Polymorphism in the alpha(1)-antichymotrypsin (ACT) gene promoter: effect on expression in transfected glial and liver cell lines and plasma ACT concentrations.

PubWeight™: 0.80‹?›

🔗 View Article (PMID 11702211)

Published in Hum Genet on September 01, 2001

Authors

K Morgan1, F Licastro, L Tilley, A Ritchie, L Morgan, S Pedrini, N Kalsheker

Author Affiliations

1: Division of Clinical Chemistry, School of Clinical Laboratory Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.

Articles by these authors

(truncated to the top 100)

Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS). Nucleic Acids Res (1989) 15.35

The most primitive osteichthyan braincase? Nature (2000) 4.91

Use of anti-inflammatory drugs by patients admitted with small or large bowel perforations and haemorrhage. Br Med J (Clin Res Ed) (1985) 4.30

Diagnosis of alpha 1-antitrypsin deficiency by enzymatic amplification of human genomic DNA and direct sequencing of polymerase chain reaction products. Nucleic Acids Res (1988) 3.00

High resolution analysis of haplotype diversity and meiotic crossover in the human TAP2 recombination hotspot. Hum Mol Genet (2000) 2.67

Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents. Pharmacol Ther (1998) 2.53

Are problem drinkers dangerous drivers? An investigation of arrest for drinking and driving, serum gamma glutamyltranspeptidase activities, blood alcohol concentrations, and road traffic accidents: the Tayside Safe Driving Project. Br Med J (Clin Res Ed) (1985) 2.36

APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol Psychiatry (2011) 2.31

Trafficking and assembly of the cytoadherence complex in Plasmodium falciparum-infected human erythrocytes. EMBO J (2001) 2.17

Year one dental visit. Pediatr Dent (2001) 2.14

Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism. Ann Neurol (2000) 1.99

Increased plasma levels of interleukin-1, interleukin-6 and alpha-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain? J Neuroimmunol (2000) 1.76

Metabolism and translocation of allantoin in ureide-producing grain legumes. Plant Physiol (1982) 1.68

Use of community genetic screening to prevent HFE-associated hereditary haemochromatosis. Lancet (2005) 1.68

Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials. Biochem J (1999) 1.62

The isolation of a clone for human alpha 1-antitrypsin and the detection of alpha 1-antitrypsin in mRNA from liver and leukocytes. Biochem Biophys Res Commun (1983) 1.62

Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD. Eur Respir J (2008) 1.59

De Novo Purine Synthesis in Nitrogen-Fixing Nodules of Cowpea (Vigna unguiculata [L.] Walp.) and Soybean (Glycine max [L.] Merr.). Plant Physiol (1982) 1.54

Common variable immunodeficiency: how many diseases? Immunol Today (1997) 1.48

Three markers of adult non-myelin-forming Schwann cells, 217c(Ran-1), A5E3 and GFAP: development and regulation by neuron-Schwann cell interactions. Development (1990) 1.47

Variation in the tumour necrosis factor gene is not associated with susceptibility to COPD. Eur Respir J (2007) 1.45

A review of the effects of exercise on appetite regulation: an obesity perspective. Int J Obes (Lond) (2008) 1.45

The use of antisense mRNA to inhibit the tonoplast H+ ATPase in carrot. Plant Cell (1992) 1.43

The ring-infected erythrocyte surface antigen of Plasmodium falciparum associates with spectrin in the erythrocyte membrane. Mol Biochem Parasitol (1991) 1.41

Inhibition of heme detoxification processes underlies the antimalarial activity of terpene isonitrile compounds from marine sponges. J Med Chem (2001) 1.41

Gardnerella vaginalis in prepubertal girls. Am J Dis Child (1987) 1.34

Inaccurate in vivo plasma potassium measurements due to in vitro changes in unseparated blood. Clin Chem (1984) 1.31

Models for respiratory cancer in nickel refinery workers. J Natl Cancer Inst (1986) 1.30

The Plasmodium falciparum protein RESA interacts with the erythrocyte cytoskeleton and modifies erythrocyte thermal stability. Mol Biochem Parasitol (1994) 1.27

Effect of type of haematology analyser on CD4 count. Lancet (1992) 1.26

Evidence for a role for a Plasmodium falciparum homologue of Sec31p in the export of proteins to the surface of malaria parasite-infected erythrocytes. J Cell Sci (2001) 1.25

The Schwann cell precursor and its fate: a study of cell death and differentiation during gliogenesis in rat embryonic nerves. Neuron (1994) 1.24

The oral glucose tolerance test (OGTT): effect of rate of ingestion of carbohydrate and different carbohydrate preparations. Diabetes Care (1989) 1.22

A homologue of Sar1p localises to a novel trafficking pathway in malaria-infected erythrocytes. Eur J Cell Biol (1999) 1.21

Thyroid disease in the elderly. Part 2. Predictability of subclinical hypothyroidism. J Fam Pract (1994) 1.20

Intraocular pressure-lowering efficacy of bimatoprost 0.03% and travoprost 0.004% in patients with glaucoma or ocular hypertension. Br J Ophthalmol (2006) 1.18

Arthritis self-management program variations: three studies. Arthritis Care Res (1998) 1.18

Thyroid disease in the elderly. Part 1. Prevalence of undiagnosed hypothyroidism. J Fam Pract (1994) 1.16

Changes in DNA synthesis rate in the Schwann cell lineage in vivo are correlated with the precursor--Schwann cell transition and myelination. Eur J Neurosci (1993) 1.16

Heterogeneity of the respiratory syncytial virus 22K protein revealed by Western blotting with monoclonal antibodies. J Gen Virol (1987) 1.16

An mRNA from human brain encodes an isoform of the B subunit of the vacuolar H(+)-ATPase. J Biol Chem (1990) 1.14

Quinoline antimalarials: mechanisms of action and resistance. Int J Parasitol (1997) 1.13

Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling. J Cell Biol (1999) 1.12

The purification of four respiratory syncytial virus proteins and their evaluation as protective agents against experimental infection in BALB/c mice. J Gen Virol (1988) 1.11

Altered postprandial hormone and metabolic responses in a simulated shift work environment. J Endocrinol (1998) 1.11

Switch recombination breakpoints are strictly correlated with DNA recognition motifs for immunoglobulin S gamma 3 DNA-binding proteins. J Exp Med (1992) 1.10

Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin. The significance of the intrinsic GTPase rate in determining the transforming ability of ras. J Biol Chem (1993) 1.09

Elective ilioinguinal lymph node irradiation. Int J Radiat Oncol Biol Phys (1984) 1.08

Proteinase inhibitory function in inflammatory lung disease. I. Acute bacterial pneumonia. Am Rev Respir Dis (1984) 1.08

Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine. Biochem Pharmacol (1996) 1.08

Erythrocyte membrane vesiculation: model for the molecular mechanism of protein sorting. Proc Natl Acad Sci U S A (1997) 1.07

The composition of intracellular granules from the metal-accumulating cells of the common garden snail (Helix aspersa). Biochem J (1981) 1.07

Role of cyclic AMP and proliferation controls in Schwann cell differentiation. Ann N Y Acad Sci (1991) 1.06

Targeting the EGF receptor in ovarian cancer with the tyrosine kinase inhibitor ZD 1839 ("Iressa"). Br J Cancer (2002) 1.05

A polymorphism in the tumor necrosis factor-alpha gene promoter region may predispose to a poor prognosis in COPD. Chest (2000) 1.04

Molecular basis of the Rh antigen RH48 (JAL). Vox Sang (2008) 1.04

Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease. J Med Genet (2004) 1.04

Serum immunoglobulins and lymphocyte subpopulations derangement in Turner's syndrome. J Immunogenet (1981) 1.03

An assessment of the fluidity gradient of the lipid bilayer as determined by a set of n-(9-anthroyloxy) fatty acids (n = 2, 6, 9, 12, 16). J Biol Chem (1979) 1.03

Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo. Cancer Res (1992) 1.03

Angiotensinogen: molecular biology, biochemistry and physiology. Int J Biochem Cell Biol (1996) 1.02

Genetic factors regulating inflammation and DNA methylation associated with prostate cancer. Prostate Cancer Prostatic Dis (2012) 1.02

DNA polymorphisms of the human alpha 1 antitrypsin gene in normal subjects and in patients with pulmonary emphysema. J Med Genet (1987) 1.02

Longitudinal change of refractive error in infants during the first year of life. Eye (Lond) (1995) 1.01

Raised alpha-fetoprotein levels in amniotic fluid and maternal serum associated with distension of the fetal bladder caused by absence of urethra. J Med Genet (1978) 1.01

Expression of CEL2 and CEL4, two proteins from Agaricus bisporus with similarity to fungal cellobiohydrolase I and beta-mannanase, respectively, is regulated by the carbon source. Microbiology (1997) 1.01

Gene polymorphism affecting alpha1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk. Ann Neurol (2000) 1.00

04 and A007-sulfatide antibodies bind to embryonic Schwann cells prior to the appearance of galactocerebroside; regulation of the antigen by axon-Schwann cell signals and cyclic AMP. Development (1990) 1.00

Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue. J Endocrinol (1991) 0.99

Enhanced myeloid progenitor cell cycling and apoptosis in mice lacking the chemokine receptor, CCR2. Blood (1999) 0.99

Dual targeting of Src and ER prevents acquired antihormone resistance in breast cancer cells. Breast Cancer Res Treat (2008) 0.99

Thymic hormone deficiency in normal ageing and Down's syndrome: is there a primary failure of the thymus? Lancet (1984) 0.98

Specific inhibition of the eubacterial DNA ligase by arylamino compounds. Antimicrob Agents Chemother (1999) 0.98

Genetic risk factors in Alzheimer's disease. Mol Pathol (1998) 0.97

Identification of an endoplasmic reticulum-resident calcium-binding protein with multiple EF-hand motifs in asexual stages of Plasmodium falciparum. Mol Biochem Parasitol (1997) 0.96

Leptospirosis in California sea lions (Zalophus californianus) stranded along the central California coast, 1981-1994. J Wildl Dis (1996) 0.96

Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease. Genes Immun (2003) 0.96

"In vivo" determination of hip joint separation and the forces generated due to impact loading conditions. J Biomech (2001) 0.96

Orthopaedic bone cement: do we know what we are using? J Bone Joint Surg Br (2008) 0.96

Plasmodium falciparum: mapping the membrane-binding domain in the ring-infected erythrocyte surface antigen. Exp Parasitol (1994) 0.95

Delayed gastric emptying occurs following acarbose administration and is a further mechanism for its anti-hyperglycaemic effect. Diabet Med (1998) 0.94

Removal of twelve C-terminal amino acids from firefly luciferase abolishes activity. Biochem Biophys Res Commun (1990) 0.94

Rotational diffusion of the erythrocyte integral membrane protein band 3: effect of hemichrome binding. Biochemistry (1992) 0.94

ATP-dependent translocation of amino phospholipids across the human erythrocyte membrane. FEBS Lett (1986) 0.94

Distortion of maternal-fetal angiotensin II type 1 receptor allele transmission in pre-eclampsia. J Med Genet (1998) 0.93

An evaluation of the growth, carcass and meat quality characteristics of Omani goat breeds. Meat Sci (2004) 0.93

Src as a therapeutic target in anti-hormone/anti-growth factor-resistant breast cancer. Endocr Relat Cancer (2006) 0.93

Histidine-rich protein 2 of the malaria parasite, Plasmodium falciparum, is involved in detoxification of the by-products of haemoglobin degradation. Mol Biochem Parasitol (2001) 0.93

Is treatment with interferon-alpha effective in all patients with metastatic renal carcinoma? A new approach to the investigation of interactions. Br J Cancer (2004) 0.93

Synthesis and activity of some antimalarial bisquinolines. J Med Chem (1995) 0.93

Interferon-alpha and survival in renal cell cancer. Br J Urol (1995) 0.92

Physiological interpretation of electrical impedance epigastrography measurements. Physiol Meas (2003) 0.92

Association between the polymorphisms of TLR4 and CD14 genes and Alzheimer's disease. Curr Pharm Des (2008) 0.92

Myelinated, but not unmyelinated axons, reversibly down-regulate N-CAM in Schwann cells. J Neurocytol (1987) 0.92

Proteolytic digestion of band 3 at an external site alters the erythrocyte membrane organisation and may facilitate malarial invasion. Mol Biochem Parasitol (1993) 0.92

Two novel aspirin analogues show selective cytotoxicity in primary chronic lymphocytic leukaemia cells that is associated with dual inhibition of Rel A and COX-2. Cell Prolif (2011) 0.92

Effect of Matrigel on the tumorigenicity of human breast and ovarian carcinoma cell lines. Int J Cancer (1996) 0.92

Response of circulating immunoreactive somatostatin to nutritional stimuli in normal subjects. Gastroenterology (1981) 0.92

Novel bisquinoline antimalarials. Synthesis, antimalarial activity, and inhibition of haem polymerisation. Biochem Pharmacol (1996) 0.92

Effect of a comprehensive infection control program on the incidence of infections in long-term care facilities. Am J Infect Control (2000) 0.91