Published in Biochem J on October 01, 2002
Binding of calcium ions and SNAP-25 to the hexa EF-hand protein secretagogin. Biochem J (2007) 1.09
Ca2+ signaling in airway epithelial cells facilitates leukocyte recruitment and transepithelial migration. J Leukoc Biol (2009) 0.89
Characterization of a new p94-like calpain form in human lymphocytes. Biochem J (2003) 0.88
Electrostatic interactions of domain III stabilize the inactive conformation of mu-calpain. Biochem J (2004) 0.79
Calpeptin, not calpain, directly inhibits an ion channel of the inner mitochondrial membrane. Protoplasma (2015) 0.76
Homology modeling study of bovine μ-calpain inhibitor-binding domains. Int J Mol Sci (2014) 0.76
Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci U S A (1985) 68.48
Calcium binding and conformational response in EF-hand proteins. Trends Biochem Sci (1996) 3.13
Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes. Nat Struct Biol (1997) 1.96
Calpain: a protease in search of a function? Biochem Biophys Res Commun (1998) 1.82
Diversity of conformational states and changes within the EF-hand protein superfamily. Proteins (1999) 1.79
Crystal structure of calcium bound domain VI of calpain at 1.9 A resolution and its role in enzyme assembly, regulation, and inhibitor binding. Nat Struct Biol (1997) 1.78
The structure of calpain. J Biochem (2001) 1.70
Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation. EMBO J (1999) 1.70
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. Proc Natl Acad Sci U S A (2000) 1.65
A Ca(2+) switch aligns the active site of calpain. Cell (2002) 1.65
Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin? Bioessays (1992) 1.42
Domain III of calpain is a ca2+-regulated phospholipid-binding domain. Biochem Biophys Res Commun (2001) 1.22
Casein zymography: a method to study mu-calpain, m-calpain, and their inhibitory agents. Arch Biochem Biophys (1995) 1.21
Site-site communication in the EF-hand Ca2+-binding protein calbindin D9k. Nat Struct Biol (2000) 1.18
The EF-hand domain: a globally cooperative structural unit. Protein Sci (2002) 1.17
Solvation energetics and conformational change in EF-hand proteins. Protein Sci (2001) 1.08
Autolysis, Ca2+ requirement, and heterodimer stability in m-calpain. J Biol Chem (1997) 1.04
Recombinant calpain II: improved expression systems and production of a C105A active-site mutant for crystallography. Protein Eng (1995) 1.00
Dissociation and aggregation of calpain in the presence of calcium. J Biol Chem (2001) 0.98
Structure and physiology of calpain, an enigmatic protease. Biochem Biophys Res Commun (1998) 0.97
Roles of individual EF-hands in the activation of m-calpain by calcium. Biochem J (2000) 0.95
Calpain zymography with casein or fluorescein isothiocyanate casein. Methods Mol Biol (2000) 0.93
EF-hands embrace. Nat Struct Biol (1997) 0.90
Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system. Biochem J (1996) 0.88
Functional properties of recombinant calpain I and of mutants lacking domains III and IV of the catalytic subunit. J Biol Chem (1997) 0.86
Long-range effects on calcium binding and conformational change in the N-domain of calmodulin. Biochemistry (2001) 0.85
Dissociation of m-calpain subunits occurs after autolysis of the N-terminus of the catalytic subunit, and is not required for activation. J Biochem (2001) 0.84
Primary sequences of rat mu-calpain large and small subunits are, respectively, moderately and highly similar to those of human. Biochim Biophys Acta (1996) 0.83
Expression of m-calpain in Escherichia coli. Methods Mol Biol (2000) 0.80
Molecular and catalytic characterization of intact heterodimeric and derived monomeric calpains isolated under different conditions from pig polymorphonuclear leukocytes. Biochemistry (1988) 0.78
Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation. Protein Sci (2006) 3.73
Antifreeze proteins: an unusual receptor-ligand interaction. Trends Biochem Sci (2002) 1.89
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin. Nature (2008) 1.84
A Ca(2+) switch aligns the active site of calpain. Cell (2002) 1.65
An antifreeze protein folds with an interior network of more than 400 semi-clathrate waters. Science (2014) 1.65
Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain. Mol Cell Biol (2002) 1.64
Identification of an ITPase/XTPase in Escherichia coli by structural and biochemical analysis. Structure (2005) 1.63
Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis. J Biol Chem (2006) 1.54
Novel structure of the conserved gram-negative lipopolysaccharide transport protein A and mutagenesis analysis. J Mol Biol (2008) 1.47
Anchored clathrate waters bind antifreeze proteins to ice. Proc Natl Acad Sci U S A (2011) 1.45
Determination of peptide substrate specificity for mu-calpain by a peptide library-based approach: the importance of primed side interactions. J Biol Chem (2005) 1.44
Mechanism of bacterial cell-surface attachment revealed by the structure of cellulosomal type II cohesin-dockerin complex. Proc Natl Acad Sci U S A (2005) 1.43
Structural and biochemical evidence for an enzymatic quinone redox cycle in Escherichia coli: identification of a novel quinol monooxygenase. J Biol Chem (2004) 1.39
m-Calpain is required for preimplantation embryonic development in mice. BMC Dev Biol (2006) 1.37
Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines. J Clin Invest (2009) 1.37
Fluorescence microscopy evidence for quasi-permanent attachment of antifreeze proteins to ice surfaces. Biophys J (2007) 1.36
A hyperactive, Ca2+-dependent antifreeze protein in an Antarctic bacterium. FEMS Microbiol Lett (2005) 1.31
Crystal structure of beta-helical antifreeze protein points to a general ice binding model. Structure (2002) 1.28
The basis for hyperactivity of antifreeze proteins. Cryobiology (2006) 1.24
Glycine-rich antifreeze proteins from snow fleas. Science (2005) 1.23
Crystal structure of PhnH: an essential component of carbon-phosphorus lyase in Escherichia coli. J Bacteriol (2007) 1.22
Antifreeze protein from freeze-tolerant grass has a beta-roll fold with an irregularly structured ice-binding site. J Mol Biol (2012) 1.20
Structure of Escherichia coli tyrosine kinase Etk reveals a novel activation mechanism. EMBO J (2008) 1.20
Structure-function relationships in calpains. Biochem J (2012) 1.20
Development of α-helical calpain probes by mimicking a natural protein-protein interaction. J Am Chem Soc (2012) 1.18
Superheating of ice crystals in antifreeze protein solutions. Proc Natl Acad Sci U S A (2010) 1.17
A beta-helical antifreeze protein isoform with increased activity. Structural and functional insights. J Biol Chem (2002) 1.15
Identification of an Escherichia coli O157:H7 heme oxygenase with tandem functional repeats. Proc Natl Acad Sci U S A (2005) 1.14
Direct visualization of spruce budworm antifreeze protein interacting with ice crystals: basal plane affinity confers hyperactivity. Biophys J (2008) 1.14
Conditional disruption of ubiquitous calpains in the mouse. Genesis (2006) 1.13
Microfluidic experiments reveal that antifreeze proteins bound to ice crystals suffice to prevent their growth. Proc Natl Acad Sci U S A (2013) 1.12
Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs. Cancer Res (2007) 1.11
The odorant-binding proteins of Drosophila melanogaster: annotation and characterization of a divergent gene family. Gene (2002) 1.09
Hyperactive antifreeze protein in a fish. Nature (2004) 1.05
Identification of a disulfide switch in BsSco, a member of the Sco family of cytochrome c oxidase assembly proteins. Biochemistry (2005) 1.05
Crystal structure of the alpha-kinase domain of Dictyostelium myosin heavy chain kinase A. Sci Signal (2010) 1.04
A Ca2+-dependent bacterial antifreeze protein domain has a novel beta-helical ice-binding fold. Biochem J (2008) 1.04
A facile method for determining ice recrystallization inhibition by antifreeze proteins. Biochem Biophys Res Commun (2003) 1.04
Structural and biochemical analysis reveal pirins to possess quercetinase activity. J Biol Chem (2005) 1.03
Lateral transfer of a lectin-like antifreeze protein gene in fishes. PLoS One (2008) 1.03
Calpains mediate p53 activation and neuronal death evoked by DNA damage. J Biol Chem (2003) 1.02
Purification of antifreeze proteins by adsorption to ice. Biochem Biophys Res Commun (2003) 1.01
Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase. Nature (2010) 1.00
Autophosphorylation activates Dictyostelium myosin II heavy chain kinase A by providing a ligand for an allosteric binding site in the alpha-kinase domain. J Biol Chem (2010) 0.99
Structure of PhnP, a phosphodiesterase of the carbon-phosphorus lyase pathway for phosphonate degradation. J Biol Chem (2009) 0.99
Identification of the ice-binding face of a plant antifreeze protein. FEBS Lett (2009) 0.98
Targeting synuclein-gamma to counteract drug resistance in cancer. Expert Opin Ther Targets (2008) 0.98
Structure of the Escherichia coli O157:H7 heme oxygenase ChuS in complex with heme and enzymatic inactivation by mutation of the heme coordinating residue His-193. J Biol Chem (2006) 0.96
Spruce budworm antifreeze protein: changes in structure and dynamics at low temperature. J Mol Biol (2003) 0.96
The complex structure of calmodulin bound to a calcineurin peptide. Proteins (2008) 0.96
Identification of the ice-binding face of antifreeze protein from Tenebrio molitor. FEBS Lett (2002) 0.96
New insights into ice growth and melting modifications by antifreeze proteins. J R Soc Interface (2012) 0.94
Re-evaluation of a bacterial antifreeze protein as an adhesin with ice-binding activity. PLoS One (2012) 0.94
Compound ice-binding site of an antifreeze protein revealed by mutagenesis and fluorescent tagging. Biochemistry (2010) 0.94
Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode. Biochemistry (2006) 0.94
Insertion sequence 1 of muscle-specific calpain, p94, acts as an internal propeptide. J Biol Chem (2004) 0.94
Crystal structure of PhnZ in complex with substrate reveals a di-iron oxygenase mechanism for catabolism of organophosphonates. Proc Natl Acad Sci U S A (2014) 0.93
Emerging structural insights into bacterial tyrosine kinases. Trends Biochem Sci (2009) 0.93
X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors. J Med Chem (2008) 0.92
Calpain silencing by a reversible intrinsic mechanism. Nat Struct Biol (2003) 0.92
Structural modeling of snow flea antifreeze protein. Biophys J (2006) 0.92
The Thr- and Ala-rich hyperactive antifreeze protein from inchworm folds as a flat silk-like β-helix. Biochemistry (2011) 0.92
Crystal structure of an insect antifreeze protein and its implications for ice binding. J Biol Chem (2013) 0.91
Scaffoldin conformation and dynamics revealed by a ternary complex from the Clostridium thermocellum cellulosome. J Biol Chem (2012) 0.91
Analysis of ice-binding sites in fish type II antifreeze protein by quantum mechanics. Biophys J (2002) 0.91
A novel PCR strategy for high-efficiency, automated site-directed mutagenesis. Nucleic Acids Res (2005) 0.91
Chloramphenicol biosynthesis: the structure of CmlS, a flavin-dependent halogenase showing a covalent flavin-aspartate bond. J Mol Biol (2010) 0.91
The protease core of the muscle-specific calpain, p94, undergoes Ca2+-dependent intramolecular autolysis. FEBS Lett (2002) 0.90
Ice restructuring inhibition activities in antifreeze proteins with distinct differences in thermal hysteresis. Cryobiology (2010) 0.90
Ca2+ dependency of calpain 3 (p94) activation. Biochemistry (2006) 0.90
Crystal structure of a novel prokaryotic Ser/Thr kinase and its implication in the Cpx stress response pathway. Mol Microbiol (2007) 0.90
Modulator of drug activity B from Escherichia coli: crystal structure of a prokaryotic homologue of DT-diaphorase. J Mol Biol (2006) 0.90
Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells. Mol Cell Biol (2008) 0.89
Hyperactive antifreeze protein from winter flounder is a very long rod-like dimer of alpha-helices. J Biol Chem (2005) 0.89
Structural motif-based homology modeling of CYP27A1 and site-directed mutational analyses affecting vitamin D hydroxylation. Biophys J (2006) 0.89
Development of calpain-specific inactivators by screening of positional scanning epoxide libraries. J Biol Chem (2007) 0.89
Homodimerization of calpain 3 penta-EF-hand domain. Biochem J (2005) 0.89
Structure and mechanism of PhnP, a phosphodiesterase of the carbon-phosphorus lyase pathway. Biochemistry (2011) 0.89
Calpain activation by cooperative Ca2+ binding at two non-EF-hand sites. J Biol Chem (2003) 0.89
Crystal structure of a micro-like calpain reveals a partially activated conformation with low Ca2+ requirement. Structure (2003) 0.89
Ice-binding site of snow mold fungus antifreeze protein deviates from structural regularity and high conservation. Proc Natl Acad Sci U S A (2012) 0.89
Enhancing the activity of a beta-helical antifreeze protein by the engineered addition of coils. Biochemistry (2004) 0.88
Structural and biochemical characterization of gentisate 1,2-dioxygenase from Escherichia coli O157:H7. Mol Microbiol (2006) 0.88
Calpain is required for MMP-2 and u-PA expression in SV40 large T-antigen-immortalized cells. Biochem Biophys Res Commun (2002) 0.88
Insights into higher-order organization of the cellulosome revealed by a dissect-and-build approach: crystal structure of interacting Clostridium thermocellum multimodular components. J Mol Biol (2010) 0.88
Structure and dynamics of a beta-helical antifreeze protein. Biochemistry (2002) 0.87
Expression and purification of sea raven type II antifreeze protein from Drosophila melanogaster S2 cells. Protein Expr Purif (2005) 0.87
Calpastatin simultaneously binds four calpains with different kinetic constants. FEBS Lett (2007) 0.87
Novel dimeric β-helical model of an ice nucleation protein with bridged active sites. BMC Struct Biol (2011) 0.87
Elevated temperature and tyrosine iodination aid in the crystallization and structure determination of an antifreeze protein. Acta Crystallogr D Biol Crystallogr (2002) 0.86