Published in Blood on June 01, 2002
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol (2007) 5.48
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Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population. Blood (2008) 1.28
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Quantitative trait analysis reveals transforming growth factor-beta2 as a positive regulator of early hematopoietic progenitor and stem cell function. J Exp Med (2004) 1.06
Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization. J Exp Med (2013) 1.02
Combining transcriptional profiling and genetic linkage analysis to uncover gene networks operating in hematopoietic stem cells and their progeny. Immunogenetics (2008) 0.90
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CD201 and CD27 identify hematopoietic stem and progenitor cells across multiple murine strains independently of Kit and Sca-1. Exp Hematol (2015) 0.87
Transforming growth factor-beta2 is involved in quantitative genetic variation in thymic involution. Blood (2005) 0.86
A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF-beta 2 responsiveness. J Immunol (2008) 0.83
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Mapping temporally varying quantitative trait loci in time-to-failure experiments. Genetics (2006) 0.79
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QTL analyses of lineage-negative mouse bone marrow cells labeled with Sca-1 and c-Kit. Mamm Genome (2008) 0.76
Quantitative trait gene Slit2 positively regulates murine hematopoietic stem cell numbers. Sci Rep (2016) 0.75
Measuring the aging process in stem cells. Methods Mol Biol (2015) 0.75
Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice. Stem Cell Reports (2017) 0.75
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet (2003) 3.96
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle. Development (2011) 2.99
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature (2013) 2.62
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell (2012) 2.60
Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones. Blood (2009) 2.58
CG dinucleotide clustering is a species-specific property of the genome. Nucleic Acids Res (2007) 2.48
The aging of lympho-hematopoietic stem cells. Nat Immunol (2002) 2.42
Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell (2012) 2.33
Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood (2005) 2.32
Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat Biotechnol (2011) 2.22
The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice. Nat Genet (2007) 2.17
The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood (2006) 2.10
Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways. Blood (2006) 1.98
Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells. Cancer Res (2003) 1.86
Prdm16 is a physiologic regulator of hematopoietic stem cells. Blood (2011) 1.86
Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A (2007) 1.86
G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands. Blood (2011) 1.82
Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proc Natl Acad Sci U S A (2007) 1.74
Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene. Proc Natl Acad Sci U S A (2009) 1.67
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell (2012) 1.54
TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells. J Clin Invest (2007) 1.53
Site-specific integration of adeno-associated virus involves partial duplication of the target locus. Proc Natl Acad Sci U S A (2009) 1.35
Increased hematopoietic stem cell mobilization in aged mice. Blood (2006) 1.34
Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica (2010) 1.34
Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms. Exp Hematol (2003) 1.31
The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress. Blood (2007) 1.22
Congenic interval of CD45/Ly-5 congenic mice contains multiple genes that may influence hematopoietic stem cell engraftment. Blood (2009) 1.18
p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death. Blood (2007) 1.18
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nat Med (2010) 1.16
Stem cells, aging, and cancer: inevitabilities and outcomes. Oncogene (2004) 1.15
Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell Stem Cell (2008) 1.15
Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element. Proc Natl Acad Sci U S A (2005) 1.15
Lin-Sca1+kit- bone marrow cells contain early lymphoid-committed precursors that are distinct from common lymphoid progenitors. J Immunol (2008) 1.14
A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover. Blood (2002) 1.13
Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses. Nat Nanotechnol (2013) 1.12
Effects of aging on hematopoietic stem and progenitor cells. Curr Opin Immunol (2009) 1.08
Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proc Natl Acad Sci U S A (2011) 1.07
Genetic control of stem-cell properties and stem cells in aging. Curr Opin Hematol (2003) 1.07
Quantitative trait analysis reveals transforming growth factor-beta2 as a positive regulator of early hematopoietic progenitor and stem cell function. J Exp Med (2004) 1.06
Mutagenic potential of temozolomide in bone marrow cells in vivo. Blood (2006) 1.06
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Aging of the microenvironment influences clonality in hematopoiesis. PLoS One (2012) 1.00
Influences of inbreeding and genetics on telomere length in mice. Mamm Genome (2002) 0.98
Altering AAV tropism with mosaic viral capsids. Mol Ther (2005) 0.96
Immunoaging induced by hematopoietic stem cell aging. Curr Opin Immunol (2011) 0.95
Aging stem cells, latexin, and longevity. Exp Cell Res (2008) 0.94
Cytidine deaminase genotype and toxicity of cytosine arabinoside therapy in children with acute myeloid leukemia. Br J Haematol (2008) 0.94
Evidence of mobilization of pluripotent stem cells into peripheral blood of patients with myocardial ischemia. Exp Hematol (2010) 0.92
The positive regulatory effect of TGF-beta2 on primitive murine hemopoietic stem and progenitor cells is dependent on age, genetic background, and serum factors. J Immunol (2004) 0.92
Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells. Cancer Res (2008) 0.92
E2F1 expression is deregulated and plays an oncogenic role in sporadic Burkitt's lymphoma. Cancer Res (2009) 0.92
Contribution of an aged microenvironment to aging-associated myeloproliferative disease. PLoS One (2012) 0.91
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Blood (2009) 0.88
Genetic analysis of progenitor cell mobilization by granulocyte colony-stimulating factor: verification and mechanisms for loci on murine chromosomes 2 and 11. Exp Hematol (2004) 0.87
R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. J Biol Chem (2011) 0.87
Transforming growth factor-beta2 is involved in quantitative genetic variation in thymic involution. Blood (2005) 0.86
RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors. J Exp Med (2013) 0.85
Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11. Mech Ageing Dev (2002) 0.84
Mouse strain determines cardiac growth potential. PLoS One (2013) 0.84
Progenitor cell origin plays a role in fate choices of mature B cells. J Immunol (2009) 0.83
A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF-beta 2 responsiveness. J Immunol (2008) 0.83
B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development. Proc Natl Acad Sci U S A (2014) 0.83
Analysis of the hematopoietic potential of muscle-derived cells in mice. Blood (2002) 0.83
Isolation of neural precursor cells from Alzheimer's disease and aged control postmortem brain. Neurobiol Aging (2005) 0.82
Quantitative trait locus (QTL) mapping in aging systems. Methods Mol Biol (2007) 0.81
Transduction of pancreatic islets with pseudotyped adeno-associated virus: effect of viral capsid and genome conversion. Transplantation (2005) 0.81
Age-related changes in niche cells influence hematopoietic stem cell function. Cell Stem Cell (2010) 0.81
Stem cells of the respiratory system: from identification to differentiation into functional epithelium. Bioessays (2012) 0.81
Targeting erythroblast-specific apoptosis in experimental anemia. Apoptosis (2008) 0.80
Comprehensive hematopoietic stem cell isolation methods. Methods Mol Biol (2013) 0.79
Identification and in vivo analysis of murine hematopoietic stem cells. Methods Enzymol (2010) 0.78
Transplantation and aging. Biol Blood Marrow Transplant (2006) 0.78
A quantitative trait locus on chr.4 regulates thymic involution. J Gerontol A Biol Sci Med Sci (2010) 0.77
Imaging hematopoietic stem cells in the marrow of long bones in vivo. Methods Mol Biol (2011) 0.77
Stem cells from birth to death: The history and the future. J Am Aging Assoc (2002) 0.77
Age-related accumulation of a novel CD44 + CD25lowgammadelta T-cell population in hematopoietic organs of the mouse. J Gerontol A Biol Sci Med Sci (2006) 0.76
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Novel approaches for immune reconstitution and adaptive immune modeling with human pluripotent stem cells. BMC Med (2011) 0.76
Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. EMBO J (2017) 0.75
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Possible leukemogenic potential of temozolomide. Pediatr Blood Cancer (2009) 0.75
Measuring the aging process in stem cells. Methods Mol Biol (2015) 0.75
Corrigendum: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nat Immunol (2017) 0.75