Skin cancer in organ transplant recipients: Epidemiology, pathogenesis, and management.

PubWeight™: 3.20‹?› | Rank: Top 1%

🔗 View Article (PMID 12077575)

Published in J Am Acad Dermatol on July 01, 2002

Authors

Daniel Berg1, Clark C Otley

Author Affiliations

1: Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA, USA.

Associated clinical trials:

Fractional Laser-assisted Daylight Photodynamic Therapy Versus Daylight Photodynamic for Treatment of Actinic Keratoses | NCT01898936

Articles citing this

Increased risk for non-melanoma skin cancer in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol (2010) 2.80

From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. J Clin Invest (2012) 2.01

Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease. Gastroenterology (2012) 1.97

Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques. J Invest Dermatol (2010) 1.84

Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med (2008) 1.67

Non-AIDS-defining malignancies in HIV-infected persons: etiologic puzzles, epidemiologic perils, prevention opportunities. AIDS (2009) 1.64

Efficacy of an educational intervention with kidney transplant recipients to promote skin self-examination for squamous cell carcinoma detection. Arch Dermatol (2011) 1.51

Association Between Malignancy and Topical Use of Pimecrolimus. JAMA Dermatol (2015) 1.42

Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J Invest Dermatol (2009) 1.13

Histopathological variants of cutaneous squamous cell carcinoma: a review. J Skin Cancer (2010) 1.13

Roles of the immune system in skin cancer. Br J Dermatol (2011) 1.12

Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis. J Biol Chem (2010) 1.10

Melanoma in immunosuppressed patients. Mayo Clin Proc (2012) 1.07

Bowen's disease - a review of newer treatment options. Ther Clin Risk Manag (2008) 1.02

Pathogenesis of nonmelanoma skin cancers in organ transplant recipients. Arch Biochem Biophys (2011) 1.00

Malignancy after renal transplantation: the role of immunosuppression. Nat Rev Nephrol (2010) 0.98

Topical immunomodulation under systemic immunosuppression: results of a multicentre, randomized, placebo-controlled safety and efficacy study of imiquimod 5% cream for the treatment of actinic keratoses in kidney, heart, and liver transplant patients. Br J Dermatol (2007) 0.97

Keratotic skin lesions and other risk factors are associated with skin cancer in organ-transplant recipients: a case-control study in The Netherlands, United Kingdom, Germany, France, and Italy. J Invest Dermatol (2007) 0.97

Actinic keratosis treatment as a key component of preventive strategies for nonmelanoma skin cancer. J Clin Aesthet Dermatol (2010) 0.96

Genomic analysis of metastatic cutaneous squamous cell carcinoma. Clin Cancer Res (2015) 0.96

Cutaneous malignancies among HIV-infected persons. Arch Intern Med (2009) 0.96

Azathioprine. Safety profile in multiple sclerosis patients. Neurol Sci (2007) 0.93

Deregulation of XPC and CypA by cyclosporin A: an immunosuppression-independent mechanism of skin carcinogenesis. Cancer Prev Res (Phila) (2012) 0.92

Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E-selectin expression in human squamous cell carcinomas. J Invest Dermatol (2012) 0.92

Cyclosporine a mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: role of TGFβ signaling pathway. Mol Carcinog (2011) 0.91

Unbiased approach for virus detection in skin lesions. PLoS One (2013) 0.89

Risk of squamous cell skin cancer after organ transplant associated with antibodies to cutaneous papillomaviruses, polyomaviruses, and TMC6/8 (EVER1/2) variants. Cancer Med (2014) 0.88

Fitzpatrick skin phototype is an independent predictor of squamous cell carcinoma risk after solid organ transplantation. J Am Acad Dermatol (2012) 0.88

Regression of advanced melanoma upon withdrawal of immunosuppression: case series and literature review. Med Oncol (2009) 0.88

Risk factors for tumor occurrence in patients with myasthenia gravis. J Neurol (2009) 0.86

Increased Tc22 and Treg/CD8 ratio contribute to aggressive growth of transplant associated squamous cell carcinoma. PLoS One (2013) 0.85

Skin cancer in organ transplant recipients: more than the immune system. J Am Acad Dermatol (2014) 0.84

Skin Carcinogenesis Studies Using Mouse Models with Altered Polyamines. Cancer Growth Metastasis (2015) 0.84

Procarcinogenic effects of cyclosporine A are mediated through the activation of TAK1/TAB1 signaling pathway. Biochem Biophys Res Commun (2011) 0.83

Sun-protective behaviors in populations at high risk for skin cancer. Psychol Res Behav Manag (2013) 0.83

Benign and malignant skin lesions in renal transplant recipients. Indian J Dermatol (2009) 0.83

Calcineurin inhibitors reduce nuclear localization of transcription factor NFAT in UV-irradiated keratinocytes and reduce DNA repair. J Mol Histol (2006) 0.81

Voriconazole Exposure and Risk of Cutaneous Squamous Cell Carcinoma, Aspergillus Colonization, Invasive Aspergillosis and Death in Lung Transplant Recipients. Am J Transplant (2015) 0.80

Fingolimod Real World Experience: Efficacy and Safety in Clinical Practice. Neurosci J (2015) 0.80

The unintended effects of a boxed warning. J Clin Aesthet Dermatol (2009) 0.79

Progression of cancer from indolent to aggressive despite antigen retention and increased expression of interferon-gamma inducible genes. Cancer Immun (2011) 0.79

Distinct innate immune gene expression profiles in non-melanoma skin cancer of immunocompetent and immunosuppressed patients. PLoS One (2012) 0.79

Squamous cell carcinoma with aggressive subclinical extension: 5-year retrospective review of diagnostic predictors. J Am Acad Dermatol (2015) 0.78

The development of squamous cell carcinoma in a patient after kidney transplantation: a case report. Postepy Dermatol Alergol (2013) 0.78

Perceptions of Risk of Developing Skin Cancer for Diverse Audiences: Enhancing Relevance of Sun Protection to Reduce the Risk. J Cancer Educ (2016) 0.78

Effect of immunosuppressants tacrolimus and mycophenolate mofetil on the keratinocyte UVB response. Photochem Photobiol (2014) 0.78

Knowledge, understanding, and use of preventive strategies against nonmelanoma skin cancer in healthy and immunosuppressed individuals undergoing Mohs surgery. Dermatol Surg (2013) 0.78

Extrinsic aging: UV-mediated skin carcinogenesis. Dermatoendocrinol (2012) 0.78

Cohort profile: the skin cancer after organ transplant study. Int J Epidemiol (2012) 0.78

ACG Clinical Guideline: Preventive Care in Inflammatory Bowel Disease. Am J Gastroenterol (2017) 0.78

Differential expression of stromal MMP-1, MMP-9 and TIMP-1 in basal cell carcinomas of immunosuppressed patients and controls. Virchows Arch (2007) 0.77

Factors affecting sunscreen use and sun avoidance in a U.S. national sample of organ transplant recipients. Br J Dermatol (2013) 0.77

Neoplastic disease after liver transplantation: Focus on de novo neoplasms. World J Gastroenterol (2015) 0.77

Mucosal Candida infection and colonisation as well as associated risk factors in solid organ transplant recipients. Eur J Clin Microbiol Infect Dis (2009) 0.77

Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway. Cancer Prev Res (Phila) (2011) 0.77

Chromosomal aberrations in UVB-induced tumors of immunosuppressed mice. Genes Chromosomes Cancer (2009) 0.77

Use of photodynamic therapy for treatment of actinic keratoses in organ transplant recipients. Biomed Res Int (2012) 0.76

New agents for prevention of ultraviolet-induced nonmelanoma skin cancer. Semin Cutan Med Surg (2011) 0.76

Cyclosporine A immunosuppression drives catastrophic squamous cell carcinoma through IL-22. JCI Insight (2016) 0.76

Risk of non-melanoma skin cancer in autoimmune hepatitis. Dig Dis Sci (2010) 0.76

Yearly Burden of Skin Cancer in Non-Caucasian and Caucasian Solid-organ Transplant Recipients. J Clin Aesthet Dermatol (2015) 0.75

Solar elastosis in its papular form: uncommon, mistakable. Case Rep Dermatol (2014) 0.75

Advances in the management of cutaneous squamous cell carcinoma. F1000Prime Rep (2014) 0.75

Squamous cell carcinomas escape immune surveillance via inducing chronic activation and exhaustion of CD8+ T Cells co-expressing PD-1 and LAG-3 inhibitory receptors. Oncotarget (2016) 0.75

Comparison of the incidence of skin cancers in patients on dialysis and after kidney transplantation. Postepy Dermatol Alergol (2017) 0.75

Skin Cancer in the Crosshairs: Highlights from the Biennial Scientific Retreat of International Transplant Skin Cancer Collaborative and Skin Care in Organ Transplant Recipients Europe. Transplant Direct (2015) 0.75

Molecular signaling cascades involved in nonmelanoma skin carcinogenesis. Biochem J (2016) 0.75

Ultraviolet radiation-induced differential microRNA expression in the skin of hairless SKH1 mice, a widely used mouse model for dermatology research. Oncotarget (2016) 0.75

Eyelid carcinoma in patients with systemic lymphoma. J Ophthalmic Vis Res (2010) 0.75

Viruses in case series of tumors: Consistent presence in different cancers in the same subject. PLoS One (2017) 0.75

Recurrent and metastatic squamous cell carcinoma in lung transplant recipient on voriconazole: Lessons learned. JAAD Case Rep (2015) 0.75

Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation. Cell Signal (2016) 0.75

Kaposi sarcoma in an patient with atopic dermatitis treated with ciclosporin. BMJ Case Rep (2013) 0.75

Updates on Psoriasis and Cutaneous Oncology: Proceedings from the 2015 MauiDerm Meeting. J Clin Aesthet Dermatol (2015) 0.75

Withdrawal of immunosuppressive therapy after developing melanoma. J Am Acad Dermatol (2004) 0.75

Malignant and noninvasive skin tumours in renal transplant recipients. Dermatol Res Pract (2014) 0.75

Risk of skin cancer in patients with diabetes mellitus: A nationwide retrospective cohort study in Taiwan. Medicine (Baltimore) (2016) 0.75

Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study. Biomed Res Int (2015) 0.75

Type 2 diabetes mellitus and risk of cutaneous squamous cell carcinoma. J Am Acad Dermatol (2016) 0.75

Interleukin-22 and Cyclosporine in Aggressive Cutaneous Squamous Cell Carcinoma. Dermatol Clin (2017) 0.75

Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation. Cancer Med (2016) 0.75

Variants at the OCA2/HERC2 locus affect time to first cutaneous squamous cell carcinoma in solid organ transplant recipients collected using two different study designs. Br J Dermatol (2017) 0.75

Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders. J Clin Med (2017) 0.75

Cutaneous squamous cell carcinoma of the scalp in the immunocompromised patient: review of 53 cases. Oral Maxillofac Surg (2016) 0.75

Articles by these authors

Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years. JAMA (2005) 5.52

Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol (2010) 2.83

In-transit melanoma: an individualized approach. Oncology (Williston Park) (2011) 2.24

Adjuvant local irradiation for Merkel cell carcinoma. Arch Dermatol (2006) 1.76

Clinical outcome of cutaneous flaps versus full-thickness skin grafts after Mohs surgery on the nose. Dermatol Surg (2009) 1.41

Antibiotic prophylaxis in dermatologic surgery: updated guidelines. Dermatol Surg (2005) 1.38

Complications With New Oral Anticoagulants Dabigatran and Rivaroxaban in Cutaneous Surgery. Dermatol Surg (2015) 1.38

Botulinum toxin to improve facial wound healing: A prospective, blinded, placebo-controlled study. Mayo Clin Proc (2006) 1.17

In-transit metastasis from primary cutaneous squamous cell carcinoma in organ transplant recipients and nonimmunosuppressed patients: clinical characteristics, management, and outcome in a series of 21 patients. Dermatol Surg (2004) 1.12

A meta-analysis of the prognostic significance of sentinel lymph node status in Merkel cell carcinoma. Dermatol Surg (2002) 1.11

Chronic lymphocytic leukemia is associated with decreased survival of patients with malignant melanoma and Merkel cell carcinoma in a SEER population-based study. J Clin Oncol (2012) 1.10

Defining the clinical course of metastatic skin cancer in organ transplant recipients: a multicenter collaborative study. Arch Dermatol (2003) 1.09

A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: creation and rationale for inclusion of tumor (T) characteristics. J Am Acad Dermatol (2011) 1.06

Comparison of mohs micrographic surgery and wide excision for extramammary Paget's disease. Dermatol Surg (2003) 1.05

Prognostic factors in Merkel cell carcinoma: analysis of 240 cases. J Am Acad Dermatol (2012) 1.00

Unknown primary Merkel cell carcinoma: 23 new cases and a review. J Am Acad Dermatol (2012) 0.98

Increased metastasis and mortality from cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia. J Am Acad Dermatol (2005) 0.98

Malignant melanoma in solid transplant recipients: collection of database cases and comparison with surveillance, epidemiology, and end results data for outcome analysis. Arch Dermatol (2011) 0.97

Incidence of and risk factors for skin cancer after heart transplant. Arch Dermatol (2009) 0.97

Immunosuppression and skin cancer: pathogenetic insights, therapeutic challenges, and opportunities for innovation. Arch Dermatol (2002) 0.95

More than 2 decades of treating atypical fibroxanthoma at mayo clinic: what have we learned from 91 patients? Dermatol Surg (2008) 0.95

The predictive value of imaging studies in evaluating regional lymph node involvement in Merkel cell carcinoma. J Am Acad Dermatol (2012) 0.94

High recurrence rates of squamous cell carcinoma after Mohs' surgery in patients with chronic lymphocytic leukemia. Dermatol Surg (2005) 0.92

Mohs' micrographic surgery for basal-cell carcinoma of the face. Lancet (2005) 0.92

Cost-effectiveness of Mohs micrographic surgery vs surgical excision for basal cell carcinoma of the face. Arch Dermatol (2006) 0.92

Outcomes of melanoma in recipients of solid organ transplant. J Am Acad Dermatol (2008) 0.92

Thrombotic complications related to discontinuation of warfarin and aspirin therapy perioperatively for cutaneous operation. J Am Acad Dermatol (2003) 0.91

Educational outcomes regarding skin cancer in organ transplant recipients: Randomized intervention of intensive vs standard education. Arch Dermatol (2006) 0.90

Antibiotic prophylaxis in dermatologic surgery: advisory statement 2008. J Am Acad Dermatol (2008) 0.90

Role of multiple scouting biopsies before Mohs micrographic surgery for extramammary Paget's disease. Dermatol Surg (2005) 0.88

Prognostic factors for life expectancy in nonagenarians with nonmelanoma skin cancer: implications for selecting surgical candidates. J Am Acad Dermatol (2002) 0.86

High recurrence rates of Basal cell carcinoma after mohs surgery in patients with chronic lymphocytic leukemia. Arch Dermatol (2004) 0.85

Natural history of merkel cell carcinoma following locoregional recurrence. Ann Surg Oncol (2012) 0.84

Surgical Management of Hidradenitis Suppurativa: Outcomes of 590 Consecutive Patients. Dermatol Surg (2016) 0.84

Comparison of full-thickness skin grafts versus second-intention healing for Mohs defects of the helix. Dermatol Surg (2015) 0.83

Primary closure vs second-intention treatment of skin punch biopsy sites: a randomized trial. Arch Dermatol (2005) 0.83

A Comparison of Mohs Micrographic Surgery and Wide Local Excision for Treatment of Dermatofibrosarcoma Protuberans With Long-Term Follow-up: The Mayo Clinic Experience. Dermatol Surg (2016) 0.81

Complications of cutaneous surgery in patients taking clopidogrel-containing anticoagulation. J Am Acad Dermatol (2011) 0.81

Patient preferences for facial sunscreens: a split-face, randomized, blinded trial. J Am Acad Dermatol (2007) 0.81

Perioperative management of anticoagulants and platelet inhibitors for cutaneous surgery: a survey of current practice. Dermatol Surg (2002) 0.80

Specialty clinics for the dermatologic care of solid-organ transplant recipients. Dermatol Surg (2004) 0.80

Characteristics of sebaceous carcinoma and early outcomes of treatment using Mohs micrographic surgery versus wide local excision: an update of the Mayo Clinic experience over the past 2 decades. Dermatol Surg (2014) 0.79

Melanocytes in nonlesional sun-exposed skin: a multicenter comparative study. J Am Acad Dermatol (2011) 0.79

Randomized controlled trial of acitretin versus placebo in patients at high-risk for basal cell or squamous cell carcinoma of the skin (North Central Cancer Treatment Group Study 969251). Cancer (2011) 0.79

Chemotherapy in the management of advanced cutaneous squamous cell carcinoma in organ transplant recipients: theoretical and practical considerations. Dermatol Surg (2004) 0.79

The effects of sirolimus on wound healing in dermatologic surgery. Dermatol Surg (2007) 0.79

Upstaging From Melanoma in Situ to Invasive Melanoma on the Head and Neck After Complete Surgical Resection. Dermatol Surg (2015) 0.78

Comparison of MITF and Melan-A Immunohistochemistry During Mohs Surgery for Lentigo Maligna-Type Melanoma In Situ and Lentigo Maligna Melanoma. Dermatol Surg (2016) 0.77

Allograft and overall survival of patients with posttransplant skin cancer. Dermatol Surg (2011) 0.77

Lymphocytic infiltrates and subclinical epithelial tumor extension in patients with chronic leukemia and solid-organ transplantation. Dermatol Surg (2003) 0.77

Five-year outcomes of wide excision and Mohs micrographic surgery for primary lentigo maligna in an academic practice cohort. Dermatol Surg (2015) 0.77

The use of oral midazolam for perioperative anxiolysis of healthy patients undergoing Mohs surgery: conclusions from randomized controlled and prospective studies. J Am Acad Dermatol (2011) 0.76

Cutaneous surgeons cannot predict blood-thinner status by intraoperative visual inspection. Plast Reconstr Surg (2002) 0.76

Excision vs Mohs surgery for basal cell carcinoma. Arch Facial Plast Surg (2003) 0.75

Wide local excision or mohs micrographic surgery for primary dermatofibrosarcoma protuberans. Am J Clin Oncol (2011) 0.75

Effect of Non-Hodgkin Lymphoma on Survival in Patients With Malignant Fibrous Histiocytoma, Kaposi Sarcoma, and Sebaceous Carcinoma: A SEER Population-Based Study. Dermatol Surg (2016) 0.75

Skin cancer after pancreas transplantation. J Am Acad Dermatol (2012) 0.75

Oxidized regenerated cellulose gauze for hemostasis of a two-stage interpolation flap pedicle. Dermatol Surg (2004) 0.75

The use of pulsed dye laser in the treatment of melanoma metastatic to the skin: a Mayo Clinic case series. J Am Acad Dermatol (2010) 0.75

Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013. Dermatol Surg (2015) 0.75

Megasession: excision of numerous skin cancers in a single session. Dermatol Surg (2005) 0.75

Outcomes of basal cell carcinomas directly invading the parotid gland. Dermatol Surg (2015) 0.75

Surgical Treatment and Outcomes of Patients With Extramammary Paget Disease: A Cohort Study. Dermatol Surg (2017) 0.75

Pacemakers and implantable cardiac defibrillators in dermatologic surgery. Dermatol Surg (2006) 0.75

Erythematous plaques on the flexural surfaces. Arch Dermatol (2005) 0.75

Patient Satisfaction and Quality of Life Following Surgery for Hidradenitis Suppurativa. Dermatol Surg (2017) 0.75

Atypical fibroxanthoma in the setting of chronic lymphocytic leukemia and other non-Hodgkin lymphomas. Dermatol Surg (2011) 0.75

Thomas B Fitzpatrick MD: 1948-51: the residency years and preparation for doctoral thesis: Mayo Clinic. J Invest Dermatol (2004) 0.75

Complications of systemic retinoid therapy in organ transplant recipients with squamous cell carcinoma. Dermatol Surg (2004) 0.75