Published in Am J Respir Crit Care Med on October 15, 2001
Lymphangioleiomyomatosis - a wolf in sheep's clothing. J Clin Invest (2012) 1.87
Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells. Proc Natl Acad Sci U S A (2009) 1.75
Lymphangioleiomyomatosis: what do we know and what are we looking for? Eur Respir Rev (2011) 1.73
TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. J Cell Biol (2004) 1.66
Sustained effects of sirolimus on lung function and cystic lung lesions in lymphangioleiomyomatosis. Am J Respir Crit Care Med (2014) 1.48
Molecular pathogenesis of lymphangioleiomyomatosis: lessons learned from orphans. Am J Respir Cell Mol Biol (2006) 1.47
Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts. PLoS One (2014) 1.45
Modulation of cell migration and invasiveness by tumor suppressor TSC2 in lymphangioleiomyomatosis. Am J Respir Cell Mol Biol (2005) 1.30
The pathogenesis and imaging of the tuberous sclerosis complex. Pediatr Radiol (2008) 1.20
Phenotypic characterization of disseminated cells with TSC2 loss of heterozygosity in patients with lymphangioleiomyomatosis. Am J Respir Crit Care Med (2010) 1.17
Rapamycin-insensitive up-regulation of MMP2 and other genes in tuberous sclerosis complex 2-deficient lymphangioleiomyomatosis-like cells. Am J Respir Cell Mol Biol (2009) 1.15
mTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of pro-metastatic factors in LAM pathogenesis. Lymphat Res Biol (2010) 1.05
Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy. Proc Am Thorac Soc (2010) 0.99
Clinical features, epidemiology, and therapy of lymphangioleiomyomatosis. Clin Epidemiol (2015) 0.95
Clinical utility of diagnostic guidelines and putative biomarkers in lymphangioleiomyomatosis. Respir Res (2012) 0.92
Frequency of undiagnosed cystic lung disease in patients with sporadic renal angiomyolipomas. Chest (2011) 0.92
Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis. Proc Natl Acad Sci U S A (2013) 0.92
Smooth muscle-like cells in pulmonary lymphangioleiomyomatosis. Proc Am Thorac Soc (2008) 0.91
Lymphangioleiomyomatosis and tuberous sclerosis complex. Lung (2008) 0.83
The loss of tuberin promotes cell invasion through the ß-catenin pathway. Am J Respir Cell Mol Biol (2009) 0.82
Women with TSC: Relationship between Clinical, Lung Function and Radiological Features in a Genotyped Population Investigated for Lymphangioleiomyomatosis. PLoS One (2016) 0.82
Management of lymphangioleiomyomatosis. F1000Prime Rep (2014) 0.79
Lymphatic endothelial differentiation in pulmonary lymphangioleiomyomatosis cells. J Histochem Cytochem (2013) 0.79
TSC2 modulates cell adhesion and migration via integrin-α1β1. Am J Physiol Lung Cell Mol Physiol (2012) 0.79
Genetic heterogeneity of circulating cells from patients with lymphangioleiomyomatosis with and without lung transplantation. Am J Respir Crit Care Med (2015) 0.77
Retrospective review of combined sirolimus and simvastatin therapy in lymphangioleiomyomatosis. Chest (2015) 0.76
Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway. Cell Death Dis (2014) 0.76
Wild type mesenchymal cells contribute to the lung pathology of lymphangioleiomyomatosis. PLoS One (2015) 0.76
EPIDEMIOLOGY, PATHOGENESIS and DIAGNOSIS of LYMPHANGIOLEIOMYOMATOSIS. Expert Opin Orphan Drugs (2016) 0.75
Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis. Am J Respir Cell Mol Biol (2015) 0.75
Doxycycline reduces the migration of tuberous sclerosis complex-2 null cells - effects on RhoA-GTPase and focal adhesion kinase. J Cell Mol Med (2015) 0.75
Construction of a GT polymorphism map of human 9q. Genomics (1992) 8.92
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science (1997) 6.10
Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci U S A (2000) 4.30
Apparent renal cell carcinomas in tuberous sclerosis are heterogeneous: the identification of malignant epithelioid angiomyolipoma. Am J Surg Pathol (1998) 3.31
The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis. Oncogene (2009) 2.14
Evidence that lymphangiomyomatosis is caused by TSC2 mutations: chromosome 16p13 loss of heterozygosity in angiomyolipomas and lymph nodes from women with lymphangiomyomatosis. Am J Hum Genet (1998) 2.13
Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer Res (1998) 2.04
Loss of the polycystic kidney disease (PKD1) region of chromosome 16p13 in renal cyst cells supports a loss-of-function model for cyst pathogenesis. J Clin Invest (1997) 2.00
Malignant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complex. Cancer (1998) 1.65
Tuberous sclerosis-associated renal cell carcinoma. Clinical, pathological, and genetic features. Am J Pathol (1996) 1.52
Frequent estrogen and progesterone receptor immunoreactivity in renal angiomyolipomas from women with pulmonary lymphangioleiomyomatosis. Chest (2000) 1.48
The spectrum of mutations in TSC1 and TSC2 in women with tuberous sclerosis and lymphangiomyomatosis. Am J Respir Crit Care Med (2001) 1.35
Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription. Oncogene (2011) 1.23
Renal angiomyolipomas, cysts, and cancer in tuberous sclerosis complex. Semin Pediatr Neurol (1998) 1.21
Pulmonary lymphangioleiomyomatosis in a man. Am J Respir Crit Care Med (2000) 1.20
Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers. Ann Neurol (2001) 1.16
Mutational analysis of the tuberous sclerosis gene TSC2 in patients with pulmonary lymphangioleiomyomatosis. J Med Genet (2000) 1.15
Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. Oncogene (2009) 1.14
The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomas. Mod Pathol (1999) 1.13
Aggressive variants of chromophobe renal cell carcinoma. Cancer (1996) 1.07
New developments in the neurobiology of the tuberous sclerosis complex. Neurology (1999) 1.04
Comprehensive mutational analysis of the TSC1 gene: observations on frequency of mutation, associated features, and nonpenetrance. Ann Hum Genet (1998) 1.00
A novel missense mutation in the GTPase activating protein homology region of TSC2 in two large families with tuberous sclerosis complex. J Med Genet (2001) 0.95
Autophagy: mechanisms, regulation, and its role in tumorigenesis. Biochemistry (Mosc) (2013) 0.89
Kinase mTOR: regulation and role in maintenance of cellular homeostasis, tumor development, and aging. Biochemistry (Mosc) (2014) 0.87
Mitochondrial DNA polymorphism in the French population. Biomed Pharmacother (1999) 0.85
Rabin8 Protein Interacts with GTPase Rheb and Inhibits Phosphorylation of Ser235/Ser236 in Small Ribosomal Subunit Protein S6. Acta Naturae (2011) 0.82
The human actin-regulatory protein cap G: gene structure and chromosome location. Genomics (1994) 0.80
Mitochondrial DNA polymorphism in the Vietnamese population. Eur J Immunogenet (1999) 0.79
Expression of wild type and mutant TSC2, but not TSC1, causes an increase in the G1 fraction of the cell cycle in HEK293 cells. J Med Genet (2002) 0.76
Analysis of interphase cells for the Philadelphia translocation using painting probe made by inter-Alu-polymerase chain reaction from a radiation hybrid. Blood (1994) 0.75
Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1. Ann Hum Genet (1997) 0.75
Heterogeneity of four beta-thalassemia mutations in Greece. Hemoglobin (1999) 0.75
Mitochondrial DNA polymorphisms of a west Algerian population (Oran region). Biomed Pharmacother (1999) 0.75
Cosmid contigs spanning 9q34 including the candidate region for TSC1. Eur J Hum Genet (1995) 0.75