Published in Toxicol Sci on January 01, 2002
Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies. Environ Health Perspect (2008) 0.97
Effect of PCBs on the lactational transfer of methyl mercury in mice: PBPK modeling. Environ Toxicol Pharmacol (2009) 0.77
Physiologically based pharmacokinetic modeling of zinc oxide nanoparticles and zinc nitrate in mice. Int J Nanomedicine (2015) 0.77
Interpreting copper bioaccumulation dynamics in tilapia using systems-level explorations of pulsed acute/chronic exposures. Ecotoxicology (2014) 0.76
Application of biologically based computer modeling to simple or complex mixtures. Environ Health Perspect (2002) 1.42
A possible role of multidrug resistance-associated protein 2 (Mrp2) in hepatic excretion of PCB126, an environmental contaminant: PBPK/PD modeling. Toxicol Sci (2008) 1.40
Computational and ultrastructural toxicology of a nanoparticle, Quantum Dot 705, in mice. Environ Sci Technol (2008) 1.30
BioMOL: a computer-assisted biological modeling tool for complex chemical mixtures and biological processes at the molecular level. Environ Health Perspect (2002) 1.23
Chemical mixtures research: significance and future perspectives. Environ Health Perspect (2002) 1.03
Biochemical reaction network modeling: predicting metabolism of organic chemical mixtures. Environ Sci Technol (2005) 0.99
In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane. Environ Health Perspect (2002) 0.98
Molecular circuits, biological switches, and nonlinear dose-response relationships. Environ Health Perspect (2002) 0.89
Computational toxicology of chloroform: reverse dosimetry using Bayesian inference, Markov chain Monte Carlo simulation, and human biomonitoring data. Environ Health Perspect (2008) 0.89
Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: application of cDNA microarray technology. Environ Health Perspect (2002) 0.87
Evaluation of potential toxicity from co-exposure to three CNS depressants (toluene, ethylbenzene, and xylene) under resting and working conditions using PBPK modeling. J Occup Environ Hyg (2005) 0.86
A physiologically based pharmacokinetic model of rifampin in mice. Antimicrob Agents Chemother (2013) 0.86
Characterization of the pharmacokinetics of gasoline using PBPK modeling with a complex mixtures chemical lumping approach. Inhal Toxicol (2003) 0.85
A physiologically based pharmacokinetic model for lactational transfer of PCB 153 with or without PCB 126 in mice. Arch Toxicol (2006) 0.85
PBPK modeling of complex hydrocarbon mixtures: gasoline. Environ Toxicol Pharmacol (2004) 0.84
Population physiologically based pharmacokinetic modeling for the human lactational transfer of PCB-153 with consideration of worldwide human biomonitoring results. Environ Health Perspect (2008) 0.83
p21(WAF1/CIP1) inhibits cell cycle progression but not G2/M-phase transition following methylmercury exposure. Toxicol Appl Pharmacol (2002) 0.82
Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk. Crit Rev Toxicol (2014) 0.82
Investigations of methylmercury-induced alterations in neurogenesis. Environ Health Perspect (2002) 0.82
Physiologically based pharmacokinetic (PBPK) models for lifetime exposure to PCB 153 in male and female harbor porpoises (Phocoena phocoena): model development and evaluation. Environ Sci Technol (2010) 0.79
Gene expression changes associated with altered growth and differentiation in benzo[a]pyrene or arsenic exposed normal human epidermal keratinocytes. J Appl Toxicol (2008) 0.79
Gene expression patterns as potential molecular biomarkers for malignant transformation in human keratinocytes treated with MNNG, arsenic, or a metal mixture. Toxicol Sci (2003) 0.78
Predicting activation enthalpies of cytochrome-P450-mediated hydrogen abstractions. 2. Comparison of semiempirical PM3, SAM1, and AM1 with a density functional theory method. J Chem Inf Model (2009) 0.78
Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. Toxicol Sci (2003) 0.77
Effect of PCBs on the lactational transfer of methyl mercury in mice: PBPK modeling. Environ Toxicol Pharmacol (2009) 0.77
Application of Bayesian population physiologically based pharmacokinetic (PBPK) modeling and Markov chain Monte Carlo simulations to pesticide kinetics studies in protected marine mammals: DDT, DDE, and DDD in harbor porpoises. Environ Sci Technol (2013) 0.77
Hepatic sequestration of chlordecone and hexafluoroacetone evaluated by pharmacokinetic modeling. Toxicology (2007) 0.76
Application of PBPK modeling in support of the derivation of toxicity reference values for 1,1,1-trichloroethane. Regul Toxicol Pharmacol (2007) 0.76
Quantitative analysis of liver GST-P foci promoted by a chemical mixture of hexachlorobenzene and PCB 126: implication of size-dependent cellular growth kinetics. Arch Toxicol (2007) 0.76
An updated physiologically based pharmacokinetic model for hexachlorobenzene: incorporation of pathophysiological states following partial hepatectomy and hexachlorobenzene treatment. Toxicol Sci (2006) 0.76
An in silico approach for evaluating a fraction-based, risk assessment method for total petroleum hydrocarbon mixtures. J Toxicol (2012) 0.75
A non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises. Toxicol Appl Pharmacol (2011) 0.75
Lifetime PCB 153 bioaccumulation and pharmacokinetics in pilot whales: Bayesian population PBPK modeling and Markov chain Monte Carlo simulations. Chemosphere (2013) 0.75
A physiologically-based pharmacokinetic model of methotrexate incorporating hepatic excretion via multidrug-resistance-associated protein 2 (Mrp2) in mice, rats, dogs, and humans. Conf Proc IEEE Eng Med Biol Soc (2017) 0.75
Computational toxicology: Physiologically based pharmacokinetic models (PBPK) for lifetime exposure and bioaccumulation of polybrominated diphenyl ethers (PBDEs) in marine mammals. Environ Pollut (2012) 0.75
Pitfalls and related improvements of in vivo gas uptake pharmacokinetic experimental systems. Inhal Toxicol (2005) 0.75
Development of a physiologically based pharmacokinetic model for volatile fractions of gasoline using chemical lumping analysis. Environ Sci Technol (2004) 0.75
Pharmacokinetics and pharmacodynamics of CD4-anchoring bi-functional fusion inhibitor in monkeys. Pharm Res (2013) 0.75
A novel, sensitive method for determining benzo[a]pyrene-diones using high-performance liquid chromatography with post-column zinc reduction. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 0.75
A reaction network model for CYP2E1-mediated metabolism of toxicant mixtures. Environ Toxicol Pharmacol (2004) 0.75
Effects of developmental exposure to lead, magnesium and zinc mixtures on spatial learning and expression of NMDA receptor subunit mRNA in Fischer 344 rats. Toxicol Lett (2002) 0.75