PubRank

Malcolm E Molyneux

Author PubWeight™ 218.23‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Differentiating the pathologies of cerebral malaria by postmortem parasite counts. Nat Med 2004 7.42
2 Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. J Infect Dis 2002 5.75
3 Severe anemia in Malawian children. N Engl J Med 2008 5.20
4 Malarial retinopathy: a newly established diagnostic sign in severe malaria. Am J Trop Med Hyg 2006 5.14
5 Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet 2009 4.30
6 Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype. Genome Res 2009 3.99
7 Epidemics of invasive Salmonella enterica serovar enteritidis and S. enterica Serovar typhimurium infection associated with multidrug resistance among adults and children in Malawi. Clin Infect Dis 2008 3.89
8 Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study. Lancet 2005 3.48
9 Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study. Lancet Neurol 2010 3.47
10 Bacteremia in Malawian children with severe malaria: prevalence, etiology, HIV coinfection, and outcome. J Infect Dis 2007 3.19
11 Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults. Science 2010 2.91
12 Non-typhoidal salmonella bacteraemia among HIV-infected Malawian adults: high mortality and frequent recrudescence. AIDS 2002 2.83
13 Placental monocyte infiltrates in response to Plasmodium falciparum malaria infection and their association with adverse pregnancy outcomes. Am J Trop Med Hyg 2003 2.76
14 Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria. J Infect Dis 2003 2.70
15 Perfusion abnormalities in children with cerebral malaria and malarial retinopathy. J Infect Dis 2009 2.69
16 Prognostic significance and course of retinopathy in children with severe malaria. Arch Ophthalmol 2004 2.60
17 A community-based study of the incidence of trimethoprim-sulfamethoxazole-preventable infections in Malawian adults living with HIV. J Acquir Immune Defic Syndr 2005 2.47
18 Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. Blood 2013 2.35
19 Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Malawi after 10 years as first line treatment: five year prospective study. BMJ 2004 2.35
20 The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children. J Clin Invest 2008 2.35
21 Maternal syphilis infection is associated with increased risk of mother-to-child transmission of HIV in Malawi. AIDS 2006 2.34
22 Glycerol adjuvant therapy in adults with bacterial meningitis in a high HIV seroprevalence setting in Malawi: a double-blind, randomised controlled trial. Lancet Infect Dis 2011 2.32
23 A trial of a 7-valent pneumococcal conjugate vaccine in HIV-infected adults. N Engl J Med 2010 2.30
24 Rabies encephalitis in malaria-endemic area, Malawi, Africa. Emerg Infect Dis 2007 2.21
25 Antenatal receipt of sulfadoxine-pyrimethamine does not exacerbate pregnancy-associated malaria despite the expansion of drug-resistant Plasmodium falciparum: clinical outcomes from the QuEERPAM study. Clin Infect Dis 2012 2.19
26 Plasma concentrations of parasite histidine-rich protein 2 distinguish between retinopathy-positive and retinopathy-negative cerebral malaria in Malawian children. J Infect Dis 2012 2.16
27 High pneumococcal DNA loads are associated with mortality in Malawian children with invasive pneumococcal disease. Pediatr Infect Dis J 2007 2.10
28 The effect of Plasmodium falciparum malaria on peripheral and placental HIV-1 RNA concentrations in pregnant Malawian women. AIDS 2004 2.01
29 Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria: a retrospective case-control study*. Crit Care Med 2012 1.97
30 Effects of HIV-1 serostatus, HIV-1 RNA concentration, and CD4 cell count on the incidence of malaria infection in a cohort of adults in rural Malawi. J Infect Dis 2005 1.88
31 The distribution and intensity of parasite sequestration in comatose Malawian children. J Infect Dis 2006 1.85
32 Pneumococcal disease in HIV-infected Malawian adults: acute mortality and long-term survival. AIDS 2002 1.79
33 Decreasing burden of malaria in pregnancy in Malawian women and its relationship to use of intermittent preventive therapy or bed nets. PLoS One 2010 1.73
34 Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria. Hum Mol Genet 2007 1.72
35 Retinal pathology of pediatric cerebral malaria in Malawi. PLoS One 2009 1.71
36 Impairment of humoral immunity to Plasmodium falciparum malaria in pregnancy by HIV infection. Lancet 2004 1.71
37 Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi. Antimicrob Agents Chemother 2005 1.69
38 Importance of antibody and complement for oxidative burst and killing of invasive nontyphoidal Salmonella by blood cells in Africans. Proc Natl Acad Sci U S A 2010 1.68
39 Placental tumor necrosis factor alpha but not gamma interferon is associated with placental malaria and low birth weight in Malawian women. Infect Immun 2003 1.68
40 Using malarial retinopathy to improve the classification of children with cerebral malaria. Trans R Soc Trop Med Hyg 2008 1.67
41 A prospective study of bloodstream infections as cause of fever in Malawi: clinical predictors and implications for management. Trop Med Int Health 2004 1.67
42 Invasive non-typhoid salmonellae establish systemic intracellular infection in HIV-infected adults: an emerging disease pathogenesis. Clin Infect Dis 2010 1.63
43 Antibodies to variant surface antigens of Plasmodium falciparum-infected erythrocytes and adhesion inhibitory antibodies are associated with placental malaria and have overlapping and distinct targets. J Infect Dis 2004 1.63
44 The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children. Crit Care 2010 1.62
45 Circulating endothelial microparticles in malawian children with severe falciparum malaria complicated with coma. JAMA 2004 1.60
46 Complement activation and the resulting placental vascular insufficiency drives fetal growth restriction associated with placental malaria. Cell Host Microbe 2013 1.57
47 Identification of malaria retinopathy improves the specificity of the clinical diagnosis of cerebral malaria: findings from a prospective cohort study. Am J Trop Med Hyg 2010 1.56
48 Host response to malaria during pregnancy: placental monocyte recruitment is associated with elevated beta chemokine expression. J Immunol 2003 1.55
49 Differential antibody responses to Plasmodium falciparum merozoite proteins in Malawian children with severe malaria. J Infect Dis 2008 1.51
50 Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes. Hum Mol Genet 2009 1.50
51 Neuroimaging findings in children with retinopathy-confirmed cerebral malaria. Eur J Radiol 2009 1.47
52 Endothelium-based biomarkers are associated with cerebral malaria in Malawian children: a retrospective case-control study. PLoS One 2010 1.43
53 Supraorbital postmortem brain sampling for definitive quantitative confirmation of cerebral sequestration of Plasmodium falciparum parasites. J Infect Dis 2012 1.42
54 Redefining cerebral malaria by including malaria retinopathy. Future Microbiol 2011 1.40
55 Brain swelling and death in children with cerebral malaria. N Engl J Med 2015 1.37
56 Mycobacterium tuberculosis resides in nonacidified vacuoles in endocytically competent alveolar macrophages from patients with tuberculosis and HIV infection. J Immunol 2004 1.36
57 Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. Malar J 2009 1.35
58 Association between the pharmacokinetics and in vivo therapeutic efficacy of sulfadoxine-pyrimethamine in Malawian children. Antimicrob Agents Chemother 2005 1.35
59 Transcribed var genes associated with placental malaria in Malawian women. Infect Immun 2006 1.32
60 The impact of routine infant immunization with Haemophilus influenzae type b conjugate vaccine in Malawi, a country with high human immunodeficiency virus prevalence. Vaccine 2006 1.30
61 Plasmodium falciparum: PCR detection and genotyping of isolates from peripheral, placental, and cord blood of pregnant Malawian women and their infants. Trans R Soc Trop Med Hyg 2002 1.28
62 Tissue distribution of migration inhibitory factor and inducible nitric oxide synthase in falciparum malaria and sepsis in African children. Malar J 2003 1.28
63 Long term outcome of severe anaemia in Malawian children. PLoS One 2008 1.28
64 Epidemiology of rotavirus infection in children in Blantyre, Malawi, 1997-2007. J Infect Dis 2010 1.27
65 The diagnostic and prognostic accuracy of five markers of serious bacterial infection in Malawian children with signs of severe infection. PLoS One 2009 1.24
66 Detection and characterization of human caliciviruses in hospitalized children with acute gastroenteritis in Blantyre, Malawi. J Med Virol 2005 1.23
67 Differential var gene expression in the organs of patients dying of falciparum malaria. Mol Microbiol 2007 1.22
68 CD16+ monocyte subset preferentially harbors HIV-1 and is expanded in pregnant Malawian women with Plasmodium falciparum malaria and HIV-1 infection. J Infect Dis 2007 1.22
69 Placental malaria induces variant-specific antibodies of the cytophilic subtypes immunoglobulin G1 (IgG1) and IgG3 that correlate with adhesion inhibitory activity. Infect Immun 2005 1.21
70 Surveillance Programme of IN-patients and Epidemiology (SPINE): implementation of an electronic data collection tool within a large hospital in Malawi. PLoS Med 2013 1.19
71 Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations. J Infect Dis 2009 1.17
72 Relationship between human immunodeficiency virus type 1 coinfection, anemia, and levels and function of antibodies to variant surface antigens in pregnancy-associated malaria. Clin Vaccine Immunol 2009 1.14
73 Using an improved phagocytosis assay to evaluate the effect of HIV on specific antibodies to pregnancy-associated malaria. PLoS One 2010 1.12
74 Poor potential coverage for 7-valent pneumococcal conjugate vaccine, Malawi. Emerg Infect Dis 2003 1.10
75 Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi. PLoS One 2008 1.09
76 Entomological indices of malaria transmission in Chikhwawa district, Southern Malawi. Malar J 2012 1.09
77 Lymphocyte subsets in healthy Malawians: implications for immunologic assessment of HIV infection in Africa. J Allergy Clin Immunol 2009 1.09
78 Genetic analysis of circulating and sequestered populations of Plasmodium falciparum in fatal pediatric malaria. J Infect Dis 2006 1.08
79 Maternal-fetal microtransfusions and HIV-1 mother-to-child transmission in Malawi. PLoS Med 2005 1.08
80 Finger-prick blood samples can be used interchangeably with venous samples for CD4 cell counting indicating their potential for use in CD4 rapid tests. AIDS 2007 1.08
81 Socio-demographic characteristics associated with HIV and syphilis seroreactivity among pregnant women in Blantyre, Malawi, 2000-2004. Malawi Med J 2008 1.07
82 Effect of transmission setting and mixed species infections on clinical measures of malaria in Malawi. PLoS One 2008 1.06
83 Liver pathology in Malawian children with fatal encephalopathy. Hum Pathol 2011 1.06
84 PCR improves diagnostic yield from lung aspiration in Malawian children with radiologically confirmed pneumonia. PLoS One 2011 1.05
85 Induction of HO-1 in tissue macrophages and monocytes in fatal falciparum malaria and sepsis. Malar J 2003 1.05
86 Does this patient have malaria? JAMA 2010 1.04
87 Diagnostic accuracy and clinical utility of a simplified low cost method of counting CD4 cells with flow cytometry in Malawi: diagnostic accuracy study. BMJ 2007 1.03
88 Malaria during pregnancy and foetal haematological status in Blantyre, Malawi. Malar J 2005 1.03
89 Clinical manifestations of new versus recrudescent malaria infections following anti-malarial drug treatment. Malar J 2012 1.03
90 Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults. J Infect Dis 2003 1.02
91 Bacterial meningitis in Malawian adults, adolescents, and children during the era of antiretroviral scale-up and Haemophilus influenzae type b vaccination, 2000-2012. Clin Infect Dis 2014 1.02
92 Pathophysiological mechanisms of severe anaemia in Malawian children. PLoS One 2010 1.02
93 Primary macrophages from HIV-infected adults show dysregulated cytokine responses to Salmonella, but normal internalization and killing. AIDS 2007 1.01
94 Parasites bearing a single copy of the multi-drug resistance gene (pfmdr-1) with wild-type SNPs predominate amongst Plasmodium falciparum isolates from Malawi. Acta Trop 2009 1.00
95 Detection and characterisation of human astroviruses in children with acute gastroenteritis in Blantyre, Malawi. J Med Virol 2002 0.99
96 Impact of human immunodeficiency virus infection on the etiology and outcome of severe pneumonia in Malawian children. Pediatr Infect Dis J 2011 0.99
97 The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1. J Immunol 2011 0.99
98 Domestic smoke exposure is associated with alveolar macrophage particulate load. Trop Med Int Health 2009 0.99
99 Sampling of supraorbital brain tissue after death: improving on the clinical diagnosis of cerebral malaria. J Infect Dis 2005 0.99
100 Lung fluid immunoglobulin from HIV-infected subjects has impaired opsonic function against pneumococci. Clin Infect Dis 2007 0.98
101 Detection of raised intracranial pressure by ultrasound measurement of optic nerve sheath diameter in African children. Trop Med Int Health 2008 0.96
102 Immune activation and induction of HIV-1 replication within CD14 macrophages during acute Plasmodium falciparum malaria coinfection. AIDS 2002 0.96
103 Placental hypoxia during placental malaria. J Infect Dis 2008 0.96
104 Blood culture collection technique and pneumococcal surveillance in Malawi during the four year period 2003-2006: an observational study. BMC Infect Dis 2008 0.95
105 A histological method for quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria. Malar J 2013 0.95
106 Chemokine responses are increased in HIV-infected Malawian children with invasive pneumococcal disease. J Acquir Immune Defic Syndr 2007 0.94
107 Comparative population structure of Plasmodium malariae and Plasmodium falciparum under different transmission settings in Malawi. Malar J 2011 0.94
108 Malaria and vitamin A deficiency in African children: a vicious circle? Malar J 2009 0.94
109 Antibodies that induce phagocytosis of malaria infected erythrocytes: effect of HIV infection and correlation with clinical outcomes. PLoS One 2011 0.93
110 Pneumococcal conjugate vaccine is immunogenic in lung fluid of HIV-infected and immunocompetent adults. J Allergy Clin Immunol 2007 0.92
111 Performance characteristics of combinations of host biomarkers to identify women with occult placental malaria: a case-control study from Malawi. PLoS One 2011 0.91
112 Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children. J Infect Dis 2013 0.91
113 Are Plasmodium falciparum parasites present in peripheral blood genetically the same as those sequestered in the tissues? Am J Trop Med Hyg 2006 0.90
114 Risk factors and mechanisms of preterm delivery in Malawi. Am J Reprod Immunol 2004 0.89
115 Elevated plasma von Willebrand factor and propeptide levels in Malawian children with malaria. PLoS One 2011 0.89
116 Human cerebral malaria and Plasmodium falciparum genotypes in Malawi. Malar J 2012 0.88
117 Inhaled delivery of 23-valent pneumococcal polysaccharide vaccine does not result in enhanced pulmonary mucosal immunoglobulin responses. Vaccine 2008 0.87
118 Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia. AIDS 2010 0.87
119 Association of the GNAS locus with severe malaria. Hum Genet 2008 0.87
120 Genotypic homogeneity of multidrug resistant S. Typhimurium infecting distinct adult and childhood susceptibility groups in Blantyre, Malawi. PLoS One 2012 0.86
121 Association between sputum smear status and local immune responses at the site of disease in HIV-infected patients with pulmonary tuberculosis. Tuberculosis (Edinb) 2007 0.86
122 TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression. Malar J 2009 0.86
123 Impact of human immunodeficiency virus infection in pregnant women on variant-specific immunity to malaria. Clin Vaccine Immunol 2008 0.86
124 The effect of quinine on the electroretinograms of children with pediatric cerebral malaria. J Infect Dis 2003 0.85
125 Reduced interleukin-8 response to Streptococcus pneumoniae by alveolar macrophages from adults with HIV/AIDS. AIDS 2005 0.85
126 Etiology of suspected pneumonia in adults admitted to a high-dependency unit in Blantyre, Malawi. Am J Trop Med Hyg 2011 0.85
127 HIV-1 infection is associated with altered innate pulmonary immunity. J Infect Dis 2005 0.84
128 Circulating soluble endoglin levels in pregnant women in Cameroon and Malawi--associations with placental malaria and fetal growth restriction. PLoS One 2011 0.84
129 Malarial retinopathy and fluorescein angiography findings in a Malawian child with cerebral malaria. Lancet Infect Dis 2010 0.82
130 The effects of malaria and intermittent preventive treatment during pregnancy on fetal anemia in Malawi. Clin Infect Dis 2012 0.82
131 Treatment of childhood Plasmodium falciparum malaria: current challenges. Expert Rev Anti Infect Ther 2007 0.82
132 Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis. PLoS One 2010 0.81
133 Schistosomiasis does not contribute to death or recurrence of nontyphoid Salmonella bacteremia in human immunodeficiency virus-infected Malawian adults. Clin Infect Dis 2003 0.80
134 Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three African populations. PLoS One 2009 0.80
135 Prevalence of raised intracranial pressure in cerebral malaria detected by optic nerve sheath ultrasound. Am J Trop Med Hyg 2012 0.80
136 Alveolar macrophages from HIV-infected patients with pulmonary tuberculosis retain the capacity to respond to stimulation by lipopolysaccharide. Microbes Infect 2007 0.80
137 Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children. BMC Med Genomics 2012 0.79
138 The alveolar microenvironment of patients infected with human immunodeficiency virus does not modify alveolar macrophage interactions with Streptococcus pneumoniae. Clin Vaccine Immunol 2013 0.78
139 Soluble CD163, a product of monocyte/macrophage activation, is inversely associated with haemoglobin levels in placental malaria. PLoS One 2013 0.78
140 Affordable pediatric CD4 counting by flow cytometry in Malawi. Cytometry B Clin Cytom 2008 0.78
141 Expression of merozoite surface protein markers by Plasmodium falciparum-infected erythrocytes in peripheral blood and tissues of children with fatal malaria. Infect Immun 2006 0.78
142 The pathogenesis of pediatric cerebral malaria: eye exams, autopsies, and neuroimaging. Ann N Y Acad Sci 2015 0.77
143 HIV infected adults do not have an excess of colonising bacteria in their large airways. BMC Infect Dis 2003 0.75
144 Evoked potentials in pediatric cerebral malaria. Neurol Int 2011 0.75
145 Detection of enteric adenoviruses in children with acute gastro-enteritis in Blantyre, Malawi. Ann Trop Paediatr 2002 0.75
146 What can we learn from the retina in severe malaria? Adv Exp Med Biol 2010 0.75