Published in Nat Immunol on March 01, 2002
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00
CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. J Clin Invest (2011) 6.38
Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest (2007) 6.31
Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci U S A (2008) 5.29
Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am J Hum Genet (2002) 4.84
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell (2007) 4.56
Redox regulation of cell survival. Antioxid Redox Signal (2008) 4.33
Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest (2003) 4.14
Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev (2009) 4.10
IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. J Clin Invest (2005) 4.07
The immune system and cardiac repair. Pharmacol Res (2008) 3.42
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol (2006) 3.31
CD40 regulates the processing of NF-kappaB2 p100 to p52. EMBO J (2002) 3.30
NF-κB in the liver--linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol (2011) 3.28
Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions. Mol Cell (2012) 3.26
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc Natl Acad Sci U S A (2012) 3.24
Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J (2004) 3.01
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J (2003) 2.97
Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation. EMBO J (2003) 2.97
Nf-kappa B, chemokine gene transcription and tumour growth. Nat Rev Immunol (2002) 2.81
Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. Antioxid Redox Signal (2008) 2.67
Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A (2007) 2.43
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. EMBO J (2006) 2.41
Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era. Blood (2010) 2.33
NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc Natl Acad Sci U S A (2004) 2.33
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med (2005) 2.21
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest (2005) 2.20
RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF. EMBO J (2003) 2.17
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology (2012) 2.15
IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A (2004) 2.12
NF-kappaB and virus infection: who controls whom. EMBO J (2003) 2.08
IAP inhibitors enhance co-stimulation to promote tumor immunity. J Exp Med (2010) 2.07
Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci U S A (2006) 2.07
IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. Mol Cell Biol (2006) 2.05
MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor. Cancer Res (2009) 2.04
Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J Clin Invest (2010) 2.02
Macrophage activation redirects yersinia-infected host cell death from apoptosis to caspase-1-dependent pyroptosis. PLoS Pathog (2007) 2.01
Suppression of PTEN expression by NF-kappa B prevents apoptosis. Mol Cell Biol (2004) 2.01
IL-1beta causes an increase in intestinal epithelial tight junction permeability. J Immunol (2007) 1.96
HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation. Mol Cell Biol (2003) 1.96
Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination. Am J Pathol (2007) 1.94
c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis. Mol Cell Biol (2004) 1.93
Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol (2011) 1.92
Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila. Genes Dev (2004) 1.91
Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins. Infect Immun (2006) 1.91
Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A (2008) 1.90
The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res (2009) 1.89
Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis. Proc Natl Acad Sci U S A (2007) 1.89
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J (2008) 1.87
Regulation of reactive oxygen species generation in cell signaling. Mol Cells (2011) 1.85
Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents. Proc Natl Acad Sci U S A (2006) 1.85
Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal (2011) 1.82
Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia (2006) 1.81
PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis. Cell Death Differ (2009) 1.81
RNA interference directed against viral and cellular targets inhibits human immunodeficiency Virus Type 1 replication. J Virol (2002) 1.80
Flagellin suppresses epithelial apoptosis and limits disease during enteric infection. Am J Pathol (2006) 1.77
Differential requirement for Rel/nuclear factor kappa B family members in natural killer T cell development. J Exp Med (2003) 1.77
The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways. J Exp Med (2002) 1.76
Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology (2014) 1.73
Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. Mol Cell Biol (2006) 1.72
Biphasic dose response in low level light therapy - an update. Dose Response (2011) 1.69
Emerging and diverse roles of protein kinase C in immune cell signalling. Biochem J (2003) 1.69
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol (2008) 1.68
TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity. J Biol Chem (2008) 1.67
Cytokine-induced signaling networks prioritize dynamic range over signal strength. Cell (2008) 1.65
Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling. EMBO J (2007) 1.65
Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol (2003) 1.63
IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat Cell Biol (2012) 1.63
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. Genes Dev (2009) 1.62
The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol (2002) 1.61
Dynamics within the CD95 death-inducing signaling complex decide life and death of cells. Mol Syst Biol (2010) 1.57
PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J Exp Med (2005) 1.57
NF-kappaB is essential for the progression of KSHV- and EBV-infected lymphomas in vivo. Blood (2005) 1.56
Nuclear factor-kappaB/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progression. Neoplasia (2004) 1.56
Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis. J Clin Invest (2007) 1.56
Tumor necrosis factor alpha inhibition of hepatitis B virus replication involves disruption of capsid Integrity through activation of NF-kappaB. J Virol (2003) 1.55
Visualization of AP-1 NF-kappaB ternary complexes in living cells by using a BiFC-based FRET. Proc Natl Acad Sci U S A (2008) 1.55
Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals. Arthritis Rheum (2004) 1.52
NF-κB, stem cells and breast cancer: the links get stronger. Breast Cancer Res (2011) 1.51
S-glutathionylation: from molecular mechanisms to health outcomes. Antioxid Redox Signal (2011) 1.49
A translocated bacterial protein protects vascular endothelial cells from apoptosis. PLoS Pathog (2006) 1.49
Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. Am J Physiol Gastrointest Liver Physiol (2005) 1.49
GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation. Biochem J (2005) 1.48
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med (2005) 1.46
Cell death pathways in photodynamic therapy of cancer. Cancers (Basel) (2011) 1.45
RelA repression of RelB activity induces selective gene activation downstream of TNF receptors. Proc Natl Acad Sci U S A (2005) 1.45
CARMA1-mediated NF-kappaB and JNK activation in lymphocytes. Immunol Rev (2009) 1.44
Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol (2004) 1.43
Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Proc Natl Acad Sci U S A (2007) 1.42
EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway. Oncogene (2011) 1.42
Role of nuclear factor-kappa B in melanoma. Cancer Metastasis Rev (2005) 1.41
Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications. Blood (2009) 1.41
Inflammation-activated protein kinases as targets for drug development. Proc Am Thorac Soc (2005) 1.40
CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells. J Immunol (2009) 1.40
Negative regulation of NF-kappaB signaling by PIAS1. Mol Cell Biol (2005) 1.38
Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia. EMBO J (2006) 1.37
Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3. Cancer Res (2008) 1.36
Role of JNK activation in apoptosis: a double-edged sword. Cell Res (2005) 3.48
c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis. Mol Cell Biol (2004) 1.93
JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell (2004) 1.73
The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol (2002) 1.61
Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. J Biol Chem (2006) 1.59
Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis. Cell Host Microbe (2008) 1.59
The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma. Cancer Res (2006) 1.43
NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell (2006) 1.41
Novel strategies for inhibition of the p38 MAPK pathway. Trends Pharmacol Sci (2007) 1.38
Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta. J Immunol (2003) 1.34
Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase. J Biol Chem (2008) 1.27
Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice. Diabetes (2011) 1.26
Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7. Cancer Res (2005) 1.21
Activation of nuclear factor-kappaB is necessary for myotrophin-induced cardiac hypertrophy. J Cell Biol (2002) 1.21
Novel roles for protein kinase Cdelta-dependent signaling pathways in acute hypoxic stress-induced autophagy. J Biol Chem (2008) 1.16
Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15. J Exp Med (2009) 1.14
TNF-alpha-induced apoptosis of macrophages following inhibition of NF-kappa B: a central role for disruption of mitochondria. J Immunol (2004) 1.11
Androgen and its receptor promote Bax-mediated apoptosis. Mol Cell Biol (2006) 1.10
Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ. Nat Immunol (2013) 1.08
Signaling intermediates required for NF-kappa B activation and IL-8 expression in CF bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol (2002) 1.07
Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation. Cell (2013) 1.06
MAPK pathways mediate hyperoxia-induced oncotic cell death in lung epithelial cells. Free Radic Biol Med (2003) 1.05
Dynamic positive feedback phosphorylation of mixed lineage kinase 3 by JNK reversibly regulates its distribution to Triton-soluble domains. J Biol Chem (2006) 1.04
Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1. Proc Natl Acad Sci U S A (2010) 1.02
PKC delta signaling: a dual role in regulating hypoxic stress-induced autophagy and apoptosis. Autophagy (2009) 1.02
Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death. J Neurochem (2003) 0.96
Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1. J Biol Chem (2008) 0.96
Cyclic AMP inhibits p38 activation via CREB-induced dynein light chain. Mol Cell Biol (2006) 0.96
Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells. Am J Respir Cell Mol Biol (2003) 0.95
Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment. J Biol Chem (2005) 0.92
Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation. Proc Natl Acad Sci U S A (2009) 0.90
BAD Ser128 is not phosphorylated by c-Jun NH2-terminal kinase for promoting apoptosis. Cancer Res (2005) 0.89
Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation. Proc Natl Acad Sci U S A (2011) 0.87
SIP30 is regulated by ERK in peripheral nerve injury-induced neuropathic pain. J Biol Chem (2009) 0.85
Activation of c-Jun NH2-terminal kinase is required for gemcitabine's cytotoxic effect in human lung cancer H1299 cells. FEBS Lett (2005) 0.84
Integration of apoptosis signal-regulating kinase 1-mediated stress signaling with the Akt/protein kinase B-IκB kinase cascade. Mol Cell Biol (2013) 0.82
Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis. J Biol Chem (2009) 0.80
Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells. Int J Biochem Cell Biol (2010) 0.80
c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells. PLoS One (2012) 0.79
IKK antagonizes CD95 ligation-mediated apoptosis by regulating NF-kappaB activity. Mol Immunol (2006) 0.75