Published in Neuron on January 17, 2002
A sympathetic neuron autonomous role for Egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation. J Neurosci (2013) 1.08
GDNF promotes tubulogenesis of GFRalpha1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase. J Cell Biol (2003) 1.08
A cross-talk between TrkB and Ret tyrosine kinases receptors mediates neuroblastoma cells differentiation. PLoS One (2008) 1.03
BDNF-TrkB signaling through Erk1/2 MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids. Mol Psychiatry (2013) 0.94
The differential axonal degradation of Ret accounts for cell-type-specific function of glial cell line-derived neurotrophic factor as a retrograde survival factor. J Neurosci (2010) 0.93
Chat in the trophic web: NGF activates Ret by inter-RTK signaling. Neuron (2002) 0.90
Complexity of receptor tyrosine kinase signal processing. Cold Spring Harb Perspect Biol (2013) 0.89
CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. J Neurosci (2008) 0.88
p75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A (2009) 0.83
Medullary thyroid carcinoma: molecular signaling pathways and emerging therapies. J Thyroid Res (2011) 0.81
Dynamic expression of neurotrophic factor receptors in postnatal spinal motoneurons and in mouse model of ALS. J Neurobiol (2006) 0.81
Role of hypoxia and HIF2α in development of the sympathoadrenal cell lineage and chromaffin cell tumors with distinct catecholamine phenotypic features. Adv Pharmacol (2013) 0.80
HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo. Oncotarget (2016) 0.78
NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib. Oncotarget (2015) 0.76
Expression of axonal protein degradation machinery in sympathetic neurons is regulated by nerve growth factor. J Neurosci Res (2012) 0.76
Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFRα3. Proc Natl Acad Sci U S A (2016) 0.75
Exon Skipping in the RET Gene Encodes Novel Isoforms That Differentially Regulate RET Protein Signal Transduction. J Biol Chem (2016) 0.75
Medullary Thyroid Cancer: Clinical Characteristics and New Insights into Therapeutic Strategies Targeting Tyrosine Kinases. Mol Diagn Ther (2017) 0.75
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science (2004) 7.29
Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci U S A (2007) 4.24
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab (2007) 4.16
FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J Biol Chem (2002) 2.90
Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration. Neuron (2012) 2.88
JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron (2003) 2.86
Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med (2004) 2.84
NS21: re-defined and modified supplement B27 for neuronal cultures. J Neurosci Methods (2008) 2.68
Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations. J Neurosci (2007) 2.56
Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex. J Neurosci (2010) 2.55
A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nat Neurosci (2009) 2.42
Haploinsufficiency at the Nkx3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation. Cancer Cell (2003) 2.40
Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. Nat Med (2007) 2.38
Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate. Biol Reprod (2005) 2.35
Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination. Proc Natl Acad Sci U S A (2005) 2.29
Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide. J Neurosci (2009) 2.15
Lipid rafts in neuronal signaling and function. Trends Neurosci (2002) 2.06
Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element. Endocrinology (2005) 2.04
Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. J Neurosci (2006) 1.89
Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron (2009) 1.88
Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Neuron (2002) 1.88
Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol (2002) 1.83
A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles. Genome Res (2006) 1.78
Assembly and maintenance of nodes of ranvier rely on distinct sources of proteins and targeting mechanisms. Neuron (2012) 1.75
Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy. Neuron (2013) 1.70
Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J Cell Biol (2002) 1.69
Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo. J Neurosci (2009) 1.69
Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development (2007) 1.61
Critical and distinct roles for key RET tyrosine docking sites in renal development. Genes Dev (2006) 1.54
Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress. J Neurosci (2008) 1.54
Nab proteins are essential for peripheral nervous system myelination. Nat Neurosci (2005) 1.53
AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development. Dev Cell (2009) 1.44
Mixed-lineage kinases: a target for the prevention of neurodegeneration. Annu Rev Pharmacol Toxicol (2004) 1.43
Transplantation of embryonic stem cells overexpressing Bcl-2 promotes functional recovery after transient cerebral ischemia. Neurobiol Dis (2005) 1.42
Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: role in neurodegenerative diseases. Neurotoxicology (2004) 1.41
Deciphering peripheral nerve myelination by using Schwann cell expression profiling. Proc Natl Acad Sci U S A (2002) 1.40
Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains. Mov Disord (2010) 1.39
The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction. Cell Rep (2013) 1.39
Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway. J Neurosci (2010) 1.37
Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle. Arch Neurol (2007) 1.36
Thymocyte development in early growth response gene 1-deficient mice. J Immunol (2002) 1.34
Sarm1-mediated axon degeneration requires both SAM and TIR interactions. J Neurosci (2013) 1.32
The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis: identification of the nuclear pore complex as a potential target of the JNK pathway. J Cell Biol (2005) 1.32
Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. PLoS One (2009) 1.30
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A (2011) 1.29
Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis. Development (2004) 1.29
RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. J Neurosci (2006) 1.27
Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons. J Biol Chem (2010) 1.26
The claw paw mutation reveals a role for Lgi4 in peripheral nerve development. Nat Neurosci (2005) 1.24
Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Development (2007) 1.20
Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci (2003) 1.20
Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration. J Neurosci (2012) 1.18
Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration. J Biol Chem (2011) 1.16
SCG10 is a JNK target in the axonal degeneration pathway. Proc Natl Acad Sci U S A (2012) 1.16
Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function. J Neurosci (2011) 1.15
Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss. J Neurosci (2007) 1.13
Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems. Sci Signal (2012) 1.11
Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival. J Biol Chem (2004) 1.11
Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation. J Neurosci (2006) 1.11
Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons. J Neurosci (2002) 1.10
MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes. J Neurosci (2011) 1.09
Exogenous smac induces competence and permits caspase activation in sympathetic neurons. J Neurosci (2002) 1.07
Improved magnetic resonance imaging detection of prostate cancer in a transgenic mouse model. Cancer Res (2002) 1.05
A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration. J Neurosci (2012) 1.05
Nerve growth factor promotes the survival of sympathetic neurons through the cooperative function of the protein kinase C and phosphatidylinositol 3-kinase pathways. J Biol Chem (2004) 1.05
Multiple channel interactions explain the protection of sympathetic neurons from apoptosis induced by nerve growth factor deprivation. J Neurosci (2002) 1.04
GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration. Neuron (2004) 1.04
Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation. J Neurosci (2009) 1.04
RET signaling is required for survival and normal function of nonpeptidergic nociceptors. J Neurosci (2010) 1.03
Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions. Biomaterials (2010) 1.02
Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: support for nigral targeting in Parkinson's disease. Neurobiol Dis (2011) 1.02
Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors. Structure (2006) 1.02
Expression profiles provide insights into early malignant potential and skeletal abnormalities in multiple endocrine neoplasia type 2B syndrome tumors. Cancer Res (2004) 1.00
Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. J Biol Chem (2004) 1.00
The transcriptional cofactor nab2 is induced by tgf-Beta and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma. PLoS One (2009) 1.00
Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death. Proc Natl Acad Sci U S A (2011) 0.99
Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling. J Neurosci (2009) 0.97
The long and short isoforms of Ret function as independent signaling complexes. J Biol Chem (2002) 0.97
Transcription factor Egr-1 is required for long-term fear memory and anxiety. Sheng Li Xue Bao (2005) 0.96
Selective contribution of Egr1 (zif/268) to persistent inflammatory pain. J Pain (2005) 0.96
Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice. J Clin Invest (2010) 0.95
The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. J Cell Sci (2009) 0.94
Mice lacking the immediate early gene Egr3 respond to the anti-aggressive effects of clozapine yet are relatively resistant to its sedating effects. Neuropsychopharmacology (2007) 0.94
Glial cell line-derived neurotrophic factor promotes the survival of early postnatal spinal motor neurons in the lateral and medial motor columns in slice culture. J Neurosci (2002) 0.94
ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. J Neurosci (2003) 0.93
Dopamine-dependent compensation maintains motor behavior in mice with developmental ablation of dopaminergic neurons. J Neurosci (2013) 0.92
Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3. Carcinogenesis (2007) 0.92
Mixed-lineage kinase inhibitors require the activation of Trk receptors to maintain long-term neuronal trophism and survival. J Pharmacol Exp Ther (2004) 0.91
Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11. J Neurosci (2008) 0.91