Detection of erythropoietin in human liquor: intrinsic erythropoietin production in the brain. Kidney Int (1997) 1.22
Calf thymus DNA polymerase delta: purification, biochemical and functional properties of the enzyme after its separation from DNA polymerase alpha, a DNA dependent ATPase and proliferating cell nuclear antigen. Nucleic Acids Res (1988) 1.20
Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietin. Blood (2001) 1.19
Hypoxia-inducible factor-1 alpha is regulated at the post-mRNA level. Kidney Int (1997) 1.15
Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway. Oncogene (2006) 1.14
Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding site. Eur J Biochem (1998) 1.14
General applicability of chicken egg yolk antibodies: the performance of IgY immunoglobulins raised against the hypoxia-inducible factor 1alpha. FASEB J (1999) 1.12
Neuroprotection by hypoxic preconditioning: HIF-1 and erythropoietin protect from retinal degeneration. Semin Cell Dev Biol (2005) 1.12
Oxygen- and dioxin-regulated gene expression in mouse hepatoma cells. Kidney Int (1997) 1.11
Generation and application of chicken egg-yolk antibodies. Comp Biochem Physiol A Mol Integr Physiol (2002) 1.11
Non-canonical HIF-2α function drives autonomous breast cancer cell growth via an AREG-EGFR/ErbB4 autocrine loop. Oncogene (2011) 1.08
Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis. Oncogene (2010) 1.07
Na-K-ATPase in rat cerebellar granule cells is redox sensitive. Am J Physiol Regul Integr Comp Physiol (2005) 1.05
Hypoxia affects expression of circadian genes PER1 and CLOCK in mouse brain. FASEB J (2001) 1.05
Mouse hypoxia-inducible factor-1alpha is encoded by two different mRNA isoforms: expression from a tissue-specific and a housekeeping-type promoter. Blood (1998) 1.04
Calf thymus DNA polymerase delta independent of proliferating cell nuclear antigen (PCNA). Nucleic Acids Res (1989) 1.03
Necrogenesis and Fas/APO-1 (CD95) expression in primary (de novo) and secondary glioblastomas. J Neuropathol Exp Neurol (1998) 1.03
The mouse gene for hypoxia-inducible factor-1alpha--genomic organization, expression and characterization of an alternative first exon and 5' flanking sequence. Eur J Biochem (1997) 1.02
Efficient translation of mouse hypoxia-inducible factor-1alpha under normoxic and hypoxic conditions. Biochim Biophys Acta (2000) 1.01
Maintaining blood-brain barrier integrity: pericytes perform better than astrocytes during prolonged oxygen deprivation. J Cell Physiol (2009) 1.01
Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression. Pflugers Arch (2001) 1.00
Characterization of a hypoxia-inducible factor (HIF-1alpha ) from rainbow trout. Accumulation of protein occurs at normal venous oxygen tension. J Biol Chem (2001) 0.99
Epolones induce erythropoietin expression via hypoxia-inducible factor-1 alpha activation. Blood (2000) 0.98
Erythropoietin modulates intracellular calcium in a human neuroblastoma cell line. J Physiol (1999) 0.98
The heat-stable antigen can alter very late antigen 4-mediated adhesion. J Exp Med (1994) 0.98
Refolding of bacteriorhodopsin. Protease V8 fragmentation and chromophore reconstitution from proteolytic V8 fragments. Eur J Biochem (1988) 0.97
Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry. Cell Death Dis (2012) 0.97
Oxygen tension modulates beta-globin switching in embryoid bodies. FASEB J (1999) 0.95
Hypoxia tolerance in animals: biology and application. Physiol Biochem Zool (2010) 0.95
Tissue-specific expression of a FMR1/beta-galactosidase fusion gene in transgenic mice. Hum Mol Genet (1995) 0.95
Isolation and characterization of human blood platelet mRNA and construction of a cDNA library in lambda gt11. Confirmation of the platelet derivation by identification of GPIb coding mRNA and cloning of a GPIb coding cDNA insert. Thromb Haemost (1989) 0.95
Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors. Biochem Biophys Res Commun (2001) 0.94
Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction. Cancer Res (1998) 0.93
Oxygen sensing, HIF-1alpha stabilization and potential therapeutic strategies. Pflugers Arch (2001) 0.92
Chronic excessive erythrocytosis induces endothelial activation and damage in mouse brain. Am J Physiol Regul Integr Comp Physiol (2005) 0.90
Oxygen-regulated expression of TGF-beta 3, a growth factor involved in trophoblast differentiation. Placenta (2003) 0.90
Expression of the Tyro4/Mek4/Cek4 gene specifically marks a subset of embryonic motor neurons and their muscle targets. Mol Cell Neurosci (1996) 0.89
The hypoxia-inducible factor-1 DNA recognition site is cAMP-responsive. Kidney Int (1997) 0.88
Hypoxia-regulated gene expression in fetal wound regeneration and adult wound repair. Pediatr Surg Int (2000) 0.88
Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes. J Appl Physiol (1985) (2011) 0.87
Expression of ErbB3, ErbB4, and neuregulin-1 mRNA during tooth development. Dev Dyn (2002) 0.86
The PAS-domain kinase PASKIN: a new sensor in energy homeostasis. Cell Mol Life Sci (2009) 0.86
Chondroitin sulphate-binding molecules may pattern central projections of sensory axons within the cranial mesenchyme of the developing mouse. Dev Biol (1999) 0.86
A polyoma-based episomal vector efficiently expresses exogenous genes in mouse embryonic stem cells. Nucleic Acids Res (1996) 0.85
Timing the arrival at 2340 m altitude for aerobic performance. Scand J Med Sci Sports (2007) 0.85
Genetically modified mouse models in studies on cutaneous wound healing. Exp Physiol (2000) 0.84