Published in Bone on January 01, 2002
Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice. Nat Med (2015) 2.15
Paget disease of bone. J Clin Invest (2005) 1.92
Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling. EMBO J (2006) 1.63
p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation. Biochem J (2004) 1.45
Strength of TRAF6 signalling determines osteoclastogenesis. EMBO Rep (2005) 1.30
Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions. J Clin Invest (2006) 1.20
Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling. J Biol Chem (2009) 1.11
The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling. J Biol Chem (2013) 1.00
Bone morphogenetic proteins signal via SMAD and mitogen-activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis. J Biol Chem (2013) 0.97
Insulin-like growth factor-binding protein-2 is required for osteoclast differentiation. J Bone Miner Res (2012) 0.95
Inactivation of glycogen synthase kinase-3β is required for osteoclast differentiation. J Biol Chem (2011) 0.94
AKT Pathway Affects Bone Regeneration in Nonunion Treated with Umbilical Cord-Derived Mesenchymal Stem Cells. Cell Biochem Biophys (2015) 0.93
Fisetin Inhibits Osteoclast Differentiation via Downregulation of p38 and c-Fos-NFATc1 Signaling Pathways. Evid Based Complement Alternat Med (2012) 0.93
A dominant function of p38 mitogen-activated protein kinase signaling in receptor activator of nuclear factor-kappaB ligand expression and osteoclastogenesis induction by Aggregatibacter actinomycetemcomitans and Escherichia coli lipopolysaccharide. J Periodontal Res (2008) 0.88
Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis. J Biol Chem (2008) 0.86
Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK. J Cell Physiol (2008) 0.85
Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice. Arthritis Res Ther (2010) 0.85
IKK{beta} as a target for treatment of inflammation induced bone loss. Ann Rheum Dis (2005) 0.85
Transgenic mice with OIP-1/hSca overexpression targeted to the osteoclast lineage develop an osteopetrosis bone phenotype. J Pathol (2007) 0.85
The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors. Sci Signal (2015) 0.85
Anti-osteoclastogenic activity of matairesinol via suppression of p38/ERK-NFATc1 signaling axis. BMC Complement Altern Med (2014) 0.84
Glycosaminoglycans modulate RANKL-induced osteoclastogenesis. J Cell Biochem (2010) 0.83
Differentially expressed genes strongly correlated with femur strength in rats. Genomics (2009) 0.83
Hexane-Soluble Fraction of the Common Fig, Ficus carica, Inhibits Osteoclast Differentiation in Murine Bone Marrow-Derived Macrophages and RAW 264.7 Cells. Korean J Physiol Pharmacol (2009) 0.82
Lysine392, a K63-linked ubiquitination site in NEMO, mediates inflammatory osteoclastogenesis and osteolysis. J Orthop Res (2011) 0.82
Molecular signaling pathways mediating osteoclastogenesis induced by prostate cancer cells. BMC Cancer (2013) 0.81
The phosphoinositide 3-kinase isoform PI3Kβ regulates osteoclast-mediated bone resorption in humans and mice. Arthritis Rheumatol (2014) 0.81
Biphasic silica/apatite co-mineralized collagen scaffolds stimulate osteogenesis and inhibit RANKL-mediated osteoclastogenesis. Acta Biomater (2015) 0.80
Choline kinase β mutant mice exhibit reduced phosphocholine, elevated osteoclast activity, and low bone mass. J Biol Chem (2014) 0.80
The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts. PLoS One (2013) 0.80
A benzamide-linked small molecule NDMC101 inhibits NFATc1 and NF-κB activity: a potential osteoclastogenesis inhibitor for experimental arthritis. J Clin Immunol (2012) 0.78
TRP14 inhibits osteoclast differentiation via its catalytic activity. Mol Cell Biol (2014) 0.77
KMUP-1 suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss: roles of MAPKs, Akt, NF-κB and calcium/calcineurin/NFATc1 pathways. PLoS One (2013) 0.77
Aspirin inhibits osteoclastogenesis by suppressing the activation of NF-κB and MAPKs in RANKL-induced RAW264.7 cells. Mol Med Rep (2016) 0.77
Methanol Extract of Croton Pycnanthus Benth. Inhibits Osteoclast Differentiation by Suppressing the MAPK and NF-κB Signaling Pathways. J Bone Metab (2014) 0.77
Inhibition of osteoclastogenesis by RNA interference targeting RANK. BMC Musculoskelet Disord (2012) 0.77
Molecular regulatory mechanisms of osteoclastogenesis through cytoprotective enzymes. Redox Biol (2016) 0.76
Angelica sinensis extract inhibits RANKL-mediated osteoclastogenesis by down-regulated the expression of NFATc1 in mouse bone marrow cells. BMC Complement Altern Med (2014) 0.75
Bromo-honaucin A inhibits osteoclastogenic differentiation in RAW 264.7 cells via Akt and ERK signaling pathways. Eur J Pharmacol (2015) 0.75
FOXO1 inhibits osteoclastogenesis partially by antagnozing MYC. Sci Rep (2015) 0.75
Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis. PLoS One (2017) 0.75
RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell (1991) 5.89
ABFs, a family of ABA-responsive element binding factors. J Biol Chem (2000) 4.98
Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc Natl Acad Sci U S A (2009) 4.58
Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer. Int J Radiat Oncol Biol Phys (1999) 4.24
alpha-Synuclein gene duplication is present in sporadic Parkinson disease. Neurology (2007) 3.62
Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. EMBO J (1999) 3.50
Hemolytic-uremic syndrome in a six-year-old girl after a urinary tract infection with Shiga-toxin-producing Escherichia coli O103:H2. N Engl J Med (1996) 3.30
The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release. Mol Cell (2001) 2.91
Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys (2001) 2.83
Long-term metformin use reduces gastric cancer risk in type 2 diabetics without insulin treatment: a nationwide cohort study. Aliment Pharmacol Ther (2014) 2.66
The prediction of abdominal visceral fat level from body composition and anthropometry: ROC analysis. Int J Obes Relat Metab Disord (1999) 2.41
Protease Ti, a new ATP-dependent protease in Escherichia coli, contains protein-activated ATPase and proteolytic functions in distinct subunits. J Biol Chem (1988) 2.40
The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis. Immunopharmacology (1999) 2.36
Antineutrophil cytoplasmic autoantibody associated vasculitis and renal failure in Behçet disease. Nephrol Dial Transplant (1993) 2.33
The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation. J Biol Chem (1999) 2.29
Mischievous magnets: unexpected health hazard in children. J Pediatr Surg (1996) 2.10
Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. Biochem J (2000) 2.09
Second-line chemotherapy versus supportive cancer treatment in advanced gastric cancer: a meta-analysis. Ann Oncol (2013) 2.02
Lipopolysaccharide induces hyporesponsiveness to its own action in RAW 264.7 cells. J Biol Chem (1989) 2.00
A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. J Biol Chem (1997) 2.00
Is obesity still increasing among pregnant women? Prepregnancy obesity trends in 20 states, 2003-2009. Prev Med (2013) 1.97
Pre-hospital notification reduced the door-to-needle time for iv t-PA in acute ischaemic stroke. Eur J Neurol (2009) 1.97
Biochemical characterization of the protein tyrosine kinase homology domain of the ErbB3 (HER3) receptor protein. Biochem J (1997) 1.91
Mutations in the rpoB gene of Mycobacterium tuberculosis that interfere with PCR-single-strand conformation polymorphism analysis for rifampin susceptibility testing. J Clin Microbiol (1997) 1.89
Changing trends in clinical manifestations of laryngeal tuberculosis. Laryngoscope (2000) 1.88
Biliary papillomatosis: clinical, cholangiographic and cholangioscopic findings. Endoscopy (1998) 1.85
Maternal obesity and risk of cesarean delivery: a meta-analysis. Obes Rev (2007) 1.85
Specific DWI lesion patterns predict prognosis after acute ischaemic stroke within the MCA territory. J Neurol Neurosurg Psychiatry (2005) 1.81
Analysis of long terminal repeat circle junctions of human immunodeficiency virus type 1. J Virol (1990) 1.80
Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas. Cancer Res (1999) 1.74
Multicentre study of the safety of laparoscopic subtotal gastrectomy for gastric cancer in the elderly. Br J Surg (2009) 1.69
Prospective analysis of psychosocial outcomes in breast reconstruction: one-year postoperative results from the Michigan Breast Reconstruction Outcome Study. Plast Reconstr Surg (2000) 1.64
Intravenous calcitriol regresses myocardial hypertrophy in hemodialysis patients with secondary hyperparathyroidism. Am J Kidney Dis (1999) 1.63
An archaebacterial ATPase, homologous to ATPases in the eukaryotic 26 S proteasome, activates protein breakdown by 20 S proteasomes. J Biol Chem (1999) 1.63
Electric modulation of conduction in multiferroic Ca-doped BiFeO3 films. Nat Mater (2009) 1.59
Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer. Oncogene (1999) 1.59
High-level tuber expression and sucrose inducibility of a potato Sus4 sucrose synthase gene require 5' and 3' flanking sequences and the leader intron. Plant Cell (1995) 1.56
Teaching NeuroImage: Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) from midbrain infarction. Neurology (2008) 1.55
Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer. Cancer Res (1998) 1.55
Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol (1999) 1.55
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia (2012) 1.55
Proapoptotic effects of tau cleavage product generated by caspase-3. Neurobiol Dis (2001) 1.55
IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling. Cell Death Differ (2009) 1.53
Impregnation of vancomycin, gentamicin, and cefotaxime in a cement spacer for two-stage cementless reconstruction in infected total hip arthroplasty. J Arthroplasty (2001) 1.51
Cross-cultural adaptation and validation of Korean Western Ontario and McMaster Universities (WOMAC) and Lequesne osteoarthritis indices for clinical research. Osteoarthritis Cartilage (2001) 1.49
Resident perception of academic skills training and impact on academic career choice. Acad Emerg Med (2000) 1.48
Clinical and angiographic follow-up of stent-only therapy for acute intracranial vertebrobasilar dissecting aneurysms. AJNR Am J Neuroradiol (2009) 1.47
Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer. Cancer Res (1999) 1.47
New experiences with absolute ethanol sclerotherapy in the management of a complex form of congenital venous malformation. J Vasc Surg (2001) 1.47
Extensive partial unilateral lentiginosis. J Eur Acad Dermatol Venereol (2006) 1.46
Coexistence of ankylosing spondylitis and mixed connective tissue disease in a single patient. Clin Exp Rheumatol (1999) 1.46
Preoperative detection and predictors of level V lymph node metastasis in patients with papillary thyroid carcinoma. Br J Surg (2012) 1.45
Expression of osteopontin messenger RNA by macrophages in atherosclerotic plaques. A possible association with calcification. Am J Pathol (1993) 1.45
Substrate recognition by the ClpA chaperone component of ClpAP protease. J Biol Chem (2000) 1.45
The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. Oncogene (2008) 1.45
Surrogate consent for dementia research: a national survey of older Americans. Neurology (2009) 1.44
Primary angiosarcoma of the spleen. CT and MR imaging. Acta Radiol (1994) 1.43
Binary phase spatial modulation using photoinduced anisotropy in amorphous As(2)S(3) thin film. Appl Opt (1995) 1.39
Osteoclastogenesis is enhanced by activated B cells but suppressed by activated CD8(+) T cells. Eur J Immunol (2001) 1.38
False-positive growth of Mycobacterium tuberculosis attributable to laboratory contamination confirmed by restriction fragment length polymorphism analysis. Int J Tuberc Lung Dis (2001) 1.38
Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates. Chemical aspects involved in the balance between oxidative and nitrosative stress. J Biol Chem (1997) 1.37
The first human case of Trichinella spiralis infection in Korea. Korean J Parasitol (2000) 1.37
A potato Sus3 sucrose synthase gene contains a context-dependent 3' element and a leader intron with both positive and negative tissue-specific effects. Plant Cell (1995) 1.35
Site-directed mutagenesis of the dual translational initiation sites of the clpB gene of Escherichia coli and characterization of its gene products. J Biol Chem (1993) 1.35
The JAK2 V617F mutation in de novo acute myelogenous leukemias. Oncogene (2006) 1.34
Skene's duct cysts in female newborns. J Pediatr Surg (1992) 1.33
Fluorous synthesis: a fluorous-phase strategy for improving separation efficiency in organic synthesis. Science (1997) 1.33
Identification of lipopolysaccharide-binding proteins in 70Z/3 cells by photoaffinity cross-linking. J Biol Chem (1990) 1.33
N-butyl-2-cyanoacrylate pulmonary embolism after endoscopic injection sclerotherapy for gastric variceal bleeding. J Comput Assist Tomogr (2001) 1.33
Molecular mechanism of staurosporine-induced apoptosis in osteoblasts. Pharmacol Res (2000) 1.32
Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers. Cancer Res (2001) 1.31
A tetrodotoxin-producing Vibrio strain, LM-1, from the puffer fish Fugu vermicularis radiatus. Appl Environ Microbiol (2000) 1.31
Maternal cigarette smoking during pregnancy and the risk of having a child with cleft lip/palate. Plast Reconstr Surg (2000) 1.30
Expression of Fas and Fas-related molecules in human hepatocellular carcinoma. Hum Pathol (2001) 1.27
Multiple cis-active elements in the long control region of bovine papillomavirus type 1 (BPV-1). Nucleic Acids Res (1987) 1.27
Convenient colorimetric and fluorometric assays for S-nitrosothiols. Anal Biochem (1996) 1.25
Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose. Ann Emerg Med (2000) 1.25
TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption. FASEB J (1998) 1.25
Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK. J Biol Chem (2001) 1.24
Bioactive metals: preparation and properties. J Mater Sci Mater Med (2004) 1.23
MR imaging findings of paravertebral gossypiboma. AJNR Am J Neuroradiol (2007) 1.22
Mesenchymal progenitor cells in the human umbilical cord. Ann Hematol (2004) 1.22
Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar. J Invest Dermatol (2000) 1.21
Somatic mutations of the trefoil factor family 1 gene in gastric cancer. Gastroenterology (2000) 1.21
Heptameric ring structure of the heat-shock protein ClpB, a protein-activated ATPase in Escherichia coli. J Mol Biol (2000) 1.21
Parenteral anticoagulation for prolonging survival in patients with cancer who have no other indication for anticoagulation. Cochrane Database Syst Rev (2007) 1.20
Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28. J Immunol (1995) 1.20
Bonding of alkali- and heat-treated tantalum implants to bone. J Biomed Mater Res (2000) 1.19
B-lymphocyte-stimulating polysaccharide from mushroom Phellinus linteus. Chem Pharm Bull (Tokyo) (1995) 1.19
Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus. Int Immunopharmacol (2003) 1.18
Direct identification of Vibrio vulnificus in clinical specimens by nested PCR. J Clin Microbiol (1998) 1.18
Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL. Cell Death Differ (2006) 1.18
The incidence, risk factors and prognostic implications of venous thromboembolism in patients with gastric cancer. J Thromb Haemost (2009) 1.18
Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary. Endocrinology (1995) 1.17
Clonorchiasis: sonographic findings in 59 proved cases. AJR Am J Roentgenol (1989) 1.17