Published in Protein Eng on May 01, 2002
Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes. J Virol (2011) 2.53
Structural basis of respiratory syncytial virus neutralization by motavizumab. Nat Struct Mol Biol (2010) 1.89
Functional interaction between paramyxovirus fusion and attachment proteins. J Biol Chem (2008) 1.78
Targeting a binding pocket within the trimer-of-hairpins: small-molecule inhibition of viral fusion. Proc Natl Acad Sci U S A (2004) 1.30
Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein. J Virol (2003) 1.28
Orally active fusion inhibitor of respiratory syncytial virus. Antimicrob Agents Chemother (2004) 1.26
Respiratory syncytial virus-neutralizing monoclonal antibodies motavizumab and palivizumab inhibit fusion. J Virol (2010) 1.03
Cholesterol-rich microdomains as docking platforms for respiratory syncytial virus in normal human bronchial epithelial cells. J Virol (2011) 1.02
Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms. Antimicrob Agents Chemother (2005) 0.96
Examination of a fusogenic hexameric core from human metapneumovirus and identification of a potent synthetic peptide inhibitor from the heptad repeat 1 region. J Virol (2006) 0.94
Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function. Virol J (2006) 0.91
Identification of antibody neutralization epitopes on the fusion protein of human metapneumovirus. J Gen Virol (2008) 0.87
Identification and evaluation of a highly effective fusion inhibitor for human metapneumovirus. Antimicrob Agents Chemother (2007) 0.84
Enlarged FAMSBASE: protein 3D structure models of genome sequences for 41 species. Nucleic Acids Res (2003) 0.81
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell (2005) 13.59
The structural biology of type I viral membrane fusion. Nat Rev Mol Cell Biol (2003) 4.21
Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc Natl Acad Sci U S A (2007) 3.41
BCL-2 family antagonists for cancer therapy. Nat Rev Drug Discov (2008) 3.24
To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions. Mol Cell (2008) 2.97
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. Cell (2013) 2.75
How insulin engages its primary binding site on the insulin receptor. Nature (2013) 2.52
Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III. J Mol Biol (2004) 2.33
Structure of the insulin receptor ectodomain reveals a folded-over conformation. Nature (2006) 2.22
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J Cell Biol (2008) 2.04
The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity (2012) 1.89
A designed ankyrin repeat protein evolved to picomolar affinity to Her2. J Mol Biol (2007) 1.71
Structure-guided design of a selective BCL-X(L) inhibitor. Nat Chem Biol (2013) 1.68
A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathog (2011) 1.61
Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain. J Am Chem Soc (2011) 1.49
A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak. Mol Cell (2007) 1.47
The insulin and EGF receptor structures: new insights into ligand-induced receptor activation. Trends Biochem Sci (2007) 1.37
Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists. Proc Natl Acad Sci U S A (2010) 1.36
High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angew Chem Int Ed Engl (2009) 1.34
Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells. J Biol Chem (2003) 1.33
Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor. Bioessays (2009) 1.24
Structural studies of the resistance of influenza virus neuramindase to inhibitors. J Med Chem (2002) 1.20
Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands. J Biol Chem (2009) 1.09
Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes. Proc Natl Acad Sci U S A (2011) 1.09
Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design. Chembiochem (2011) 1.04
Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins. J Biol Chem (2009) 1.03
Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. J Biol Chem (2011) 1.02
Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1. PLoS Pathog (2010) 1.02
α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase. Proc Natl Acad Sci U S A (2012) 0.99
The insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation. Bioessays (2013) 0.98
The X-ray structure of a hemipteran ecdysone receptor ligand-binding domain: comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design. J Biol Chem (2005) 0.98
N-linked glycans of the human insulin receptor and their distribution over the crystal structure. Proteins (2008) 0.97
Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine. J Mol Biol (2009) 0.95
Regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) expression by interleukin-1 beta in pancreatic beta cells. J Biol Chem (2010) 0.94
A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides. Biochemistry (2009) 0.94
Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells. Diabetes (2006) 0.93
Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor families. Curr Opin Struct Biol (2012) 0.90
Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum. Acta Crystallogr D Biol Crystallogr (2005) 0.88
Ecdysone receptors: from the Ashburner model to structural biology. Annu Rev Entomol (2012) 0.87
Landmarks in insulin research. Front Endocrinol (Lausanne) (2011) 0.86
Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms. J Mol Biol (2006) 0.86
Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins. Structure (2011) 0.86
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. J Med Chem (2013) 0.86
Evaluation of MicroRNA375 as a Novel Biomarker for Graft Damage in Clinical Islet Transplantation. Transplantation (2015) 0.83
Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins. J Virol (2012) 0.82
Alleviation of instant blood-mediated inflammatory reaction in autologous conditions through treatment of human islets with NF-κB inhibitors. Transplantation (2014) 0.79
De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization. J Med Chem (2014) 0.78
Tethered neuraminidase inhibitors that bind an influenza virus: a first step towards a diagnostic method for influenza. Angew Chem Int Ed Engl (2003) 0.78
Effect of the Duration of Chronic Pancreatitis on Pancreas Islet Yield and Metabolic Outcome Following Islet Autotransplantation. J Gastrointest Surg (2015) 0.77
Isoforms of the heteropteran Nezara viridula ecdysone receptor: protein characterisation, RH5992 insecticide binding and homology modelling. Pest Manag Sci (2011) 0.76
Monitoring of beta cell replacement outcomes. Panminerva Med (2016) 0.75
The Characteristics of Aborted Procedures in Total Pancreatectomy With Islet Autotransplantation for Chronic Pancreatitis. Pancreas (2017) 0.75
Current issues in allogeneic islet transplantation. Curr Opin Organ Transplant (2017) 0.75