Published in Biophys J on April 01, 2002
Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev (2010) 11.25
The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Pharmacol Rev (2005) 1.96
Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands. Biophys J (2004) 1.40
A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction. Nat Neurosci (2012) 1.18
The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives. Chem Rev (2013) 0.98
Modeling noncompetitive antagonism of a nicotinic acetylcholine receptor. Biophys J (2004) 0.85
KvAP-based model of the pore region of shaker potassium channel is consistent with cadmium- and ligand-binding experiments. Biophys J (2005) 0.84
Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors. Eur J Pharmacol (2012) 0.80
The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science (1998) 39.86
MOLMOL: a program for display and analysis of macromolecular structures. J Mol Graph (1996) 39.73
RASMOL: biomolecular graphics for all. Trends Biochem Sci (1995) 33.76
The glutamate receptor ion channels. Pharmacol Rev (1999) 15.06
Monte Carlo-minimization approach to the multiple-minima problem in protein folding. Proc Natl Acad Sci U S A (1987) 5.84
Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature (2001) 5.44
Functional characterization of a potassium-selective prokaryotic glutamate receptor. Nature (1999) 2.77
Simulations of ion permeation through a potassium channel: molecular dynamics of KcsA in a phospholipid bilayer. Biophys J (2000) 2.69
Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. Science (1992) 2.64
The GluR2 (GluR-B) hypothesis: Ca(2+)-permeable AMPA receptors in neurological disorders. Trends Neurosci (1997) 2.38
Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data. Neuropharmacology (1999) 2.32
Structural determinants of barium permeation and rectification in non-NMDA glutamate receptor channels. J Neurosci (1992) 1.76
Dimensions of the narrow portion of a recombinant NMDA receptor channel. Biophys J (1995) 1.72
Identification by mutagenesis of a Mg(2+)-block site of the NMDA receptor channel. Nature (1992) 1.68
Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+. J Physiol (1998) 1.59
Structural conservation of ion conduction pathways in K channels and glutamate receptors. Proc Natl Acad Sci U S A (1995) 1.57
Dimensions and ion selectivity of recombinant AMPA and kainate receptor channels and their dependence on Q/R site residues. J Physiol (1996) 1.54
Permeation and block of rat GluR6 glutamate receptor channels by internal and external polyamines. J Physiol (1997) 1.50
Structural similarities between glutamate receptor channels and K(+) channels examined by scanning mutagenesis. J Gen Physiol (2001) 1.44
Block of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by polyamines and polyamine toxins. J Pharmacol Exp Ther (1996) 1.39
Argiotoxin detects molecular differences in AMPA receptor channels. Neuron (1993) 1.15
The selectivity filter of the N-methyl-D-aspartate receptor: a tryptophan residue controls block and permeation of Mg2+. Mol Pharmacol (1998) 1.12
Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J Physiol (1997) 1.07
Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins. J Pharmacol Exp Ther (1993) 1.06
Amino acid substitutions in the pore of rat glutamate receptors at sites influencing block by polyamines. J Physiol (1999) 1.03
Block and modulation of N-methyl-D-aspartate receptors by polyamines and protons: role of amino acid residues in the transmembrane and pore-forming regions of NR1 and NR2 subunits. Mol Pharmacol (1997) 0.99
Structural model of a synthetic Ca2+ channel with bound Ca2+ ions and dihydropyridine ligand. Biophys J (1996) 0.98
An analysis of philanthotoxin block for recombinant rat GluR6(Q) glutamate receptor channels. J Physiol (1998) 0.98
Antagonism of responses to excitatory amino acids on rat cortical neurones by the spider toxin, argiotoxin636. Br J Pharmacol (1989) 0.97
N1-dansyl-spermine and N1-(n-octanesulfonyl)-spermine, novel glutamate receptor antagonists: block and permeation of N-methyl-D-aspartate receptors. Mol Pharmacol (1997) 0.96
Channel-lining residues of the AMPA receptor M2 segment: structural environment of the Q/R site and identification of the selectivity filter. J Neurosci (2001) 0.95
Comparative patch-clamp studies with freshly dissociated rat hippocampal and striatal neurons on the NMDA receptor antagonistic effects of amantadine and memantine. Eur J Neurosci (1996) 0.95
Binding sites for exogenous and endogenous non-competitive inhibitors of the nicotinic acetylcholine receptor. Biochim Biophys Acta (1998) 0.93
Glutamate receptor requirement for neuronal death from anoxia-reoxygenation: an in Vitro model for assessment of the neuroprotective effects of estrogens. Cell Mol Neurobiol (1999) 0.93
Numb diverts notch pathway off the tramtrack. Neuron (1996) 0.92
The role of hydrophobic interactions in binding of polyamines to non NMDA receptor ion channels. Neuropharmacology (1999) 0.88
Structural determinants of the blocker binding site in glutamate and NMDA receptor channels. Neuropharmacology (1998) 0.87
Intersegment hydrogen bonds as possible structural determinants of the N/Q/R site in glutamate receptors. Biophys J (1999) 0.85
Spermine blocks synaptic transmission mediated by Ca(2+)-permeable AMPA receptors. Neuroreport (1996) 0.83
Benzyl-polyamines: novel, potent N-methyl-D-aspartate receptor antagonists. J Pharmacol Exp Ther (1997) 0.83
Philanthotoxin blocks quisqualate-, AMPA- and kainate-, but not NMDA-, induced excitation of rat brainstem neurones in vivo. Br J Pharmacol (1990) 0.83
Possible influence of intramolecular hydrogen bonds on the three-dimensional structure of polyamine amides and their interaction with ionotropic glutamate receptors. Receptors Channels (2000) 0.82
Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol (2000) 0.81
Assigning functions to residues in the acetylcholine receptor channel region (review). Mol Membr Biol (1998) 0.78
Different arrangement of hydrophobic and nucleophilic components of channel binding sites in N-methyl-D-aspartate and AMPA receptors of rat brain is revealed by channel blockade. Neurosci Lett (2000) 0.77
Cholinergic regulation of the evoked quantal release at frog neuromuscular junction. J Physiol (2004) 0.98
N-methyl-D-aspartate receptor channel blockers prevent pentylenetetrazole-induced convulsions and morphological changes in rat brain neurons. J Neurosci Res (2014) 0.88
Targeting ionotropic receptors with polyamine-containing toxins. Toxicon (2004) 0.87
Modeling noncompetitive antagonism of a nicotinic acetylcholine receptor. Biophys J (2004) 0.85
Mechanisms of non-steroid anti-inflammatory drugs action on ASICs expressed in hippocampal interneurons. J Neurochem (2008) 0.84
Latrophilin is required for toxicity of black widow spider venom in Caenorhabditis elegans. Biochem J (2004) 0.83
Novel class of spider toxin: active principle from the yellow sac spider Cheiracanthium punctorium venom is a unique two-domain polypeptide. J Biol Chem (2010) 0.83
Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors. Mol Pharmacol (2003) 0.83
Modulation of the kinetics of evoked quantal release at mouse neuromuscular junctions by calcium and strontium. J Neurochem (2006) 0.81
A venom-derived neurotoxin, CsTx-1, from the spider Cupiennius salei exhibits cytolytic activities. J Biol Chem (2012) 0.81
Blockade of NMDA receptor channels by 9-aminoacridine and its derivatives. Neurosci Lett (2008) 0.77
Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model. Neuroreport (2016) 0.76
Common binding site for externally and internally applied AMPA receptor channel blockers. J Mol Neurosci (2009) 0.76
Single channel study of deltamethrin interactions with wild-type and mutated rat Na(V)1.2 sodium channels expressed in Xenopus oocytes. Neurotoxicology (2009) 0.76
Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist. Bioorg Med Chem Lett (2002) 0.76
Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations. Neuropharmacology (2012) 0.75
Tuning wasp toxin structure for nicotinic receptor antagonism: cyclohexylalanine-containing analogues as potent and voltage-dependent blockers. ChemMedChem (2006) 0.75
The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism. J Med Chem (2005) 0.75