1
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Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.
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Mol Biol Cell
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2005
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6.79
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2
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Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks.
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Nat Cell Biol
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2004
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4.87
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3
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HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.
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EMBO J
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2004
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4.26
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4
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MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.
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Proc Natl Acad Sci U S A
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2009
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3.64
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5
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p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence.
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Nat Cell Biol
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2009
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2.46
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6
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Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence.
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Cancer Res
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2008
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2.45
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7
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Delayed kinetics of DNA double-strand break processing in normal and pathological aging.
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Aging Cell
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2007
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1.84
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8
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Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence.
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Epigenetics Chromatin
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2008
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1.50
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9
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Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells.
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Blood
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2004
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1.32
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10
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The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions.
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Oncogene
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2002
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1.22
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11
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p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes.
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J Clin Invest
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2013
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1.21
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12
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Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.
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Nat Cell Biol
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2010
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1.14
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13
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Upregulation of the KIAA1199 gene is associated with cellular mortality.
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Cancer Lett
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2005
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1.10
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14
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Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.
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Cancer Res
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2007
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1.04
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15
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Human papillomavirus E2 down-regulates the human telomerase reverse transcriptase promoter.
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J Biol Chem
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2002
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0.98
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16
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Telomerase as an important target of androgen signaling blockade for prostate cancer treatment.
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Mol Cancer Ther
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2010
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0.93
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17
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Identification of a </= 600-kb region on human chromosome 1q42.3 inducing cellular senescence.
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Oncogene
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2003
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0.91
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18
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Role of Ets/Id proteins for telomerase regulation in human cancer cells.
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Exp Mol Pathol
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2003
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0.89
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19
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Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas.
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PLoS One
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2010
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0.85
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20
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Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression system.
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Oncogene
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2002
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0.85
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21
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Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.
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PLoS One
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2012
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0.85
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22
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Evidence for inactivation of distinct telomerase repressor genes in different types of human cancers.
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Int J Cancer
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2005
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0.77
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