Impairment of myocardial contractility by anticancer anthracyclines: role of secondary alcohol metabolites and evidence of reduced toxicity by a novel disaccharide analogue.

PubWeight™: 0.83‹?›

🔗 View Article (PMC 1573059)

Published in Br J Pharmacol on November 01, 2001

Authors

G Minotti1, M Parlani, E Salvatorelli, P Menna, A Cipollone, F Animati, C A Maggi, S Manzini

Author Affiliations

1: Department of Drug Sciences, G. D'Annunzio University School of Pharmacy, Via dei Vestini, 66013 Chieti, Italy. gminotti@unich.it

Articles cited by this

Flavonoids as antioxidants. J Nat Prod (2000) 6.02

The anthracyclines: will we ever find a better doxorubicin? Semin Oncol (1992) 3.28

Doxorubicin cardiotoxicity: analysis of prevailing hypotheses. FASEB J (1990) 2.41

Human carbonyl reductase overexpression in the heart advances the development of doxorubicin-induced cardiotoxicity in transgenic mice. Cancer Res (2000) 1.39

Role of iron in anthracycline cardiotoxicity: new tunes for an old song? FASEB J (1999) 1.21

The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase/iron regulatory protein-1 in cytosolic fractions from human myocardium. FASEB J (1998) 1.03

Time-related increases in cardiac concentrations of doxorubicinol could interact with doxorubicin to depress myocardial contractile function. Br J Pharmacol (1993) 1.03

Anthracyclines and their C-13 alcohol metabolites: growth inhibition and DNA damage following incubation with human tumor cells in culture. Cancer Chemother Pharmacol (1992) 1.00

Anthracycline metabolism and toxicity in human myocardium: comparisons between doxorubicin, epirubicin, and a novel disaccharide analogue with a reduced level of formation and [4Fe-4S] reactivity of its secondary alcohol metabolite. Chem Res Toxicol (2000) 0.99

Development of daunorubicin resistance in tumour cells by induction of carbonyl reduction. Biochem Pharmacol (2000) 0.96

Doxorubicin metabolism and toxicity in human myocardium: role of cytoplasmic deglycosidation and carbonyl reduction. Chem Res Toxicol (2000) 0.92

Secondary alcohol metabolites mediate iron delocalization in cytosolic fractions of myocardial biopsies exposed to anticancer anthracyclines. Novel linkage between anthracycline metabolism and iron-induced cardiotoxicity. J Clin Invest (1995) 0.91

Effect of barbiturates on hydroxyl radicals, lipid peroxidation, and hypoxic cell death in human NT2-N neurons. Anesthesiology (2000) 0.91

Doxorubicin disaccharide analogue: apoptosis-related improvement of efficacy in vivo. J Natl Cancer Inst (1997) 0.90

Superoxide anion production by adriamycinol from cardiac sarcosomes and by mitochondrial NADH dehydrogenase. Anticancer Res (1987) 0.89

Monohydroxyethylrutoside as protector against chronic doxorubicin-induced cardiotoxicity. Br J Pharmacol (1995) 0.87

Paradoxical inhibition of cardiac lipid peroxidation in cancer patients treated with doxorubicin. Pharmacologic and molecular reappraisal of anthracycline cardiotoxicity. J Clin Invest (1996) 0.86

Protection against daunorubicin cytotoxicity by expression of a cloned human carbonyl reductase cDNA in K562 leukemia cells. Cancer Res (1995) 0.86

Comparison of doxorubicin- and MEN 10755-induced long-term progressive cardiotoxicity in the rat. J Cardiovasc Pharmacol (2000) 0.85

Doxorubicin: mechanism of cardiodepressant actions in guinea pigs. J Pharmacol Exp Ther (1988) 0.85

Improved efficacy and enlarged spectrum of activity of a novel anthracycline disaccharide analogue of doxorubicin against human tumor xenografts. Clin Cancer Res (1998) 0.84

Effect of MEN 10755, a new disaccharide analogue of doxorubicin, on sarcoplasmic reticulum Ca(2+) handling and contractile function in rat heart. Br J Pharmacol (2000) 0.83

Tissue distribution, antitumour activity and in vivo apoptosis induction by MEN10755 in nude mice. Eur J Cancer (2001) 0.80

Cytofluorescence localization and disposition of doxorubicin and doxorubicinol in rat cardiac tissue. Eur J Cancer Clin Oncol (1988) 0.80

Inhibition of aldo-keto reductases by phenobarbital alters metabolism, pharmacokinetics and toxicity of doxorubicin in rats. J Pharm Pharmacol (1999) 0.79

Comparison of cardiac actions of doxorubicin, pirarubicin and aclarubicin in isolated guinea-pig heart. Eur J Pharmacol (1993) 0.78

Cytokines, iron homeostasis, and cancer. Adv Exp Med Biol (1994) 0.77

Articles by these authors

Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest (1994) 3.51

Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 1: General considerations. Experientia (1986) 1.53

Spontaneous release of acetylcholine from autonomic nerves in the bladder. Br J Pharmacol (2009) 1.47

Myogenic and neurogenic factors in the control of pyeloureteral motility and ureteral peristalsis. Pharmacol Rev (1998) 1.47

Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells. Microvasc Res (1990) 1.45

The nonstop transvesical cystometrogram in urethane-anesthetized rats: a simple procedure for quantitative studies on the various phases of urinary bladder voiding cycle. J Pharmacol Methods (1986) 1.43

Ruthenium red as a capsaicin antagonist. Life Sci (1991) 1.36

Further evidence for involvement of adenosine-5'-triphosphate in non-adrenergic non-cholinergic relaxation of the isolated rat duodenum. Eur J Pharmacol (1985) 1.33

The tachykinin NK1 receptor. Part II: Distribution and pathophysiological roles. Neuropeptides (1998) 1.32

The tachykinin NK1 receptor. Part I: ligands and mechanisms of cellular activation. Neuropeptides (1997) 1.27

In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther (1991) 1.24

Synthesis, DNA-binding properties, and antitumor activity of novel distamycin derivatives. J Med Chem (1989) 1.24

Secretion, pain and sneezing induced by the application of capsaicin to the nasal mucosa in man. Br J Pharmacol (1988) 1.23

Role of NK1 tachykinin receptors in thermonociception: effect of (+/-)-CP 96,345, a non-peptide substance P antagonist, on the hot plate test in mice. Neurosci Lett (1991) 1.22

Analysis of factors involved in determining urinary bladder voiding cycle in urethan-anesthetized rats. Am J Physiol (1986) 1.22

An electrophysiological analysis of the effect of reactive blue 2, a putative P2-purinoceptor antagonist, on inhibitory junction potentials of rat caecum. Eur J Pharmacol (1986) 1.18

Anthracyclines: selected new developments. Curr Med Chem Anticancer Agents (2001) 1.18

A potent and selective agonist for NK-2 tachykinin receptor. Peptides (1989) 1.14

Suitability of urethane anesthesia for physiopharmacological investigations. Part 3: Other systems and conclusions. Experientia (1986) 1.14

Electrophysiological and antiarrhythmic properties of propafenon in isolated cardiac preparations. J Cardiovasc Pharmacol (1982) 1.13

The antagonism induced by ruthenium red of the actions of capsaicin on the peripheral terminals of sensory neurons: further studies. Eur J Pharmacol (1988) 1.12

Simultaneous release by bradykinin of substance P- and calcitonin gene-related peptide immunoreactivities from capsaicin-sensitive structures in guinea-pig heart. Br J Pharmacol (1988) 1.11

Pharmacological evidence that at least two different non-adrenergic non-cholinergic inhibitory systems are present in the rat small intestine. Eur J Pharmacol (1986) 1.11

Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF. Circ Res (1997) 1.10

Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 2: Cardiovascular system. Experientia (1986) 1.10

Doxorubicin irreversibly inactivates iron regulatory proteins 1 and 2 in cardiomyocytes: evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor therapy. Cancer Res (2001) 1.10

Characterization of nociceptin receptors in the periphery: in vitro and in vivo studies. Naunyn Schmiedebergs Arch Pharmacol (1999) 1.08

Characterization of the capsaicin-sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder. Br J Pharmacol (1994) 1.04

Pharmacological evidence for the existence of two components in the twitch response to field stimulation of detrusor strips from the rat urinary bladder. J Auton Pharmacol (1985) 1.04

Low pH-induced release of calcitonin gene-related peptide from capsaicin-sensitive sensory nerves: mechanism of action and biological response. Neuroscience (1991) 1.04

A comparison of bradykinin- and capsaicin-induced myocardial and coronary effects in isolated perfused heart of guinea-pig: involvement of substance P and calcitonin gene-related peptide release. Br J Pharmacol (1989) 1.04

Effect of capsaicin on PAF-induced bronchial hyperresponsiveness and pulmonary cell accumulation in the rabbit. Br J Pharmacol (1991) 1.04

Involvement of 5-hydroxytryptamine1A receptors in the modulation of micturition reflexes in the anesthetized rat. J Pharmacol Exp Ther (1992) 1.03

Peripheral effects of neurokinins: functional evidence for the existence of multiple receptors. J Auton Pharmacol (1987) 1.02

Electrophysiological evidence for different release mechanism of ATP and NO as inhibitory NANC transmitters in guinea-pig colon. Br J Pharmacol (1994) 1.01

Extrinsic origin of the capsaicin-sensitive innervation of rat duodenum: possible involvement of calcitonin gene-related peptide (CGRP) in the capsaicin-induced activation of intramural non-adrenergic non-cholinergic neurons. Naunyn Schmiedebergs Arch Pharmacol (1986) 1.01

Intestinal epithelial barrier dysfunction in disease and possible therapeutical interventions. Curr Med Chem (2011) 1.01

Capsaicin-like activity of some natural pungent substances on peripheral endings of visceral primary afferents. Naunyn Schmiedebergs Arch Pharmacol (1990) 1.00

Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide. Br J Pharmacol (1996) 1.00

Tachykinins as modulators of the micturition reflex in the central and peripheral nervous system. Regul Pept (2001) 1.00

The role of neuropeptides in the regulation of the micturition reflex. J Auton Pharmacol (1986) 1.00

A highly selective NK-2 tachykinin receptor antagonist containing D-tryptophan. Eur J Pharmacol (1990) 0.99

Proliferation and migration of endothelial cells is promoted by endothelins via activation of ETB receptors. Am J Physiol (1995) 0.99

Beneficial effect of capsaicin application to the nasal mucosa in cluster headache. Clin J Pain (1989) 0.99

Functional characterization of substance P receptors on cultured human spinal cord astrocytes: synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production. Glia (1997) 0.99

Evidence that GABAA receptors mediate relaxation of rat duodenum by activating intramural nonadrenergic-noncholinergic neurones. J Auton Pharmacol (1984) 0.99

Anthracycline metabolism and toxicity in human myocardium: comparisons between doxorubicin, epirubicin, and a novel disaccharide analogue with a reduced level of formation and [4Fe-4S] reactivity of its secondary alcohol metabolite. Chem Res Toxicol (2000) 0.99

Knee osteoarthritis: a role for bradykinin? Inflamm Res (2008) 0.98

The tachykinin NK1 receptor mediates the migration-promoting effect of substance P on human skin fibroblasts in culture. Naunyn Schmiedebergs Arch Pharmacol (1996) 0.98

Simultaneous recording of vesical and urethral pressure in urethane-anesthetized rats: effect of neuromuscular blocking agents on the activity of the external urethral sphincter. J Pharmacol Methods (1991) 0.98

Tachykinins activate guinea-pig alveolar macrophages: involvement of NK2 and NK1 receptors. Br J Pharmacol (1990) 0.98

Prejunctional modulatory action of neuropeptide Y on peripheral terminals of capsaicin-sensitive sensory nerves. Br J Pharmacol (1989) 0.98

Sensory nerves, vascular endothelium and neurogenic relaxation of the guinea-pig isolated pulmonary artery. Naunyn Schmiedebergs Arch Pharmacol (1990) 0.97

Capsaicin desensitization protects from antigen-induced bronchospasm in conscious guinea-pigs. Eur J Pharmacol (1987) 0.97

Activity of SR 142801 at peripheral tachykinin receptors. Eur J Pharmacol (1995) 0.97

GABAA and GABAB receptors in detrusor strips from guinea-pig bladder dome. J Auton Pharmacol (1985) 0.97

Modulatory activity of GABAB receptors on cholinergic tone in guinea-pig distal colon. Br J Pharmacol (1985) 0.97

Effect of synthetic tachykinin analogues on airway microvascular leakage in rats and guinea-pigs: evidence for the involvement of NK-1 receptors. J Auton Pharmacol (1991) 0.97

Further evidence for the existence of NK2 tachykinin receptor subtypes. Br J Pharmacol (1991) 0.96

Arachidonic acid and bradykinin share a common pathway to release neuropeptide from capsaicin-sensitive sensory nerve fibers of the guinea pig heart. J Pharmacol Exp Ther (1991) 0.96

Bradykinin-induced release of calcitonin gene-related peptide from capsaicin-sensitive nerves in guinea-pig atria: mechanism of action and calcium requirements. Neuroscience (1990) 0.96

Cationic protein-induced sensory nerve activation: role of substance P in airway hyperresponsiveness and plasma protein extravasation. J Clin Invest (1994) 0.96

The effect of thiorphan and epithelium removal on contractions and tachykinin release produced by activation of capsaicin-sensitive afferents in the guinea-pig isolated bronchus. Naunyn Schmiedebergs Arch Pharmacol (1990) 0.96

Direct evidence that capsaicin-induced plasma protein extravasation is mediated through tachykinin NK1 receptors. Eur J Pharmacol (1991) 0.96

Endogenous tachykinins play a role in IL-1-induced neutrophil accumulation: involvement of NK-1 receptors. Immunology (1993) 0.96

The role of the capsaicin-sensitive innervation of the rat urinary bladder in the activation of micturition reflex. Naunyn Schmiedebergs Arch Pharmacol (1986) 0.95

Tachykinin NK1 receptor subtypes in the rat urinary bladder. Br J Pharmacol (1994) 0.95

Tachykinin receptors are involved in the "local efferent" motor response to capsaicin in the guinea-pig small intestine and oesophagus. Neuroscience (1999) 0.95

Cardioprotective effects of zofenopril, a new angiotensin-converting enzyme inhibitor, on doxorubicin-induced cardiotoxicity in the rat. Eur J Pharmacol (2001) 0.95

Pharmacological evidence for the existence of multiple P2 receptors in the circular muscle of guinea-pig colon. Br J Pharmacol (1998) 0.94

The presence of mucosa reduces the contractile response of the guinea-pig urinary bladder to substance P. J Pharm Pharmacol (1987) 0.94

Antioxidant and cardioprotective properties of the sulphydryl angiotensin-converting enzyme inhibitor zofenopril. J Int Med Res (2005) 0.94

Octylonium bromide: a smooth muscle relaxant which interferes with calcium ions mobilization. Arch Int Pharmacodyn Ther (1983) 0.94

Involvement of spinal tachykinin NK1 and NK2 receptors in detrusor hyperreflexia during chemical cystitis in anaesthetized rats. Eur J Pharmacol (1994) 0.94

The role of tachykinins via NK1 receptors in progression of human gliomas. Life Sci (2000) 0.94

Evidence for a role of tachykinins as sensory transmitters in the activation of micturition reflex. Neuroscience (1993) 0.94

Postnatal development of myogenic contractile activity and excitatory innervation of rat urinary bladder. Am J Physiol (1984) 0.94

The behavioral response induced by intravesical instillation of capsaicin rats is mediated by pudendal urethral sensory fibers. Life Sci (1994) 0.94

Ascending enteric reflex contraction: roles of acetylcholine and tachykinins in relation to distension and propagation of excitation. J Pharmacol Exp Ther (1993) 0.93

The effects of topical capsaicin on rat urinary bladder motility in vivo. Eur J Pharmacol (1984) 0.93

Competitive inhibition by capsazepine of [3H]resiniferatoxin binding to central (spinal cord and dorsal root ganglia) and peripheral (urinary bladder and airways) vanilloid (capsaicin) receptors in the rat. J Pharmacol Exp Ther (1993) 0.92

Modulatory action of galanin on responses due to antidromic activation of peripheral terminals of capsaicin-sensitive sensory nerves. Eur J Pharmacol (1989) 0.92