Published in Mol Genet Metab on February 01, 2002
OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci U S A (2004) 5.34
Quality control of mitochondria: protection against neurodegeneration and ageing. EMBO J (2008) 3.39
Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. Mol Biol Cell (2009) 2.49
Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell (2003) 2.49
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Mitochondrial fusion and division: Regulation and role in cell viability. Semin Cell Dev Biol (2009) 1.51
The C. elegans Opa1 homologue EAT-3 is essential for resistance to free radicals. PLoS Genet (2008) 1.40
OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation. Hum Mol Genet (2010) 1.30
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Optic disc morphology of patients with OPA1 autosomal dominant optic atrophy. Br J Ophthalmol (2003) 1.17
Human Myo19 is a novel myosin that associates with mitochondria. Curr Biol (2009) 1.14
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Dominant optic atrophy. Orphanet J Rare Dis (2012) 1.11
OPA1 expression in the normal rat retina and optic nerve. J Comp Neurol (2005) 1.06
Alu-element insertion in an OPA1 intron sequence associated with autosomal dominant optic atrophy. Mol Vis (2010) 0.94
Cytoplasmic irradiation results in mitochondrial dysfunction and DRP1-dependent mitochondrial fission. Cancer Res (2013) 0.92
Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder. Nat Genet (2015) 0.89
High-resolution en face images of microcystic macular edema in patients with autosomal dominant optic atrophy. Biomed Res Int (2013) 0.86
The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity. ACS Med Chem Lett (2012) 0.83
Historical perspective on mitochondrial medicine. Dev Disabil Res Rev (2010) 0.83
Mitochondrial mutations: newly discovered players in neuronal degeneration. Neuroscientist (2011) 0.82
A multiple sclerosis-like disorder in patients with OPA1 mutations. Ann Clin Transl Neurol (2016) 0.75
Characterization of two novel intronic OPA1 mutations resulting in aberrant pre-mRNA splicing. BMC Med Genet (2017) 0.75
A novel mutation in a case of dominant optic atrophy? Indian J Ophthalmol (2014) 0.75
Assessment of the retinal posterior pole in dominant optic atrophy by spectral-domain optical coherence tomography and microperimetry. PLoS One (2017) 0.75
A novel mutation of the OPA1 gene in a Japanese patient with autosomal dominant optic atrophy. Graefes Arch Clin Exp Ophthalmol (2007) 0.75
A novel mutation producing premature termination codon at the OPA1 gene causes autosomal dominant optic atrophy. J Neurol (2005) 0.75
Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem (2002) 5.61
OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes. Brain (2007) 3.35
The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett (2002) 2.30
Separate fusion of outer and inner mitochondrial membranes. EMBO Rep (2005) 1.93
TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet (2009) 1.93
Molecular screening of 980 cases of suspected hereditary optic neuropathy with a report on 77 novel OPA1 mutations. Hum Mutat (2009) 1.67
OPA1 cleavage depends on decreased mitochondrial ATP level and bivalent metals. Exp Cell Res (2007) 1.55
Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies. J Clin Invest (2016) 1.41
OPA1-associated disorders: phenotypes and pathophysiology. Int J Biochem Cell Biol (2009) 1.40
Lack of fundus autofluorescence to 488 nanometers from childhood on in patients with early-onset severe retinal dystrophy associated with mutations in RPE65. Ophthalmology (2004) 1.39
[Mitochondrial morphology and dynamics: actors, mechanisms and functions]. Med Sci (Paris) (2010) 1.39
The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms. EMBO Rep (2010) 1.36
Mitochondrial dynamics and disease, OPA1. Biochim Biophys Acta (2006) 1.35
Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy. Am J Hum Genet (2007) 1.33
Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential. Biol Cell (2008) 1.33
Bardet-Biedl syndrome: a study of the renal and cardiovascular phenotypes in a French cohort. Clin J Am Soc Nephrol (2010) 1.32
Effects of OPA1 mutations on mitochondrial morphology and apoptosis: relevance to ADOA pathogenesis. J Cell Physiol (2007) 1.30
Whole-exome sequencing identifies mutations in GPR179 leading to autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet (2012) 1.25
OPA1 functions in mitochondria and dysfunctions in optic nerve. Int J Biochem Cell Biol (2009) 1.19
Whole-exome sequencing identifies LRIT3 mutations as a cause of autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet (2012) 1.18
OPA1 R445H mutation in optic atrophy associated with sensorineural deafness. Ann Neurol (2005) 1.18
OPA1 links human mitochondrial genome maintenance to mtDNA replication and distribution. Genome Res (2010) 1.17
Genotyping microarray for CSNB-associated genes. Invest Ophthalmol Vis Sci (2009) 1.10
Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling. J Cell Biol (2014) 1.09
Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin. Mol Cell Biol (2005) 1.09
Expression of the Opa1 mitochondrial protein in retinal ganglion cells: its downregulation causes aggregation of the mitochondrial network. Invest Ophthalmol Vis Sci (2005) 1.06
BBS1 mutations in a wide spectrum of phenotypes ranging from nonsyndromic retinitis pigmentosa to Bardet-Biedl syndrome. Arch Ophthalmol (2012) 1.06
Spectrum of rhodopsin mutations in French autosomal dominant rod-cone dystrophy patients. Invest Ophthalmol Vis Sci (2010) 1.05
The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse. Brain (2012) 1.03
Exploring the pharmacological properties of insect nicotinic acetylcholine receptors. Trends Pharmacol Sci (2006) 0.99
Studying mitochondria in an attractive model: Schizosaccharomyces pombe. Methods Mol Biol (2007) 0.99
Mutations in IMPG1 cause vitelliform macular dystrophies. Am J Hum Genet (2013) 0.96
Importance of mitochondrial dynamin-related protein 1 in hypothalamic glucose sensitivity in rats. Antioxid Redox Signal (2012) 0.95
OPA1 (dys)functions. Semin Cell Dev Biol (2010) 0.94
A novel CACNA1F mutation in a french family with the incomplete type of X-linked congenital stationary night blindness. Am J Ophthalmol (2003) 0.93
Reversible optic neuropathy with OPA1 exon 5b mutation. Ann Neurol (2008) 0.93
OPA1 loss of function affects in vitro neuronal maturation. Brain (2013) 0.92
Homozygous deletion related to Alu repeats in RLBP1 causes retinitis punctata albescens. Invest Ophthalmol Vis Sci (2006) 0.92
High frequency of COH1 intragenic deletions and duplications detected by MLPA in patients with Cohen syndrome. Eur J Hum Genet (2010) 0.91
Phenotypic diversity and mutation spectrum in hypotrichosis with juvenile macular dystrophy. J Invest Dermatol (2003) 0.91
Characterization of Ca2+ signalling in postnatal mouse retinal ganglion cells: involvement of OPA1 in Ca2+ clearance. Ophthalmic Genet (2010) 0.90
Downregulation of otospiralin, a novel inner ear protein, causes hair cell degeneration and deafness. J Neurosci (2002) 0.90
Homozygous mutation in MERTK causes severe autosomal recessive retinitis pigmentosa. Eur J Ophthalmol (2012) 0.90
Screening genes of the retinoid metabolism: novel LRAT mutation in leber congenital amaurosis. Am J Ophthalmol (2006) 0.89
Molecular analysis of the TMPRSS3 gene in Moroccan families with non-syndromic hearing loss. Biochem Biophys Res Commun (2012) 0.88
Combining gene mapping and phenotype assessment for fast mutation finding in non-consanguineous autosomal recessive retinitis pigmentosa families. Eur J Hum Genet (2011) 0.87
Identification of preferentially expressed mRNAs in retina and cochlea. DNA Cell Biol (2002) 0.87
Relative frequencies of inherited retinal dystrophies and optic neuropathies in Southern France: assessment of 21-year data management. Ophthalmic Epidemiol (2013) 0.86
Novel KCNV2 mutations in cone dystrophy with supernormal rod electroretinogram. Am J Ophthalmol (2008) 0.85
Homozygosity mapping in autosomal recessive retinitis pigmentosa families detects novel mutations. Mol Vis (2013) 0.85
FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase. J Biol Chem (2010) 0.84
Systematic screening of BEST1 and PRPH2 in juvenile and adult vitelliform macular dystrophies: a rationale for molecular analysis. Ophthalmology (2011) 0.84
Sensorineural hearing loss in OPA1-linked disorders. Brain (2013) 0.84
Why mitochondria must fuse to maintain their genome integrity. Antioxid Redox Signal (2013) 0.83
Mutational analysis of the RB1 gene in Moroccan patients with retinoblastoma. Mol Vis (2011) 0.82
Processing of the dynamin Msp1p in S. pombe reveals an evolutionary switch between its orthologs Mgm1p in S. cerevisiae and OPA1 in mammals. FEBS Lett (2010) 0.82
Analysis of CLDN14 gene in deaf Moroccan patients with non-syndromic hearing loss. Gene (2013) 0.81
Dissecting the pathogenic mechanisms of mutations in the pore region of the human cone photoreceptor cyclic nucleotide-gated channel. Hum Mutat (2010) 0.81
Gene structure and chromosomal localization of mouse Opa1 : its exclusion from the Bst locus. BMC Genet (2003) 0.80
Simple and efficient: validation of a cotton wick electrode for animal electroretinography. Ophthalmic Res (2010) 0.80
RRH, encoding the RPE-expressed opsin-like peropsin, is not mutated in retinitis pigmentosa and allied diseases. Ophthalmic Genet (2007) 0.79
Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways. EMBO Rep (2011) 0.79
Msp1p is an intermembrane space dynamin-related protein that mediates mitochondrial fusion in a Dnm1p-dependent manner in S. pombe. FEBS Lett (2005) 0.79
REMOTE ISCHEMIC CONDITIONING INFLUENCES MITOCHONDRIAL DYNAMICS. Shock (2016) 0.78
Early-onset foveal involvement in retinitis punctata albescens with mutations in RLBP1. JAMA Ophthalmol (2013) 0.78
Screening for a canine model of choroideremia exclusively identifies nonpathogenic CHM variants. Ophthalmic Res (2010) 0.78
Transmembrane segments of the dynamin Msp1p uncouple its functions in the control of mitochondrial morphology and genome maintenance. J Cell Sci (2009) 0.78
How can we prevent myopia progression? Eur J Ophthalmol (2015) 0.78
Gene structure, chromosomal localization, and mutation screening of the human gene for the inner ear protein otospiralin. Neurogenetics (2003) 0.77
What similarity between human and fission yeast proteins is required for orthology? Yeast (2002) 0.77
A novel locus (CORD12) for autosomal dominant cone-rod dystrophy on chromosome 2q24.2-2q33.1. BMC Med Genet (2011) 0.77
Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies. J Clin Invest (2016) 0.77
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases]. Med Sci (Paris) (2013) 0.77
Cataract as a phenotypic marker for a mutation in WFS1, the Wolfram syndrome gene. Eur J Ophthalmol (2012) 0.76
Microcebus murinus retina: a new model to assess prion-related neurotoxicity in primates. Neurobiol Dis (2010) 0.76
Choroideremia: towards a therapy. Am J Ophthalmol (2013) 0.76
Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies. J Clin Invest (2017) 0.75
Clinical utility gene card for: blue cone monochromatism. Eur J Hum Genet (2011) 0.75
Concern Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies. J Clin Invest (2016) 0.75
Clinical utility gene card for: achromatopsia. Eur J Hum Genet (2011) 0.75
Fatp1 deficiency affects retinal light response and dark adaptation, and induces age-related alterations. PLoS One (2012) 0.75
Genetic and molecular analysis of the CLDN14 gene in Moroccan family with non-syndromic hearing loss. Indian J Hum Genet (2013) 0.75
[Genetic ocular diseases]. Rev Prat (2015) 0.75
Screening genes of the visual cycle RGR, RBP1 and RBP3 identifies rare sequence variations. Ophthalmic Genet (2010) 0.75
Corrigendum: Alterations of mitochondrial dynamics allow retrograde propagation of locally initiated axonal insults. Sci Rep (2016) 0.75