Published in Mol Cell on February 01, 2002
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell (2007) 5.09
Oncogenic activation of NF-kappaB. Cold Spring Harb Perspect Biol (2010) 3.30
Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev (2008) 2.89
Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation. Proc Natl Acad Sci U S A (2004) 2.19
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways. J Clin Invest (2005) 2.06
Heat shock proteins: essential proteins for apoptosis regulation. J Cell Mol Med (2008) 1.93
Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr Rev (2009) 1.88
The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways. J Exp Med (2002) 1.76
Cdc37 goes beyond Hsp90 and kinases. Cell Stress Chaperones (2003) 1.64
Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol (2003) 1.63
Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling. Genes Dev (2004) 1.46
CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. Mol Cell Biol (2004) 1.44
IKK biology. Immunol Rev (2012) 1.40
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A (2008) 1.39
Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability. Biochem J (2003) 1.37
Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells. Mol Biol Cell (2006) 1.37
Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control. Proc Am Thorac Soc (2009) 1.31
IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapy. Mol Cell Biol (2003) 1.29
The anti-death machinery in IKK/NF-kappaB signaling. J Clin Immunol (2005) 1.27
New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. Drug Resist Updat (2009) 1.27
Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation. Mol Cell Biol (2003) 1.26
Apoptosis versus cell differentiation: role of heat shock proteins HSP90, HSP70 and HSP27. Prion (2007) 1.26
Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression. J Exp Med (2012) 1.23
Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination. Mol Cell Biol (2007) 1.23
Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget (2015) 1.15
Inhibitory kappa B Kinases as targets for pharmacological regulation. Br J Pharmacol (2012) 1.14
20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling. J Pharmacol Exp Ther (2009) 1.13
Viral mediated redirection of NEMO/IKKγ to autophagosomes curtails the inflammatory cascade. PLoS Pathog (2012) 1.11
Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation. J Leukoc Biol (2013) 1.10
Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation. PLoS One (2010) 1.06
Oxidative-nitrosative stress and post-translational protein modifications: implications to lung structure-function relations. Arginase modulates NF-kappaB activity via a nitric oxide-dependent mechanism. Am J Respir Cell Mol Biol (2007) 1.00
Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy. Curr Mol Med (2012) 0.99
High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction. Am J Physiol Cell Physiol (2008) 0.97
HILI inhibits TGF-β signaling by interacting with Hsp90 and promoting TβR degradation. PLoS One (2012) 0.95
Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins. PLoS Pathog (2012) 0.95
Heat shock protein 90 controls HIV-1 reactivation from latency. Proc Natl Acad Sci U S A (2014) 0.95
Poxvirus MC160 protein utilizes multiple mechanisms to inhibit NF-kappaB activation mediated via components of the tumor necrosis factor receptor 1 signal transduction pathway. J Virol (2009) 0.95
RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells. Ann N Y Acad Sci (2010) 0.93
Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. Dis Model Mech (2013) 0.93
Nonphagocytic oxidase 1 causes death in lung epithelial cells via a TNF-RI-JNK signaling axis. Am J Respir Cell Mol Biol (2006) 0.91
Functioning of the Hsp90 machine in chaperoning checkpoint kinase I (Chk1) and the progesterone receptor (PR). Cell Stress Chaperones (2007) 0.90
HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization. Cancer Res (2014) 0.90
TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB. Mol Cell Biol (2003) 0.89
Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice. Blood Cancer J (2013) 0.88
Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. Mol Cell Biol (2009) 0.88
Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth. Mol Cell Biol (2005) 0.88
Regulation of stability of cyclin-dependent kinase CDK11p110 and a caspase-processed form, CDK11p46, by Hsp90. Biochem J (2004) 0.87
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation. J Biol Chem (2007) 0.87
Obligatory role of heat shock protein 90 in iNOS induction. Am J Physiol Cell Physiol (2011) 0.86
NF-κB as a target for oncogenic viruses. Curr Top Microbiol Immunol (2011) 0.86
Co-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: a highly active combination against human mantle cell lymphoma (MCL) cells. Cancer Biol Ther (2009) 0.86
A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity. J Biol Chem (2011) 0.86
Isoflavone-deprived soy peptide suppresses mammary tumorigenesis by inducing apoptosis. Exp Mol Med (2009) 0.85
Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells. BMC Microbiol (2007) 0.85
A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-κB. Clin Cancer Res (2013) 0.85
Mechanisms of Hsp90 regulation. Biochem J (2016) 0.84
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death. Cell Death Dis (2016) 0.84
Exploiting features of adenovirus replication to support mammalian kinase production. Nucleic Acids Res (2003) 0.84
5,7-dihydroxy-3,4,6-trimethoxyflavone inhibits the inflammatory effects induced by Bacteroides fragilis enterotoxin via dissociating the complex of heat shock protein 90 and I kappaB alpha and I kappaB kinase-gamma in intestinal epithelial cell culture. Clin Exp Immunol (2009) 0.83
Hepatitis B virus polymerase suppresses NF-κB signaling by inhibiting the activity of IKKs via interaction with Hsp90β. PLoS One (2014) 0.82
Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis. Cell Death Dis (2016) 0.82
HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-κB activation and HTLV-1 replication. J Virol (2013) 0.82
The heat shock proteins as targets for radiosensitization and chemosensitization in cancer. Cancer Biol Ther (2011) 0.82
Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90. Cell Death Differ (2010) 0.82
Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells. Mol Cancer Ther (2010) 0.82
Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges. Pharmaceuticals (Basel) (2011) 0.81
Heat shock protein 90 regulates IκB kinase complex and NF-κB activation in angiotensin II-induced cardiac cell hypertrophy. Exp Mol Med (2010) 0.81
High-throughput screen of natural product libraries for hsp90 inhibitors. Biology (Basel) (2014) 0.81
Heat shock protein 90 inhibition abrogates TLR4-mediated NF-κB activity and reduces renal ischemia-reperfusion injury. Sci Rep (2015) 0.79
Promising personalized therapeutic options for diffuse large B-cell Lymphoma Subtypes with oncogene addictions. Clin Cancer Res (2012) 0.79
HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms. Mediators Inflamm (2015) 0.78
Maximal adamantyl-substituted retinoid-related molecule-induced apoptosis requires NF-κB noncanonical and canonical pathway activation. Cell Death Differ (2010) 0.78
TNFα signaling regulates cystic epithelial cell proliferation through Akt/mTOR and ERK/MAPK/Cdk2 mediated Id2 signaling. PLoS One (2015) 0.78
Inhibitor-κB kinase attenuates Hsp90-dependent endothelial nitric oxide synthase function in vascular endothelial cells. Am J Physiol Cell Physiol (2015) 0.77
Network-based analysis of differentially expressed genes in cerebrospinal fluid (CSF) and blood reveals new candidate genes for multiple sclerosis. PeerJ (2016) 0.77
17-DMAG, an HSP90 Inhibitor, Ameliorates Multiple Organ Dysfunction Syndrome via Induction of HSP70 in Endotoxemic Rats. PLoS One (2016) 0.76
Clathrin complexes with the inhibitor kappa B kinase signalosome: imaging the interactome. Physiol Rep (2014) 0.75
Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90. OMICS (2016) 0.75
Expanding the Interactome of the Noncanonical NF-κB Signaling Pathway. J Proteome Res (2016) 0.75
The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm. Int J Mol Sci (2016) 0.75
Myocyte derived Hsp90 modulates collagen upregulation via biphasic activation of STAT-3 in fibroblasts during cardiac hypertrophy. Mol Cell Biol (2016) 0.75
Characterization of HSP90 isoforms in transformed bovine leukocytes infected with Theileria annulata. Cell Microbiol (2016) 0.75
A novel heterocyclic compound: catena-poly[[[diaquasodium(I)]-di-mu-aqua] hemi(1,5-dihydroxy-4,8,9-trioxa-2,6-diazabicyclo[3.3.1]nona-2,6-diene-3,7-diolate)]. Acta Crystallogr C (2007) 65.39
TNF-R1 signaling: a beautiful pathway. Science (2002) 7.98
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci U S A (2009) 3.39
Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. Mol Cell Biol (2005) 2.57
The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesis. J Exp Med (2003) 2.20
Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling. J Biol Chem (2003) 1.85
T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem (2002) 1.75
Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers. Biochem J (2005) 1.51
Essential role of a GXXXG motif for membrane channel formation by Helicobacter pylori vacuolating toxin. J Biol Chem (2003) 1.50
Heterogeneity among Helicobacter pylori strains in expression of the outer membrane protein BabA. Infect Immun (2004) 1.45
Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor. Nat Chem (2012) 1.39
Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site. Chem Biol (2011) 1.20
Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet. Proc Natl Acad Sci U S A (2013) 1.20
Genome-wide transcriptional profiling in a histidine kinase mutant of Helicobacter pylori identifies members of a regulon. J Bacteriol (2002) 1.16
Synthesis and antimicrobial activities of 7-O-modified genistein derivatives. Eur J Med Chem (2007) 1.10
Ion mobility spectrometry-mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors. J Am Chem Soc (2013) 1.06
Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers. Protein Sci (2012) 1.05
Deamidation accelerates amyloid formation and alters amylin fiber structure. J Am Chem Soc (2012) 1.03
Palladium-catalyzed intermolecular coupling of aryl chlorides and sulfonamides under microwave irradiation. Org Lett (2003) 0.99
Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proc Natl Acad Sci U S A (2012) 0.94
Structure of the nuclear factor κB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation. J Biol Chem (2012) 0.90
Prevalence and risk factors of fatty liver disease in the Shuiguohu district of Wuhan city, central China. Postgrad Med J (2007) 0.90
Bis{2-[bis-(3,5-dimethyl-1H-pyrazol-1-yl-κN(2))meth-yl]pyridine-κN}cobalt(II) dinitrate. Acta Crystallogr Sect E Struct Rep Online (2012) 0.86
Gastrointestinal tract distribution of Salmonella enteritidis in orally infected mice with a species-specific fluorescent quantitative polymerase chain reaction. World J Gastroenterol (2007) 0.86
[The clinical significance of the expression of costimulatory molecule PD-L1 in nasopharyngeal carcinoma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (2008) 0.81
TGFB1 T29C polymorphism and breast cancer risk: a meta-analysis based on 10,417 cases and 11,455 controls. Breast Cancer Res Treat (2010) 0.81
Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation. J Leukoc Biol (2008) 0.81
Quantitative studies of the regular distribution pattern for Salmonella enteritidis in the internal organs of mice after oral challenge by a specific real-time polymerase chain reaction. World J Gastroenterol (2008) 0.80
Genomic Comparison of cag pathogenicity island (PAI)-positive and -negative Helicobacter pylori strains: identification of novel markers for cag PAI-positive strains. Infect Immun (2005) 0.80
Synergistic bactericidal effects and mechanisms of low intensity ultrasound and antibiotics against bacteria: a review. Ultrason Sonochem (2011) 0.79
Serovar-specific real-time quantitative detection of Salmonella enteritidis in the gastrointestinal tract of ducks after oral challenge. Avian Dis (2008) 0.79
Low expression of basic fibroblastic growth factor in mesenchymal stem cells and bone marrow of children with aplastic anemia. Pediatr Hematol Oncol (2013) 0.78
Quantitative analysis of free fatty acids in rat plasma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry with meso-tetrakis porphyrin as matrix. Anal Biochem (2006) 0.78
Integrated system for temperature-controlled fast protein liquid chromatography comprising improved copolymer modified beaded agarose adsorbents and a travelling cooling zone reactor arrangement. J Chromatogr A (2013) 0.77
Amyloid formation in heterogeneous environments: islet amyloid polypeptide glycosaminoglycan interactions. J Mol Biol (2012) 0.77
A study of the distribution patterns and levels of Salmonella enteritidis in the immune organs of ducklings after oral challenge by serovar-specific real-time PCR. Avian Dis (2008) 0.77
Structure-guided optimization of small molecule c-Abl activators. J Comput Aided Mol Des (2014) 0.76
Microstructure and mechanical properties of horns derived from three domestic bovines. Mater Sci Eng C Mater Biol Appl (2013) 0.76
Aspirin, diabetes, and amyloid: re-examination of the inhibition of amyloid formation by aspirin and ketoprofen. ACS Chem Biol (2014) 0.76
Dimethyl 2,2'-[2,2'-bi(1H-1,3-benzimidazole)-1,1'-di-yl]diacetate. Acta Crystallogr Sect E Struct Rep Online (2012) 0.75
Aqua-[1-(pyrazin-2-yl)ethanone oximato-κ²N,N'][1-(pyrazin-2-yl)ethanone oxime-κ²N,N'](thio-cyanato-κN)nickel(II). Acta Crystallogr Sect E Struct Rep Online (2012) 0.75
Application of an indirect immunofluorescent staining method for detection of Salmonella enteritidis in paraffin slices and antigen location in infected duck tissues. World J Gastroenterol (2008) 0.75
An inhibitory antibody against dipeptidyl peptidase IV improves glucose tolerance in vivo. J Biol Chem (2012) 0.75
Copper(i)-catalyzed ring-opening cyanation of cyclopropanols. Org Biomol Chem (2017) 0.75
[Effect of quercetin on proliferation and apoptosis of human nasopharyngeal carcinoma HEN1 cells]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (2007) 0.75
Rapid CO breath test screening of drugs for protective effects on ribavirin-induced hemolysis in a rabbit model: a pilot study. J Breath Res (2016) 0.75
[Effects of Shenxiong pill on infarct brain volumes and NF-kappaB expression in SD rats with middle cerebral artery occlusion (MCAO)]. Sichuan Da Xue Xue Bao Yi Xue Ban (2014) 0.75
[An experimental investigation of deep burn by constant low heat]. Zhonghua Shao Shang Za Zhi (2002) 0.75
Cytotoxicity and its test methodology for a bioabsorbable nitrided iron stent. J Biomed Mater Res B Appl Biomater (2014) 0.75
Effect of ramipril on the electrophysiological characteristics of ventricular myocardium after myocardial infarction in rabbits. J Cardiovasc Med (Hagerstown) (2012) 0.75
[Genetic correlations between quality traits and other economic traits in japonica rice]. Yi Chuan (2005) 0.75
[Significance of ultrasound bone measurement in diagnosis of hyperthyroidism]. Zhonghua Yi Xue Za Zhi (2005) 0.75
[Mechanical properties and biological evaluation of buffalo horn material]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi (2014) 0.75
[Special space food: microecological health food]. Space Med Med Eng (Beijing) (2003) 0.75
[Effect of weight loss induced by laparoscopic adjustable gastric banding on immunity of morbid obesity]. Zhonghua Wai Ke Za Zhi (2005) 0.75