Published in Expert Opin Investig Drugs on January 01, 2002
Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci U S A (2006) 1.61
Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling. J Neurosci (2011) 1.55
Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness. J Med Chem (2011) 1.24
Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention. Proc Natl Acad Sci U S A (2014) 1.22
The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain Behav Immun (2009) 1.07
An update and appraisal of the cilomilast Phase III clinical development programme for chronic obstructive pulmonary disease. Br J Clin Pharmacol (2006) 0.89
Phosphodiesterase 4-targeted treatments for autoimmune diseases. BMC Med (2013) 0.88
Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors. ChemMedChem (2009) 0.87
A Phase I Study of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib (LEE011) in Patients with Advanced Solid Tumors and Lymphomas. Clin Cancer Res (2016) 0.85
Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases. J Biomol Screen (2008) 0.85
Effects of dibutyryl cyclic-AMP on survival and neuronal differentiation of neural stem/progenitor cells transplanted into spinal cord injured rats. PLoS One (2011) 0.84
Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior. Psychopharmacology (Berl) (2014) 0.83
Effect of elevated intracellular cAMP levels on actomyosin contraction in bovine trabecular meshwork cells. Invest Ophthalmol Vis Sci (2011) 0.83
Treating COPD with PDE 4 inhibitors. Int J Chron Obstruct Pulmon Dis (2007) 0.83
Reduction of microglial activity in a model of multiple sclerosis by dipyridamole. J Neuroinflammation (2013) 0.82
PDE 7 inhibitors: new potential drugs for the therapy of spinal cord injury. PLoS One (2011) 0.82
Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther (2015) 0.81
Selecting screening candidates for kinase and G protein-coupled receptor targets using neural networks. J Chem Inf Comput Sci (2002) 0.79
Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: a new use of silicon bioisosteres in medicinal chemistry. Bioorg Med Chem Lett (2006) 0.78
7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma. Bioorg Med Chem Lett (2002) 0.75
8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma. Bioorg Med Chem Lett (2002) 0.75
Synthesis and profile of SCH351591, a novel PDE4 inhibitor. Bioorg Med Chem Lett (2002) 0.75
8-Methoxyquinolines as PDE4 inhibitors. Bioorg Med Chem Lett (2002) 0.75
Action of (R)-sila-venlafaxine and reboxetine to antagonize cisplatin-induced acute and delayed emesis in the ferret. Toxicol Appl Pharmacol (2008) 0.75
(R)-sila-venlafaxine: a selective noradrenaline reuptake inhibitor for the treatment of emesis. Bioorg Med Chem Lett (2006) 0.75
Silicon analogues of the nonpeptidic GnRH antagonist AG-045572: syntheses, crystal structure analyses, and pharmacological characterization. ChemMedChem (2011) 0.75