Published in J Neurosci on May 01, 2002
CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. J Neurosci (2009) 2.69
Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci (2009) 1.88
A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. J Neuroinflammation (2007) 1.70
RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. FASEB J (2009) 1.39
Oxidative stress signaling in Alzheimer's disease. Curr Alzheimer Res (2008) 1.38
5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease. Ann Neurol (2012) 1.31
Ras and Rap signaling in synaptic plasticity and mental disorders. Neuroscientist (2010) 1.29
Role of redox signaling in neuroinflammation and neurodegenerative diseases. Biomed Res Int (2013) 1.25
Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease. J Biol Chem (2005) 1.25
Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice. Am J Pathol (2003) 1.24
Nuclear and cytosolic JNK signalling in neurons. Nat Rev Neurosci (2014) 1.17
The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS. Aging Dis (2010) 1.09
The Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease. J Signal Transduct (2012) 1.08
Neuroprotective strategies in Alzheimer's disease. NeuroRx (2004) 1.05
Dysregulation of mitogen-activated protein kinase signaling pathways in simian immunodeficiency virus encephalitis. Am J Pathol (2004) 1.04
Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. J Neurosci (2010) 1.04
Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα. Mol Neurodegener (2011) 1.03
In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice. PLoS One (2009) 1.02
Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease. Neurobiol Dis (2010) 1.01
Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J Neurochem (2007) 1.00
FoxO3a is activated and executes neuron death via Bim in response to β-amyloid. Cell Death Dis (2013) 0.96
c-Jun N-terminal kinase regulates soluble Aβ oligomers and cognitive impairment in AD mouse model. J Biol Chem (2011) 0.96
Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model. Mol Neurodegener (2010) 0.94
Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice. Am J Pathol (2006) 0.93
N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease. J Biol Chem (2010) 0.92
Pharmacotherapeutic targets in Alzheimer's disease. J Cell Mol Med (2008) 0.91
c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer's Disease. Front Pharmacol (2016) 0.90
The 12-15-lipoxygenase is a modulator of Alzheimer's-related tau pathology in vivo. Aging Cell (2013) 0.87
Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis. Biochim Biophys Acta (2006) 0.87
Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimer's disease. Mol Biol Cell (2009) 0.87
The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: in vivo and in vitro evidence. Biol Psychiatry (2013) 0.87
Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proc Natl Acad Sci U S A (2005) 0.86
A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesis. J Neurosci (2013) 0.85
The CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide. J Neuroinflammation (2011) 0.84
Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors. Eur J Neurosci (2011) 0.84
Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex. Neurobiol Dis (2007) 0.83
Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease. J Neurosci (2012) 0.82
p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer's disease. Acta Neuropathol Commun (2014) 0.81
p53-dependent SIRT6 expression protects Aβ42-induced DNA damage. Sci Rep (2016) 0.80
GSTT1 is upregulated by oxidative stress through p38-MK2 signaling pathway in human granulosa cells: possible association with mitochondrial activity. Aging (Albany NY) (2011) 0.80
Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple-transgenic mice. Mol Psychiatry (2015) 0.79
Involvement of JNK in the embryonic development and organogenesis in zebrafish. Mar Biotechnol (NY) (2013) 0.79
The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target. BMC Neurosci (2008) 0.79
Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis. Mol Cell Biol (2010) 0.79
In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells. Mol Neurodegener (2016) 0.78
Hippocampal Injections of Oligomeric Amyloid β-peptide (1-42) Induce Selective Working Memory Deficits and Long-lasting Alterations of ERK Signaling Pathway. Front Aging Neurosci (2016) 0.78
REGION-SPECIFIC NEURON AND SYNAPSE LOSS IN THE HIPPOCAMPUS OF APP(SL)/PS1 KNOCK-IN MICE. Transl Neurosci (2013) 0.77
Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice. Front Aging Neurosci (2015) 0.77
Are there roles for brain cell senescence in aging and neurodegenerative disorders? Biogerontology (2014) 0.76
Reduced cortical BACE1 content with one bout of exercise is accompanied by declines in AMPK, Akt, and MAPK signaling in obese, glucose-intolerant mice. J Appl Physiol (1985) (2015) 0.76
p38 MAPK Inhibition Improves Synaptic Plasticity and Memory in Angiotensin II-dependent Hypertensive Mice. Sci Rep (2016) 0.76
Psychostimulant-Induced Endoplasmic Reticulum Stress and Neurodegeneration. Mol Neurobiol (2016) 0.76
Early changes in behavior deficits, amyloid beta-42 deposits and MAPK activation in doubly transgenic mice co-expressing NSE-controlled human mutant PS2 and APPsw. Cell Mol Neurobiol (2005) 0.76
Inhibiting p38 mitogen-activated protein kinase attenuates cerebral ischemic injury in Swedish mutant amyloid precursor protein transgenic mice. Neural Regen Res (2012) 0.76
XG-102 administered to healthy male volunteers as a single intravenous infusion: a randomized, double-blind, placebo-controlled, dose-escalating study. Pharmacol Res Perspect (2014) 0.75
Alpha 1-Antichymotrypsin, an Inflammatory Protein Overexpressed in the Brains of Patients with Alzheimer's Disease, Induces Tau Hyperphosphorylation through c-Jun N-Terminal Kinase Activation. Int J Alzheimers Dis (2013) 0.75
Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase. Neural Plast (2017) 0.75
An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling. J Biol Chem (2016) 0.75
The Role of Presenilin-1 in the Excitotoxicity of Ethanol Withdrawal. J Pharmacol Exp Ther (2016) 0.75
3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone protects against beta amyloid-induced neurotoxicity through antioxidative activity and interference with cell signaling. BMC Complement Altern Med (2017) 0.75
DNA-PK and P38 MAPK: A Kinase Collusion in Alzheimer's Disease? Brain Disord Ther (2017) 0.75
Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury. Exp Neurol (2004) 2.21
AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice. Proc Natl Acad Sci U S A (2006) 1.74
De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers. Proc Natl Acad Sci U S A (2009) 1.58
De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications. Acc Chem Res (2010) 1.52
FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction. Neurobiol Aging (2002) 1.44
Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans. Arch Neurol (2007) 1.38
Antimicrobial activity of an abiotic host defense peptide mimic. Biochim Biophys Acta (2006) 1.27
Activity of an antimicrobial peptide mimetic against planktonic and biofilm cultures of oral pathogens. Antimicrob Agents Chemother (2007) 1.24
Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome. Exp Neurol (2005) 1.21
Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell Host Microbe (2012) 1.16
Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease. Neurobiol Aging (2005) 1.12
EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. Neuropharmacology (2011) 1.09
A transgenic rat model of Alzheimer's disease with extracellular Abeta deposition. Neurobiol Aging (2007) 1.08
Synthetic mimics of antimicrobial peptides with immunomodulatory responses. J Am Chem Soc (2012) 1.00
The roles of dopamine transport inhibition and dopamine release facilitation in wake enhancement and rebound hypersomnolence induced by dopaminergic agents. Sleep (2009) 0.92
Synthetic mimics of antimicrobial peptides from triaryl scaffolds. J Med Chem (2011) 0.88
Identification of synthetic host defense peptide mimics that exert dual antimicrobial and anti-inflammatory activities. Clin Vaccine Immunol (2012) 0.87
The novel α7 nicotinic acetylcholine receptor agonist EVP-6124 enhances dopamine, acetylcholine, and glutamate efflux in rat cortex and nucleus accumbens. Psychopharmacology (Berl) (2014) 0.87
Derivatives of human complement component C3 for therapeutic complement depletion: a novel class of therapeutic agents. Adv Exp Med Biol (2008) 0.86
Role of Amphiphilicity in the Design of Synthetic Mimics of Antimicrobial Peptides with Gram-negative Activity. ACS Med Chem Lett (2013) 0.86
CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-alpha release from lipopolysaccharide-treated cells and mice. Eur J Pharmacol (2005) 0.86
[F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment. Neurobiol Dis (2011) 0.85
New horizons for host defense peptides and lantibiotics. Curr Opin Pharmacol (2012) 0.84
A rapid gene delivery-based mouse model for early-stage Alzheimer disease-type tauopathy. J Neuropathol Exp Neurol (2013) 0.83
New bactericidal surgical suture coating. Langmuir (2012) 0.82
Amyloid deposition and advanced age fails to induce Alzheimer's type progression in a double knock-in mouse model. Aging Dis (2011) 0.82
CEP-26401 (irdabisant), a potent and selective histamine H₃ receptor antagonist/inverse agonist with cognition-enhancing and wake-promoting activities. J Pharmacol Exp Ther (2011) 0.81
Glycine transporter (GlyT1) inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice. Biochem Pharmacol (2010) 0.81
Protein tyrosine phosphatases are up-regulated and participate in cell death induced by polyglutamine expansion. J Biol Chem (2002) 0.80
De novo design of self-assembling foldamers that inhibit heparin-protein interactions. ACS Chem Biol (2014) 0.79
Armodafinil promotes wakefulness and activates Fos in rat brain. Pharmacol Biochem Behav (2009) 0.78
Anion mediated activation of guanidine rich small molecules. Org Biomol Chem (2011) 0.78
Molecular and biochemical characterisation of a serine acetyltransferase of onion, Allium cepa (L.). Phytochemistry (2005) 0.76
Identification of pyridazin-3-one derivatives as potent, selective histamine H₃ receptor inverse agonists with robust wake activity. Bioorg Med Chem Lett (2011) 0.75
Characterization of pharmacological and wake-promoting properties of the dopaminergic stimulant sydnocarb in rats. J Pharmacol Exp Ther (2011) 0.75
Continuous infusion of the α7 nicotinic acetylcholine receptor agonist EVP-6124 produces no signs of tolerance at memory-enhancing doses in rats: a pharmacokinetic and behavioral study. Behav Pharmacol (2015) 0.75