Published in J Cell Physiol on March 01, 2002
Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells. Am J Pathol (2003) 2.66
Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion. Proc Natl Acad Sci U S A (2003) 2.40
Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells. Oncol Rep (2012) 2.16
Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis. Proc Natl Acad Sci U S A (2002) 1.61
The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. Int J Cell Biol (2010) 1.51
Cyclooxygenases in hepatocellular carcinoma. World J Gastroenterol (2006) 1.31
Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study. Br J Cancer (2004) 1.31
Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. Proc Natl Acad Sci U S A (2003) 1.30
Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer. Mol Cancer (2003) 1.14
Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anticancer Agents Med Chem (2012) 1.14
PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3). Carcinogenesis (2009) 1.13
ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences. Mol Biol Cell (2003) 1.08
Cancer cell signaling pathways targeted by spice-derived nutraceuticals. Nutr Cancer (2011) 1.07
Marine n-3 and saturated fatty acids in relation to risk of colorectal cancer in Singapore Chinese: a prospective study. Int J Cancer (2009) 1.06
PharmGKB summary: very important pharmacogene information for PTGS2. Pharmacogenet Genomics (2011) 1.03
PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesis. FASEB J (2009) 1.02
Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: possible role in tumor promotion and angiogenesis. World J Gastroenterol (2005) 1.00
Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: a study from northern India. World J Gastroenterol (2008) 0.97
Mechanisms of resistance to photodynamic therapy. Curr Med Chem (2011) 0.96
Allellic variants in regulatory regions of cyclooxygenase-2: association with advanced colorectal adenoma. Br J Cancer (2005) 0.96
Mechanisms of oxysterol-induced carcinogenesis. Lipids Health Dis (2011) 0.96
Mechanistic aspects of COX-2 expression in colorectal neoplasia. Recent Results Cancer Res (2013) 0.95
Expression of 5-lipoxygenase in human colorectal cancer. World J Gastroenterol (2006) 0.95
Prostaglandin E2 stimulates Fas ligand expression via the EP1 receptor in colon cancer cells. Br J Cancer (2008) 0.94
The effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy. Int J Clin Exp Med (2013) 0.94
Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis. Br J Cancer (2003) 0.94
Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial. Cancer Epidemiol Biomarkers Prev (2009) 0.92
Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription. Nucleic Acids Res (2008) 0.92
Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells. Exp Mol Med (2008) 0.90
Expression of cyclooxygenase-2 in colorectal cancer and its clinical significance. World J Gastroenterol (2005) 0.90
Nonsteroidal anti-inflammatory drugs in colorectal cancer: from prevention to therapy. Br J Cancer (2003) 0.90
Lung cancer: a classic example of tumor escape and progression while providing opportunities for immunological intervention. Clin Dev Immunol (2012) 0.89
COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status. BMC Cancer (2011) 0.89
Epstein-Barr virus protein can upregulate cyclo-oxygenase-2 expression through association with the suppressor of metastasis Nm23-H1. J Virol (2006) 0.89
PLA2G16 Expression in Human Osteosarcoma Is Associated with Pulmonary Metastasis and Poor Prognosis. PLoS One (2015) 0.88
-765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia. World J Gastroenterol (2006) 0.88
COX-2-765G>C polymorphism increases the risk of cancer: a meta-analysis. PLoS One (2013) 0.87
Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions. World J Gastroenterol (2006) 0.87
Biological roles of CCAAT/Enhancer-binding protein delta during inflammation. J Biomed Sci (2015) 0.85
Potential role of cyclooxygenase-2 on the regulation of the drug efflux transporter ABCG2 in breast cancer cell lines. J Cancer Res Clin Oncol (2010) 0.84
Increased NF-kappaB DNA binding but not transcriptional activity during apoptosis induced by the COX-2-selective inhibitor NS-398 in colorectal carcinoma cells. Br J Cancer (2003) 0.84
Cyclooxygenase-2 and p53 expression as prognostic indicators in conventional renal cell carcinoma. Yonsei Med J (2005) 0.84
Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers. Oncotarget (2015) 0.82
The Role of PPARgamma Receptors and Leukotriene B(4) Receptors in Mediating the Effects of LY293111 in Pancreatic Cancer. PPAR Res (2009) 0.82
Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton. J Biol Chem (2010) 0.82
Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cyclooxygenase-2. J Transl Med (2011) 0.81
Autocrine prostaglandin E₂ signaling promotes promonocytic leukemia cell survival via COX-2 expression and MAPK pathway. BMB Rep (2015) 0.81
Influence of age and gender on association between -765G > C COX-2 genetic polymorphism and gastric adenocarcinoma risk: a case-control study in Iran. Gastroenterol Hepatol Bed Bench (2012) 0.81
Concern Discoidin Domain Receptors: Potential Actors and Targets in Cancer. Front Pharmacol (2016) 0.80
Anti-cancer effects of celecoxib on nasopharyngeal carcinoma HNE-1 cells expressing COX-2 oncoprotein. Cytotechnology (2010) 0.80
Systemic therapy for cervical cancer with potentially regulatable oncolytic adenoviruses. PLoS One (2008) 0.80
Antitumor effect of the selective COX-2 inhibitor celecoxib on endometrial adenocarcinoma in vitro and in vivo. Oncol Lett (2012) 0.80
Altered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout mice. PLoS One (2013) 0.80
Adenovirus type 5 E1A-induced apoptosis in COX-2-overexpressing breast cancer cells. Breast Cancer Res (2007) 0.79
VEGF gene expression in adult human thymus fat: a correlative study with hypoxic induced factor and cyclooxygenase-2. PLoS One (2009) 0.79
Multi-Target Approaches in Colon Cancer Chemoprevention Based on Systems Biology of Tumor Cell-Signaling. Gene Regul Syst Bio (2008) 0.79
Cyclooxygenase-2 expression and angiogenesis in colorectal cancer. World J Gastroenterol (2003) 0.78
miR-21 inhibits the effects of cyclooxygenase-2 inhibitor NS398 on apoptosis and invasion in gastric cancer cells. Onco Targets Ther (2015) 0.77
Role of heme oxygenase-1 in inflammatory response induced by mechanical stretch in synovial cells. Inflamm Res (2011) 0.77
Expression of Cyclooxygenase-2 and Bcl-2 in human gastric adenomas. Korean J Intern Med (2005) 0.77
RhoGDI deficiency induces constitutive activation of Rho GTPases and COX-2 pathways in association with breast cancer progression. Oncotarget (2015) 0.77
The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage. Biochem J (2003) 0.76
Screen and analysis of key disease genes for precancerous lesions of oral buccal mucosa induced by DMBA in golden hamsters. Oncol Lett (2010) 0.75
Cyclooxygenase-2 -1195G>A (rs689466) polymorphism and cancer susceptibility: an updated meta-analysis involving 50,672 subjects. Int J Clin Exp Med (2015) 0.75
Potency of non-steroidal anti-inflammatory drugs in chemotherapy. Mol Clin Oncol (2014) 0.75
Inhibitory Effect of IFN-beta, on the Antitumor Activity of Celecoxib in U87 Glioma Model. J Korean Neurosurg Soc (2009) 0.75
Niflumic acid exhibits anti-tumor activity in nasopharyngeal carcinoma cells through affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Int J Clin Exp Pathol (2015) 0.75
Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of a 12R-LOX-chaperone complex. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma. J Clin Pathol (2006) 0.75
Common Variants of the Prostaglandin-Endoperoxide Synthase 2 Gene and Hepatocellular Carcinoma Susceptibility. Medicine (Baltimore) (2015) 0.75
Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma. Exp Ther Med (2016) 0.75
A small amount of cyclooxygenase 2 (COX2) is constitutively expressed in platelets. Platelets (2016) 0.75
Cyclooxygenase-2 and B-cell lymphoma-2 expression in cystitis glandularis and primary vesicle adenocarcinoma. BMC Urol (2014) 0.75
Paulistine-The Functional Duality of a Wasp Venom Peptide Toxin. Toxins (Basel) (2016) 0.75
Non-Steroidal Anti-Inflammatory Drugs in the Carcinogenesis of the Gastrointestinal Tract. Pharmaceuticals (Basel) (2010) 0.75
Adaptor Protein p62 Promotes Skin Tumor Growth and Metastasis and is Induced by UVA Radiation. J Biol Chem (2017) 0.75
Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells. Oncol Lett (2017) 0.75
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet (2006) 9.56
Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science (2007) 2.25
Outside-in signals delivered by matrix metalloproteinase-1 regulate platelet function. Circ Res (2002) 2.10
Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. J Biol Chem (2005) 1.73
The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. Crit Care Med (2002) 1.66
Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. J Exp Med (2003) 1.58
Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands. Curr Opin Hematol (2002) 1.43
Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes. Crit Rev Clin Lab Sci (2003) 1.39
Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates. Circulation (2005) 1.33
The role of cyclooxygenase-2 and prostaglandins in colon cancer. Prostaglandins Other Lipid Mediat (2006) 1.29
Diacylglycerol kinases. Cell Signal (2004) 1.25
The emerging roles of PAF acetylhydrolase. J Lipid Res (2008) 1.22
Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling. Proc Natl Acad Sci U S A (2005) 1.21
Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A (2006) 1.20
Cell-cell interactions: leukocyte-endothelial interactions. Curr Opin Hematol (2003) 1.19
Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. J Clin Invest (2006) 1.18
Association between 5-lipoxygenase expression and plaque instability in humans. Arterioscler Thromb Vasc Biol (2005) 1.15
Association of diacylglycerol kinase zeta with protein kinase C alpha: spatial regulation of diacylglycerol signaling. J Cell Biol (2003) 1.11
Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. Shock (2006) 1.09
Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2. Biochem Biophys Res Commun (2002) 1.08
IFN-epsilon mediates TNF-alpha-induced STAT1 phosphorylation and induction of retinoic acid-inducible gene-I in human cervical cancer cells. J Immunol (2007) 1.01
Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta. J Biol Chem (2003) 1.00
Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism. Cell Signal (2004) 1.00
The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. J Biol Chem (2006) 0.99
Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. EMBO J (2009) 0.98
Fish oil fix. Nat Med (2005) 0.97
Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression. Cancer Lett (2008) 0.97
DGKι regulates presynaptic release during mGluR-dependent LTD. EMBO J (2010) 0.94
Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli. J Biol Chem (2007) 0.94
Celecoxib inhibits meningioma tumor growth in a mouse xenograft model. Cancer (2007) 0.93
Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein. J Immunol (2002) 0.92
Activation of vascular cells by PAF-like lipids in oxidized LDL. Vascul Pharmacol (2002) 0.92
Cyclooxygenase-2 transactivates the epidermal growth factor receptor through specific E-prostanoid receptors and tumor necrosis factor-alpha converting enzyme. Cell Signal (2007) 0.91
The p38 MAPK pathway mediates transcriptional activation of the plasma platelet-activating factor acetylhydrolase gene in macrophages stimulated with lipopolysaccharide. J Biol Chem (2004) 0.89
Platelets, endothelial cells, inflammatory chemokines, and restenosis: complex signaling in the vascular play book. Circulation (2002) 0.88
Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase. Mem Inst Oswaldo Cruz (2005) 0.87
Molecular basis for susceptibility of plasma platelet-activating factor acetylhydrolase to oxidative inactivation. FASEB J (2007) 0.87
Diacylglycerol kinases: regulation and signaling roles. Thromb Haemost (2002) 0.87
Controversies in COX-2 selective inhibition. J Rheumatol (2002) 0.86
Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a. Mol Cancer (2003) 0.86
Can licorice lick colon cancer? J Clin Invest (2009) 0.85
Lung production of platelet-activating factor acetylhydrolase in oleic acid-induced acute lung injury. Prostaglandins Leukot Essent Fatty Acids (2007) 0.81
Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections. J Immunol (2008) 0.81
Bacterial clearance is improved in septic mice by platelet-activating factor-acetylhydrolase (PAF-AH) administration. PLoS One (2013) 0.77
New roles for an old drug: inhibition of gene expression by dipyridamole in platelet-leukocyte aggregates. Trends Cardiovasc Med (2006) 0.77
Molecular characterization of the constitutive expression of the plasma platelet-activating factor acetylhydrolase gene in macrophages. Biochem J (2003) 0.76
Ubiquitous expression of cyclooxygenase-2 in meningiomas and decrease in cell growth following in vitro treatment with the inhibitor celecoxib: potential therapeutic application. J Neurosurg (2005) 0.75