Treatment of periodontitis by local administration of minocycline microspheres: a controlled trial.

PubWeight™: 1.35‹?› | Rank: Top 10%

🔗 View Article (PMID 11759865)

Published in J Periodontol on November 01, 2001

Authors

R C Williams1, D W Paquette, S Offenbacher, D F Adams, G C Armitage, K Bray, J Caton, D L Cochran, C H Drisko, J P Fiorellini, W V Giannobile, S Grossi, D M Guerrero, G K Johnson, I B Lamster, I Magnusson, R J Oringer, G R Persson, T E Van Dyke, L F Wolff, E A Santucci, B E Rodda, J Lessem

Author Affiliations

1: Department of Periodontology, University of North Carolina, School of Dentistry, Chapel Hill 27599-7450, USA. ray_williams@dentistry.unc.edu

Articles citing this

Diagnostic biomarkers for oral and periodontal diseases. Dent Clin North Am (2005) 1.56

Oral fluid-based biomarkers of alveolar bone loss in periodontitis. Ann N Y Acad Sci (2007) 1.39

Cell- and gene-based therapeutic strategies for periodontal regenerative medicine. J Periodontol (2011) 1.04

Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes. Proc Natl Acad Sci U S A (2013) 1.03

Crevicular fluid biomarkers and periodontal disease progression. J Clin Periodontol (2013) 0.94

An in vitro model of ciprofloxacin and minocycline transport by oral epithelial cells. J Periodontol (2002) 0.91

Intraperiodontal pocket: An ideal route for local antimicrobial drug delivery. J Adv Pharm Technol Res (2012) 0.88

Effect of a controlled release device containing minocycline microspheres on the treatment of chronic periodontitis: A comparative study. J Indian Soc Periodontol (2009) 0.88

Antibacterial efficacy of exogenous nitric oxide on periodontal pathogens. J Dent Res (2014) 0.83

Cryotherapy and topical minocycline as adjunctive measures to control pain after third molar surgery: an exploratory study. J Oral Maxillofac Surg (2011) 0.82

Non-surgical chemotherapeutic treatment strategies for the management of periodontal diseases. Dent Clin North Am (2010) 0.82

Treatment modalities and evaluation models for periodontitis. Int J Pharm Investig (2012) 0.82

Kinetic-dependent Killing of Oral Pathogens with Nitric Oxide. J Dent Res (2015) 0.79

Activation and resolution of periodontal inflammation and its systemic impact. Periodontol 2000 (2015) 0.79

Anti-biofilm action of nitric oxide-releasing alkyl-modified poly(amidoamine) dendrimers against Streptococcus mutans. Acta Biomater (2015) 0.79

Comparative evaluation of locally delivered minocycline and metronidazole in the treatment of periodontitis. Contemp Clin Dent (2013) 0.79

Topical application of herbal formula for the treatment of ligature-induced periodontitis. J Periodontal Implant Sci (2015) 0.78

Minocycline Ointment as a Local Drug Delivery in the Treatment of Generalized Chronic Periodontitis - A Clinical Study. J Clin Diagn Res (2016) 0.77

The application of microencapsulation techniques in the treatment of endodontic and periodontal diseases. Pharmaceutics (2011) 0.77

Metal ion-assisted self-assembly of complexes for controlled and sustained release of minocycline for biomedical applications. Biofabrication (2015) 0.76

Comparison of Periochip (chlorhexidine gluconate 2.5 mg) and Arestin (Minocycline hydrochloride 1 mg) in the management of chronic periodontitis. Indian J Dent (2015) 0.75

The risk reduction of recurrent periodontal pathogens of local application minocycline HCl 2% gel, used as an adjunct to scaling and root planing for chronic periodontitis treatment. Ther Clin Risk Manag (2017) 0.75

Clinical trial subjects: "panning gold". Front Public Health (2013) 0.75

Microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation. J Korean Assoc Oral Maxillofac Surg (2015) 0.75

Platelet-Derived Growth Factor Delivery via Nanofibrous Scaffolds for Soft-Tissue Repair. Adv Skin Wound Care (2010) 0.75

Articles by these authors

Periodontal disease and cardiovascular disease. J Periodontol (1996) 5.78

The complications of coronary arteriography. Circulation (1973) 4.22

Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet (1999) 4.07

Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J Biomed Mater Res (1991) 3.57

Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv Dent Res (1998) 3.01

Periodontal disease and adverse pregnancy outcomes: a systematic review. BJOG (2006) 2.98

Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol (2001) 2.97

Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science (1991) 2.92

Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontol 2000 (1997) 2.62

Ability of commercial demineralized freeze-dried bone allograft to induce new bone formation. J Periodontol (1996) 2.58

Craniofacial tissue engineering by stem cells. J Dent Res (2006) 2.48

RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis. FASEB J (2005) 2.47

Renal failure in the patient with cirrhosis. The role of active vasoconstriction. Am J Med (1970) 2.43

Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63). J Biomed Mater Res (1995) 2.43

High surface energy enhances cell response to titanium substrate microstructure. J Biomed Mater Res A (2005) 2.39

Acute-phase inflammatory response to periodontal disease in the US population. J Dent Res (2000) 2.38

Identification of unrecognized diabetes and pre-diabetes in a dental setting. J Dent Res (2011) 2.34

Relationship between the percentage of subgingival spirochetes and the severity of periodontal disease. J Periodontol (1982) 2.31

Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies. J Dent Res (2005) 2.27

Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A (1995) 2.25

Relationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities (ARIC) study. Arterioscler Thromb Vasc Biol (2001) 2.20

Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect Immun (1999) 2.19

Chlorhexidine and preservation of sound tooth structure in older adults. A placebo-controlled trial. Caries Res (2007) 2.14

[Patella infera. Apropos of 128 cases]. Rev Chir Orthop Reparatrice Appar Mot (1982) 2.12

Discovery of new human beta-defensins using a genomics-based approach. Gene (2001) 2.08

Analysis of saliva for periodontal diagnosis--a review. J Clin Periodontol (2000) 2.04

Patient and personnel exposure during CT fluoroscopy-guided interventional procedures. Radiology (2000) 1.97

Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma. Cancer Res (1993) 1.95

Enhanced bone apposition to a chemically modified SLA titanium surface. J Dent Res (2004) 1.93

Response of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition. Biomaterials (1998) 1.89

Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. J Clin Invest (2000) 1.82

Interactive MR-guided biopsy in an open-configuration MR imaging system. Radiology (1995) 1.79

Haim-Munk syndrome and Papillon-Lefèvre syndrome are allelic mutations in cathepsin C. J Med Genet (2000) 1.78

Periodontitis: a risk factor for coronary heart disease? Ann Periodontol (1998) 1.77

Surface roughness modulates the local production of growth factors and cytokines by osteoblast-like MG-63 cells. J Biomed Mater Res (1996) 1.77

Ability of commercial demineralized freeze-dried bone allograft to induce new bone formation is dependent on donor age but not gender. J Periodontol (1998) 1.76

The use of crevicular fluid prostaglandin E2 levels as a predictor of periodontal attachment loss. J Periodontal Res (1986) 1.72

The role of surveillance endoscopic retrograde cholangiopancreatography in preventing episodic cholangitis in patients with recurrent common bile duct stones. Endoscopy (1998) 1.64

Web-based digital radiology teaching file: facilitating case input at time of interpretation. AJR Am J Roentgenol (1998) 1.63

Effect of systemic matrix metalloproteinase inhibition on periodontal wound repair: a proof of concept trial. J Periodontol (2004) 1.62

Reciprocal influence of salt intake on adrenal glomerulosa and renal vascular responses to angiotensin II in normal man. J Clin Invest (1974) 1.59

Complications of angiography. Radiology (1981) 1.59

Idiopathic recurrent pancreatitis. An approach to diagnosis and treatment. Dig Dis Sci (1989) 1.58

Comparison of the effects of cetylpyridinium chloride with an essential oil mouth rinse on dental plaque and gingivitis - a six-month randomized controlled clinical trial. J Clin Periodontol (2007) 1.57

Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. J Clin Invest (1996) 1.57

Periostin is essential for the integrity and function of the periodontal ligament during occlusal loading in mice. J Periodontol (2008) 1.56

Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-alpha and IL-1 beta production by human monocytes. J Immunol (1994) 1.53

Effect of heparin on vascular smooth muscle cells. I. Cell metabolism. J Cell Physiol (1985) 1.50

Pressure measurements from biliary and pancreatic segments of sphincter of Oddi. Comparison between patients with functional abdominal pain, biliary, or pancreatic disease. Dig Dis Sci (1991) 1.48

Toll-like receptors regulate B cell cytokine production in patients with diabetes. Diabetologia (2010) 1.48

Maternal periodontitis and prematurity. Part II: Maternal infection and fetal exposure. Ann Periodontol (2001) 1.48

Shape and volume changes during "isovolumetric relaxation" in normal and asynergic ventricles. Circulation (1974) 1.48

Neutrophil chemotaxis dysfunction in human periodontitis. Infect Immun (1980) 1.48

Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study. J Clin Invest (1995) 1.47

Nuclear lamins of erythrocyte and liver. J Biol Chem (1980) 1.47

Osteoblasts generate an osteogenic microenvironment when grown on surfaces with rough microtopographies. Eur Cell Mater (2003) 1.46

A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflamm Res (1997) 1.46

Inflammation and uncoupling as mechanisms of periodontal bone loss. J Dent Res (2010) 1.45

Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy. Prostate (2008) 1.45

Endoscopic treatment of problems encountered after laparoscopic cholecystectomy [corrected]. Gastrointest Endosc (1993) 1.45

A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease. J Periodontol (1997) 1.44

Expediting the turnaround of radiology reports: use of total quality management to facilitate radiologists' report signing. AJR Am J Roentgenol (1994) 1.44

Differentiation of monocytes to macrophages primes cells for lipopolysaccharide stimulation via accumulation of cytoplasmic nuclear factor kappaB. Infect Immun (1999) 1.43

Senescence and the renal vasculature in normal man. Circ Res (1974) 1.43

Assessment of alveolar bone levels from intraoral radiographs in subjects between ages 15 and 94 years seeking dental care. J Clin Periodontol (1998) 1.42

The association between periodontal diseases and cardiovascular diseases: a state-of-the-science review. Ann Periodontol (2001) 1.42

Sequence analysis of the Alcaligenes eutrophus chromosomally encoded ribulose bisphosphate carboxylase large and small subunit genes and their gene products. J Bacteriol (1987) 1.40

A profile of the physiological disposition and gastro-intestinal effects of fenoprofen in man. Curr Med Res Opin (1974) 1.39

Peri-implant inflammation defined by the implant-abutment interface. J Dent Res (2006) 1.39

Interface shear strength of titanium implants with a sandblasted and acid-etched surface: a biomechanical study in the maxilla of miniature pigs. J Biomed Mater Res (1999) 1.38

Metabolism of [2-14C]acetate and its use in assessing hepatic Krebs cycle activity and gluconeogenesis. J Biol Chem (1991) 1.38

Hypersensitive dentin: testing of procedures for mechanical and chemical obliteration of dentinal tubuli. J Periodontol (1993) 1.38

Inhibition of neutrophil chemotaxis by soluble bacterial products. J Periodontol (1982) 1.38

Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. Biochemistry (2000) 1.38

Interaction of Porphyromonas gingivalis with gingival epithelial cells maintained in culture. Oral Microbiol Immunol (1992) 1.37

Adjunctive use of a subgingival controlled-release chlorhexidine chip reduces probing depth and improves attachment level compared with scaling and root planing alone. J Periodontol (1998) 1.37

Integrin alpha2beta1 plays a critical role in osteoblast response to micron-scale surface structure and surface energy of titanium substrates. Proc Natl Acad Sci U S A (2008) 1.37

Saliva/pathogen biomarker signatures and periodontal disease progression. J Dent Res (2011) 1.37

Nucleotide sequence of bean golden mosaic virus and a model for gene regulation in geminiviruses. Proc Natl Acad Sci U S A (1985) 1.35

Titanium surface roughness alters responsiveness of MG63 osteoblast-like cells to 1 alpha,25-(OH)2D3. J Biomed Mater Res (1998) 1.35

Periodontal medicine: the emergence of a new branch of periodontology. Periodontol 2000 (2000) 1.35

Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2. Bone (2002) 1.34

Microrough implant surface topographies increase osteogenesis by reducing osteoclast formation and activity. J Biomed Mater Res A (2004) 1.33

Relationship of periodontal disease and edentulism to stroke/TIA. J Dent Res (2003) 1.32

Pathogen-related oral spirochetes from dental plaque are invasive. Infect Immun (1991) 1.32

Effect of salivary agglutinins of reactions between hydroxyapatite and a serotype c strain of Streptococcus mutans. Caries Res (1976) 1.31

Tentative method of analysis for sulfur dioxide content of the atmosphere (colorimetric). 42401-0169T. Health Lab Sci (1970) 1.31

Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis. J Leukoc Biol (2005) 1.31

Histometric evaluation of periodontal surgery. II. Connective tissue attachment levels after four regenerative procedures. J Clin Periodontol (1980) 1.30

Effects of a Porphyromonas gingivalis infection on inflammatory mediator response and pregnancy outcome in hamsters. Infect Immun (1994) 1.30

Risk indicators for periodontal disease in a racially diverse urban population. J Clin Periodontol (1996) 1.30

Alterations in the signal-transducing molecules of T cells and NK cells in colorectal tumor-infiltrating, gut mucosal and peripheral lymphocytes: correlation with the stage of the disease. Int J Cancer (1995) 1.29

Prevalence of dental caries and treatment needs in the school-going children of rural areas in Udaipur district. J Indian Soc Pedod Prev Dent (2007) 1.29

Periodontal infections and pre-term birth: early findings from a cohort of young minority women in New York. Eur J Oral Sci (2001) 1.28

beta-adrenergic blockade in essential hypertension: reduced renin release despite renal vasoconstriction. Circ Res (1976) 1.28

Inflammatory mediator response as a potential risk marker for periodontal diseases in insulin-dependent diabetes mellitus patients. J Periodontol (1997) 1.28