PubRank

T H Ottenhoff

Author PubWeight™ 100.88‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science 1998 4.24
2 Selection of a human T helper type 1-like T cell subset by mycobacteria. J Exp Med 1991 3.41
3 Detection of active tuberculosis infection by T cell responses to early-secreted antigenic target 6-kDa protein and culture filtrate protein 10. J Infect Dis 2000 2.70
4 Mycobacterium leprae-specific protein antigens defined by cloned human helper T cells. Nature 1986 2.59
5 Antigenic equivalence of human T-cell responses to Mycobacterium tuberculosis-specific RD1-encoded protein antigens ESAT-6 and culture filtrate protein 10 and to mixtures of synthetic peptides. Infect Immun 2000 2.29
6 Purification of his-tagged proteins by immobilized chelate affinity chromatography: the benefits from the use of organic solvent. Protein Expr Purif 2000 2.00
7 Binary and ternary complexes between T-cell receptor, class II MHC and superantigen in vitro. Nature 1994 1.79
8 Cloned suppressor T cells from a lepromatous leprosy patient suppress Mycobacterium leprae reactive helper T cells. Nature 1986 1.69
9 Mannose receptor-mediated uptake of antigens strongly enhances HLA class II-restricted antigen presentation by cultured dendritic cells. Eur J Immunol 1997 1.60
10 Improved immunogenicity and protective efficacy of a tuberculosis DNA vaccine encoding Ag85 by protein boosting. Infect Immun 2001 1.60
11 Molecular and immunological analysis of a fibronectin-binding protein antigen secreted by Mycobacterium leprae. Mol Microbiol 1992 1.59
12 HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading. Curr Biol 1997 1.57
13 Use of ESAT-6 and CFP-10 antigens for diagnosis of extrapulmonary tuberculosis. J Infect Dis 2001 1.56
14 Selective stimulation of T helper 2 cytokine responses by the anti-psoriasis agent monomethylfumarate. Eur J Immunol 1996 1.52
15 Identification of major epitopes of Mycobacterium tuberculosis AG85B that are recognized by HLA-A*0201-restricted CD8+ T cells in HLA-transgenic mice and humans. J Immunol 2000 1.48
16 Tuberculin skin testing compared with T-cell responses to Mycobacterium tuberculosis-specific and nonspecific antigens for detection of latent infection in persons with recent tuberculosis contact. Clin Diagn Lab Immunol 2001 1.45
17 Evidence for an HLA-DR4-associated immune-response gene for Mycobacterium tuberculosis. A clue to the pathogenesis of rheumatoid arthritis? Lancet 1986 1.43
18 The reconstitution of cell-mediated immunity in the cutaneous lesions of lepromatous leprosy by recombinant interleukin 2. J Exp Med 1989 1.39
19 Analysis of cytokine production by Mycobacterium-reactive T cells. Failure to explain Mycobacterium leprae-specific nonresponsiveness of peripheral blood T cells from lepromatous leprosy patients. J Immunol 1993 1.33
20 Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides. J Immunol 1992 1.27
21 Mycobacteria induce CD4+ T cells that are cytotoxic and display Th1-like cytokine secretion profile: heterogeneity in cytotoxic activity and cytokine secretion levels. Eur J Immunol 1993 1.26
22 Natural T-helper immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: identification of 3 human leukocyte antigen class II-restricted epitopes. Int J Cancer 2001 1.25
23 High-efficiency expression and solubilization of functional T cell antigen receptor heterodimers. Science 1992 1.18
24 Molecular localization and polymorphism of HLA class II restriction determinants defined by Mycobacterium leprae-reactive helper T cell clones from leprosy patients. J Exp Med 1986 1.18
25 Induction of antigen-specific CD4+ HLA-DR-restricted cytotoxic T lymphocytes as well as nonspecific nonrestricted killer cells by the recombinant mycobacterial 65-kDa heat-shock protein. Eur J Immunol 1990 1.18
26 HLA-DR3 molecules can bind peptides carrying two alternative specific submotifs. J Immunol 1994 1.14
27 T cell epitopes on the 36K and 65K Mycobacterium leprae antigens defined by human T cell clones. Eur J Immunol 1988 1.13
28 Increased intracellular survival of Mycobacterium smegmatis containing the Mycobacterium leprae thioredoxin-thioredoxin reductase gene. Infect Immun 1997 1.10
29 Identification of HLA class II-restricted determinants of Mycobacterium tuberculosis-derived proteins by using HLA-transgenic, class II-deficient mice. Proc Natl Acad Sci U S A 1998 1.10
30 HLA class II restriction repertoire of antigen-specific T cells. I. The main restriction determinants for antigen presentation are associated with HLA-D/DR and not with DP and DQ. Hum Immunol 1985 1.10
31 Uncommon presentations of tuberculosis: the potential value of a novel diagnostic assay based on the Mycobacterium tuberculosis-specific antigens ESAT-6 and CFP-10. Int J Tuberc Lung Dis 2001 1.10
32 Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor beta1 (IL-12Rbeta1): evidence for an IL-12Rbeta1-independent pathway of IL-12 responsiveness in human T cells. J Exp Med 2000 1.09
33 Cellular, humoral, and gamma interferon responses to Mycobacterium leprae and BCG antigens in healthy individuals exposed to leprosy. Scand J Immunol 1988 1.08
34 Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10. Blood 2000 1.07
35 Evolutionary conservation of major histocompatibility complex-DR/peptide/T cell interactions in primates. J Exp Med 1993 1.04
36 Identification of Mycobacterium leprae antigens from a cosmid library: characterization of a 15-kilodalton antigen that is recognized by both the humoral and cellular immune systems in leprosy patients. Infect Immun 1991 1.04
37 [Research into new methods for diagnosing, treating and preventing tuberculosis]. Ned Tijdschr Geneeskd 2003 1.02
38 Immunological and functional characterization of Mycobacterium leprae protein antigens: an overview. Mol Microbiol 1995 1.01
39 Identification of a conserved universal Th epitope in HIV-1 reverse transcriptase that is processed and presented to HIV-specific CD4+ T cells by at least four unrelated HLA-DR molecules. J Immunol 1999 1.00
40 A systematic molecular analysis of the T cell-stimulating antigens from Mycobacterium leprae with T cell clones of leprosy patients. Identification of a novel M. leprae HSP 70 fragment by M. leprae-specific T cells. J Immunol 1991 1.00
41 Unresponsiveness to Mycobacterium leprae in lepromatous leprosy in vitro: reversible or not? Int J Lepr Other Mycobact Dis 1984 1.00
42 HLA class-II-restricted Mycobacterium leprae-reactive T-cell clones from leprosy patients established with a minimal requirement for autologous mononuclear cells. Scand J Immunol 1986 0.96
43 Immunization with human papillomavirus type 16 (HPV16) oncoprotein-loaded dendritic cells as well as protein in adjuvant induces MHC class I-restricted protection to HPV16-induced tumor cells. Cancer Res 1998 0.95
44 HLA-DR binding analysis of peptides from islet antigens in IDDM. Diabetes 1998 0.92
45 Novel mechanisms in the immunopathogenesis of leprosy nerve damage: the role of Schwann cells, T cells and Mycobacterium leprae. Immunol Cell Biol 2000 0.91
46 The identification of a common pathogen-specific HLA class I A*0201-restricted cytotoxic T cell epitope encoded within the heat shock protein 65. Eur J Immunol 2001 0.91
47 Mapping of multiple HLA class II-restricted T-cell epitopes of the mycobacterial 70-kilodalton heat shock protein. Infect Immun 1994 0.91
48 The mammalian cell entry operon 1 (mce1) of mycobacterium leprae and mycobacterium tuberculosis. Microb Pathog 1999 0.91
49 Identification and functional characterization of thioredoxin of Mycobacterium tuberculosis. Infect Immun 1995 0.90
50 Binding of a major T cell epitope of mycobacteria to a specific pocket within HLA-DRw17(DR3) molecules. Eur J Immunol 1992 0.90
51 Human suppressor T cell clones lack CD28. Eur J Immunol 1990 0.90
52 HLA class II+ human keratinocytes present Mycobacterium leprae antigens to CD4+ Th1-like cells. Scand J Immunol 1993 0.90
53 Clip binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs. Mol Immunol 1995 0.90
54 Purification and functional analysis of the Mycobacterium leprae thioredoxin/thioredoxin reductase hybrid protein. J Biol Chem 1995 0.88
55 Multifocal osteomyelitis caused by nontuberculous mycobacteria in patients with a genetic defect of the interferon-gamma receptor. Neth J Med 2001 0.88
56 HLA class-II immune response genes and products in leprosy. Prog Allergy 1985 0.87
57 Cellular immune response to human cartilage glycoprotein-39 (HC gp-39)-derived peptides in rheumatoid arthritis and other inflammatory conditions. Rheumatology (Oxford) 2000 0.87
58 Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries. J Immunol 1998 0.87
59 T cell receptor and peptide-contacting residues in the HLA-DR17(3) beta 1 chain. Eur J Immunol 1994 0.86
60 Epstein-Barr virus-transformed B cell lines present M. leprae antigens to T cells. Scand J Immunol 1985 0.86
61 Human leukocyte antigens (HLA) and mycobacterial disease. Springer Semin Immunopathol 1988 0.85
62 Mycobacterium leprae-specific, HLA class II-restricted killing of human Schwann cells by CD4+ Th1 cells: a novel immunopathogenic mechanism of nerve damage in leprosy. J Immunol 2001 0.85
63 Molecular mimicry in diabetes mellitus: the homologous domain in coxsackie B virus protein 2C and islet autoantigen GAD65 is highly conserved in the coxsackie B-like enteroviruses and binds to the diabetes associated HLA-DR3 molecule. Diabetologia 1998 0.85
64 IL-2 and IL-12 act in synergy to overcome antigen-specific T cell unresponsiveness in mycobacterial disease. J Immunol 1997 0.85
65 Definition of a human suppressor T-cell epitope. Proc Natl Acad Sci U S A 1994 0.85
66 Association of HLA specificity LB-E12 (MB1, DC1, MT1) with lepromatous leprosy in a Venezuelan population. Tissue Antigens 1984 0.84
67 A method for producing monoclonal antibodies to human T-cell-receptor beta-chain variable regions. Proc Natl Acad Sci U S A 1993 0.84
68 HLA class II restriction repertoire of antigen-specific T cells. II. Evidence for a new restriction determinant associated with DRw52 and LB-Q1. Hum Immunol 1985 0.82
69 Immunology of Leprosy: lessons from and for leprosy. Int J Lepr Other Mycobact Dis 1994 0.81
70 HLA-class II-associated control of antigen recognition by T cells in leprosy: a prominent role for the 30/31-kDa antigens. J Immunol 1999 0.80
71 Flexibility in T-cell receptor ligand repertoires depends on MHC and T-cell receptor clonotype. Immunology 1997 0.80
72 Bronchoalveolar lavage cells from sarcoidosis patients and healthy controls can efficiently present antigens. J Intern Med 1999 0.79
73 Altered peptide ligands of islet autoantigen Imogen 38 inhibit antigen specific T cell reactivity in human type-1 diabetes. J Autoimmun 1998 0.79
74 A DR17-restricted T cell epitope from a secreted Mycobacterium tuberculosis antigen only binds to DR17 molecules at neutral pH. Eur J Immunol 1997 0.78
75 HLA-DR/DQ transgenic, class II deficient mice as a novel model to select for HSP T cell epitopes with immunotherapeutic or preventative vaccine potential. Biotherapy 1998 0.78
76 HLA class II restricted helper and suppressor clones reactive with Mycobacterium leprae. Lepr Rev 1986 0.78
77 Role of the CDR1 region of the TCR beta chain in the binding to purified MHC-peptide complex. Int Immunol 1994 0.78
78 Putting numbers on mycobacterium activated T cell subsets. Clin Exp Immunol 1996 0.78
79 Mannose receptor mediated uptake of antigens strongly enhances HLA-class II restricted antigen presentation by cultured dendritic cells. Adv Exp Med Biol 1997 0.78
80 A novel, highly efficient peptide-HLA class I binding assay using unfolded heavy chain molecules: identification of HIV-1 derived peptides that bind to HLA-A*0201 and HLA-A*0301. J Immunol Methods 1997 0.78
81 Presence of human T-cell responses to the Mycobacterium leprae 45-kilodalton antigen reflects infection with or exposure to M. leprae. Clin Diagn Lab Immunol 2001 0.78
82 Limitations of homology searching for identification of T-cell antigens with library derived mimicry epitopes. Vaccine 1999 0.77
83 Mycobacterium leprae-specific T cells from a tuberculoid leprosy patient suppress HLA-DR3-restricted T cell responses to an immunodominant epitope on 65-kDa hsp of mycobacteria. J Immunol 1990 0.77
84 The biologic importance of conserved major histocompatibility complex class II motifs in primates. Hum Immunol 1993 0.77
85 The impact of DR3 microvariation on peptide binding: the combinations of specific DR beta residues critical to binding differ for different peptides. Hum Immunol 1996 0.76
86 HLA antigens and neural reversal reactions in Ethiopian borderline tuberculoid leprosy patients. Int J Lepr Other Mycobact Dis 1987 0.76
87 First International Conference on the Pathogenesis of Mycobacterial Infections: a summary. Clin Infect Dis 1992 0.76
88 T cell receptor structure and function: analysis by expression of portions of isolated subunits. Adv Exp Med Biol 1992 0.76
89 Intradermal recombinant interleukin 2 enhances peripheral blood T-cell responses to mitogen and antigens in patients with lepromatous leprosy. Scand J Immunol 1990 0.75
90 Infections with non-tuberculous mycobacteria and salmonellae in patients with genetic defects in the interleukin-12/interferon-gamma-mediated pathway of macrophage activation. Neth J Med 2001 0.75
91 The role of Schwann cells, T cells and Mycobacterium leprae in the immunopathogenesis of nerve damage in leprosy. Lepr Rev 2000 0.75
92 Susceptibility alleles at HLA-DRB1, -DQA1, and -DQB1 loci in Ethiopian childhood insulin-dependent diabetes mellitus. Hum Immunol 1994 0.75
93 [From gene to disease; mutations in interleukin-12-receptor-beta 1- and interferon-gamma-receptor-1 lead to nontuberculous mycobacterial infections and salmonellosis]. Ned Tijdschr Geneeskd 2000 0.75
94 Allorecognition of artificial nerve guides filed with human Schwann cells: an in vitro piloot study. Transplantation 2000 0.75
95 HLA-DR and -DQ antigens in malnutrition-related diabetes mellitus in Ethiopians: a clue to its etiology? Tissue Antigens 1989 0.75
96 Antibodies to sulfatide in leprosy and leprosy reactions. Am J Trop Med Hyg 1999 0.75
97 Setting a course for intervening in host-pathogen interactions. Trends Immunol 2001 0.75
98 Repeatedly negative tuberculin skin tests followed by active tuberculosis in an immunocompetent individual. Neth J Med 2001 0.75