Published in Am J Sports Med on January 18, 2002
Major biological obstacles for persistent cell-based regeneration of articular cartilage. Arthritis Res Ther (2007) 1.85
One-step bone marrow-derived cell transplantation in talar osteochondral lesions. Clin Orthop Relat Res (2009) 1.48
Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results. Arthritis Res Ther (2007) 1.45
Treatment of focal articular cartilage defects in the knee: a systematic review. Clin Orthop Relat Res (2008) 1.40
Clinical cartilage restoration: evolution and overview. Clin Orthop Relat Res (2011) 1.28
Cartilage, SOX9 and Notch signals in chondrogenesis. J Anat (2006) 1.25
Continuous passive motion applied to whole joints stimulates chondrocyte biosynthesis of PRG4. Osteoarthritis Cartilage (2006) 1.24
Stem cell homing in musculoskeletal injury. Biomaterials (2010) 1.23
Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy. Curr Stem Cell Res Ther (2009) 1.22
Success rates and immunologic responses of autogenic, allogenic, and xenogenic treatments to repair articular cartilage defects. Tissue Eng Part B Rev (2009) 1.20
Immunohistochemical study of collagen types I and II and procollagen IIA in human cartilage repair tissue following autologous chondrocyte implantation. Knee (2009) 1.19
MR imaging of osteochondral grafts and autologous chondrocyte implantation. Eur Radiol (2006) 1.17
Autologous chondrocyte implantation for joint preservation in patients with early osteoarthritis. Clin Orthop Relat Res (2009) 1.16
A Randomized, Controlled Trial Comparing Autologous Matrix-Induced Chondrogenesis (AMIC®) to Microfracture: Analysis of 1- and 2-Year Follow-Up Data of 2 Centers. Open Orthop J (2013) 1.14
Clinical application of scaffolds for cartilage tissue engineering. Knee Surg Sports Traumatol Arthrosc (2008) 1.13
MR imaging of cartilage and its repair in the knee--a review. Eur Radiol (2009) 1.12
Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results. Arthritis Res Ther (2009) 1.10
Evaluation of articular cartilage repair using biodegradable nanofibrous scaffolds in a swine model: a pilot study. J Tissue Eng Regen Med (2009) 1.10
Concepts in gene therapy for cartilage repair. Injury (2008) 1.08
Tissue engineering and cell based therapies, from the bench to the clinic: the potential to replace, repair and regenerate. Reprod Biol Endocrinol (2003) 1.07
Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients. Cytotherapy (2012) 0.99
Clinical outcomes of patellar chondral lesions treated with juvenile particulated cartilage allografts. Iowa Orthop J (2014) 0.97
New trends for knee cartilage regeneration: from cell-free scaffolds to mesenchymal stem cells. Curr Rev Musculoskelet Med (2012) 0.96
Does operative fixation of an osteochondritis dissecans loose body result in healing and long-term maintenance of knee function? Am J Sports Med (2009) 0.96
Accuracy of quantitative magnetic resonance imaging in the detection of ex vivo focal cartilage defects. Ann Rheum Dis (2005) 0.94
The use of autologous chondrocyte implantation following and combined with anterior cruciate ligament reconstruction. Int Orthop (2005) 0.94
Current concepts of articular cartilage restoration techniques in the knee. Sports Health (2014) 0.94
Knee Articular Cartilage Repair and Restoration Techniques: A Review of the Literature. Sports Health (2015) 0.92
The role of autologous chondrocyte implantation in the treatment of symptomatic chondromalacia patellae. Int Orthop (2012) 0.92
Articular Cartilage Injury in Athletes. Cartilage (2010) 0.92
Induction of CD44 cleavage in articular chondrocytes. Arthritis Rheum (2010) 0.92
Evolution of autologous chondrocyte repair and comparison to other cartilage repair techniques. Biomed Res Int (2014) 0.91
Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC). J Clin Orthop Trauma (2016) 0.90
Autologous chondrocyte implantation for the treatment of cartilage lesions of the knee: a systematic review of randomized studies. Knee Surg Sports Traumatol Arthrosc (2010) 0.89
Surgical management of osteochondritis dissecans of the knee. Curr Rev Musculoskelet Med (2013) 0.89
An instrumented scaffold can monitor loading in the knee joint. J Biomed Mater Res B Appl Biomater (2006) 0.86
Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts. J Clin Invest (2004) 0.86
Can osteochondral grafting be augmented with microfracture in an extended-size lesion of articular cartilage? Am J Sports Med (2010) 0.86
New Frontiers for Cartilage Repair and Protection. Cartilage (2012) 0.86
Evaluating osteochondral defect repair potential of autologous rabbit bone marrow cells on type II collagen scaffold. Cytotechnology (2010) 0.85
Stem cells and gene therapy for cartilage repair. Stem Cells Int (2012) 0.85
Magnetic Resonance Imaging of Cartilage Repair: A Review. Cartilage (2011) 0.85
MR imaging evaluation of the postoperative knee: ligaments, menisci, and articular cartilage. Skeletal Radiol (2005) 0.85
Glenohumeral joint preservation: a review of management options for young, active patients with osteoarthritis. Adv Orthop (2012) 0.84
MR appearance of autologous chondrocyte implantation in the knee: correlation with the knee features and clinical outcome. Skeletal Radiol (2005) 0.84
Chondral Injury in Patellofemoral Instability. Cartilage (2014) 0.84
An osteochondral culture model to study mechanisms involved in articular cartilage repair. Tissue Eng Part C Methods (2011) 0.84
Cell-based tissue engineering strategies used in the clinical repair of articular cartilage. Biomaterials (2016) 0.84
The meniscal healing process. Muscles Ligaments Tendons J (2012) 0.83
Characterization of chondrocyte scaffold carriers for cell-based gene therapy in articular cartilage repair. J Biomed Mater Res A (2013) 0.83
Surface markers for chondrogenic determination: a highlight of synovium-derived stem cells. Cells (2012) 0.82
Sequential outcome following autologous chondrocyte implantation of the knee: a six-year follow-up. Int Orthop (2009) 0.82
The effect of platelet-rich plasma on osteochondral defects treated with mosaicplasty. Int Orthop (2014) 0.82
Rehabilitation following Microfracture of the Knee. Cartilage (2010) 0.81
Long-term clinical results and MRI changes after autologous chondrocyte implantation in the knee of young and active middle aged patients. J Orthop Traumatol (2015) 0.81
Surgical treatment of articular cartilage defects in the knee: are we winning? Adv Orthop (2012) 0.81
Cartilage repair: A review of Stanmore experience in the treatment of osteochondral defects in the knee with various surgical techniques. Indian J Orthop (2010) 0.81
New and Emerging Techniques in Cartilage Repair: MACI. Oper Tech Sports Med (2013) 0.81
Arthroscopic Delivery of Matrix-Induced Autologous Chondrocyte Implant: International Experience and Technique Recommendations. Cartilage (2012) 0.81
PKCε signalling activates ERK1/2, and regulates aggrecan, ADAMTS5, and miR377 gene expression in human nucleus pulposus cells. PLoS One (2013) 0.81
Persisting high levels of synovial fluid markers after cartilage repair: a pilot study. Clin Orthop Relat Res (2008) 0.81
First-generation versus second-generation autologous chondrocyte implantation for treatment of cartilage defects of the knee: a matched-pair analysis on long-term clinical outcome. Int Orthop (2014) 0.81
Scientific Evidence Base for Cartilage Injury and Repair in the Athlete. Cartilage (2012) 0.80
Cell Seeding Densities in Autologous Chondrocyte Implantation Techniques for Cartilage Repair. Cartilage (2012) 0.79
Cell-based therapy improves function in adolescents and young adults with patellar osteochondritis dissecans. Clin Orthop Relat Res (2013) 0.79
Cell-Seeded Collagen Matrix-Supported Autologous Chondrocyte Transplantation (ACT-CS): A Consensus Statement on Surgical Technique. Cartilage (2012) 0.79
Heat-shock proteins and their role in chondrocyte protection, an application for autologous transplantation. Inflammopharmacology (2005) 0.79
In Vivo Evaluation of Different Surgical Procedures for Autologous Chondrocyte Implantation. Cartilage (2013) 0.78
An ex vivo continuous passive motion model in a porcine knee for assessing primary stability of cell-free collagen gel plugs. BMC Musculoskelet Disord (2010) 0.78
The effect of chemically defined medium on spontaneous calcium signaling of in situ chondrocytes during long-term culture. J Biomech (2015) 0.78
Increasing the Dose of Autologous Chondrocytes Improves Articular Cartilage Repair: Histological and Molecular Study in the Sheep Animal Model. Cartilage (2014) 0.78
Matrix-Associated and Autologous Chondrocyte Transplantation in the Ankle: Clinical and MRI Follow-up after 2 to 11 Years. Cartilage (2011) 0.78
The present state of treatments for articular cartilage defects in the knee. Ann R Coll Surg Engl (2012) 0.78
Functional cartilage repair capacity of de-differentiated, chondrocyte- and mesenchymal stem cell-laden hydrogels in vitro. Osteoarthritis Cartilage (2014) 0.78
Sensitivity of quantitative UTE MRI to the biomechanical property of the temporomandibular joint disc. Skeletal Radiol (2014) 0.78
Operative Fixation of Chondral Loose Bodies in Osteochondritis Dissecans in the Knee: A Report of 5 Cases. Orthop J Sports Med (2013) 0.77
Effect of risedronate in a minipig cartilage defect model with allograft. J Orthop Res (2009) 0.77
Patients Scheduled for Chondrocyte Implantation Treatment with MACI Have Larger Defects than Those Enrolled in Clinical Trials. Cartilage (2015) 0.77
Next Generation Mesenchymal Stem Cell (MSC)-Based Cartilage Repair Using Scaffold-Free Tissue Engineered Constructs Generated with Synovial Mesenchymal Stem Cells. Cartilage (2015) 0.76
Spanish experience in autologous chondrocyte implantation. Open Orthop J (2010) 0.76
Identification of the chondrocyte lineage using microfibril-associated glycoprotein-2, a novel marker that distinguishes chondrocytes from synovial cells. Tissue Eng Part C Methods (2010) 0.76
Combined autologous chondrocyte implantation (ACI) with supra-condylar femoral varus osteotomy, following lateral growth-plate damage in an adolescent knee: 8-year follow-up. Sports Med Arthrosc Rehabil Ther Technol (2011) 0.76
Surgical treatment options for the young and active middle-aged patient with glenohumeral arthritis. Adv Orthop (2012) 0.76
From gristle to chondrocyte transplantation: treatment of cartilage injuries. Philos Trans R Soc Lond B Biol Sci (2015) 0.76
Is the transplant quality at the time of surgery adequate for matrix-guided autologous cartilage transplantation? A pilot study. Clin Orthop Relat Res (2013) 0.75
Long-Term Evaluation of Autologous Chondrocyte Implantation: Minimum 7-Year Follow-Up. Cartilage (2012) 0.75
Long-Term Outcomes after Autologous Chondrocyte Implantation: A Systematic Review at Mean Follow-Up of 11.4 Years. Cartilage (2016) 0.75
Development of a Tool to Predict Outcome of Autologous Chondrocyte Implantation. Cartilage (2016) 0.75
Human articular chondrocytes express functional leukotriene B4 receptors. J Anat (2015) 0.75
Biomechanical outcomes of cartilage repair of the knee. J Knee Surg (2012) 0.75
Image-Guided Techniques Improve the Short-Term Outcome of Autologous Osteochondral Cartilage Repair Surgeries: An Animal Trial. Cartilage (2013) 0.75
Influence of biological scaffold regulation on the proliferation of chondrocytes and the repair of articular cartilage. Am J Transl Res (2016) 0.75
Incomplete defect filling after third generation autologous chondrocyte implantation. Arch Med Sci (2016) 0.75
Acrylamide Polymer Double-Network Hydrogels: Candidate Cartilage Repair Materials with Cartilage-Like Dynamic Stiffness and Attractive Surgery-Related Attachment Mechanics. Cartilage (2011) 0.75
Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells. Tissue Eng Part A (2015) 0.75
[Surgical treatment of knee joint osteoarthritis in the middle-aged patient]. Wien Med Wochenschr (2007) 0.75
Biphasic Finite Element Modeling Reconciles Mechanical Properties of Tissue-Engineered Cartilage Constructs Across Testing Platforms. Tissue Eng Part A (2017) 0.75
Articular cartilage defects in 1,000 knee arthroscopies. Arthroscopy (2002) 2.78
Autologous chondrocyte implantation: a long-term follow-up. Am J Sports Med (2010) 2.43
Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: results at two to ten years. J Bone Joint Surg Am (2003) 2.24
Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS). J Bone Joint Surg Am (2003) 2.24
Derivation, characterization, and differentiation of human embryonic stem cells. Stem Cells (2004) 1.89
Articular cartilage engineering with autologous chondrocyte transplantation. A review of recent developments. J Bone Joint Surg Am (2003) 1.44
The subchondral bone in articular cartilage repair: current problems in the surgical management. Knee Surg Sports Traumatol Arthrosc (2010) 1.36
Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model. Spine (Phila Pa 1976) (2009) 1.26
Cartilage repair: past and future--lessons for regenerative medicine. J Cell Mol Med (2009) 1.24
Proliferation and differentiation potential of chondrocytes from osteoarthritic patients. Arthritis Res Ther (2005) 1.23
Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation. Arthritis Res Ther (2009) 1.21
Differentiating human embryonic stem cells express a unique housekeeping gene signature. Stem Cells (2007) 1.18
Cartilage tissue engineering for degenerative joint disease. Adv Drug Deliv Rev (2006) 1.18
Molecular signature of cardiomyocyte clusters derived from human embryonic stem cells. Stem Cells (2008) 1.16
Human embryonic stem cell-derived mesenchymal progenitors--potential in regenerative medicine. Stem Cell Res (2009) 1.16
Gene expression during redifferentiation of human articular chondrocytes. Osteoarthritis Cartilage (2004) 1.15
Identification of cell proliferation zones, progenitor cells and a potential stem cell niche in the intervertebral disc region: a study in four species. Spine (Phila Pa 1976) (2009) 1.14
Autologous chondrocyte implantation in cartilage lesions of the knee: long-term evaluation with magnetic resonance imaging and delayed gadolinium-enhanced magnetic resonance imaging technique. Am J Sports Med (2010) 1.09
C-kit+ CD45- cells found in the adult human heart represent a population of endothelial progenitor cells. Basic Res Cardiol (2010) 1.09
Identification of a stem cell niche in the zone of Ranvier within the knee joint. J Anat (2009) 1.09
Correlation between magnetic resonance imaging and clinical outcomes after knee cartilage repair: letter to the editor. Am J Sports Med (2013) 1.08
Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors. J Orthop Res (2007) 1.06
Coculture of human embryonic stem cells and human articular chondrocytes results in significantly altered phenotype and improved chondrogenic differentiation. Stem Cells (2009) 1.06
Studies of polyurethane urea bands for ACL reconstruction. J Mater Sci Mater Med (2002) 1.02
Indentation stiffness of repair tissue after autologous chondrocyte transplantation. Clin Orthop Relat Res (2005) 0.96
Notch and HES5 are regulated during human cartilage differentiation. Cell Tissue Res (2006) 0.96
Autologous chondrocyte transplantation of the ankle. Foot Ankle Clin (2003) 0.94
Secular trends in sex hormones and fractures in men and women. Eur J Endocrinol (2012) 0.93
Human embryonic stem cells: current technologies and emerging industrial applications. Crit Rev Oncol Hematol (2007) 0.93
Adaptation of human embryonic stem cells to feeder-free and matrix-free culture conditions directly on plastic surfaces. J Biotechnol (2007) 0.92
Footprint-free human induced pluripotent stem cells from articular cartilage with redifferentiation capacity: a first step toward a clinical-grade cell source. Stem Cells Transl Med (2014) 0.92
Malalignment and cartilage lesions in the patellofemoral joint treated with autologous chondrocyte implantation. Knee Surg Sports Traumatol Arthrosc (2010) 0.92
Bacterial cellulose as a potential meniscus implant. J Tissue Eng Regen Med (2007) 0.92
Is magnetic resonance imaging reliable in predicting clinical outcome after articular cartilage repair of the knee? A systematic review and meta-analysis. Am J Sports Med (2013) 0.91
Evaluation of p16 and Id1 status and endogenous reference genes in human chondrosarcoma by real-time PCR. Int J Oncol (2005) 0.89
Articular cartilage stem cell signalling. Arthritis Res Ther (2009) 0.89
Clonal derivation and characterization of human embryonic stem cell lines. J Biotechnol (2005) 0.89
Expression of genes involved in the regulation of p16 in psoriatic involved skin. Arch Dermatol Res (2006) 0.88
Support of concept that migrating progenitor cells from stem cell niches contribute to normal regeneration of the adult mammal intervertebral disc: a descriptive study in the New Zealand white rabbit. Spine (Phila Pa 1976) (2012) 0.88
Neither Notch1 expression nor cellular size correlate with mesenchymal stem cell properties of adult articular chondrocytes. Cells Tissues Organs (2008) 0.88
Poly-L-D-lactic acid scaffold in the repair of porcine knee cartilage lesions. Tissue Eng (2007) 0.87
Strategies for patient profiling in articular cartilage repair of the knee: a prospective cohort of patients treated by one experienced cartilage surgeon. Knee Surg Sports Traumatol Arthrosc (2012) 0.86
The presence of local mesenchymal progenitor cells in human degenerated intervertebral discs and possibilities to influence these in vitro: a descriptive study in humans. Stem Cells Dev (2012) 0.85
Sustained embryoid body formation and culture in a non-laborious three dimensional culture system for human embryonic stem cells. Cytotechnology (2011) 0.85
Economic evaluation of BST-CarGel as an adjunct to microfracture vs microfracture alone in knee cartilage surgery. J Med Econ (2014) 0.84
Human adipose-derived stem cells contribute to chondrogenesis in coculture with human articular chondrocytes. Tissue Eng Part A (2009) 0.84
Assaying cardiac biomarkers for toxicity testing using biosensing and cardiomyocytes derived from human embryonic stem cells. J Biotechnol (2010) 0.84
Left atrium of the human adult heart contains a population of side population cells. Basic Res Cardiol (2012) 0.83
Expression of microRNAs and their target mRNAs in human stem cell-derived cardiomyocyte clusters and in heart tissue. Physiol Genomics (2010) 0.83
Human articular chondrocytes--plasticity and differentiation potential. Cells Tissues Organs (2006) 0.83
Long-term maintenance of human articular cartilage in culture for biomaterial testing. Biomaterials (2005) 0.83
Identification of AHNAK as a novel autoantigen in systemic lupus erythematosus. Biochem Biophys Res Commun (2002) 0.83
Superior osteogenic capacity of human embryonic stem cells adapted to matrix-free growth compared to human mesenchymal stem cells. Tissue Eng Part A (2010) 0.83
Similar cellular migration patterns from niches in intervertebral disc and in knee-joint regions detected by in situ labeling: an experimental study in the New Zealand white rabbit. Stem Cell Res Ther (2013) 0.82
Cardiomyocyte clusters derived from human embryonic stem cells share similarities with human heart tissue. J Mol Cell Biol (2010) 0.82
Transcriptional profiling of human embryonic stem cells differentiating to definitive and primitive endoderm and further toward the hepatic lineage. Stem Cells Dev (2010) 0.82
Hash4, a novel human achaete-scute homologue found in fetal skin. Genomics (2004) 0.82
Persisting high levels of synovial fluid markers after cartilage repair: a pilot study. Clin Orthop Relat Res (2008) 0.81
Effects of high mobility group box protein-1, interleukin-1β, and interleukin-6 on cartilage matrix metabolism in three-dimensional equine chondrocyte cultures. Connect Tissue Res (2010) 0.81
Notch signaling in chondrogenesis. Int Rev Cell Mol Biol (2009) 0.80
Human serum for culture of articular chondrocytes. Cell Transplant (2005) 0.80
The effects of PPAR-γ inhibition on gene expression and the progression of induced osteogenic differentiation of human mesenchymal stem cells. Connect Tissue Res (2014) 0.80
Cartilage repair with chondrocytes: clinical and cellular aspects. Novartis Found Symp (2003) 0.79
Effect of cell seeding concentration on the quality of tissue engineered constructs loaded with adult human articular chondrocytes. J Tissue Eng Regen Med (2008) 0.79
The helix-loop-helix transcription factor Id1 is highly expressed in psoriatic involved skin. Acta Derm Venereol (2003) 0.79
Cardiomyogenic gene expression profiling of differentiating human embryonic stem cells. J Biotechnol (2007) 0.78
An inflammatory equine model demonstrates dynamic changes of immune response and cartilage matrix molecule degradation in vitro. Connect Tissue Res (2015) 0.77
... more bricks to the building of cartilage knowledge? Knee Surg Sports Traumatol Arthrosc (2009) 0.77
Novel 3D culture system with similarities to the human heart for studies of the cardiac stem cell niche. Regen Med (2010) 0.77
Optimization of a chondrogenic medium through the use of factorial design of experiments. Biores Open Access (2012) 0.77
Consideration of religious sentiments while selecting a biological product for knee arthroscopy. Knee Surg Sports Traumatol Arthrosc (2012) 0.76
High density sphere culture of adult cardiac cells increases the levels of cardiac and progenitor markers and shows signs of vasculogenesis. Biomed Res Int (2012) 0.76
SSEA-4+ CD34- cells in the adult human heart show the molecular characteristics of a novel cardiomyocyte progenitor population. Cells Tissues Organs (2014) 0.75
Nanosized fibers' effect on adult human articular chondrocytes behavior. Mater Sci Eng C Mater Biol Appl (2012) 0.75
Cell and matrix modulation in prenatal and postnatal equine growth cartilage, zones of Ranvier and articular cartilage. J Anat (2014) 0.75
Triphasic and quadriphasic waveforms are superior to biphasic waveforms for synchronized beating of cardiomyocytes. J Electrocardiol (2012) 0.75
Physical exercise affects slow cycling cells in the rat heart and reveals a new potential niche area in the atrioventricular junction. J Mol Histol (2015) 0.75
Bipolar radiofrequency plasma ablation induces proliferation and alters cytokine expression in human articular cartilage chondrocytes. Arthroscopy (2012) 0.75
Virtual ligand-based screening reveals purmorphamine analogs with the capacity to induce the osteogenic differentiation of human mesenchymal stem cells. Cells Tissues Organs (2012) 0.75
A formulation comparison between micro- and nanosuspensions: the importance of particle size for absorption of a model compound, following repeated oral administration to rats during early development. Drug Dev Ind Pharm (2010) 0.75