Published in Neuron on October 25, 2001
Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors. EMBO J (2005) 2.91
Imaging of receptor trafficking by using alpha-bungarotoxin-binding-site-tagged receptors. Proc Natl Acad Sci U S A (2004) 2.00
Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites. Proc Natl Acad Sci U S A (2002) 1.78
Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor. Proc Natl Acad Sci U S A (2002) 1.32
An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors. EMBO J (2003) 1.19
Tracking cell surface GABAB receptors using an alpha-bungarotoxin tag. J Biol Chem (2008) 1.12
Conotoxins targeting nicotinic acetylcholine receptors: an overview. Mar Drugs (2014) 1.09
Continuum simulations of acetylcholine diffusion with reaction-determined boundaries in neuromuscular junction models. Biophys Chem (2007) 1.09
End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease. Physiol Rev (2012) 1.06
Electron microscopic evidence for nucleation and growth of 3D acetylcholine receptor microcrystals in structured lipid-detergent matrices. Proc Natl Acad Sci U S A (2003) 1.03
Inside-out Ca(2+) signalling prompted by STIM1 conformational switch. Nat Commun (2015) 0.91
Molecular dissection of Cl--selective Cys-loop receptor points to components that are dispensable or essential for channel activity. J Biol Chem (2011) 0.87
Gamma-aminobutyric acid type B (GABA(B)) receptor internalization is regulated by the R2 subunit. J Biol Chem (2011) 0.87
A role of the sulfonylurea receptor 1 in endocytic trafficking of ATP-sensitive potassium channels. Traffic (2011) 0.85
Homology modeling and dynamics of the extracellular domain of rat and human neuronal nicotinic acetylcholine receptor subtypes alpha4beta2 and alpha7. J Mol Model (2008) 0.85
Spatial and temporal expression patterns of nicotinic acetylcholine α9 and α10 subunits in the embryonic and early postnatal inner ear. Neuroscience (2011) 0.83
Searching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function. Mol Biosyst (2009) 0.83
Snake neurotoxin α-bungarotoxin is an antagonist at native GABA(A) receptors. Neuropharmacology (2015) 0.81
Identification of a single amino acid in GluN1 that is critical for glycine-primed internalization of NMDA receptors. Mol Brain (2013) 0.80
In silico point mutation and evolutionary trace analysis applied to nicotinic acetylcholine receptors in deciphering ligand-binding surfaces. J Mol Model (2010) 0.80
Hydrophobic photolabeling studies identify the lipid-protein interface of the 5-HT3A receptor. Biochemistry (2009) 0.80
Probing pore constriction in a ligand-gated ion channel by trapping a metal ion in the pore upon agonist dissociation. J Biol Chem (2010) 0.79
Dimeric α-cobratoxin X-ray structure: localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors. J Biol Chem (2012) 0.79
K(V)4.2 channels tagged in the S1-S2 loop for alpha-bungarotoxin binding provide a new tool for studies of channel expression and localization. Channels (Austin) (2010) 0.79
Alpha-bungarotoxin binding to acetylcholine receptor membranes studied by low angle X-ray diffraction. Biophys J (2003) 0.79
Mutation of single murine acetylcholine receptor subunits reveals differential contribution of P121 to acetylcholine binding and channel opening. Pflugers Arch (2005) 0.79
α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties. PLoS One (2015) 0.78
A single mutation in the acetylcholine receptor δ-subunit causes distinct effects in two types of neuromuscular synapses. J Neurosci (2014) 0.77
Binding of long-chain alpha-neurotoxin would stabilize the resting state of nAChR: a comparative study with alpha-conotoxin. Theor Biol Med Model (2009) 0.76
Two-dimensional measurement of proton T1rho relaxation in unlabeled proteins: mobility changes in alpha-bungarotoxin upon binding of an acetylcholine receptor peptide. Biochemistry (2005) 0.76
Ringhalexin from Hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex. Sci Rep (2016) 0.76
Of snakes, snails, and surrogates. Neuron (2001) 0.75
Analysis of binding centers in nicotinic receptors with the aid of synthetic peptides. Dokl Biochem Biophys (2016) 0.75
Utrophin is lacking at the neuromuscular junctions in the extraocular muscles of normal cat: artefact or true? Histochem Cell Biol (2005) 0.75
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature (2001) 11.78
Three-dimensional tertiary structure of yeast phenylalanine transfer RNA. Science (1974) 11.02
An atypical topoisomerase II from Archaea with implications for meiotic recombination. Nature (1997) 7.06
Simultaneous comparison of three protein sequences. Proc Natl Acad Sci U S A (1985) 6.96
Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res (2004) 6.49
Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation (2004) 6.43
Catalytic properties and specificity of the extracellular nuclease of Staphylococcus aureus. J Biol Chem (1967) 6.29
The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch. Nature (2000) 6.10
The pitch of chromatin DNA is reflected in its nucleotide sequence. Proc Natl Acad Sci U S A (1980) 5.88
wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models. Acta Crystallogr D Biol Crystallogr (1997) 5.58
Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein. Proc Natl Acad Sci U S A (1997) 4.99
The general structure of transfer RNA molecules. Proc Natl Acad Sci U S A (1974) 4.30
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev (2001) 4.06
Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbB protein. Cell (1985) 4.02
Clustering of meiotic double-strand breaks on yeast chromosome III. Proc Natl Acad Sci U S A (1997) 3.98
Clinical problem-solving. Where did good old clinical diagnosis go? N Engl J Med (1997) 3.94
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry (2008) 3.85
CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma. Nature (1994) 3.70
A glia-derived acetylcholine-binding protein that modulates synaptic transmission. Nature (2001) 3.69
Specific chemical and structural damage to proteins produced by synchrotron radiation. Proc Natl Acad Sci U S A (2000) 3.53
Crystal structure of yeast phenylalanine transfer RNA. II. Structural features and functional implications. J Mol Biol (1978) 3.41
Crystal structure of yeast phenylalanine transfer RNA. I. Crystallographic refinement. J Mol Biol (1978) 3.19
Changes in chromatin structure at recombination initiation sites during yeast meiosis. EMBO J (1994) 3.16
Three-dimensional structures of avidin and the avidin-biotin complex. Proc Natl Acad Sci U S A (1993) 3.02
Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A (1993) 2.95
XUTs are a class of Xrn1-sensitive antisense regulatory non-coding RNA in yeast. Nature (2011) 2.79
RNA-ligant interactions. (I) Magnesium binding sites in yeast tRNAPhe. Nucleic Acids Res (1977) 2.79
Effect of the orientation of donor and acceptor on the probability of energy transfer involving electronic transitions of mixed polarization. Biochemistry (1978) 2.68
Conserved sequence elements upstream of the gene encoding yeast ribosomal protein L25 are involved in transcription activation. EMBO J (1986) 2.64
Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins. Protein Sci (1993) 2.55
A 3D building blocks approach to analyzing and predicting structure of proteins. Proteins (1989) 2.53
Distribution of end-to-end distances of oligopeptides in solution as estimated by energy transfer. Proc Natl Acad Sci U S A (1975) 2.50
Structure of oxidized poplar plastocyanin at 1.6 A resolution. J Mol Biol (1983) 2.41
Antigenicity of some new synthetic polypeptides and polypeptidyl gelatins. Biochem J (1964) 2.40
Open "back door" in a molecular dynamics simulation of acetylcholinesterase. Science (1994) 2.37
The nucleotide mapping of DNA double-strand breaks at the CYS3 initiation site of meiotic recombination in Saccharomyces cerevisiae. EMBO J (1995) 2.32
An improved method for the purification of staphylococcal nuclease. J Biol Chem (1967) 2.27
Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis. Proc Natl Acad Sci U S A (1990) 2.26
Recombination between similar but not identical DNA sequences during yeast transformation occurs within short stretches of identity. Cell (1992) 2.21
Experience-dependent changes in cerebral activation during human REM sleep. Nat Neurosci (2000) 2.18
An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase. Proc Natl Acad Sci U S A (1993) 2.14
Determinants of brain iron in multiple sclerosis: a quantitative 3T MRI study. Neurology (2011) 2.11
Insertional mutation of the Drosophila nuclear lamin Dm0 gene results in defective nuclear envelopes, clustering of nuclear pore complexes, and accumulation of annulate lamellae. J Cell Biol (1997) 2.07
High sensitivity and specificity of immunohistochemistry for the detection of hormone receptors in breast carcinoma: comparison with biochemical determination in a prospective study of 793 cases. Histopathology (2000) 2.06
All-D-magainin: chirality, antimicrobial activity and proteolytic resistance. FEBS Lett (1990) 2.05
The MET2 gene of Saccharomyces cerevisiae: molecular cloning and nucleotide sequence. Gene (1986) 2.04
Criteria for an increased specificity of MRI interpretation in elderly subjects with suspected multiple sclerosis. Neurology (1988) 2.03
Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors. Protein Sci (2000) 1.99
Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides. Nat Med (1995) 1.99
Refined crystal structure of dogfish M4 apo-lactate dehydrogenase. J Mol Biol (1987) 1.98
Structural features that stabilize halophilic malate dehydrogenase from an archaebacterium. Science (1995) 1.95
Homologous, homeologous, and illegitimate repair of double-strand breaks during transformation of a wild-type strain and a rad52 mutant strain of Saccharomyces cerevisiae. Mol Cell Biol (1994) 1.92
The control in cis of the position and the amount of the ARG4 meiotic double-strand break of Saccharomyces cerevisiae. EMBO J (1993) 1.91
Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 1. General introduction. J Biol Chem (1976) 1.91
GermOnline, a cross-species community knowledgebase on germ cell differentiation. Nucleic Acids Res (2004) 1.90
Preferential codon usage in genes. Gene (1981) 1.90
Adenine-guanine base pairing ribosomal RNA. Nucleic Acids Res (1982) 1.89
Protein Data Bank archives of three-dimensional macromolecular structures. Methods Enzymol (1997) 1.89
Crystal structure of a naturally occurring dinucleoside phoaphate: uridylyl 3',5'-adenosine phosphate model for RNA chain folding. J Mol Biol (1972) 1.87
Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia. Mol Psychiatry (2011) 1.86
POL32, a subunit of the Saccharomyces cerevisiae DNA polymerase delta, defines a link between DNA replication and the mutagenic bypass repair pathway. Curr Genet (2000) 1.82
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A. Nat Struct Biol (1997) 1.76
Crystal structure of a eukaryotic initiator tRNA. Nature (1979) 1.75
Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA. EMBO J (1997) 1.75
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure (1999) 1.74
Idealized atomic coordinates of yeast phenylalanine transfer RNA. Biochem Biophys Res Commun (1976) 1.73
Initiation of recombination in Saccharomyces cerevisiae haploid meiosis. Proc Natl Acad Sci U S A (1994) 1.72
Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system. J Biol Chem (1997) 1.71
The Saccharomyces cerevisiae ARG4 initiator of meiotic gene conversion and its associated double-strand DNA breaks can be inhibited by transcriptional interference. Proc Natl Acad Sci U S A (1992) 1.71
B-type cyclins CLB5 and CLB6 control the initiation of recombination and synaptonemal complex formation in yeast meiosis. Curr Biol (2001) 1.70
Acetylcholinesterase: electrostatic steering increases the rate of ligand binding. Biochemistry (1993) 1.69
Immunological assay for plant hormones using specific antibodies to indoleacetic acid and gibberellic acid. Biochim Biophys Acta (1969) 1.68
Immunological studies of plant hormones. Detection and estimation by immunological assays. Eur J Biochem (1971) 1.68
Recombination at work for meiosis. Curr Opin Genet Dev (1998) 1.67
Reinfection with rubella in pregnant women. Lancet (1971) 1.67
Humoral antibodies to acetylcholine receptor in patients with myasthenia gravis. Lancet (1975) 1.66
Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment. Eur J Neurosci (2011) 1.64
Angiogenesis therapy: amidst the hype, the neglected potential for serious side effects. Circulation (2001) 1.64
Functional hierarchy between two OSE2 elements in the control of osteocalcin gene expression in vivo. J Biol Chem (1998) 1.63
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry (2010) 1.63
Dissociation between bone resorption and bone formation in osteopenic transgenic mice. Proc Natl Acad Sci U S A (1998) 1.63
EEG and cardiac activation during periodic leg movements in sleep: support for a hierarchy of arousal responses. Neurology (1999) 1.62
Aberrant 4:4 asci, disparity in the direction of conversion, and frequencies of conversion in Ascobolus immersus. Cold Spring Harb Symp Quant Biol (1979) 1.61
Hydrogen bonding in yeast phenylalanine transfer RNA. Proc Natl Acad Sci U S A (1975) 1.60
Cellular immune response to acetylcholine receptor-rich fraction, in patients with myasthenia gravis. Clin Exp Immunol (1975) 1.59
Insights into protein adaptation to a saturated salt environment from the crystal structure of a halophilic 2Fe-2S ferredoxin. Nat Struct Biol (1996) 1.58
Possibility of nonkinked packing of DNA in chromatin. Proc Natl Acad Sci U S A (1978) 1.58
Structure of a human lysosomal sulfatase. Structure (1997) 1.57
Origins of gene conversion and reciprocal exchange in Ascobolus. Cold Spring Harb Symp Quant Biol (1984) 1.57
In vitro proliferative responses and antibody titers specific to human acetylcholine receptor synthetic peptides in patients with myasthenia gravis and relation to HLA class II genes. J Clin Invest (1988) 1.57
Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level. Biochemistry (1999) 1.55
Links between replication and recombination in Saccharomyces cerevisiae: a hypersensitive requirement for homologous recombination in the absence of Rad27 activity. Proc Natl Acad Sci U S A (2001) 1.54
The renal effect of low-dose dopamine in high-risk patients undergoing coronary angiography. J Am Coll Cardiol (1999) 1.53
Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target. Structure (1995) 1.52
Cutinase, a lipolytic enzyme with a preformed oxyanion hole. Biochemistry (1994) 1.51
Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine. Biochemistry (2002) 1.49
Mutations in the MRE11, RAD50, XRS2, and MRE2 genes alter chromatin configuration at meiotic DNA double-stranded break sites in premeiotic and meiotic cells. Proc Natl Acad Sci U S A (1998) 1.49