Deletion of the two-component histidine kinase gene (CHK1) of Candida albicans contributes to enhanced growth inhibition and killing by human neutrophils in vitro.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 127696)

Published in Infect Immun on February 01, 2002

Authors

Antonella Torosantucci1, Paola Chiani, Flavia De Bernardis, Antonio Cassone, Jose Antonio Calera, Richard Calderone

Author Affiliations

1: Istituto Superiore di Sanita, Laboratory of Bacteriology and Mycology, Viale Regina Elena 299, Rome 00196, Italy.

Articles cited by this

Isogenic strain construction and gene mapping in Candida albicans. Genetics (1993) 17.18

Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med (1966) 7.30

Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev (2000) 5.49

Virulence factors of Candida albicans. Trends Microbiol (2001) 5.01

Nosocomial candidemia: risk factors and attributable mortality. Clin Infect Dis (1995) 2.74

Evolution of two-component signal transduction. Mol Biol Evol (2000) 2.55

Candida-specific Th1-type responsiveness in mice with experimental vaginal candidiasis. Infect Immun (1993) 1.84

Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans. J Bacteriol (1999) 1.66

A vaccine and monoclonal antibodies that enhance mouse resistance to Candida albicans vaginal infection. Infect Immun (1998) 1.60

Role of CD4+ lymphocytes in resistance to mucosal candidiasis. Infect Immun (1991) 1.55

Analysis of vaginal cell populations during experimental vaginal candidiasis. Infect Immun (1999) 1.42

Flocculation of hyphae is associated with a deletion in the putative CaHK1 two-component histidine kinase gene from Candida albicans. Microbiology (1999) 1.31

Avirulence of Candida albicans CaHK1 mutants in a murine model of hematogenously disseminated candidiasis. Infect Immun (1999) 1.30

Identification of a putative histidine kinase two-component phosphorelay gene (CaHK1) in Candida albicans. Yeast (1998) 1.28

Acute neutropenia decreases inflammation associated with murine vaginal candidiasis but has no effect on the course of infection. Infect Immun (1998) 1.24

Local anticandidal immune responses in a rat model of vaginal infection by and protection against Candida albicans. Infect Immun (2000) 1.20

Identification of a mannoprotein fraction from Candida albicans that enhances human polymorphonuclear leukocyte (PMNL) functions and stimulates lactoferrin in PMNL inhibition of candidal growth. J Infect Dis (1992) 1.13

Defective induction of interleukin-12 in human monocytes by germ-tube forms of Candida albicans. Infect Immun (2000) 0.99

Responsiveness of human polymorphonuclear cells (PMNL) to stimulation by a mannoprotein fraction (MP-F2) of Candida albicans; enhanced production of IL-6 and tumour necrosis factor-alpha (TNF-alpha) by MP-F2-stimulated PMNL from HIV-infected subjects. Clin Exp Immunol (1997) 0.94

Articles by these authors

Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group. Antimicrob Agents Chemother (2008) 3.24

A novel glyco-conjugate vaccine against fungal pathogens. J Exp Med (2005) 2.35

Effects of chloroquine on viral infections: an old drug against today's diseases? Lancet Infect Dis (2003) 2.23

Genotyping of Bacillus anthracis strains based on automated capillary 25-loci multiple locus variable-number tandem repeats analysis. BMC Microbiol (2006) 2.22

Italian Ministry of Health and the Istituto Superiore Di Sanita: from vigilance to ownership? Pathog Glob Health (2015) 2.00

Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence. PLoS One (2009) 1.59

Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus. Nat Rev Microbiol (2006) 1.56

Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Eukaryot Cell (2003) 1.53

Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus. Emerg Infect Dis (2010) 1.47

T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions. Proc Natl Acad Sci U S A (2003) 1.37

Two-component signal transduction in human fungal pathogens. FEMS Yeast Res (2006) 1.31

In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species. BMC Infect Dis (2006) 1.26

An anti-beta-glucan monoclonal antibody inhibits growth and capsule formation of Cryptococcus neoformans in vitro and exerts therapeutic, anticryptococcal activity in vivo. Infect Immun (2007) 1.26

Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria. Am J Pathol (2009) 1.26

Differential susceptibility of mitogen-activated protein kinase pathway mutants to oxidative-mediated killing by phagocytes in the fungal pathogen Candida albicans. Cell Microbiol (2007) 1.25

Characterization of the SKN7 ortholog of Aspergillus fumigatus. Fungal Genet Biol (2007) 1.24

SKN7 of Candida albicans: mutant construction and phenotype analysis. Infect Immun (2004) 1.22

Loss of mitochondrial functions associated with azole resistance in Candida glabrata results in enhanced virulence in mice. Antimicrob Agents Chemother (2011) 1.21

New insights into the antiviral effects of chloroquine. Lancet Infect Dis (2006) 1.21

Comparison of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis adhesive properties and pathogenicity. Int J Med Microbiol (2013) 1.20

Rad52 depletion in Candida albicans triggers both the DNA-damage checkpoint and filamentation accompanied by but independent of expression of hypha-specific genes. Mol Microbiol (2006) 1.17

The role of the sakA (Hog1) and tcsB (sln1) genes in the oxidant adaptation of Aspergillus fumigatus. Med Mycol (2006) 1.15

Antibody response to chlamydial heat shock protein 60 is strongly associated with acute coronary syndromes. Circulation (2003) 1.14

Increase of virulence and its phenotypic traits in drug-resistant strains of Candida albicans. Antimicrob Agents Chemother (2008) 1.11

Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis. J Infect Dis (2006) 1.11

A beta-glucan-conjugate vaccine and anti-beta-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique. Vaccine (2009) 1.09

Beta-glucan-CRM197 conjugates as candidates antifungal vaccines. Vaccine (2010) 1.09

Interplay between protective and inhibitory antibodies dictates the outcome of experimentally disseminated Candidiasis in recipients of a Candida albicans vaccine. Infect Immun (2002) 1.08

Goa1p of Candida albicans localizes to the mitochondria during stress and is required for mitochondrial function and virulence. Eukaryot Cell (2009) 1.07

Different pH requirements are associated with divergent inhibitory effects of chloroquine on human and avian influenza A viruses. Virol J (2007) 1.06

In vitro and in vivo activity of tea tree oil against azole-susceptible and -resistant human pathogenic yeasts. J Antimicrob Chemother (2003) 1.05

Protocol for real-time PCR identification of anthrax spores from nasal swabs after broth enrichment. J Clin Microbiol (2002) 1.05

Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques. J Immunol (2005) 1.05

Intravaginal and intranasal immunizations are equally effective in inducing vaginal antibodies and conferring protection against vaginal candidiasis. Infect Immun (2002) 1.03

Optimization of high-resolution melting analysis for low-cost and rapid screening of allelic variants of Bacillus anthracis by multiple-locus variable-number tandem repeat analysis. Clin Chem (2007) 1.02

The 65 kDa mannoprotein gene of Candida albicans encodes a putative beta-glucanase adhesin required for hyphal morphogenesis and experimental pathogenicity. Cell Microbiol (2007) 1.02

Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants. Antimicrob Agents Chemother (2012) 1.01

Fieldable genotyping of Bacillus anthracis and Yersinia pestis based on 25-loci Multi Locus VNTR Analysis. BMC Microbiol (2008) 1.01

The role of the Candida albicans histidine kinase [CHK1) gene in the regulation of cell wall mannan and glucan biosynthesis. FEMS Yeast Res (2003) 0.99

Therapeutic activity of an engineered synthetic killer antiidiotypic antibody fragment against experimental mucosal and systemic candidiasis. Infect Immun (2003) 0.98

Endogenous PGE2 promotes the induction of human Th17 responses by fungal ß-glucan. J Leukoc Biol (2010) 0.98

Temporal expression of the Candida albicans genes CHK1 and CSSK1, adherence, and morphogenesis in a model of reconstituted human esophageal epithelial candidiasis. Infect Immun (2002) 0.98

Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome. Eur J Immunol (2013) 0.98

A virosomal vaccine against candidal vaginitis: immunogenicity, efficacy and safety profile in animal models. Vaccine (2012) 0.97

Histidine kinases keep fungi safe and vigorous. Curr Opin Microbiol (2010) 0.97

Enzymatic dysfunction of mitochondrial complex I of the Candida albicans goa1 mutant is associated with increased reactive oxidants and cell death. Eukaryot Cell (2011) 0.97

IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis. PLoS Pathog (2013) 0.96

The Candida albicans histidine kinase Chk1p: signaling and cell wall mannan. Fungal Genet Biol (2009) 0.96

Mitochondrial membrane hyperpolarization hijacks activated T lymphocytes toward the apoptotic-prone phenotype: homeostatic mechanisms of HIV protease inhibitors. J Immunol (2003) 0.96

Native and genetically inactivated pertussis toxins induce human dendritic cell maturation and synergize with lipopolysaccharide in promoting T helper type 1 responses. J Infect Dis (2002) 0.96

Deletion of the SSK1 response regulator gene in Candida albicans contributes to enhanced killing by human polymorphonuclear neutrophils. Infect Immun (2005) 0.95

60-kDa heat shock protein of Chlamydia pneumoniae promotes a T helper type 1 immune response through IL-12/IL-23 production in monocyte-derived dendritic cells. Microbes Infect (2006) 0.95

Studies on the regulation of the two-component histidine kinase gene CHK1 in Candida albicans using the heterologous lacZ reporter gene. Microbiology (2004) 0.94

Candida albicans yeast and germ tube forms interfere differently with human monocyte differentiation into dendritic cells: a novel dimorphism-dependent mechanism to escape the host's immune response. Infect Immun (2004) 0.93

Anticandidal immunity and vaginitis: novel opportunities for immune intervention. Infect Immun (2007) 0.93

Rapid, simple, and low-cost identification of Candida species using high-resolution melting analysis. Diagn Microbiol Infect Dis (2011) 0.93

The Cek1 MAPK is a short-lived protein regulated by quorum sensing in the fungal pathogen Candida albicans. FEMS Yeast Res (2009) 0.93

Functional studies of the Ssk1p response regulator protein of Candida albicans as determined by phenotypic analysis of receiver domain point mutants. Mol Microbiol (2006) 0.93

beta-Glucan of Candida albicans cell wall causes the subversion of human monocyte differentiation into dendritic cells. J Leukoc Biol (2007) 0.92

Afyap1, encoding a bZip transcriptional factor of Aspergillus fumigatus, contributes to oxidative stress response but is not essential to the virulence of this pathogen in mice immunosuppressed by cyclophosphamide and triamcinolone. Med Mycol (2008) 0.92

Two-component signal transduction proteins as potential drug targets in medically important fungi. Infect Immun (2008) 0.92

A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine. FEMS Immunol Med Microbiol (2011) 0.92

The Ag85B protein of Mycobacterium tuberculosis may turn a protective immune response induced by Ag85B-DNA vaccine into a potent but non-protective Th1 immune response in mice. Cell Microbiol (2007) 0.91

Identification of major glucan-associated cell wall proteins of Candida albicans and their role in fluconazole resistance. Antimicrob Agents Chemother (2002) 0.91

Colonization by Candida species of the oral and vaginal mucosa in HIV-infected and noninfected women. AIDS Res Hum Retroviruses (2012) 0.91

The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response. Vaccine (2008) 0.90

Glycosylphosphatidylinositol-anchored Ecm33p influences conidial cell wall biosynthesis in Aspergillus fumigatus. Appl Environ Microbiol (2006) 0.90

Mycobacterium tuberculosis complex drug resistance in Italy. Emerg Infect Dis (2004) 0.90

Phenotypic and functional characterization of vaginal dendritic cells in a rat model of Candida albicans vaginitis. Infect Immun (2006) 0.90

Virulence and karyotype analyses of rad52 mutants of Candida albicans: regeneration of a truncated chromosome of a reintegrant strain (rad52/RAD52) in the host. Infect Immun (2005) 0.89

The sho1 sensor regulates growth, morphology, and oxidant adaptation in Aspergillus fumigatus but is not essential for development of invasive pulmonary aspergillosis. Infect Immun (2008) 0.89

The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. Antimicrob Agents Chemother (2007) 0.89

Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives. Bioorg Med Chem (2011) 0.89

Can preening contribute to influenza A virus infection in wild waterbirds? PLoS One (2010) 0.88

Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors. J Infect Dis (2005) 0.88

Cell surface changes in the Candida albicans mitochondrial mutant goa1Δ are associated with reduced recognition by innate immune cells. Cell Microbiol (2013) 0.88

Antiretroviral therapy with protease inhibitors has an early, immune reconstitution-independent beneficial effect on Candida virulence and oral candidiasis in human immunodeficiency virus-infected subjects. J Infect Dis (2002) 0.87

Cardiac tamponade and heart failure due to myopericarditis as a presentation of infection with the pandemic H1N1 2009 influenza A virus. J Clin Microbiol (2010) 0.87

Loss and fragmentation of chromosome 5 are major events linked to the adaptation of rad52-DeltaDelta strains of Candida albicans to sorbose. Fungal Genet Biol (2007) 0.87

A single SNP, G929T (Gly310Val), determines the presence of a functional and a non-functional allele of HIS4 in Candida albicans SC5314: detection of the non-functional allele in laboratory strains. Fungal Genet Biol (2007) 0.87

The MP65 gene is required for cell wall integrity, adherence to epithelial cells and biofilm formation in Candida albicans. BMC Microbiol (2011) 0.86

Gene transcription studies of Candida albicans following infection of HEp2 epithelial cells. Med Mycol (2006) 0.86

Persistent Chlamydia pneumoniae infection of cardiomyocytes is correlated with fatal myocardial infarction. Am J Pathol (2007) 0.86