Published in Methods Enzymol on January 01, 2002
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc Natl Acad Sci U S A (2007) 7.96
Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature (2008) 4.63
Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant. PLoS Biol (2012) 2.75
Prediction of drug-target interactions and drug repositioning via network-based inference. PLoS Comput Biol (2012) 2.63
Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization. Proc Natl Acad Sci U S A (2007) 2.51
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells. Nucleic Acids Res (2003) 2.49
Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell (2003) 2.48
Target hub proteins serve as master regulators of development in yeast. Genes Dev (2006) 2.39
A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences. Nucleic Acids Res (2006) 2.38
Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol. Microb Cell Fact (2008) 2.26
GRAS proteins form a DNA binding complex to induce gene expression during nodulation signaling in Medicago truncatula. Plant Cell (2009) 2.00
CER4 encodes an alcohol-forming fatty acyl-coenzyme A reductase involved in cuticular wax production in Arabidopsis. Plant Physiol (2006) 1.96
The Arabidopsis MATE transporter TT12 acts as a vacuolar flavonoid/H+ -antiporter active in proanthocyanidin-accumulating cells of the seed coat. Plant Cell (2007) 1.87
Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu. Am J Hum Genet (2006) 1.87
Prediction of Saccharomyces cerevisiae replication origins. Genome Biol (2004) 1.81
Yeast genome-wide screen reveals dissimilar sets of host genes affecting replication of RNA viruses. Proc Natl Acad Sci U S A (2005) 1.77
Plasma membrane microdomains regulate turnover of transport proteins in yeast. J Cell Biol (2008) 1.77
Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell (2009) 1.74
PHOSPHATE TRANSPORTER TRAFFIC FACILITATOR1 is a plant-specific SEC12-related protein that enables the endoplasmic reticulum exit of a high-affinity phosphate transporter in Arabidopsis. Plant Cell (2005) 1.71
The TOPLESS interactome: a framework for gene repression in Arabidopsis. Plant Physiol (2011) 1.71
A modified Saccharomyces cerevisiae strain that consumes L-Arabinose and produces ethanol. Appl Environ Microbiol (2003) 1.68
Synthesis-dependent strand annealing in meiosis. PLoS Biol (2007) 1.67
SEPALLATA3: the 'glue' for MADS box transcription factor complex formation. Genome Biol (2009) 1.65
Proteomics analysis of the tombusvirus replicase: Hsp70 molecular chaperone is associated with the replicase and enhances viral RNA replication. J Virol (2006) 1.64
Prp43p is a DEAH-box spliceosome disassembly factor essential for ribosome biogenesis. Mol Cell Biol (2006) 1.64
GTPase activity plays a key role in the pathobiology of LRRK2. PLoS Genet (2010) 1.63
Role of an internal and two 3'-terminal RNA elements in assembly of tombusvirus replicase. J Virol (2005) 1.63
A mutant of the Arabidopsis phosphate transporter PHT1;1 displays enhanced arsenic accumulation. Plant Cell (2007) 1.62
Natural isolates of Saccharomyces cerevisiae display complex genetic variation in sporulation efficiency. Genetics (2006) 1.60
Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor. Mol Biol Cell (2004) 1.59
Mitochondrial Iba57p is required for Fe/S cluster formation on aconitase and activation of radical SAM enzymes. Mol Cell Biol (2007) 1.59
Analyses of the effects of all ubiquitin point mutants on yeast growth rate. J Mol Biol (2013) 1.59
Extensive in vivo metabolite-protein interactions revealed by large-scale systematic analyses. Cell (2010) 1.58
Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity. Genes Dev (2005) 1.57
Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol. PLoS One (2010) 1.56
Severe infantile encephalomyopathy caused by a mutation in COX6B1, a nucleus-encoded subunit of cytochrome c oxidase. Am J Hum Genet (2008) 1.54
Rational diversification of a promoter providing fine-tuned expression and orthogonal regulation for synthetic biology. PLoS One (2012) 1.52
Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J (2011) 1.52
Engineering the substrate specificity of the DhbE adenylation domain by yeast cell surface display. Chem Biol (2013) 1.51
Furfural induces reactive oxygen species accumulation and cellular damage in Saccharomyces cerevisiae. Biotechnol Biofuels (2010) 1.51
A synthetic approach reveals extensive tunability of auxin signaling. Plant Physiol (2012) 1.50
Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation. Genes Dev (2008) 1.50
The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules. Mol Cell Biol (2005) 1.49
RNaseE and the other constituents of the RNA degradosome are components of the bacterial cytoskeleton. Proc Natl Acad Sci U S A (2007) 1.49
Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity. J Mol Biol (2006) 1.47
The SND proteins constitute an alternative targeting route to the endoplasmic reticulum. Nature (2016) 1.47
Development of a Comprehensive Genotype-to-Fitness Map of Adaptation-Driving Mutations in Yeast. Cell (2016) 1.47
Grapevine MATE-type proteins act as vacuolar H+-dependent acylated anthocyanin transporters. Plant Physiol (2009) 1.46
Arabidopsis thaliana transcription factors bZIP19 and bZIP23 regulate the adaptation to zinc deficiency. Proc Natl Acad Sci U S A (2010) 1.45
Engineering of Saccharomyces cerevisiae for efficient anaerobic alcoholic fermentation of L-arabinose. Appl Environ Microbiol (2007) 1.45
A major quantitative trait locus for cadmium tolerance in Arabidopsis halleri colocalizes with HMA4, a gene encoding a heavy metal ATPase. Plant Physiol (2007) 1.44
A YidC-like Protein in the Archaeal Plasma Membrane. Structure (2015) 1.44
Endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway. Mol Biol Cell (2006) 1.43
Dynamic and complex transcription factor binding during an inducible response in yeast. Genes Dev (2009) 1.43
Relationship of DFG16 to the Rim101p pH response pathway in Saccharomyces cerevisiae and Candida albicans. Eukaryot Cell (2005) 1.43
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol Syst Biol (2009) 1.43
Septin ring assembly requires concerted action of polarisome components, a PAK kinase Cla4p, and the actin cytoskeleton in Saccharomyces cerevisiae. Mol Biol Cell (2004) 1.42
Translation elongation factor 1A is a component of the tombusvirus replicase complex and affects the stability of the p33 replication co-factor. Virology (2009) 1.42
A molecular genetic toolbox for Yarrowia lipolytica. Biotechnol Biofuels (2017) 1.41
Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration. PLoS Pathog (2016) 1.40
SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling. Mol Biol Cell (2009) 1.39
Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL. J Mol Biol (2010) 1.37
Sensitivity to phosphonoacetic acid: a new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae. Genetics (2005) 1.36
Identification of essential host factors affecting tombusvirus RNA replication based on the yeast Tet promoters Hughes Collection. J Virol (2006) 1.36
Microtubule disruption stimulates P-body formation. RNA (2007) 1.35
Peptide inhibitor of cytokinesis during sporulation in Bacillus subtilis. Mol Microbiol (2008) 1.35
Non-DNA-binding cofactors enhance DNA-binding specificity of a transcriptional regulatory complex. Mol Syst Biol (2011) 1.34
Predicting essential genes in fungal genomes. Genome Res (2006) 1.34
Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein. RNA (2013) 1.34
Genome-wide screen identifies host genes affecting viral RNA recombination. Proc Natl Acad Sci U S A (2005) 1.34
Interactions between the S-domain receptor kinases and AtPUB-ARM E3 ubiquitin ligases suggest a conserved signaling pathway in Arabidopsis. Plant Physiol (2008) 1.34
Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. J Biol Chem (2008) 1.33
SEC18/NSF-independent, protein-sorting pathway from the yeast cortical ER to the plasma membrane. J Cell Biol (2005) 1.33
The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover. Genes Dev (2006) 1.32
The interaction between Sgt1p and Skp1p is regulated by HSP90 chaperones and is required for proper CBF3 assembly. Mol Cell Biol (2004) 1.32
The Arabidopsis multistress regulator TSPO is a heme binding membrane protein and a potential scavenger of porphyrins via an autophagy-dependent degradation mechanism. Plant Cell (2011) 1.31
DNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore. PLoS Genet (2008) 1.31
The role of Cdc55 in the spindle checkpoint is through regulation of mitotic exit in Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.30
A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2. Front Physiol (2010) 1.30
Protein kinase A regulates constitutive expression of small heat-shock genes in an Msn2/4p-independent and Hsf1p-dependent manner in Saccharomyces cerevisiae. Genetics (2004) 1.30
The Arabidopsis thaliana STYLISH1 protein acts as a transcriptional activator regulating auxin biosynthesis. Plant Cell (2010) 1.29
Codon-optimized bacterial genes improve L-Arabinose fermentation in recombinant Saccharomyces cerevisiae. Appl Environ Microbiol (2008) 1.29
Template-dependent 3'-5' nucleotide addition is a shared feature of tRNAHis guanylyltransferase enzymes from multiple domains of life. Proc Natl Acad Sci U S A (2009) 1.28
A genomic screen in yeast reveals novel aspects of nonstop mRNA metabolism. Genetics (2007) 1.26
Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Plant Physiol (2012) 1.26
In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination. Nucleic Acids Res (2005) 1.26
Specialized function of yeast Isa1 and Isa2 proteins in the maturation of mitochondrial [4Fe-4S] proteins. J Biol Chem (2011) 1.26
Directed evolution of pyruvate decarboxylase-negative Saccharomyces cerevisiae, yielding a C2-independent, glucose-tolerant, and pyruvate-hyperproducing yeast. Appl Environ Microbiol (2004) 1.25
CRISPR/Cas9: a molecular Swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae. FEMS Yeast Res (2015) 1.25
Unbiased selection of localization elements reveals cis-acting determinants of mRNA bud localization in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2005) 1.25
Analysis of iron-sulfur protein maturation in eukaryotes. Nat Protoc (2009) 1.25
High-temperature ethanol fermentation and transformation with linear DNA in the thermotolerant yeast Kluyveromyces marxianus DMKU3-1042. Appl Environ Microbiol (2008) 1.24
Intracellular protein interaction mapping with FRET hybrids. Proc Natl Acad Sci U S A (2006) 1.24
Screening of the yeast yTHC collection identifies essential host factors affecting tombusvirus RNA recombination. J Virol (2006) 1.23
The Arabidopsis P4-ATPase ALA3 localizes to the golgi and requires a beta-subunit to function in lipid translocation and secretory vesicle formation. Plant Cell (2008) 1.23
Metabolic engineering of the phenylpropanoid pathway in Saccharomyces cerevisiae. Appl Environ Microbiol (2005) 1.23
The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II. Mol Cell Proteomics (2010) 1.23
Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span. Eukaryot Cell (2008) 1.23
Malic acid production by Saccharomyces cerevisiae: engineering of pyruvate carboxylation, oxaloacetate reduction, and malate export. Appl Environ Microbiol (2008) 1.22
Two glucose/xylose transporter genes from the yeast Candida intermedia: first molecular characterization of a yeast xylose-H+ symporter. Biochem J (2006) 1.22
Yeast transformation by the LiAc/SS Carrier DNA/PEG method. Methods Mol Biol (2006) 2.58