Ezio Ghigo

Author PubWeight™ 133.06‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004 3.79
2 Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study. Lancet Oncol 2008 2.32
3 Hypopituitarism. Lancet 2007 2.27
4 Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol 2002 1.97
5 Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review. JAMA 2007 1.59
6 The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index. Eur J Endocrinol 2005 1.59
7 Copeptin (CTproAVP), a new tool for understanding the role of vasopressin in pathophysiology. Clin Chem Lab Med 2014 1.49
8 Endocrine function is altered in chronic migraine patients with medication-overuse. Headache 2006 1.47
9 Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 2002 1.45
10 Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling. Endocrinology 2006 1.43
11 Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes. J Clin Endocrinol Metab 2004 1.39
12 Dual effects of IGFBP-3 on endothelial cell apoptosis and survival: involvement of the sphingolipid signaling pathways. FASEB J 2004 1.32
13 Residual pituitary function after brain injury-induced hypopituitarism: a prospective 12-month study. J Clin Endocrinol Metab 2005 1.32
14 Extracellular vesicles as an emerging mechanism of cell-to-cell communication. Endocrine 2012 1.32
15 Traumatic brain injury and subarachnoid haemorrhage are conditions at high risk for hypopituitarism: screening study at 3 months after the brain injury. Clin Endocrinol (Oxf) 2004 1.29
16 Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart. Cardiovasc Res 2009 1.26
17 Long-term safety of pegvisomant in patients with acromegaly: comprehensive review of 1288 subjects in ACROSTUDY. J Clin Endocrinol Metab 2012 1.24
18 Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol 2002 1.24
19 Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function. Diabetes 2007 1.22
20 The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects. J Clin Endocrinol Metab 2003 1.12
21 Unraveling the role of the ghrelin gene peptides in the endocrine pancreas. J Mol Endocrinol 2010 1.09
22 Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions. Am J Physiol Endocrinol Metab 2007 1.06
23 Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur J Endocrinol 2004 1.05
24 Effect of food restriction on ghrelin in normal-cycling female rats and in pregnancy. Obes Res 2002 1.04
25 Metabolic and endocrine effects of physiological increments in plasma ghrelin concentrations. Nutr Metab Cardiovasc Dis 2005 1.03
26 Cardiovascular actions of the ghrelin gene-derived peptides and growth hormone-releasing hormone. Exp Biol Med (Maywood) 2011 1.02
27 A novel mutation in the human aromatase gene: insights on the relationship among serum estradiol, longitudinal growth and bone mineral density in an adult man under estrogen replacement treatment. Bone 2008 1.01
28 The IGF system. Acta Diabetol 2010 1.01
29 Neuroendocrine alterations in obese patients with sleep apnea syndrome. Int J Endocrinol 2010 1.01
30 Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor. Eur J Pharmacol 2004 1.01
31 Obstructive sleep apnoea syndrome impairs insulin sensitivity independently of anthropometric variables. Clin Endocrinol (Oxf) 2003 1.01
32 Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes. Eur J Endocrinol 2009 1.00
33 Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor. Mol Cell Endocrinol 2006 0.99
34 Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin. Eur J Pharmacol 2003 0.98
35 Alprazolam (a benzodiazepine activating GABA receptor) reduces the neuroendocrine responses to insulin-induced hypoglycaemia in humans. Clin Endocrinol (Oxf) 2003 0.97
36 Proliferative and protective effects of growth hormone secretagogues on adult rat hippocampal progenitor cells. Endocrinology 2008 0.96
37 Endocrine and metabolic responses to extreme altitude and physical exercise in climbers. Eur J Endocrinol 2007 0.95
38 Ghrelin secretion in childhood is refractory to the inhibitory effect of feeding. J Clin Endocrinol Metab 2004 0.95
39 Unacylated ghrelin rescues endothelial progenitor cell function in individuals with type 2 diabetes. Diabetes 2010 0.95
40 Cut-off limits of the GH response to GHRH plus arginine test and IGF-I levels for the diagnosis of GH deficiency in late adolescents and young adults. Eur J Endocrinol 2007 0.94
41 Long-term follow-up in adrenal incidentalomas: an Italian multicenter study. J Clin Endocrinol Metab 2014 0.94
42 The antiproliferative effect of synthetic peptidyl GH secretagogues in human CALU-1 lung carcinoma cells. Endocrinology 2002 0.93
43 Metabolic and cardiovascular outcomes in patients with Cushing's syndrome of different aetiologies during active disease and 1 year after remission. Clin Endocrinol (Oxf) 2011 0.93
44 Prolactin induces regional vasoconstriction through the beta2-adrenergic and nitric oxide mechanisms. Endocrinology 2007 0.92
45 Heterogeneity of ghrelin/growth hormone secretagogue receptors. Toward the understanding of the molecular identity of novel ghrelin/GHS receptors. Neuroendocrinology 2007 0.92
46 Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans. Clin Endocrinol (Oxf) 2004 0.92
47 High-dose intramuscular octreotide in patients with acromegaly inadequately controlled on conventional somatostatin analogue therapy: a randomised controlled trial. Eur J Endocrinol 2009 0.91
48 Obestatin regulates adipocyte function and protects against diet-induced insulin resistance and inflammation. FASEB J 2012 0.91
49 Association of craniopharyngioma and pituitary adenoma. Endocrine 2013 0.88
50 Ghrelin drives GH secretion during fasting in man. Eur J Endocrinol 2002 0.88
51 Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats. J Mol Endocrinol 2010 0.88
52 Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans. J Clin Endocrinol Metab 2002 0.88
53 GH-releasing hormone induces cardioprotection in isolated male rat heart via activation of RISK and SAFE pathways. Endocrinology 2013 0.88
54 Acylated ghrelin inhibits spontaneous luteinizing hormone pulsatility and responsiveness to naloxone but not that to gonadotropin-releasing hormone in young men: evidence for a central inhibitory action of ghrelin on the gonadal axis. J Clin Endocrinol Metab 2008 0.87
55 Short ghrelin peptides neither displace ghrelin binding in vitro nor stimulate GH release in vivo. Endocrinology 2002 0.87
56 Ghrelin in fetal thyroid and follicular tumors and cell lines: expression and effects on tumor growth. Am J Pathol 2003 0.87
57 Corticotrope hypersecretion coupled with cortisol hypo-responsiveness to stimuli is present in patients with autoimmune endocrine diseases: evidence for subclinical primary hypoadrenalism? Eur J Endocrinol 2006 0.87
58 Ghrelin, hypothalamus-pituitary-adrenal (HPA) axis and Cushing's syndrome. Pituitary 2004 0.87
59 Effect of acute and prolonged mineralocorticoid receptor blockade on spontaneous and stimulated hypothalamic-pituitary-adrenal axis in humans. Eur J Endocrinol 2010 0.86
60 Unacylated ghrelin promotes skeletal muscle regeneration following hindlimb ischemia via SOD-2-mediated miR-221/222 expression. J Am Heart Assoc 2013 0.86
61 Diagnosis of GH deficiency in the transition period: accuracy of insulin tolerance test and insulin-like growth factor-I measurement. Eur J Endocrinol 2005 0.86
62 The nutritional control of ghrelin secretion in humans: the effects of enteral vs. parenteral nutrition. Eur J Nutr 2006 0.86
63 The GH-releasing effect of ghrelin, a natural GH secretagogue, is only blunted by the infusion of exogenous somatostatin in humans. Clin Endocrinol (Oxf) 2002 0.85
64 Acylated ghrelin as a provocative test for the diagnosis of GH deficiency in adults. Eur J Endocrinol 2012 0.85
65 GPR103b functions in the peripheral regulation of adipogenesis. Mol Endocrinol 2010 0.85
66 Ghrelin and anterior pituitary function. Front Horm Res 2010 0.85
67 Metabolic and cardiovascular outcomes in a group of adult patients with Turner's syndrome under hormonal replacement therapy. Eur J Endocrinol 2011 0.84
68 Ghrelin and the endocrine pancreas. Endocrine 2003 0.84
69 Hypothalamus-pituitary-adrenal hyperactivity in human aging is partially refractory to stimulation by mineralocorticoid receptor blockade. J Clin Endocrinol Metab 2005 0.84
70 Hypopituitarism following brain injury: when does it occur and how best to test? Pituitary 2012 0.84
71 Endocrine actions of cortistatin: in vivo studies. Mol Cell Endocrinol 2007 0.84
72 Myocardial insulin-like growth factor-1 and insulin-like growth factor binding protein-3 gene expression in failing hearts harvested from patients undergoing cardiac transplantation. J Heart Lung Transplant 2009 0.84
73 Acetylcholine regulates ghrelin secretion in humans. J Clin Endocrinol Metab 2004 0.84
74 Growth hormone-releasing peptide hexarelin reduces neonatal brain injury and alters Akt/glycogen synthase kinase-3beta phosphorylation. Endocrinology 2005 0.83
75 BClI polymorphism of the glucocorticoid receptor gene is associated with increased obesity, impaired glucose metabolism and dyslipidaemia in patients with Addison's disease. Clin Endocrinol (Oxf) 2012 0.83
76 Dehydroepiandrosterone, 17alpha-hydroxyprogesterone and aldosterone responses to the low-dose (1 micro g) ACTH test in subjects with preclinical adrenal autoimmunity. Clin Endocrinol (Oxf) 2002 0.83
77 Impact of snacking pattern on overweight and obesity risk in a cohort of 11- to 13-year-old adolescents. J Pediatr Gastroenterol Nutr 2014 0.83
78 Preliminary data on biochemical remission of acromegaly after somatostatin analogs withdrawal. Eur J Endocrinol 2008 0.83
79 Free fatty acids exert an inhibitory effect on adrenocorticotropin and cortisol secretion in humans. J Clin Endocrinol Metab 2004 0.83
80 Ghrelin: much more than a natural growth hormone secretagogue. Isr Med Assoc J 2002 0.83
81 Endocrine and non-endocrine actions of ghrelin. Horm Res 2003 0.83
82 Des-acyl ghrelin fragments and analogues promote survival of pancreatic β-cells and human pancreatic islets and prevent diabetes in streptozotocin-treated rats. J Med Chem 2012 0.82
83 GHRH and GH secretagogues: clinical perspectives and safety. Pediatr Endocrinol Rev 2004 0.82
84 Growth hormone treatment in human ageing: benefits and risks. Hormones (Athens) 2008 0.81
85 Endocrine and metabolic actions of ghrelin. Endocr Dev 2009 0.81
86 Neuroregulation of the hypothalamus-pituitary-adrenal (HPA) axis in humans: effects of GABA-, mineralocorticoid-, and GH-Secretagogue-receptor modulation. ScientificWorldJournal 2006 0.81
87 Variations of pituitary function over time after brain injuries: the lesson from a prospective study. Pituitary 2005 0.81
88 Do muscle fiber conduction slowing and decreased levels of circulating muscle proteins represent sensitive markers of steroid myopathy? A pilot study in Cushing's disease. Eur J Endocrinol 2011 0.81
89 Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility. Hum Reprod 2012 0.81
90 Growth hormone levels in the diagnosis of growth hormone deficiency in adulthood. Pituitary 2007 0.81
91 Role of mineralocorticoid receptors on the hypothalamus-pituitary-adrenal axis in humans. Endocrine 2012 0.80
92 Ghrelin: a new hormone with endocrine and non-endocrine activities. Pediatr Endocrinol Rev 2004 0.80
93 Marked GH secretion after ghrelin alone or combined with GH-releasing hormone (GHRH) in obese patients. Clin Endocrinol (Oxf) 2004 0.80
94 In vitro and in vivo stability and pharmacokinetic profile of unacylated ghrelin (UAG) analogues. Eur J Pharm Sci 2012 0.79
95 Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice. Endocrinology 2014 0.79
96 Brain-gut communication: cortistatin, somatostatin and ghrelin. Trends Endocrinol Metab 2007 0.79
97 Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. J Clin Endocrinol Metab 2002 0.79
98 Ghrelin and synthetic growth hormone secretagogues are cardioactive molecules with identities and differences. Semin Vasc Med 2004 0.79
99 Mortality outcomes of different sulphonylurea drugs: the results of a 14-year cohort study of type 2 diabetic patients. Eur J Endocrinol 2013 0.79
100 Paediatric pituitary adenomas: a decade of change. Horm Res Paediatr 2014 0.79
101 PubMed search strategies for the identification of etiologic associations between hypothalamic-pituitary disorders and other medical conditions. Pituitary 2013 0.78
102 Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats. Endocrinology 2007 0.78
103 Tall stature without growth hormone: four male patients with aromatase deficiency. J Clin Endocrinol Metab 2010 0.78
104 Effects of free fatty acids on ACTH and cortisol secretion in anorexia nervosa. Eur J Endocrinol 2006 0.78
105 Endocrine responses to ghrelin in adult patients with isolated childhood-onset growth hormone deficiency. Clin Endocrinol (Oxf) 2002 0.78
106 Neuroendocrine effects of citalopram infusion in anorexia nervosa. Psychoneuroendocrinology 2006 0.78
107 Obestatin enhances in vitro generation of pancreatic islets through regulation of developmental pathways. PLoS One 2013 0.78
108 Obestatin: is it really doing something? Front Horm Res 2014 0.78
109 Traumatic brain injury and hypopituitarism. ScientificWorldJournal 2005 0.78
110 Insulin-like growth factor I levels and the diagnosis of adult growth hormone deficiency. Horm Res 2004 0.78
111 Glucose metabolism in patients with subclinical Cushing's syndrome. Endocrine 2012 0.77
112 Muscle fiber conduction slowing and decreased levels of circulating muscle proteins after short-term dexamethasone administration in healthy subjects. J Clin Endocrinol Metab 2010 0.77
113 Effects of cetrorelix, a GnRH-receptor antagonist, on gonadal axis in women with functional hypothalamic amenorrhea. Gynecol Endocrinol 2011 0.77
114 Obestatin: a new metabolic player in the pancreas and white adipose tissue. IUBMB Life 2013 0.77
115 Acetylcholine does not play a major role in mediating the endocrine responses to ghrelin, a natural ligand of the GH secretagogue receptor, in humans. Clin Endocrinol (Oxf) 2003 0.77
116 Effects of glucose, free fatty acids or arginine load on the GH-releasing activity of ghrelin in humans. Clin Endocrinol (Oxf) 2002 0.77
117 Enhanced oxidative stress and platelet activation in patients with Cushing's syndrome. Clin Endocrinol (Oxf) 2014 0.77
118 Neuroendocrine and metabolic activities of ghrelin gene products. Peptides 2011 0.77
119 Ghrelin and synthetic GH secretagogues. Best Pract Res Clin Endocrinol Metab 2002 0.77
120 Effects of acute hexarelin administration on cardiac performance in patients with coronary artery disease during by-pass surgery. Eur J Pharmacol 2002 0.77
121 Traumatic brain injury and hypopituitarism in children and adolescents: is the problem under-estimated? Pediatr Endocrinol Rev 2007 0.77
122 Ghrelin does not mediate the somatotroph and corticotroph responses to the stimulatory effect of glucagon or insulin-induced hypoglycaemia in humans. Clin Endocrinol (Oxf) 2004 0.77
123 Testing pituitary function in aging individuals. Endocrinol Metab Clin North Am 2005 0.77
124 GH response to ghrelin in subjects with congenital GH deficiency: evidence that ghrelin action requires hypothalamic-pituitary connections. Eur J Endocrinol 2007 0.77
125 The growth hormone-releasing hormone (GHRH) antagonist JV-1-36 inhibits proliferation and survival of human ectopic endometriotic stromal cells (ESCs) and the T HESC cell line. Fertil Steril 2009 0.77
126 Ghrelin: endocrine and non-endocrine actions. J Pediatr Endocrinol Metab 2002 0.76
127 Other than growth hormone neuroendocrine actions of ghrelin. Endocr Dev 2013 0.76
128 GHRH plus arginine in the diagnosis of acquired GH deficiency of childhood-onset. J Clin Endocrinol Metab 2002 0.76
129 GH therapy in adult GH deficiency: a review of treatment schedules and the evidence for low starting doses. Eur J Endocrinol 2013 0.76
130 The effectiveness of arginine + GHRH test compared with GHRH + GHRP-6 test in diagnosing growth hormone deficiency in adults. Clin Endocrinol (Oxf) 2003 0.76
131 Managing patients with hypopituitarism after traumatic brain injury. Curr Opin Endocrinol Diabetes Obes 2007 0.76
132 Expression of cortistatin and MrgX2, a specific cortistatin receptor, in human neuroendocrine tissues and related tumours. J Pathol 2005 0.76
133 Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B. Biochim Biophys Acta 2011 0.76
134 Targeting the ghrelin receptor: orally active GHS and cortistatin analogs. Endocrine 2003 0.76
135 Intracoronary ghrelin infusion decreases coronary blood flow in anesthetized pigs. Endocrinology 2006 0.76
136 Should every patient with traumatic brain injury be referred to an endocrinologist? Nat Clin Pract Endocrinol Metab 2007 0.76
137 Products of the ghrelin gene, the pancreatic β-cell and the adipocyte. Endocr Dev 2013 0.76
138 Pyroglutamylated RF-amide peptide (QRFP) gene is regulated by metabolic endotoxemia. Mol Endocrinol 2013 0.75
139 The negative association between total ghrelin levels, body mass and insulin secretion is lost in hypercortisolemic patients with Cushing's disease. Eur J Endocrinol 2005 0.75
140 The acute effect of fludrocortisone on basal and hCRH-stimulated hypothalamic--pituitary--adrenal (HPA) axis in humans. Pituitary 2013 0.75
141 Somatostatin, cortistatin and their receptors in health and disease. Foreword. Mol Cell Endocrinol 2008 0.75
142 Impact of two or three daily subcutaneous injections of hexarelin, a synthetic growth hormone (GH) secretagogue, on 24-h GH, prolactin, adrenocorticotropin and cortisol secretion in humans. Eur J Endocrinol 2002 0.75
143 Pituitary Autoimmunity. Front Horm Res 2017 0.75
144 Central ghrelin production does not substantially contribute to systemic ghrelin concentrations: a study in two subjects with active acromegaly. Eur J Endocrinol 2002 0.75
145 Acute administration of alprazolam, a benzodiazepine activating GABA receptors, inhibits cortisol secretion in patients with subclinical but not overt Cushing's syndrome. Pituitary 2013 0.75
146 Short-term effects of the long-acting insulin analog detemir and human insulin on plasma levels of insulin-like growth factor-I and its binding proteins in humans. J Clin Endocrinol Metab 2009 0.75
147 Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects. Clin Endocrinol (Oxf) 2006 0.75
148 Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses. Neuroendocrinology 2002 0.75
149 Secondary Adrenal Insufficiency: Where Is It Hidden and What Does It Look Like? Front Horm Res 2016 0.75
150 Impaired GH secretion to provocative stimuli in two families with hypocalciuric hypercalcaemia. Clin Endocrinol (Oxf) 2003 0.75
151 Hypopituitarism is a common neuro-endocrine disease: how manage to inform the medical community. Pituitary 2005 0.75
152 IGFs and IGFBPs in adult growth hormone deficiency. Endocr Dev 2005 0.75
153 Court dwarfs: an overview of European paintings from fifteenth to eighteenth century. Endocrine 2012 0.75
154 Identification of risk conditions for the development of adrenal disorders: how optimized PubMed search strategies makes the difference. Endocrine 2014 0.75
155 Long-term re-evaluation of primary aldosteronism after medical treatment reveals high proportion of normal mineralocorticoid secretion. Eur J Endocrinol 2013 0.75