Izumi Horikawa

Author PubWeight™ 40.83‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell 2005 6.79
2 Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol 2004 4.87
3 HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J 2004 4.26
4 MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. Proc Natl Acad Sci U S A 2009 3.64
5 p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence. Nat Cell Biol 2009 2.46
6 Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res 2008 2.45
7 Delayed kinetics of DNA double-strand break processing in normal and pathological aging. Aging Cell 2007 1.84
8 Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence. Epigenetics Chromatin 2008 1.50
9 Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells. Blood 2004 1.32
10 The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions. Oncogene 2002 1.22
11 p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes. J Clin Invest 2013 1.21
12 Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence. Nat Cell Biol 2010 1.14
13 Upregulation of the KIAA1199 gene is associated with cellular mortality. Cancer Lett 2005 1.10
14 Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence. Cancer Res 2007 1.04
15 Human papillomavirus E2 down-regulates the human telomerase reverse transcriptase promoter. J Biol Chem 2002 0.98
16 Telomerase as an important target of androgen signaling blockade for prostate cancer treatment. Mol Cancer Ther 2010 0.93
17 Identification of a </= 600-kb region on human chromosome 1q42.3 inducing cellular senescence. Oncogene 2003 0.91
18 Role of Ets/Id proteins for telomerase regulation in human cancer cells. Exp Mol Pathol 2003 0.89
19 Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PLoS One 2010 0.85
20 Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression system. Oncogene 2002 0.85
21 Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease. PLoS One 2012 0.85
22 Evidence for inactivation of distinct telomerase repressor genes in different types of human cancers. Int J Cancer 2005 0.77