PubRank

Tim M Townes

Author PubWeight™ 60.19‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 2007 12.41
2 ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell 2004 5.27
3 Global reorganization of replication domains during embryonic stem cell differentiation. PLoS Biol 2008 4.50
4 SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilation. Nat Med 2008 3.02
5 Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene 2005 2.50
6 KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching. Nat Genet 2010 2.39
7 Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells. Cell Stem Cell 2012 2.11
8 Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cells. Stem Cells 2009 2.01
9 Correction of sickle cell disease by homologous recombination in embryonic stem cells. Blood 2006 1.92
10 Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood 2002 1.88
11 ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo. J Exp Med 2008 1.86
12 Correction of a mouse model of sickle cell disease: lentiviral/antisickling beta-globin gene transduction of unmobilized, purified hematopoietic stem cells. Blood 2003 1.76
13 Nitric oxide-dependent generation of reactive species in sickle cell disease. Actin tyrosine induces defective cytoskeletal polymerization. J Biol Chem 2002 1.42
14 Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. J Biol Chem 2004 1.42
15 PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming. Stem Cells 2011 1.37
16 Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice. Mol Cell Biol 2006 1.26
17 Differential binding of erythroid Krupple-like factor to embryonic/fetal globin gene promoters during development. J Biol Chem 2006 1.26
18 Basic residues within the Kruppel zinc finger DNA binding domains are the critical nuclear localization determinants of EKLF/KLF-1. J Biol Chem 2002 1.17
19 Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis. Blood 2012 1.15
20 Posttranscriptional control of type I interferon genes by KSRP in the innate immune response against viral infection. Mol Cell Biol 2011 1.13
21 Excellent in vivo bystander activity of fludarabine phosphate against human glioma xenografts that express the escherichia coli purine nucleoside phosphorylase gene. Cancer Res 2004 1.03
22 A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobin. J Biol Chem 2004 1.02
23 Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts. Nucleic Acids Res 2004 1.01
24 USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. Genes Dev 2013 1.01
25 Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses. J Immunol 2010 1.00
26 SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency. Proc Natl Acad Sci U S A 2012 0.99
27 Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system. Chem Biol 2003 0.88
28 FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin. J Clin Invest 2012 0.88
29 Correction of phenotype in a thalassemia mouse model using a nonmyeloablative marrow transplantation regimen. Biol Blood Marrow Transplant 2002 0.81
30 Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species. Br J Pharmacol 2016 0.79