Published in Toxicology on January 25, 2002
Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease. Mol Nutr Food Res (2008) 2.23
Influenza A virus infection and cigarette smoke impair bronchodilator responsiveness to β-adrenoceptor agonists in mouse lung. Clin Sci (Lond) (2016) 1.40
Oxidative stress and accelerated vascular aging: implications for cigarette smoking. Front Biosci (Landmark Ed) (2009) 1.30
Acrolein-mediated injury in nervous system trauma and diseases. Mol Nutr Food Res (2011) 1.05
Emerging role of MAP kinase pathways as therapeutic targets in COPD. Int J Chron Obstruct Pulmon Dis (2006) 1.03
Proteomic profiling of acrolein adducts in human lung epithelial cells. J Proteomics (2011) 1.00
CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure. Exp Mol Pathol (2007) 0.94
Acrolein inhalation suppresses lipopolysaccharide-induced inflammatory cytokine production but does not affect acute airways neutrophilia. J Immunol (2008) 0.94
Oxidative stress, cell death, and other damage to alveolar epithelial cells induced by cigarette smoke. Tob Induc Dis (2003) 0.89
Trolox contributes to Nrf2-mediated protection of human and murine primary alveolar type II cells from injury by cigarette smoke. Cell Death Dis (2013) 0.88
Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity. Free Radic Biol Med (2008) 0.84
Acrolein oxidizes the cytosolic and mitochondrial thioredoxins in human endothelial cells. Toxicology (2007) 0.82
The standardized herbal formula, PM014, ameliorated cigarette smoke-induced lung inflammation in a murine model of chronic obstructive pulmonary disease. BMC Complement Altern Med (2013) 0.82
Acrolein-mediated conduction loss is partially restored by K+ channel blockers. J Neurophysiol (2015) 0.81
Effects of acrolein on leukotriene biosynthesis in human neutrophils. Chem Res Toxicol (2008) 0.79
Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells. Free Radic Biol Med (2013) 0.78
Inflammatory and cytotoxic effects of acrolein, nicotine, acetylaldehyde and cigarette smoke extract on human nasal epithelial cells. BMC Pulm Med (2014) 0.78
SCGB3A2 Inhibits Acrolein-Induced Apoptosis through Decreased p53 Phosphorylation. Acta Histochem Cytochem (2015) 0.77
Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanal. Chem Res Toxicol (2010) 0.76
Acute systemic accumulation of acrolein in mice by inhalation at a concentration similar to that in cigarette smoke. Neurosci Bull (2014) 0.75
Unilateral microinjection of acrolein into thoracic spinal cord produces acute and chronic injury and functional deficits. Neuroscience (2016) 0.75
Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation (2001) 14.70
Global burden of cardiovascular diseases: Part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies. Circulation (2001) 6.29
Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med (1992) 4.82
Oxygen radicals and human disease. Ann Intern Med (1987) 4.57
Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions. EMBO J (1990) 4.49
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature (1998) 4.34
Arthropod-borne viral infections of man in Nigeria, 1964-1970. Ann Trop Med Parasitol (1975) 2.98
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1. J Biol Chem (2000) 2.65
Pulmonary edema. 2. N Engl J Med (1973) 2.60
Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite. A potential additional mechanism of nitric oxide-dependent toxicity. J Biol Chem (1997) 2.48
Body mass index, waist circumference and waist:hip ratio as predictors of cardiovascular risk--a review of the literature. Eur J Clin Nutr (2009) 2.35
Ethnic comparisons of the cross-sectional relationships between measures of body size with diabetes and hypertension. Obes Rev (2008) 2.32
Glucose-6-phosphate dehydrogenase deficient red cells: resistance to infection by malarial parasites. Science (1969) 2.21
Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer. J Clin Oncol (1997) 2.17
Increased sickling of parasitised erythrocytes as mechanism of resistance against malaria in the sickle-cell trait. Lancet (1970) 2.11
Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathione. Am J Respir Cell Mol Biol (2001) 2.10
Antioxidant protection against hypochlorous acid in human plasma. J Lab Clin Med (1993) 1.95
Immunity, transferrin, and survival in kwashiorkor. Br Med J (1970) 1.89
Oxygen-derived species: their relation to human disease and environmental stress. Environ Health Perspect (1994) 1.84
A foodborne outbreak of gastroenteritis associated with Norwalk-like viruses: first molecular traceback to deli sandwiches contaminated during preparation. J Infect Dis (2000) 1.81
Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation. J Biol Chem (2001) 1.80
Cigarettes, cancer, and carotenoids: a continuing, unresolved antioxidant paradox. Am J Clin Nutr (2000) 1.80
An overview of the CERC ARTEMIS project. Proc Annu Symp Comput Appl Med Care (1995) 1.80
Dengue viruses from febrile patients in Nigeria, 1964-68. Lancet (1971) 1.79
Formation of nitrating and chlorinating species by reaction of nitrite with hypochlorous acid. A novel mechanism for nitric oxide-mediated protein modification. J Biol Chem (1996) 1.78
Pulmonary edema. 1. N Engl J Med (1973) 1.77
HDL and the inflammatory response induced by LDL-derived oxidized phospholipids. Arterioscler Thromb Vasc Biol (2001) 1.74
Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. Biochem J (1991) 1.73
Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice. Proc Natl Acad Sci U S A (1997) 1.66
Reactive nitrogen species and tyrosine nitration in the respiratory tract: epiphenomena or a pathobiologic mechanism of disease? Am J Respir Crit Care Med (1999) 1.65
The cellular src gene product regulates junctional cell-to-cell communication. Science (1988) 1.65
Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses. J Virol (2010) 1.60
Diabetes mellitus in Nigerians: a study of 832 patients. West Afr Med J Niger Pract (1971) 1.59
Oxidation of biologic molecules by ozone: the effect of pH. J Lab Clin Med (1993) 1.58
Aldehyde-induced protein modifications in human plasma: protection by glutathione and dihydrolipoic acid. J Lab Clin Med (1994) 1.56
Biochemical assessment of protein-calorie malnutrition. Lancet (1969) 1.55
Oxidants, antioxidants, and respiratory tract lining fluids. Environ Health Perspect (1994) 1.53
Localization of the sites of conduction abnormalities in a mouse model of myotonic dystrophy. J Cardiovasc Electrophysiol (1999) 1.53
A strategy for the development of secure telemedicine applications. Proc AMIA Annu Fall Symp (1997) 1.52
MR of parenchymal spinal cord signal change as a sign of active advancement in clinically progressive posttraumatic syringomyelia. AJNR Am J Neuroradiol (1998) 1.51
Glucose-6-phosphate-dehydrogenase deficiency, sickling, and malaria in African children in South Western Nigeria. Lancet (1967) 1.50
Myeloperoxidase and protein oxidation in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2000) 1.50
Proton MR spectroscopic measurement of neurometabolites in hepatic encephalopathy during oral lactulose therapy. AJNR Am J Neuroradiol (1998) 1.50
Genetic susceptibility to ozone-induced lung hyperpermeability: role of toll-like receptor 4. Am J Respir Cell Mol Biol (2000) 1.48
Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure. AIDS Res Hum Retroviruses (2008) 1.46
Fingerstick glucose determination in shock. Ann Intern Med (1991) 1.46
Tyrosine modification by reactive nitrogen species: a closer look. Arch Biochem Biophys (1995) 1.45
Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. Exp Cell Res (2000) 1.42
Increases in depression after cholesterol-lowering drug treatment. Behav Med (1996) 1.39
Dietary antioxidants and cigarette smoke-induced biomolecular damage: a complex interaction. Am J Clin Nutr (1995) 1.39
Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. Proc Natl Acad Sci U S A (1996) 1.37
Plant-produced idiotype vaccines for the treatment of non-Hodgkin's lymphoma: safety and immunogenicity in a phase I clinical study. Proc Natl Acad Sci U S A (2008) 1.34
Determination of low-molecular-mass antioxidant concentrations in human respiratory tract lining fluids. Am J Physiol (1999) 1.32
Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation. Biochem J (1992) 1.31
The systemic availability of oral glutathione. Eur J Clin Pharmacol (1992) 1.29
Erythromycin-sulfisoxazole vs amoxicillin in the treatment of acute otitis media in children. A double-blind, multiple-dose comparative study. Am J Dis Child (1985) 1.29
Expression of mucin synthesis and secretion in human tracheobronchial epithelial cells grown in culture. Am J Respir Cell Mol Biol (1990) 1.28
Whole body PET/CT for initial staging of choroidal melanoma. Br J Ophthalmol (2005) 1.25
Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts. Nat Genet (2000) 1.25
CTG repeats show bimodal amplification in E. coli. Cell (1998) 1.24
Selective disruption of genes expressed in totipotent embryonal stem cells. Genes Dev (1992) 1.24
Antioxidant protection: a function of tracheobronchial and gastrointestinal mucus. Lancet (1984) 1.23
Methadone: applied pharmacology and use as adjunctive treatment in chronic pain. Postgrad Med J (2004) 1.22
DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model. J Clin Invest (1999) 1.20
Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion. Biochem J (1994) 1.20
Screening for acute HIV infection in South Africa: finding acute and chronic disease. HIV Med (2011) 1.19
Oxygen toxicity: augmentation of antioxidant defense mechanisms in rat lung. Am J Physiol (1976) 1.18
Pseudomonas aeruginosa bacteremia in patients with AIDS. Clin Infect Dis (1994) 1.18
Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite. Evidence for hydroxyl radical production from peroxynitrite. FEBS Lett (1994) 1.17
Ozone interaction with rodent lung: effect on sulfhydryls and sulfhydryl-containing enzyme activities. J Lab Clin Med (1972) 1.17
Destruction of tocopherols, carotenoids, and retinol in human plasma by cigarette smoke. Am J Clin Nutr (1996) 1.16
Regulation of pp60c-src synthesis by inducible RNA complementary to c-src mRNA in polyomavirus-transformed rat cells. Mol Cell Biol (1986) 1.15
Cigarette smokers and oxidant stress: a continuing mystery. Am J Clin Nutr (1998) 1.15
Trimethoprim-sulphamethoxazole in pertussis: comparison with tetracycline. Arch Dis Child (1972) 1.14
Inhibition of neutrophil apoptosis by acrolein: a mechanism of tobacco-related lung disease? Am J Physiol Lung Cell Mol Physiol (2001) 1.14
Relation of symptoms to impaired stomach, small bowel, and colon motility in long-standing diabetes. Dig Dis Sci (1993) 1.13
Immunoglobulins, transferrin, caeruloplasmin and heterophile antibodies in kwashiorkor. Trop Geogr Med (1970) 1.12
Dysregulation of the adipoinsular axis -- a mechanism for the pathogenesis of hyperleptinemia and adipogenic diabetes induced by fetal programming. J Endocrinol (2001) 1.11
Variation in the percent of emphysema-like lung in a healthy, nonsmoking multiethnic sample. The MESA lung study. Ann Am Thorac Soc (2014) 1.11
Cigarette smoking and antioxidant vitamins: the smoke screen continues to clear but has a way to go. Am J Clin Nutr (1997) 1.11
Is there a difference between right and left femoral bone density? J Clin Densitom (2000) 1.11
Varicella-zoster virus ORF57, unlike its pseudorabies virus UL3.5 homolog, is dispensable for viral replication in cell culture. Virology (1998) 1.10
Human lung tumor growth established in the lung and subcutaneous tissue of mice with severe combined immunodeficiency. Cancer Res (1987) 1.10
Application of pericardial graft in the surgical management of Peyronie's disease. J Urol (2000) 1.10
Results of re-irradiation for cerebral metastases. Cancer (1980) 1.10
Tobacco-related diseases. Is there a role for antioxidant micronutrient supplementation? Clin Chest Med (2000) 1.06
A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-beta activation in the kidneys of rats used as a model of diabetes. Diabetologia (2008) 1.06
Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis. Dev Biol (2001) 1.06
Nitric oxide rapidly scavenges tyrosine and tryptophan radicals. Biochem J (1995) 1.06
Evaluation of tracheal tube introducers in simulated difficult intubation. Anaesthesia (2009) 1.05
Isolation of cellular promoters by using a retrovirus promoter trap. Proc Natl Acad Sci U S A (1990) 1.05
Pulsatile flow regulates monocyte adhesion to oxidized lipid-induced endothelial cells. Arterioscler Thromb Vasc Biol (2001) 1.05