About the possible origin and mechanism of circulating DNA apoptosis and active DNA release.

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Published in Clin Chim Acta on November 01, 2001

Authors

M Stroun1, J Lyautey, C Lederrey, A Olson-Sand, P Anker

Author Affiliations

1: Lab de Biochimie et Physiologie Vegetale, Faculté des Sciences, Pavillon des Isotopes, bvd d'Yvoy 20, 1211, Geneva, Switzerland.

Associated clinical trials:

ctDNA for Prediction of Relapse in Gastric Cancer | NCT02887612

Dynamic Monitoring Circulating Tumor DNA in Surgical Patients With Lung Cancer (DMLCctDNA) | NCT03317080

Chemotherapy and Immunotherapy as Treatment for MSS Metastatic Colorectal Cancer With High Immune Infiltrate (POCHI) | NCT04262687

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DNA replication in Solanum lycopersicum esc. after absorption of bacterial DNA. Curr Mod Biol (1967) 1.11

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Nucleic acids spontaneously released by living frog auricles. Biochem J (1972) 0.92

Circulating nucleic acids in higher organisms. Int Rev Cytol (1977) 0.92

Translocation of DNA of bacterial origin in Lycopersicum esculentum by ultracentrifugation in caesium chloride gradient. Nature (1967) 0.91

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The use of genetic instability as a clinical tool for cancer diagnosis. Semin Cancer Biol (1998) 0.89

The role of extracellular DNA in the transfer of information from T to B human lymphocytes in the course of an immune response. J Immunogenet (1980) 0.88

Neutral carrier based ion-selective electrode for the determination of total calcium in blood serum. Anal Chem (1981) 0.86

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Potentiometry of Na+ in undiluted serum and urine with use of an improved neutral carrier-based solvent polymeric membrane electrode. Clin Chem (1983) 0.84

Bacterial ribonucleic acid in the frog brain after a bacterial peritoneal infection. Science (1972) 0.84

Spontaneous extracellular synthesis of DNA released by human blood lymphocytes. Cancer Res (1976) 0.84

[Transformation of NIH/3T3 cells and SW 480 cells displaying K-ras mutation]. C R Acad Sci III (1994) 0.84

Metabolic DNA in heart and skeletal muscle and in the intestine of mice. Nature (1967) 0.83

In vitro synthesis of DNA spontaneously released by bacteria or frog auricles. Biochimie (1972) 0.82

Circulating DNA in higher organisms cancer detection brings back to life an ignored phenomenon. Cell Mol Biol (Noisy-le-grand) (2005) 0.82

Bacterial nature of radioactive DNA found in tomato plants incubated in the presence of bacterial DNA-3H. Nature (1968) 0.82

Information carried by the DNA released by antigen-stimulated lymphocytes. Immunology (1979) 0.80

Neutral carrier sodium ion-selective microelectrode for extracellular studies. Neurosci Lett (1985) 0.79

Nude mice injected with DNA released by antigen stimulated human T lymphocytes produce specific antibodies expressing human characteristics. Cell Biochem Funct (1984) 0.77

Bacterial ribonucleic acid synthesis in frog organs after intraperitoneal injection of bacteria. Biochem J (1972) 0.75

Transfer of genetic information from T to B lymphocytes in the course of an immune response. Biomedicine (1979) 0.75

Transcription of spontaneously released bacterial deoxyribonucleic acid in frog auricles. J Bacteriol (1973) 0.75

[Characteristics of nucleic acids excreted by non-stimulated normal human lymphocytes]. Schweiz Med Wochenschr (1977) 0.75

Bacterial RNA synthesis in frog auricles after intraperitoneal injection of bacteria. Experientia (1972) 0.75

[Transfer of genetic information from T to B human lymphocytes during an immune response to herpes simplex virus]. C R Seances Acad Sci D (1979) 0.75

Increased sensitivity of chronic lymphocytic leukemia lymphocytes to alkylating agents due to a deficient DNA repair mechanism. Eur J Cancer (1977) 0.75

Spontaneous release of DNA by living cells [proceedings]. Riv Istochim Norm Patol (1976) 0.75

Determination of [K+] in blood serum with a valinomycin-based silicone rubber membrane of universal applicability to body fluids. Clin Chem (1983) 0.75

Estimation of circadian variations in cell cycle phase durations in murine epidermal basal cells. Cell Tissue Kinet (1985) 0.75

Ion-selective electrodes and their clinical application in the continuous ion monitoring. Ann N Y Acad Sci (1984) 0.75

Neutral carrier electrode for continuous measurement of blood Ca2+ in the extracorporeal circulation. Clin Chem (1984) 0.75

Metabolic DNA in spinach stems in connexion with ageing. Nat New Biol (1971) 0.75

Effect of temperature on the translocation of bacterial DNA in Solanum lycopersicum Esc. Experientia (1968) 0.75

Effect of sodium citrate on the translocation of bacterial DNA in Solanum lycopersicum esc. Experientia (1968) 0.75

[Repair synthesis of DNA in normal and leukemic lymphocytes damaged by an alkylating agent. Inhibition of repair synthesis by caffeine. Preliminary report]. Schweiz Med Wochenschr (1974) 0.75

Effects of light on the translocation of bacterial DNA in Solanum lycopersicum esc. Experientia (1967) 0.75

[Transfer of information from T and B lymphocytes during immune response: role of extracellular DNA]. Schweiz Med Wochenschr (1980) 0.75

Nude mice injected with DNA excreted by antigen-stimulated human T lymphocytes synthesize specific human antibodies. Exp Cell Biol (1984) 0.75

Do leukaemic lymphocytes differ from normal lymphocytes in their ability to repair DNA damage [proceedings]? Riv Istochim Norm Patol (1976) 0.75

[Violence against children... ]. Osterr Pflegezeitschrift (2001) 0.75

[A biochemical and cytological study of the penetration of desoxyribonucleic acid in plants]. Arch Int Physiol Biochim (1966) 0.75

[Fate of DNA of bacterial origin after its migration into plants]. Arch Int Physiol Biochim (1966) 0.75