PubRank

Marc De Maeyer

Author PubWeight™ 44.45‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nat Chem Biol 2010 2.48
2 A structural basis for the unique binding features of the human vitamin D-binding protein. Nat Struct Biol 2002 1.78
3 Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations. J Virol 2003 1.54
4 Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV. PLoS Pathog 2007 1.41
5 Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant. J Neurochem 2011 1.33
6 Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360. AIDS 2004 1.28
7 Identification of the LEDGF/p75 binding site in HIV-1 integrase. J Mol Biol 2006 1.24
8 LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding. PLoS One 2011 1.19
9 Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. J Biol Chem 2002 1.11
10 Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137. Antimicrob Agents Chemother 2008 1.10
11 Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. PLoS One 2012 1.09
12 Evidence for DNA-binding domain--ligand-binding domain communications in the androgen receptor. Mol Cell Biol 2012 1.03
13 Elimination of a human T-cell region in staphylokinase by T-cell screening and computer modeling. Thromb Haemost 2002 1.03
14 Structural basis for the high Ca2+ affinity of the ubiquitous SERCA2b Ca2+ pump. Proc Natl Acad Sci U S A 2009 0.99
15 Tuning the size and properties of ClyA nanopores assisted by directed evolution. J Am Chem Soc 2013 0.95
16 The dead-end elimination method, tryptophan rotamers, and fluorescence lifetimes. Biophys J 2003 0.93
17 Impact on replicative fitness of the G48E substitution in the protease of HIV-1: an in vitro and in silico evaluation. J Acquir Immune Defic Syndr 2008 0.89
18 An alternate sucrose binding mode in the E203Q Arabidopsis invertase mutant: an X-ray crystallography and docking study. Proteins 2008 0.87
19 A consensus tetrapeptide selected by phage display adopts the conformation of a dominant discontinuous epitope of a monoclonal anti-VWF antibody that inhibits the von Willebrand factor-collagen interaction. J Biol Chem 2003 0.86
20 LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014). Expert Opin Ther Pat 2014 0.86
21 Experimental indication for the existence of multiple Trp rotamers in von Willebrand Factor A3 domain. Proteins 2004 0.84
22 Staphylokinase-specific cell-mediated immunity in humans. J Immunol 2002 0.83
23 Paratope and epitope mapping of the antithrombotic antibody 6B4 in complex with platelet glycoprotein Ibalpha. J Biol Chem 2007 0.82
24 Tryptophan rotamers as evidenced by X-ray, fluorescence lifetimes, and molecular dynamics modeling. Biophys J 2006 0.82
25 Biochemical and structural characterization of TLXI, the Triticum aestivum L. thaumatin-like xylanase inhibitor. J Enzyme Inhib Med Chem 2009 0.81
26 Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain. J Biol Chem 2005 0.81
27 Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2. Biochim Biophys Acta 2012 0.81
28 Structure based discovery of small molecule suppressors targeting bacterial lysozyme inhibitors. Biochem Biophys Res Commun 2011 0.81
29 Understanding the role of defective invertases in plants: tobacco Nin88 fails to degrade sucrose. Plant Physiol 2013 0.81
30 In vivo neutralization of a C2 domain-specific human anti-Factor VIII inhibitor by an anti-idiotypic antibody. Blood 2003 0.80
31 An optimized MM/PBSA virtual screening approach applied to an HIV-1 gp41 fusion peptide inhibitor. Proteins 2011 0.79
32 Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura. Blood 2009 0.79
33 Computational investigation of the HIV-1 Rev multimerization using molecular dynamics simulations and binding free energy calculations. Proteins 2012 0.78
34 Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev. PLoS One 2013 0.78
35 How do rotameric conformations influence the time-resolved fluorescence of tryptophan in proteins? A perspective based on molecular modeling and quantum chemistry. Curr Protein Pept Sci 2008 0.78
36 pKa modulation of the acid/base catalyst within GH32 and GH68: a role in substrate/inhibitor specificity? PLoS One 2012 0.78
37 Identification of small peptides inhibiting the integrase-LEDGF/p75 interaction through targeting the cellular co-factor. J Pept Sci 2013 0.77
38 An unusual red-edge excitation and time-dependent Stokes shift in the single tryptophan mutant protein DD-carboxypeptidase from Streptomyces: the role of dynamics and tryptophan rotamers. Protein Sci 2007 0.77
39 Exploration of the activation pathway of Deltaalpha-Chymotrypsin with molecular dynamics simulations and correlation with kinetic experiments. Eur Biophys J 2008 0.77
40 Study of recombinant antibody fragments and PAI-1 complexes combining protein-protein docking and results from site-directed mutagenesis. Structure 2007 0.77
41 Identification of a small molecule that modulates platelet glycoprotein Ib-von Willebrand factor interaction. J Biol Chem 2012 0.76
42 Protein simulations: the absorption spectrum of barnase point mutants. Protein Sci 2004 0.76
43 Validation of APRI and FIB-4 score in an Antwerp cohort of chronic hepatitis C patients. Acta Gastroenterol Belg 2015 0.76
44 Tryptophan conformations associated with partial unfolding in ribonuclease T1. Biophys J 2009 0.76
45 An integrated fragment based screening approach for the discovery of small molecule modulators of the VWF-GPIbα interaction. Chem Commun (Camb) 2012 0.76
46 Influence of limited proteolysis, detergent treatment and lyophilization on the phenoloxidase activity of Rapana thomasiana hemocyanin. Int J Biol Macromol 2009 0.76
47 Conformational stabilization at the active site of molluskan (Rapana thomasiana) hemocyanin by a cysteine-histidine thioether bridge A study by mass spectrometry and molecular modeling. Peptides 2006 0.75
48 Genome wide analysis and comparative docking studies of new diaryl furan derivatives against human cyclooxygenase-2, lipoxygenase, thromboxane synthase and prostacyclin synthase enzymes involved in inflammatory pathway. J Mol Graph Model 2009 0.75
49 Combined molecular and supramolecular bottom-up nanoengineering for enhanced nonlinear optical response: experiments, modeling, and approaching the fundamental limit. J Chem Phys 2007 0.75