Human beta defensin-1 and -2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions.

PubWeight™: 1.15‹?› | Rank: Top 10%

🔗 View Article (PMID 11710922)

Published in J Invest Dermatol on November 01, 2001

Authors

C M Chronnell1, L R Ghali, R S Ali, A G Quinn, D B Holland, J J Bull, W J Cunliffe, I A McKay, M P Philpott, S Müller-Röver

Author Affiliations

1: Centre for Cutaneous Research, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London, UK.

Articles citing this

Microbial symbiosis with the innate immune defense system of the skin. J Invest Dermatol (2011) 1.45

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity. Cell Syst (2016) 1.44

Antimicrobial peptides: old molecules with new ideas. J Invest Dermatol (2011) 1.34

Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression. J Invest Dermatol (2009) 1.23

Antimicrobial peptides in human skin disease. Eur J Dermatol (2007) 1.17

Keratinocyte expression of human beta defensin 2 following bacterial infection: role in cutaneous host defense. Clin Diagn Lab Immunol (2003) 1.13

Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes. J Invest Dermatol (2008) 1.06

Staphylococcus colonization of the skin and antimicrobial peptides. Expert Rev Dermatol (2010) 1.03

Histone H4 is a major component of the antimicrobial action of human sebocytes. J Invest Dermatol (2009) 1.03

An update on the role of the sebaceous gland in the pathogenesis of acne. Dermatoendocrinol (2011) 1.02

Severity of Staphylococcus aureus infection of the skin is associated with inducibility of human beta-defensin 3 but not human beta-defensin 2. Infect Immun (2010) 1.00

The role of inflammation in the pathology of acne. J Clin Aesthet Dermatol (2013) 0.99

Toll-like receptors: role in dermatological disease. Mediators Inflamm (2010) 0.93

Protecting the boundary: the sentinel role of host defense peptides in the skin. Cell Mol Life Sci (2011) 0.89

Antimicrobial barrier of an in vitro oral epithelial model. Arch Oral Biol (2006) 0.88

IL-17/Th17 pathway is activated in acne lesions. PLoS One (2014) 0.84

Commensal bacteria and cutaneous immunity. Semin Immunopathol (2014) 0.81

TGFβ signaling regulates lipogenesis in human sebaceous glands cells. BMC Dermatol (2013) 0.79

IL-17: a key player in the P. acnes inflammatory cascade? J Invest Dermatol (2014) 0.78

A small peptide with therapeutic potential for inflammatory acne vulgaris. PLoS One (2013) 0.77

The role of antimicrobial peptides in chronic inflammatory skin diseases. Postepy Dermatol Alergol (2016) 0.76

Articles by these authors

(truncated to the top 100)

Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science (1996) 8.06

A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol (2001) 6.12

Different trajectories of parallel evolution during viral adaptation. Science (1999) 4.94

Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family. Mol Microbiol (1990) 4.03

Combining data in phylogenetic analysis. Trends Ecol Evol (1996) 3.19

Vitiligo, thyroid disease and autoimmunity. Br J Dermatol (1968) 3.18

Dynamic fatty acylation of p21N-ras. EMBO J (1987) 2.99

A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis. J Invest Dermatol (1999) 2.92

Short-sighted evolution and the virulence of pathogenic microorganisms. Trends Microbiol (1994) 2.91

The rate of sebum excretion in man. Br J Dermatol (1969) 2.68

Characterisation and molecular cloning of the novel macrolide-streptogramin B resistance determinant from Staphylococcus epidermidis. J Antimicrob Chemother (1989) 2.62

Evolutionary reversals during viral adaptation to alternating hosts. Genetics (2000) 2.49

Prevalence of antibiotic-resistant propionibacteria on the skin of acne patients: 10-year surveillance data and snapshot distribution study. Br J Dermatol (2002) 2.34

Experimental phylogenetics: generation of a known phylogeny. Science (1992) 2.33

Evaluation of the modified Alvarado score in the diagnosis of acute appendicitis: a prospective study. Ann R Coll Surg Engl (1994) 2.32

Treatment of Behcet's syndrome with phenformin and ethyloestrenol. Lancet (1969) 2.28

Evaluation of a policy of total mesorectal excision for rectal and rectosigmoid cancers. Br J Surg (1997) 2.26

Antibiotic-resistant acne: lessons from Europe. Br J Dermatol (2003) 2.22

Screening for breast cancer detects tumours at an earlier biological stage. Br J Surg (1993) 2.16

Phenotypic and genotypic characterization of antibiotic-resistant Propionibacterium acnes isolated from acne patients attending dermatology clinics in Europe, the U.S.A., Japan and Australia. Br J Dermatol (2001) 2.14

Pathogenesis of acne. Lancet (1969) 2.10

Suicide in dermatological patients. Br J Dermatol (1997) 2.07

Virulence evolution in a virus obeys a trade-off. Proc Biol Sci (1999) 2.06

Profiles of adaptation in two similar viruses. Genetics (2001) 1.99

Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro. Br J Dermatol (1995) 1.96

16S rRNA mutation associated with tetracycline resistance in a gram-positive bacterium. Antimicrob Agents Chemother (1998) 1.94

Post-adolescent acne: a review of clinical features. Br J Dermatol (1997) 1.94

A clinical evaluation of acne scarring and its incidence. Clin Exp Dermatol (1994) 1.88

Effects of SV40 transformation on the cytoskeleton and behavioural properties of human keratinocytes. Cell Differ (1982) 1.81

The intrinsic rate of increase of HIV/AIDS: epidemiological and evolutionary implications. Math Biosci (1996) 1.76

Excess benign melanocytic naevi after chemotherapy for malignancy in childhood. BMJ (1989) 1.73

The prevalence of acne vulgaris in adolescence. Br J Dermatol (1971) 1.72

Incidence of synchronous and metachronous colorectal carcinoma. Br J Surg (1984) 1.68

Rectal retroflexion: an essential part of lower gastrointestinal endoscopic examination. Dis Colon Rectum (2001) 1.67

Rationale for integrating early postoperative intraperitoneal chemotherapy into the surgical treatment of gastrointestinal cancer. Semin Oncol (1989) 1.65

Prevalence of facial acne vulgaris in late adolescence and in adults. Br Med J (1979) 1.64

Clinical resistance to erythromycin and clindamycin in cutaneous propionibacteria isolated from acne patients is associated with mutations in 23S rRNA. Antimicrob Agents Chemother (1997) 1.63

Superior antibacterial action and reduced incidence of bacterial resistance in minocycline compared to tetracycline-treated acne patients. Br J Dermatol (1990) 1.61

Early postoperative intraperitoneal chemotherapy as an adjuvant therapy to surgery for peritoneal carcinomatosis from gastrointestinal cancer: pharmacological studies. Cancer Res (1990) 1.61

Adaptive molecular evolution for 13,000 phage generations: a possible arms race. Genetics (2005) 1.59

Experimental evolution recapitulates natural evolution. Philos Trans R Soc Lond B Biol Sci (2000) 1.56

Genetic control of sebum excretion and acne--a twin study. Br J Dermatol (1988) 1.47

Chronology and morphology of temperature-dependent sex determination. J Exp Zool (1991) 1.47

Parallel molecular evolution of deletions and nonsense mutations in bacteriophage T7. Mol Biol Evol (1997) 1.47

The pathological and biological nature of screen-detected breast carcinomas: a morphological and immunohistochemical study. J Pathol (1997) 1.47

Transformation and stimulation of DNA synthesis in NIH-3T3 cells are a titratable function of normal p21N-ras expression. EMBO J (1986) 1.46

Interactions between the oral contraceptive pill and antibiotics. Br J Dermatol (1990) 1.45

Prevalence of facial acne in adults. J Am Acad Dermatol (1999) 1.42

The human hair follicle immune system: cellular composition and immune privilege. Br J Dermatol (2000) 1.42

Alopecia areata treated with diphencyprone: is an allergic response necessary? Br J Dermatol (1990) 1.42

The effect of 3-week tamoxifen treatment on oestrogen receptor levels in primary breast tumours: a flow cytometric study. Br J Cancer (1998) 1.40

Fabrication and reorganization of dermal equivalents suitable for skin grafting after major cutaneous injury. Biomaterials (1990) 1.40

Endocrine factors in pre- and postmenopausal women with hidradenitis suppurativa. Br J Dermatol (1996) 1.40

The inter-relationship between isotretinoin/acne and depression. J Eur Acad Dermatol Venereol (1999) 1.40

Erythromycin resistant propionibacteria in antibiotic treated acne patients: association with therapeutic failure. Br J Dermatol (1989) 1.40

National survey of the use of intraoperative antibiotics for prophylaxis against postoperative endophthalmitis following cataract surgery in the UK. Br J Ophthalmol (2010) 1.39

Acne vulgaris and malignancy. Br J Dermatol (1988) 1.38

Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems. Oncogene (1988) 1.37

Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin. J Invest Dermatol (2001) 1.37

Temperature-dependent sex determination in turtles. Science (1979) 1.36

Experimental genomic evolution: extensive compensation for loss of DNA ligase activity in a virus. Mol Biol Evol (2002) 1.35

Safety of long-term high-dose minocycline in the treatment of acne. Br J Dermatol (1996) 1.35

Temperature-dependent sex determination in reptiles: proximate mechanisms, ultimate outcomes, and practical applications. Dev Genet (1994) 1.34

Estrogen and sex reversal in turtles: a dose-dependent phenomenon. Gen Comp Endocrinol (1991) 1.34

13-cis retinoic acid and acne. Lancet (1980) 1.33

Active hair growth (anagen) is associated with angiogenesis. J Invest Dermatol (2000) 1.29

Synergism between temperature and estradiol: a common pathway in turtle sex determination? J Exp Zool (1991) 1.28

Isotretinoin for acne vulgaris--10 years later: a safe and successful treatment. Br J Dermatol (1993) 1.27

Modification of human prekeratin during epidermal differentiation. Biochem J (1981) 1.27

Distributions of beneficial fitness effects in RNA. Genetics (2005) 1.25

The compliance of renal transplant recipients with advice about sun protection measures. Br J Dermatol (1998) 1.25

A dose-response study of I3-cis-retinoic acid in acne vulgaris. Br J Dermatol (1983) 1.23

Report of the Consensus Conference on Acne Classification. Washington, D.C., March 24 and 25, 1990. J Am Acad Dermatol (1991) 1.22

Expression of natural peptide antibiotics in human skin. Lancet (1997) 1.22

Generation and cyclic remodeling of the hair follicle immune system in mice. J Invest Dermatol (1998) 1.22

Interaction of Propionibacterium acnes with skin lipids in vitro. J Gen Microbiol (1993) 1.20

p53 mutations are common and early events that precede tumor invasion in squamous cell neoplasia of the skin. J Invest Dermatol (1993) 1.20

Steroid hormones reverse sex in turtles. Gen Comp Endocrinol (1986) 1.19

Alopecia areata, thyroid disease and autoimmunity. Br J Dermatol (1969) 1.19

The assessment of acne vulgaris--the Leeds technique. Br J Dermatol (1984) 1.18

Blood fibrinolytic activity in diseases of small blood vessels and the effect of low molecular weight dextran. Br J Dermatol (1969) 1.17

Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation. Cancer Res (1993) 1.16

Hereditary gingival fibromatosis. Br Med J (1969) 1.16

Properties of gastric and duodenal mucus: effect of proteolysis, disulfide reduction, bile, acid, ethanol, and hypertonicity on mucus gel structure. Gastroenterology (1985) 1.15

The cutaneous microflora of adolescent, persistent and late-onset acne patients does not differ. Br J Dermatol (2000) 1.14

Identification of large cell undifferentiated tumours in lymph nodes using leucocyte common and keratin antibodies. Histopathology (1984) 1.13

Sebum excretion in acromegaly. Br Med J (1972) 1.13

The role of IGF-I in human skin and its appendages: morphogen as well as mitogen? J Invest Dermatol (1997) 1.12

Acne and unemployment. Br J Dermatol (1986) 1.12

High frequency of loss of heterozygosity in actinic keratoses, a usually benign disease. Lancet (1994) 1.12

The primary sex ratio under environmental sex determination. J Theor Biol (1989) 1.11

Evolution at a high imposed mutation rate: adaptation obscures the load in phage T7. Genetics (2009) 1.11

Generalized hyperhidrosis following epilepsy. Br J Dermatol (1971) 1.08

Clearing of epidermolysis bullosa acquisita with cyclosporine. J Am Acad Dermatol (1990) 1.07

The effect of trimethoprim-sulphamethoxazole on sebum excretion rate and biochemistry in acne vulgaris. Br J Dermatol (1971) 1.07

Tetracycline and acne vulgaris: a clinical and laboratory investigation. Br Med J (1973) 1.07

Effects of benzoyl peroxide and erythromycin alone and in combination against antibiotic-sensitive and -resistant skin bacteria from acne patients. Br J Dermatol (1994) 1.07

Age and sex variation in skin surface lipid composition and sebum excretion rate. Br J Dermatol (1972) 1.07

Acne, hormones, and treatment. Br Med J (Clin Res Ed) (1982) 1.06

Towards defining the pathogenesis of the hairless phenotype. J Invest Dermatol (1998) 1.06