PubRank

Wenjuan Ye

Author PubWeight™ 31.41‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The genome of M. acetivorans reveals extensive metabolic and physiological diversity. Genome Res 2002 4.58
2 Substrate-targeting gamma-secretase modulators. Nature 2008 3.38
3 Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci U S A 2003 3.36
4 Purification and characterization of the human gamma-secretase complex. Biochemistry 2004 2.18
5 Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proc Natl Acad Sci U S A 2002 2.16
6 Direct and potent regulation of gamma-secretase by its lipid microenvironment. J Biol Chem 2008 2.00
7 Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. J Biol Chem 2003 1.83
8 Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. Proc Natl Acad Sci U S A 2006 1.77
9 Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution. J Mol Biol 2008 1.75
10 Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. Biochemistry 2004 1.61
11 gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site. J Biol Chem 2005 1.45
12 Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s). Biochemistry 2003 1.42
13 Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. J Biol Chem 2002 1.06
14 Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease. J Neurochem 2007 1.05
15 Effects of membrane lipids on the activity and processivity of purified γ-secretase. Biochemistry 2012 1.03
16 Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides. J Biol Chem 2002 0.92
17 Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase. Nat Cell Biol 2002 0.86