Apoptosis induced by dioscin in Hela cells.

PubWeight™: 0.96‹?› | Rank: Top 15%

🔗 View Article (PMID 11853164)

Published in Biol Pharm Bull on February 01, 2002

Authors

Jing Cai1, Mingjie Liu, Zhao Wang, Yong Ju

Author Affiliations

1: Department of Biological Science and Biotechnology, Tsinghua University, Beijing, China.

Articles citing this

Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines. Arch Toxicol (2013) 1.08

Glabridin mediate caspases activation and induces apoptosis through JNK1/2 and p38 MAPK pathway in human promyelocytic leukemia cells. PLoS One (2014) 0.83

Anticancer and apoptotic effects on cell proliferation of diosgenin isolated from Costus speciosus (Koen.) Sm. BMC Complement Altern Med (2015) 0.83

Ligand fishing with functionalized magnetic nanoparticles coupled with mass spectrometry for herbal medicine analysis: ligand fishing for herbal medicine analysis. Anal Bioanal Chem (2010) 0.80

Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines. J Biomed Sci (2014) 0.79

Proteomic Analysis of Anticancer TCMs Targeted at Mitochondria. Evid Based Complement Alternat Med (2015) 0.79

Autophagy inhibition enhances apoptosis induced by dioscin in huh7 cells. Evid Based Complement Alternat Med (2012) 0.78

Triterpenoids from Glycine max decrease invasiveness and induce caspase-mediated cell death in human SNB19 glioma cells. Clin Exp Metastasis (2003) 0.76

In-silico prediction of drug targets, biological activities, signal pathways and regulating networks of dioscin based on bioinformatics. BMC Complement Altern Med (2015) 0.76

Dioscin inhibits gastric tumor growth through regulating the expression level of lncRNA HOTAIR. BMC Complement Altern Med (2016) 0.75

N-Alkyl derivatives of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside; synthesis and antimicrobial activity. Beilstein J Org Chem (2015) 0.75

Lipid from infective L. donovani regulates acute myeloid cell growth via mitochondria dependent MAPK pathway. PLoS One (2015) 0.75

Articles by these authors

The Arabidopsis CORONATINE INSENSITIVE1 protein is a jasmonate receptor. Plant Cell (2009) 3.31

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res (2008) 2.97

A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. Am J Pathol (2003) 2.28

A novel superhydrophilic and underwater superoleophobic hydrogel-coated mesh for oil/water separation. Adv Mater (2011) 1.67

Intravascular optical coherence tomography detection of atherosclerosis and inflammation in murine aorta. Arterioscler Thromb Vasc Biol (2012) 1.61

Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells. Biochem J (2012) 1.44

New fluorescent rhodamine hydrazone chemosensor for Cu(II) with high selectivity and sensitivity. Org Lett (2006) 1.34

Inhibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis. Biochem Biophys Res Commun (2006) 1.28

Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships. J Med Chem (2009) 1.27

The antiapoptotic role of pregnane X receptor in human colon cancer cells. Mol Endocrinol (2007) 1.26

Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis. J Biol Chem (2008) 1.25

Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents. J Med Chem (2010) 1.21

Mechanism and function of synaptotagmin-mediated membrane apposition. Nat Struct Mol Biol (2011) 1.19

Chlamydia trachomatis genes whose products are related to energy metabolism are expressed differentially in active vs. persistent infection. Microbes Infect (2002) 1.19

Volumetric quantification of fibrous caps using intravascular optical coherence tomography. Biomed Opt Express (2012) 1.15

SIRT1 acts as a modulator of neointima formation following vascular injury in mice. Circ Res (2011) 1.11

Antioxidant activities of oleanolic acid in vitro: possible role of Nrf2 and MAP kinases. Chem Biol Interact (2010) 1.09

Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents. J Med Chem (2011) 1.09

An absence of CCR5 on donor cells results in acceleration of acute graft-vs-host disease. Exp Hematol (2004) 1.08

Metabolites of cerebellar neurons and hippocampal neurons play opposite roles in pathogenesis of Alzheimer's disease. PLoS One (2009) 1.07

Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity. Drug Metab Dispos (2010) 1.07

Real-time polymerase chain reaction microRNA detection based on enzymatic stem-loop probes ligation. Anal Chem (2009) 1.06

Hollow urchin-like ZnO thin films by electrochemical deposition. Adv Mater (2010) 1.05

Medroxyprogesterone acetate, but not progesterone, protects against inflammation-induced parturition and intrauterine fetal demise. Am J Obstet Gynecol (2004) 1.04

Benzyl (E)-3-(4-meth-oxy-benzyl-idene)dithio-carbazate. Acta Crystallogr Sect E Struct Rep Online (2011) 1.04

An examination of the electrostatic interactions between the N-terminal tail of the Brome Mosaic Virus coat protein and encapsidated RNAs. J Mol Biol (2012) 1.04

Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo. J Neurosci (2011) 1.04

Identification and characterization of a biomineralization related gene PFMG1 highly expressed in the mantle of Pinctada fucata. Biochemistry (2007) 1.02

Pharmacokinetics, pharmacodynamics, and safety of tolvaptan, a nonpeptide AVP antagonist, during ascending single-dose studies in healthy subjects. J Clin Pharmacol (2007) 1.02

Cytokine and chemokine mRNA produced in synovial tissue chronically infected with Chlamydia trachomatis and C. pneumoniae. J Rheumatol (2002) 1.02

Benzyl (E)-3-(2-methyl-benzyl-idene)dithio-carbazate. Acta Crystallogr Sect E Struct Rep Online (2011) 1.02

(-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis. World J Gastroenterol (2007) 1.01

Synthesis, in vitro structure-activity relationship, and in vivo studies of 2-arylthiazolidine-4-carboxylic acid amides as anticancer agents. Bioorg Med Chem (2009) 1.01

Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis. Cancer Chemother Pharmacol (2004) 1.01

[Review in the studies on tannins activity of cancer prevention and anticancer]. Zhong Yao Cai (2003) 1.00

Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission. J Neurosci (2012) 0.99

Correction of rotational distortion for catheter-based en face OCT and OCT angiography. Opt Lett (2014) 0.99

Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization. Bioorg Med Chem (2011) 0.99

Bio-inspired hierarchical macromolecule-nanoclay hydrogels for robust underwater superoleophobicity. Adv Mater (2010) 0.99

MicroRNA-144 is regulated by activator protein-1 (AP-1) and decreases expression of Alzheimer disease-related a disintegrin and metalloprotease 10 (ADAM10). J Biol Chem (2013) 0.99

Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells. Mol Biol Cell (2011) 0.98

Pathogenicity and immunogenicity of recombinant Tiantan Vaccinia Virus with deleted C12L and A53R genes. Vaccine (2008) 0.98

Motion artifacts associated with in vivo endoscopic OCT images of the esophagus. Opt Express (2011) 0.98

Structure-activity relationship studies of arylthiazolidine amides as selective cytotoxic agents for melanoma. Anticancer Res (2007) 0.97

PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons. Biochem Biophys Res Commun (2009) 0.97

Synthesis and antiproliferative activity of thiazolidine analogs for melanoma. Bioorg Med Chem Lett (2007) 0.96

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis. Carcinogenesis (2013) 0.95

Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. Elife (2014) 0.95

Mitochondrial dysfunction as an early event in the process of apoptosis induced by woodfordin I in human leukemia K562 cells. Toxicol Appl Pharmacol (2004) 0.95

Quantitative analysis of zeptomole microRNAs based on isothermal ramification amplification. RNA (2009) 0.95

A novel approach for lie detection based on F-score and extreme learning machine. PLoS One (2013) 0.95

Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions. J Mol Biol (2004) 0.95

Noninvasive intraocular pressure measurements in mice by pneumotonometry. Invest Ophthalmol Vis Sci (2005) 0.95

Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma. Bioorg Med Chem Lett (2008) 0.95

miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression. J Bone Miner Res (2012) 0.94

Biological activity of 4-substituted methoxybenzoyl-aryl-thiazole: an active microtubule inhibitor. Cancer Res (2010) 0.94

Dissection of influenza A virus M1 protein: pH-dependent oligomerization of N-terminal domain and dimerization of C-terminal domain. PLoS One (2012) 0.94

Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. Antimicrob Agents Chemother (2008) 0.94

Association of tyrosine PRL-3 phosphatase protein expression with peritoneal metastasis of gastric carcinoma and prognosis. Surg Today (2007) 0.93

Preferential eradication of acute myelogenous leukemia stem cells by fenretinide. Proc Natl Acad Sci U S A (2013) 0.92

TAT-modified nanosilver for combating multidrug-resistant cancer. Biomaterials (2012) 0.92

Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects. Mol Cell Endocrinol (2013) 0.92

Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria. Cancer Lett (2005) 0.92

The biological effects and mechanisms of calcitonin gene-related peptide on human endothelial cell. J Recept Signal Transduct Res (2013) 0.92

Lymphatic endothelial cell-secreted CXCL1 stimulates lymphangiogenesis and metastasis of gastric cancer. Int J Cancer (2011) 0.92

Population pharmacokinetics of eltrombopag in healthy subjects and patients with chronic idiopathic thrombocytopenic purpura. J Clin Pharmacol (2010) 0.91

Cloning and characterization of a novel human alcohol dehydrogenase gene (ADHFe1). DNA Seq (2002) 0.91

Biomolecule-assisted synthesis of water-soluble silver nanoparticles and their biomedical applications. Inorg Chem (2008) 0.91

Disruption of the intracellular Ca2+ homeostasis in the cardiac excitation-contraction coupling is a crucial mechanism of arrhythmic toxicity in aconitine-induced cardiomyocytes. Biochem Biophys Res Commun (2007) 0.91

Fiber-optic catheter-based polarization-sensitive OCT for radio-frequency ablation monitoring. Opt Lett (2014) 0.90

Patterns of neoplastic foci and lymph node micrometastasis within the mesorectum. Langenbecks Arch Surg (2005) 0.90

Matrix protein biglycan induces osteoblast differentiation through extracellular signal-regulated kinase and Smad pathways. Biol Pharm Bull (2010) 0.90

The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism. Nat Commun (2013) 0.90

Tolvaptan administration does not affect steady state amiodarone concentrations in patients with cardiac arrhythmias. J Cardiovasc Pharmacol Ther (2005) 0.90

Plaque and thrombus evaluation by optical coherence tomography. Int J Cardiovasc Imaging (2011) 0.89

Double antioxidant activities of rosiglitazone against high glucose-induced oxidative stress in hepatocyte. Toxicol In Vitro (2011) 0.89

Automatic stent detection in intravascular OCT images using bagged decision trees. Biomed Opt Express (2012) 0.89

Spata4 promotes osteoblast differentiation through Erk-activated Runx2 pathway. J Bone Miner Res (2011) 0.88

Human infection with Eurasian avian-like influenza A(H1N1) virus, China. Emerg Infect Dis (2013) 0.88

Pathological study of distal mesorectal cancer spread to determine a proper distal resection margin. World J Gastroenterol (2005) 0.88

Kinetic effects in the photomediated synthesis of silver nanodecahedra and nanoprisms: combined effect of wavelength and temperature. Nanoscale (2014) 0.88

High selenium impairs hepatic insulin sensitivity through opposite regulation of ROS. Toxicol Lett (2013) 0.87

Role of silencing phosphatase of regenerationg liver-3 expression by microRNA interference in the growth of gastric cancer. Chin Med J (Engl) (2008) 0.86

Mechanically induced metal-insulator transition in carbyne. Nano Lett (2014) 0.86

Optical Coherence Tomography and Fibrous Cap Characterization. Curr Cardiovasc Imaging Rep (2011) 0.86

Organogel-based thin films for self-cleaning on various surfaces. Adv Mater (2013) 0.86

Depression of intraocular pressure following inactivation of connexin43 in the nonpigmented epithelium of the ciliary body. Invest Ophthalmol Vis Sci (2009) 0.85

SKLB610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo. Cell Physiol Biochem (2011) 0.85

Porcine reproductive and respiratory syndrome in hybrid wild boars, china. Emerg Infect Dis (2011) 0.85

Antagonist of peroxisome proliferator-activated receptor gamma induces cerebellar amyloid-beta levels and motor dysfunction in APP/PS1 transgenic mice. Biochem Biophys Res Commun (2009) 0.85

Loss expression of PHLPP1 correlates with lymph node metastasis and exhibits a poor prognosis in patients with gastric cancer. J Surg Oncol (2013) 0.85

Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix. Retrovirology (2012) 0.85

Analysis of three effective components in Fructus corni and its preparations by micellar electrokinetic capillary chromatography. Biomed Chromatogr (2003) 0.85

[Studies on the pharmacological effects of saffron(Crocus sativus L.)--a review]. Zhongguo Zhong Yao Za Zhi (2002) 0.85

Antiplatelet and thermally responsive poly(N-isopropylacrylamide) surface with nanoscale topography. J Am Chem Soc (2009) 0.85

An upstream promoter element blocks the reverse transcription of the mouse insulin-degrading enzyme gene. Biochem Biophys Res Commun (2012) 0.84

Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose). Biochim Biophys Acta (2002) 0.84

Gastric emptying of water in term pregnancy. Anesthesiology (2002) 0.84

Overexpression of QM induces cell differentiation and mineralization in MC3T3-E1. Biol Pharm Bull (2005) 0.84