Published in Annu Rev Genomics Hum Genet on January 01, 2000
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Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A (2008) 2.38
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Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. Mol Neurodegener (2016) 1.38
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LDLR expression and localization are altered in mouse and human cell culture models of Alzheimer's disease. PLoS One (2010) 1.32
The C-terminal alpha-helix domain of apolipoprotein E is required for interaction with nonstructural protein 5A and assembly of hepatitis C virus. J Virol (2010) 1.31
Hepatitis C virus attachment mediated by apolipoprotein E binding to cell surface heparan sulfate. J Virol (2012) 1.28
Connectomic intermediate phenotypes for psychiatric disorders. Front Psychiatry (2012) 1.26
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The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE. Neurobiol Aging (2010) 1.25
Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels. J Biol Chem (2011) 1.23
Evidence for defective retinoid transport and function in late onset Alzheimer's disease. Proc Natl Acad Sci U S A (2003) 1.23
Vascular complications of cystathionine β-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research. Am J Physiol Heart Circ Physiol (2010) 1.23
Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism. Am J Hum Genet (2002) 1.22
Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease. Cardiovasc Diabetol (2012) 1.21
Haplotype information and linkage disequilibrium mapping for single nucleotide polymorphisms. Genome Res (2003) 1.21
A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade. Proc Natl Acad Sci U S A (2004) 1.18
Apolipoprotein E/C1 locus variants modify renal cell carcinoma risk. Cancer Res (2009) 1.18
HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging. Aging Cell (2010) 1.16
Mining genetic epidemiology data with Bayesian networks application to APOE gene variation and plasma lipid levels. J Comput Biol (2005) 1.15
The immune-modulatory role of apolipoprotein E with emphasis on multiple sclerosis and experimental autoimmune encephalomyelitis. Clin Dev Immunol (2010) 1.15
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Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice. J Neuroinflammation (2006) 1.14
Role of apolipoprotein E4 in protecting children against early childhood diarrhea outcomes and implications for later development. Med Hypotheses (2006) 1.14
Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology. J Med Chem (2012) 1.13
Family history of gallstones and the risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. Int J Cancer (2007) 1.13
Molecular mechanism of apolipoprotein E binding to lipoprotein particles. Biochemistry (2009) 1.11
Apolipoprotein epsilon3 allele is associated with persistent hepatitis C virus infection. Gut (2005) 1.11
Mixed modeling and multiple imputation for unobservable genotype clusters. Stat Med (2008) 1.10
Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers. AIDS (2012) 1.09
Hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry determine the interface and dynamics of apolipoprotein E oligomerization. Biochemistry (2011) 1.09
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Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience. Genet Med (2008) 1.08
Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease. J Alzheimers Dis (2013) 1.07
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Lipids, lipoproteins, and age-related macular degeneration. J Lipids (2011) 1.05
Lipoprotein metabolism, dyslipidemia, and nonalcoholic fatty liver disease. Semin Liver Dis (2013) 1.05
Age-related differences in white matter integrity and cognitive function are related to APOE status. Neuroimage (2010) 1.04
Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis. Free Radic Biol Med (2013) 1.03
A unified scheme for initiation and conformational adaptation of human apolipoprotein E N-terminal domain upon lipoprotein binding and for receptor binding activity. J Biol Chem (2009) 1.03
Dietary monounsaturated fat activates metabolic pathways for triglyceride-rich lipoproteins that involve apolipoproteins E and C-III. Am J Clin Nutr (2008) 1.03
Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals. Int J Epidemiol (2013) 1.03
Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China. Cancer Epidemiol Biomarkers Prev (2008) 1.01
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An optimized negative-staining protocol of electron microscopy for apoE4 POPC lipoprotein. J Lipid Res (2009) 1.00
Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. Proc Natl Acad Sci U S A (2008) 1.00
Elevated high-density lipoprotein cholesterol and age-related macular degeneration: the Alienor study. PLoS One (2014) 0.99
Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells. Mol Neurodegener (2009) 0.99
Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease. Alzheimers Res Ther (2013) 0.99
ApoE suppresses atherosclerosis by reducing lipid accumulation in circulating monocytes and the expression of inflammatory molecules on monocytes and vascular endothelium. Arterioscler Thromb Vasc Biol (2011) 0.98
Apolipoprotein E alleles can contribute to the pathogenesis of numerous clinical conditions including HSV-1 corneal disease. Exp Eye Res (2006) 0.98
Ocular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated? Future Microbiol (2011) 0.97
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Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study. BMC Med Genet (2009) 0.96
Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease. PLoS One (2013) 0.96
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