What does it mean to be natively unfolded?

Natively unfolded proteins: a point where biology waits for physics. Protein Sci (2002) 6.91

Understanding protein non-folding. Biochim Biophys Acta (2010) 4.33

Length-dependent prediction of protein intrinsic disorder. BMC Bioinformatics (2006) 3.70

Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded. Proc Natl Acad Sci U S A (2003) 3.07

The MAP2/Tau family of microtubule-associated proteins. Genome Biol (2004) 2.80

The unfoldomics decade: an update on intrinsically disordered proteins. BMC Genomics (2008) 2.72

A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures. Proc Natl Acad Sci U S A (2007) 2.62

Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res (2007) 2.61

Identification, analysis, and prediction of protein ubiquitination sites. Proteins (2010) 2.53

Protein flexibility and intrinsic disorder. Protein Sci (2004) 2.33

Characterization of molecular recognition features, MoRFs, and their binding partners. J Proteome Res (2007) 2.23

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1. EMBO J (2010) 2.12

Organization of the core structure of the postsynaptic density. Proc Natl Acad Sci U S A (2008) 2.06

Mining alpha-helix-forming molecular recognition features with cross species sequence alignments. Biochemistry (2007) 1.93

Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators. Structure (2010) 1.89

A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner. Nat Biotechnol (2009) 1.77

A decade and a half of protein intrinsic disorder: biology still waits for physics. Protein Sci (2013) 1.74

Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues. Proc Natl Acad Sci U S A (2013) 1.71

TOP-IDP-scale: a new amino acid scale measuring propensity for intrinsic disorder. Protein Pept Lett (2008) 1.70

Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein. Curr Protein Pept Sci (2009) 1.66

Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity. Proc Natl Acad Sci U S A (2007) 1.65

Improved disorder prediction by combination of orthogonal approaches. PLoS One (2009) 1.63

Prediction of amyloidogenic and disordered regions in protein chains. PLoS Comput Biol (2006) 1.58

Prokaryotic ubiquitin-like protein pup is intrinsically disordered. J Mol Biol (2009) 1.49

Intrinsic disorder in scaffold proteins: getting more from less. Prog Biophys Mol Biol (2008) 1.49

The C terminus of the Alb3 membrane insertase recruits cpSRP43 to the thylakoid membrane. J Biol Chem (2009) 1.49

Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions. J Proteome Res (2007) 1.48

Intrinsically disordered and pliable Starmaker-like protein from medaka (Oryzias latipes) controls the formation of calcium carbonate crystals. PLoS One (2014) 1.43

Conservation of intrinsic disorder in protein domains and families: I. A database of conserved predicted disordered regions. J Proteome Res (2006) 1.42

Unfoldomics of human diseases: linking protein intrinsic disorder with diseases. BMC Genomics (2009) 1.41

Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins. Nucleic Acids Res (2006) 1.39

The protein kingdom extended: ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation. Prog Biophys Mol Biol (2010) 1.38

Spritz: a server for the prediction of intrinsically disordered regions in protein sequences using kernel machines. Nucleic Acids Res (2006) 1.37

Two microtubule-associated proteins of Arabidopsis MAP65s promote antiparallel microtubule bundling. Mol Biol Cell (2008) 1.35

The K-segment of maize DHN1 mediates binding to anionic phospholipid vesicles and concomitant structural changes. Plant Physiol (2009) 1.34

DNA search efficiency is modulated by charge composition and distribution in the intrinsically disordered tail. Proc Natl Acad Sci U S A (2010) 1.29

Conservation of intrinsic disorder in protein domains and families: II. functions of conserved disorder. J Proteome Res (2006) 1.27

RNA chaperoning and intrinsic disorder in the core proteins of Flaviviridae. Nucleic Acids Res (2007) 1.24

Guiding protein aggregation with macromolecular crowding. Biochemistry (2008) 1.23

Protein disorder: conformational distribution of the flexible linker in a chimeric double cellulase. Biophys J (2005) 1.22

NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain. Nucleic Acids Res (2005) 1.19

The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome. J Biomed Biotechnol (2010) 1.16

Essential amino acids of the hantaan virus N protein in its interaction with RNA. J Virol (2005) 1.13

Calcium-dependent regulation of NEMO nuclear export in response to genotoxic stimuli. Mol Cell Biol (2006) 1.12

Beyond the random coil: stochastic conformational switching in intrinsically disordered proteins. Structure (2011) 1.12

NMR relaxation studies on the hydrate layer of intrinsically unstructured proteins. Biophys J (2004) 1.11

CSpritz: accurate prediction of protein disorder segments with annotation for homology, secondary structure and linear motifs. Nucleic Acids Res (2011) 1.10

Perturbed amelogenin secondary structure leads to uncontrolled aggregation in amelogenesis imperfecta mutant proteins. J Biol Chem (2010) 1.10

Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev (2014) 1.10

Polycation-induced oligomerization and accelerated fibrillation of human alpha-synuclein in vitro. Protein Sci (2003) 1.09

Amyloidogenesis of natively unfolded proteins. Curr Alzheimer Res (2008) 1.08

To be folded or to be unfolded? Protein Sci (2004) 1.07

Life inside a thin section: tomography. J Neurosci (2008) 1.06

Nanoimaging for protein misfolding and related diseases. J Cell Biochem (2006) 1.05

Dynamic behavior of an intrinsically unstructured linker domain is conserved in the face of negligible amino acid sequence conservation. J Mol Evol (2007) 1.04

Dissecting amelogenin protein nanospheres: characterization of metastable oligomers. J Biol Chem (2011) 1.03

Solution conformation, backbone dynamics and lipid interactions of the intrinsically unstructured malaria surface protein MSP2. J Mol Biol (2008) 1.03

Fast and faster: a designed variant of the B-domain of protein A folds in 3 microsec. Protein Sci (2004) 1.03

CDF it all: consensus prediction of intrinsically disordered proteins based on various cumulative distribution functions. FEBS Lett (2009) 1.03

Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3. Biophys J (2008) 1.03

Single-molecule spectroscopy of protein conformational dynamics in live eukaryotic cells. Nat Methods (2015) 1.02

Vaccine potentials of an intrinsically unstructured fragment derived from the blood stage-associated Plasmodium falciparum protein PFF0165c. Infect Immun (2009) 1.01

Disorder and function: a review of the dehydrin protein family. Front Plant Sci (2014) 1.00

Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function. Chem Rev (2014) 1.00

Intrinsic disorder in the C-terminal domain of the Shaker voltage-activated K+ channel modulates its interaction with scaffold proteins. Proc Natl Acad Sci U S A (2007) 0.99

Senescence-associated barley NAC (NAM, ATAF1,2, CUC) transcription factor interacts with radical-induced cell death 1 through a disordered regulatory domain. J Biol Chem (2011) 0.98

Syncytial phenotype of C-terminally truncated herpes simplex virus type 1 gB is associated with diminished membrane interactions. J Virol (2010) 0.98

Effect of Src kinase phosphorylation on disordered C-terminal domain of N-methyl-D-aspartic acid (NMDA) receptor subunit GluN2B protein. J Biol Chem (2011) 0.98

The intrinsically disordered cytoplasmic domain of the T cell receptor zeta chain binds to the nef protein of simian immunodeficiency virus without a disorder-to-order transition. Biochemistry (2008) 0.97

Common attributes of native-state structures of proteins, disordered proteins, and amyloid. Proc Natl Acad Sci U S A (2006) 0.97

What macromolecular crowding can do to a protein. Int J Mol Sci (2014) 0.96

Macromolecular crowding induces a molten globule state in the C-terminal domain of histone H1. Biophys J (2007) 0.96

Human full-length Securin is a natively unfolded protein. Protein Sci (2005) 0.96

Scale-free flow of life: on the biology, economics, and physics of the cell. Theor Biol Med Model (2009) 0.96

Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analyses. Virol J (2009) 0.96

N-terminal domains of DELLA proteins are intrinsically unstructured in the absence of interaction with GID1/gibberellic acid receptors. J Biol Chem (2010) 0.95

The importance of size and disorder in the cryoprotective effects of dehydrins. Plant Physiol (2013) 0.95

Malleable conformation of the elastic PEVK segment of titin: non-co-operative interconversion of polyproline II helix, beta-turn and unordered structures. Biochem J (2003) 0.95

The acidic domains of the Toc159 chloroplast preprotein receptor family are intrinsically disordered protein domains. BMC Biochem (2009) 0.94

Desiccation and zinc binding induce transition of tomato abscisic acid stress ripening 1, a water stress- and salt stress-regulated plant-specific protein, from unfolded to folded state. Plant Physiol (2006) 0.94

SAXS study of the PIR domain from the Grb14 molecular adaptor: a natively unfolded protein with a transient structure primer? Biophys J (2004) 0.94

The intrinsically disordered RNR inhibitor Sml1 is a dynamic dimer. Biochemistry (2008) 0.93

Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept. Expert Rev Proteomics (2010) 0.93

Compaction properties of an intrinsically disordered protein: Sic1 and its kinase-inhibitor domain. Biophys J (2011) 0.93

A comparative analysis of viral matrix proteins using disorder predictors. Virol J (2008) 0.91

Calcium-induced folding and stabilization of the intrinsically disordered RTX domain of the CyaA toxin. Biophys J (2010) 0.91

Order propensity of an intrinsically disordered protein, the cyclin-dependent-kinase inhibitor Sic1. Proteins (2009) 0.91

Dynamics of well-folded and natively disordered proteins in solution: a time-of-flight neutron scattering study. Eur Biophys J (2008) 0.91

Prediction of Intrinsic Disorder in MERS-CoV/HCoV-EMC Supports a High Oral-Fecal Transmission. PLoS Curr (2013) 0.91

Competing interactions stabilize pro- and anti-aggregant conformations of human Tau. J Biol Chem (2011) 0.90

Dancing Protein Clouds: The Strange Biology and Chaotic Physics of Intrinsically Disordered Proteins. J Biol Chem (2016) 0.90

Quantitative analyses of cryptochrome-mBMAL1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock. J Biol Chem (2011) 0.90

Kinetics of contact formation and end-to-end distance distributions of swollen disordered peptides. Biophys J (2009) 0.90

Reduced stability and increased dynamics in the human proliferating cell nuclear antigen (PCNA) relative to the yeast homolog. PLoS One (2011) 0.89

A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome. J Biol Chem (2011) 0.89

Outer membrane targeting of secretin PulD protein relies on disordered domain recognition by a dedicated chaperone. J Biol Chem (2011) 0.89

Protein intrinsic disorder and influenza virulence: the 1918 H1N1 and H5N1 viruses. Virol J (2009) 0.88

Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii. Mol Biosyst (2013) 0.88

At low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillation. J Mol Biol (2009) 0.88

Conformation of the EPEC Tir protein in solution: investigating the impact of serine phosphorylation at positions 434/463. Biophys J (2007) 0.88