Teratogenesis of holoprosencephaly.

Multiple hits during early embryonic development: digenic diseases and holoprosencephaly. Am J Hum Genet (2002) 2.49

Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes. J Clin Invest (2004) 1.74

Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse. Toxicol Sci (2008) 1.46

Human hepatocyte carcinogenesis (review). Int J Oncol (2013) 1.28

Current recommendations for the molecular evaluation of newly diagnosed holoprosencephaly patients. Am J Med Genet C Semin Med Genet (2010) 1.23

Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog. J Clin Invest (2007) 1.22

Signaling by bone morphogenetic proteins directs formation of an ectodermal signaling center that regulates craniofacial development. Dev Biol (2007) 1.20

Pathogenesis of holoprosencephaly. J Clin Invest (2009) 1.12

Multicolour FISH and quantitative PCR can detect submicroscopic deletions in holoprosencephaly patients with a normal karyotype. J Med Genet (2005) 1.11

Boc modifies the holoprosencephaly spectrum of Cdo mutant mice. Dis Model Mech (2010) 1.09

Understanding diabetic teratogenesis: where are we now and where are we going? Birth Defects Res A Clin Mol Teratol (2010) 1.08

Genesis of teratogen-induced holoprosencephaly in mice. Am J Med Genet C Semin Med Genet (2010) 0.97

Signaling by SHH rescues facial defects following blockade in the brain. Dev Dyn (2012) 0.95

Abnormal sterol metabolism in holoprosencephaly: studies in cultured lymphoblasts. J Med Genet (2007) 0.90

Cyclopia: an epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research. Am J Med Genet C Semin Med Genet (2011) 0.88

Holoprosencephaly: signaling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humans. Wiley Interdiscip Rev Dev Biol (2014) 0.88

Histogenesis of retinal dysplasia in trisomy 13. Diagn Pathol (2007) 0.88

Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects. PLoS Genet (2012) 0.87

Toxic and teratogenic silica nanowires in developing vertebrate embryos. Nanomedicine (2009) 0.84

MRI of the olfactory bulbs and sulci in human fetuses. Pediatr Radiol (2005) 0.81

Retinoic acid isomers up-regulate ATP binding cassette A1 and G1 and cholesterol efflux in rat astrocytes: implications for their therapeutic and teratogenic effects. J Pharmacol Exp Ther (2011) 0.81

Boc modifies the spectrum of holoprosencephaly in the absence of Gas1 function. Biol Open (2014) 0.80

The Genetics of Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res (2016) 0.80

3-D reconstruction of a human fetus with combined holoprosencephaly and cyclopia. Head Face Med (2009) 0.79

Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival. Hum Mol Genet (2014) 0.78

Impact of retinoic acid exposure on midfacial shape variation and manifestation of holoprosencephaly in Twsg1 mutant mice. Dis Model Mech (2014) 0.78

Streptozotocin-induced diabetes models: pathophysiological mechanisms and fetal outcomes. Biomed Res Int (2014) 0.78

Agnathia Holoprosencephaly and Situs Inversus in A Neonate Born to an Alcoholic Mother. J Clin Diagn Res (2015) 0.77

Holoprosencephaly-Polydactyly syndrome: in search of an etiology. Eur J Med Genet (2007) 0.76

Prenatal Ethanol Exposure Up-Regulates the Cholesterol Transporters ATP-Binding Cassette A1 and G1 and Reduces Cholesterol Levels in the Developing Rat Brain. Alcohol Alcohol (2014) 0.76

Novel sonic hedgehog mutation in a couple with variable expression of holoprosencephaly. Case Rep Genet (2011) 0.75

Gestational diabetes leads to down-regulation of CDK4-pRB-E2F1 pathway genes in pancreatic islets of rat offspring. Iran J Basic Med Sci (2017) 0.75

Caudal Regression Syndrome with Partial Agenesis of the Corpus callosum and Partial Lobar Holoprosencephaly: Case report. Sultan Qaboos Univ Med J (2010) 0.75

Molecular analysis of holoprosencephaly in South America. Genet Mol Biol (2014) 0.75

Gene-environment interactions in development and disease. Wiley Interdiscip Rev Dev Biol (2016) 0.75

Commonality in Down and fetal alcohol syndromes. Birth Defects Res A Clin Mol Teratol (2013) 0.75

Semi Lobar Holoprosencephaly with Vertebral Segmentation Defects. Iran J Child Neurol (2017) 0.75

Hedgehog signaling is involved in development of the neocortex. Development (2008) 1.21

Mixed-mode pattern in Doublefoot mutant mouse limb--Turing reaction-diffusion model on a growing domain during limb development. J Theor Biol (2005) 1.12

Phenotypic variability in human embryonic holoprosencephaly in the Kyoto Collection. Birth Defects Res A Clin Mol Teratol (2004) 1.08

Fetal ethanol exposure activates protein kinase A and impairs Shh expression in prechordal mesendoderm cells in the pathogenesis of holoprosencephaly. Birth Defects Res A Clin Mol Teratol (2008) 1.02

Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain. Dev Dyn (2005) 1.01

Dysregulation of the PDGFRA gene causes inflow tract anomalies including TAPVR: integrating evidence from human genetics and model organisms. Hum Mol Genet (2010) 0.99

Programmed cell death is not a necessary prerequisite for fusion of the fetal mouse palate. Int J Dev Biol (2004) 0.99

Imaging of a large collection of human embryo using a super-parallel MR microscope. Magn Reson Med Sci (2007) 0.96

Spatial and temporal expression of folate-binding protein 1 (Fbp1) is closely associated with anterior neural tube closure in mice. Dev Dyn (2003) 0.96

Regional heterogeneity in the developing palate: morphological and molecular evidence for normal and abnormal palatogenesis. Congenit Anom (Kyoto) (2006) 0.95

Developmental atlas of the early first trimester human embryo. Dev Dyn (2010) 0.94

Sequential developmental changes in holoprosencephalic mouse embryos exposed to ethanol during the gastrulation period. Birth Defects Res A Clin Mol Teratol (2007) 0.94

Human cardiac development in the first trimester: a high-resolution magnetic resonance imaging and episcopic fluorescence image capture atlas. Circulation (2009) 0.93

Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain. Mech Dev (2009) 0.92

Depletion of FGF acts as a lateral inhibitory factor in lung branching morphogenesis in vitro. Mech Dev (2002) 0.91

Mechanism of skull suture maintenance and interdigitation. J Anat (2009) 0.91

Development of the posterior neural tube in human embryos. Anat Embryol (Berl) (2004) 0.91

Palatal shelf movement during palatogenesis: a fate map of the fetal mouse palate cultured in vitro. Anat Embryol (Berl) (2004) 0.89

The cyst-branch difference in developing chick lung results from a different morphogen diffusion coefficient. Mech Dev (2008) 0.88

Development of the mouse external genitalia: unique model of organogenesis. Adv Exp Med Biol (2004) 0.87

The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves. Dev Dyn (2012) 0.86

Terminal differentiation of palatal medial edge epithelial cells in vitro is not necessarily dependent on palatal shelf contact and midline epithelial seam formation. Int J Dev Biol (2004) 0.86

Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney. Am J Physiol Renal Physiol (2007) 0.85

Involvement of apoptotic cell death and cell cycle perturbation in retinoic acid-induced cleft palate in mice. Toxicol Appl Pharmacol (2007) 0.84

Thioredoxin, an anti-oxidant protein, protects mouse embryos from oxidative stress-induced developmental anomalies. Free Radic Res (2002) 0.83

Graphic and movie illustrations of human prenatal development and their application to embryological education based on the human embryo specimens in the Kyoto collection. Dev Dyn (2006) 0.83

Embryogenesis of fused umbilical arteries in human embryos. Am J Obstet Gynecol (2005) 0.83

Imaging of the human embryo with magnetic resonance imaging microscopy and high-resolution transvaginal 3-dimensional sonography: human embryology in the 21st century. Am J Obstet Gynecol (2010) 0.83

Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice. Dev Dyn (2008) 0.82

Formation of duodenal atresias in fibroblast growth factor receptor 2IIIb-/- mouse embryos occurs in the absence of an endodermal plug. J Pediatr Surg (2012) 0.82

Terminology of developmental abnormalities in common laboratory mammals (Version 2). Birth Defects Res B Dev Reprod Toxicol (2009) 0.82

Three-dimensional analysis of inner ear development in human embryos. Anat Sci Int (2007) 0.81

Three-dimensional ontogenetic shape changes in the human cranium during the fetal period. J Anat (2008) 0.81

A mesenchyme-free culture system to elucidate the mechanism of otic vesicle morphogenesis. J Anat (2004) 0.81

Expression of Fgf15 is regulated by both activator and repressor forms of Gli2 in vitro. Biochem Biophys Res Commun (2008) 0.81

Involvement of the axially condensed tail bud mesenchyme in normal and abnormal human posterior neural tube development. Congenit Anom (Kyoto) (2008) 0.81

Embryonic hydromyelia: cystic dilatation of the lumbosacral neural tube in human embryos. Acta Neuropathol (2001) 0.80

Roles of retinoic acid signaling in normal and abnormal development of the palate and tongue. Congenit Anom (Kyoto) (2014) 0.79

Transforming growth factor beta 2 promotes the formation of the mouse cochleovestibular ganglion in organ culture. Int J Dev Biol (2005) 0.79

Terminology of developmental abnormalities in common laboratory mammals (version 2). Congenit Anom (Kyoto) (2009) 0.79

Disruption of actin cytoskeleton and anchorage-dependent cell spreading induces apoptotic death of mouse neural crest cells cultured in vitro. Anat Rec A Discov Mol Cell Evol Biol (2005) 0.79

A quantitative study of the facial nerve in mice prenatally exposed to ethanol. Congenit Anom (Kyoto) (2003) 0.78

Stressor-like effects of cocaine on heat shock protein and stress-activated protein kinase expression in the rat hippocampus: interaction with ethanol and anti-toxicity drugs. Leg Med (Tokyo) (2003) 0.78

Methylnitrosourea induces neural progenitor cell apoptosis and microcephaly in mouse embryos. Birth Defects Res B Dev Reprod Toxicol (2010) 0.78

Expression dynamics of the LIM-homeobox genes, Lhx1 and Lhx9, in the diencephalon during chick development. Int J Dev Biol (2008) 0.78

Terminology of developmental abnormalities in common laboratory mammals (version 2). Reprod Toxicol (2009) 0.78

Computerized three-dimensional analysis of the heart and great vessels in normal and holoprosencephalic human embryos. Anat Rec (Hoboken) (2007) 0.77

Harmonization of description and classification of fetal observations: achievements and problems still unresolved: report of the 7th Workshop on the Terminology in Developmental Toxicology Berlin, 4-6 May 2011. Reprod Toxicol (2012) 0.77

Rudimentary claws and pigmented nail-like structures on the distal tips of the digits of Wnt7a mutant mice: Wnt7A suppresses nail-like structure development in mice. Birth Defects Res A Clin Mol Teratol (2010) 0.77

Organ culture of the fetal mouse palate for screening the developmental toxicity of chemicals: a validation study. Congenit Anom (Kyoto) (2004) 0.77

Analysis of Fibroblast growth factor 15 cis-elements reveals two conserved enhancers which are closely related to cardiac outflow tract development. Mech Dev (2006) 0.77

Isolated levocardia: prenatal diagnosis and management. Congenit Anom (Kyoto) (2009) 0.76

Signaling cascade coordinating growth of dorsal and ventral tissues of the vertebrate brain, with special reference to the involvement of Sonic Hedgehog signaling. Anat Sci Int (2005) 0.76

Unclassifiable craniosynostosis phenotypes, FGFR2 Trp290 mutations, acanthosis nigricans, and unpaired cysteine mutations. Am J Med Genet (2002) 0.75

Muscle patterning in mouse and human abdominal wall development and omphalocele specimens of humans. Anat Rec (Hoboken) (2012) 0.75

Comparative investigations of human and rat dermatoglyphics: palmar, plantar and digital pads and flexion creases. Anat Sci Int (2002) 0.75

Amniotic fluid induces rapid epithelialization in the experimentally ruptured fetal mouse palate--implications for fetal wound healing. Int J Dev Biol (2007) 0.75

Aberrant differentiation of the axially condensed tail bud mesenchyme in human embryos with lumbosacral myeloschisis. Anat Rec (Hoboken) (2007) 0.75

Ectopic dermal ridge configurations on the interdigital webbings and postaxial marginal portion of the hindlimb in Hammertoe mutant mice (Hm). J Morphol (2008) 0.75

Methamphetamine induces apoptosis in seminiferous tubules in male mice testis. Toxicol Appl Pharmacol (2002) 0.75

Microarray profile analysis of toxic cocaine-induced alterations in the expression of mouse brain gene sequences: a possible 'protective' effect of buprenorphine. J Appl Toxicol (2004) 0.75

Letter to the editor: Hidden pituitary gland: implications for assessment. Am J Med Genet A (2013) 0.75

Ectopic dermal ridge configurations on the interdigital webbings of Hammertoe mutant mice (Hm): another possible role of programmed cell death in limb development. Birth Defects Res A Clin Mol Teratol (2005) 0.75

Magnetic resonance microscopy of chemically fixed human embryos at high spatial resolution. Magn Reson Med Sci (2015) 0.75