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1
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The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia.
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Clin Cancer Res
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2011
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2.38
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2
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Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.
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Clin Cancer Res
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2007
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1.60
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3
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A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity.
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Cancer Chemother Pharmacol
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2010
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0.94
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4
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Hypoxia-selective 3-alkyl 1,2,4-benzotriazine 1,4-dioxides: the influence of hydrogen bond donors on extravascular transport and antitumor activity.
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J Med Chem
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2007
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0.92
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5
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Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.
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Cancer Res
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2002
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0.92
|
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6
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Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards.
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Radiat Res
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2007
|
0.88
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7
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Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport.
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J Med Chem
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2007
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0.87
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8
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The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104.
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Front Oncol
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2013
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0.86
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9
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Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins.
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J Med Chem
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2008
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0.83
|
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10
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Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures.
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J Med Chem
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2005
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0.80
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11
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Hypoxia-directed drug strategies to target the tumor microenvironment.
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Adv Exp Med Biol
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2014
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0.78
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12
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In vitro and in vivo models for evaluation of GDEPT: quantifying bystander killing in cell cultures and tumors.
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Methods Mol Med
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2004
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0.78
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13
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Analysis of the hypoxia-activated dinitrobenzamide mustard phosphate pre-prodrug PR-104 and its alcohol metabolite PR-104A in plasma and tissues by liquid chromatography-mass spectrometry.
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J Chromatogr B Analyt Technol Biomed Life Sci
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2007
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0.77
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14
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Photodegradation of the benzotriazine 1,4-Di-N-oxide hypoxia-activated prodrug SN30000 in aqueous solution.
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J Pharm Sci
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2014
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0.75
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