Published in J Neurosci on July 01, 2002
Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke. Nature (2010) 5.24
GABA A receptors: subtypes provide diversity of function and pharmacology. Neuropharmacology (2008) 3.49
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A (2004) 3.21
Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes. Nat Rev Drug Discov (2011) 2.65
Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease. Neuron (2012) 2.40
Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. J Neurosci (2008) 2.27
The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci (2009) 2.12
Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation. Am J Physiol Lung Cell Mol Physiol (2011) 1.92
Structure, function, and modulation of GABA(A) receptors. J Biol Chem (2012) 1.91
Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction. Psychopharmacology (Berl) (2003) 1.86
The GABAergic deficit hypothesis of major depressive disorder. Mol Psychiatry (2010) 1.80
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Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates. Proc Natl Acad Sci U S A (2005) 1.71
Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia. Trends Pharmacol Sci (2011) 1.49
The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning. Nat Neurosci (2008) 1.46
Training-induced changes in the expression of GABAA-associated genes in the amygdala after the acquisition and extinction of Pavlovian fear. Eur J Neurosci (2007) 1.43
Activated radixin is essential for GABAA receptor alpha5 subunit anchoring at the actin cytoskeleton. EMBO J (2006) 1.39
Abuse and dependence liability of benzodiazepine-type drugs: GABA(A) receptor modulation and beyond. Pharmacol Biochem Behav (2008) 1.36
GABAA receptor RDL inhibits Drosophila olfactory associative learning. Neuron (2007) 1.35
Synaptic and nonsynaptic localization of GABAA receptors containing the alpha5 subunit in the rat brain. J Comp Neurol (2006) 1.30
Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses. Proc Natl Acad Sci U S A (2003) 1.28
TDCS guided using fMRI significantly accelerates learning to identify concealed objects. Neuroimage (2010) 1.27
13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice. Proc Natl Acad Sci U S A (2004) 1.26
Behavioral and neural analysis of GABA in the acquisition, consolidation, reconsolidation, and extinction of fear memory. Neuropsychopharmacology (2010) 1.23
Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta. J Neurosci (2006) 1.23
GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism. Annu Rev Pharmacol Toxicol (2013) 1.20
RO4938581, a novel cognitive enhancer acting at GABAA alpha5 subunit-containing receptors. Psychopharmacology (Berl) (2008) 1.17
Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice. J Psychopharmacol (2011) 1.16
Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure. Neuropharmacology (2010) 1.15
GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus. J Neurophysiol (2008) 1.14
Hooked on benzodiazepines: GABAA receptor subtypes and addiction. Trends Neurosci (2011) 1.13
Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear. Mol Pharmacol (2005) 1.10
GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders. Neuropharmacology (2009) 1.09
Mechanisms Underlying Tolerance after Long-Term Benzodiazepine Use: A Future for Subtype-Selective GABA(A) Receptor Modulators? Adv Pharmacol Sci (2012) 1.08
In the rat, chronic intermittent ethanol exposure during adolescence alters the ethanol sensitivity of tonic inhibition in adulthood. Alcohol Clin Exp Res (2011) 1.07
Memory deficits induced by inflammation are regulated by α5-subunit-containing GABAA receptors. Cell Rep (2012) 1.06
PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. Brain Res (2008) 1.05
Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits. Learn Mem (2012) 1.05
Anti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptors. Psychopharmacology (Berl) (2005) 1.04
An inverse agonist selective for alpha5 subunit-containing GABAA receptors improves encoding and recall but not consolidation in the Morris water maze. Psychopharmacology (Berl) (2006) 1.04
Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors. Br J Pharmacol (2005) 1.03
Recent advances in prion chemotherapeutics. Infect Disord Drug Targets (2009) 1.03
Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities. Neural Plast (2012) 1.00
Alpha 5 subunit-containing GABAA receptors affect the dynamic range of mouse hippocampal kainate-induced gamma frequency oscillations in vitro. J Physiol (2004) 1.00
Cyclothiazide potently inhibits gamma-aminobutyric acid type A receptors in addition to enhancing glutamate responses. Proc Natl Acad Sci U S A (2003) 1.00
Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice. PLoS One (2012) 1.00
Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J Neurochem (2011) 0.99
A novel GABA(A) receptor pharmacology: drugs interacting with the α(+) β(-) interface. Br J Pharmacol (2012) 0.98
Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer's [corrected] disease model. Nat Commun (2014) 0.98
Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice. J Neurosci (2014) 0.98
GABA(A) Receptor Dynamics and Constructing GABAergic Synapses. Front Mol Neurosci (2008) 0.97
Benzodiazepine dependence and its treatment with low dose flumazenil. Br J Clin Pharmacol (2014) 0.96
Consequences of the evolution of the GABA(A) receptor gene family. Cell Mol Neurobiol (2005) 0.96
Distinct maturation profiles of perisomatic and dendritic targeting GABAergic interneurons in the mouse primary visual cortex during the critical period of ocular dominance plasticity. J Neurophysiol (2011) 0.96
The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats. Int J Neuropsychopharmacol (2009) 0.96
Gene expression changes in GABA(A) receptors and cognition following chronic ketamine administration in mice. PLoS One (2011) 0.94
Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations. Drug Des Devel Ther (2014) 0.93
Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication. Neuropharmacology (2012) 0.90
A novel variant in GABRB2 associated with intellectual disability and epilepsy. Am J Med Genet A (2014) 0.90
Contribution of alpha1 subunit-containing gamma-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeys. Psychopharmacology (Berl) (2008) 0.89
Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference. J Neurosci (2015) 0.89
The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats. Behav Pharmacol (2012) 0.89
Effects of chronic exposure to an anabolic androgenic steroid cocktail on alpha5-receptor-mediated GABAergic transmission and neural signaling in the forebrain of female mice. Neuroscience (2009) 0.88
Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling. Am J Physiol Lung Cell Mol Physiol (2015) 0.87
The role of synaptic ion channels in synaptic plasticity. EMBO Rep (2006) 0.87
Effects of post-training hippocampal injections of midazolam on fear conditioning. Learn Mem (2005) 0.86
Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats. Psychopharmacology (Berl) (2011) 0.85
The neurobiology of mouse models syntenic to human chromosome 15q. J Neurodev Disord (2011) 0.85
Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model. Adv Pharmacol Sci (2011) 0.85
Amnestic concentrations of etomidate modulate GABAA,slow synaptic inhibition in hippocampus. Anesthesiology (2009) 0.85
Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors. Neuropsychopharmacology (2015) 0.84
Identification and characterization of anesthetic targets by mouse molecular genetics approaches. Can J Anaesth (2010) 0.84
Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition. J Pharmacol Exp Ther (2010) 0.84
α4βδ GABAA receptors and tonic inhibitory current during adolescence: effects on mood and synaptic plasticity. Front Neural Circuits (2013) 0.84
Genes and signaling pathways involved in memory enhancement in mutant mice. Mol Brain (2014) 0.84
Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory. Nat Commun (2015) 0.83
Novel discriminative stimulus effects of TPA023B, subtype-selective gamma-aminobutyric-acid(A)/benzodiazepine modulator: comparisons with zolpidem, lorazepam, and TPA023. Pharmacol Biochem Behav (2008) 0.83
Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys. Psychopharmacology (Berl) (2010) 0.83
alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation. Neuropharmacology (2009) 0.83
Age-dependent remodelling of inhibitory synapses onto hippocampal CA1 oriens-lacunosum moleculare interneurons. J Physiol (2011) 0.83
Flavonoids as GABAA receptor ligands: the whole story? J Exp Pharmacol (2012) 0.82
Neurosteroids and GABA-A Receptor Function. Front Endocrinol (Lausanne) (2011) 0.82
Behavioral effects of the benzodiazepine-positive allosteric modulator SH-053-2'F-S-CH₃ in an immune-mediated neurodevelopmental disruption model. Int J Neuropsychopharmacol (2015) 0.82
GABA transport modulates the ethanol sensitivity of tonic inhibition in the rat dentate gyrus. Alcohol (2011) 0.82
Bidirectional effects of benzodiazepine binding site ligands on active avoidance acquisition and retention: differential antagonism by flumazenil and beta-CCt. Psychopharmacology (Berl) (2005) 0.82
Allosteric modulation of GABA(A) receptor subtypes:effects on visual recognition and visuospatial working memory in rhesus monkeys [corrected]. Neuropsychopharmacology (2013) 0.82
Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation. Psychopharmacology (Berl) (2013) 0.81
Acutely increasing δGABA(A) receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus. Front Neural Circuits (2013) 0.81
Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor. Neuropharmacology (2015) 0.81
Exogenous melatonin reproduces the effects of short day lengths on hippocampal function in male white-footed mice, Peromyscus leucopus. Neuroscience (2013) 0.81
The role of α5 GABAA receptor agonists in the treatment of cognitive deficits in schizophrenia. Curr Pharm Des (2014) 0.81
Hyperpolarization-activated current (In) is reduced in hippocampal neurons from Gabra5-/- mice. PLoS One (2013) 0.81
Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells. J Neurosci (2015) 0.81
TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav Brain Res (2014) 0.81
Pathophysiological power of improper tonic GABA(A) conductances in mature and immature models. Front Neural Circuits (2013) 0.81
The influence of stress at puberty on mood and learning: role of the α4βδ GABAA receptor. Neuroscience (2012) 0.81
Adolescent alcohol exposure alters GABAA receptor subunit expression in adult hippocampus. Alcohol Clin Exp Res (2014) 0.80
PWZ-029, an inverse agonist selective for α₅ GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats. Behav Brain Res (2012) 0.80
Genetic analysis of GABRB3 as a candidate gene of autism spectrum disorders. Mol Autism (2014) 0.79
Implications of GABAergic Neurotransmission in Alzheimer's Disease. Front Aging Neurosci (2016) 0.79
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science (2005) 5.20
Functional genomic analysis of the AUXIN RESPONSE FACTOR gene family members in Arabidopsis thaliana: unique and overlapping functions of ARF7 and ARF19. Plant Cell (2005) 4.41
Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain (2007) 3.88
CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms. Nat Immunol (2007) 3.31
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A (2004) 3.21
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. J Pharmacol Exp Ther (2004) 2.83
Arabidopsis reactome: a foundation knowledgebase for plant systems biology. Plant Cell (2008) 2.50
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. J Med Chem (2004) 2.46
Functional genomic analysis of the AUXIN/INDOLE-3-ACETIC ACID gene family members in Arabidopsis thaliana. Plant Cell (2005) 2.27
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol (2003) 2.27
NMDA receptor pathways as drug targets. Nat Neurosci (2002) 2.20
A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. J Pharmacol Exp Ther (2004) 2.17
Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA. Bioorg Med Chem Lett (2006) 2.17
Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics. J Neurosci (2005) 2.03
Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms. J Neurosci (2003) 1.97
Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proc Natl Acad Sci U S A (2009) 1.87
Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia. Curr Top Med Chem (2006) 1.77
Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. J Neurosci (2005) 1.75
Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates. Proc Natl Acad Sci U S A (2005) 1.71
HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage. Nat Neurosci (2009) 1.67
TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates. J Pharmacol Exp Ther (2005) 1.61
gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions. Biochem Pharmacol (2004) 1.52
LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 1.50
Reducing safety-related drug attrition: the use of in vitro pharmacological profiling. Nat Rev Drug Discov (2012) 1.47
L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors. Neuropharmacology (2006) 1.46
The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells. J Physiol (2007) 1.42
Inhibition of tumor growth progression by antiandrogens and mTOR inhibitor in a Pten-deficient mouse model of prostate cancer. Cancer Res (2009) 1.41
Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide]. J Pharmacol Exp Ther (2005) 1.32
The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse. J Pharmacol Exp Ther (2006) 1.31
Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. J Med Chem (2003) 1.29
Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors. Proc Natl Acad Sci U S A (2010) 1.27
Group III metabotropic glutamate-receptor-mediated modulation of excitatory transmission in rodent substantia nigra pars compacta dopamine neurons. J Pharmacol Exp Ther (2005) 1.24
Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta. J Neurosci (2006) 1.23
Dual in vivo quantification of integrin-targeted and protease-activated agents in cancer using fluorescence molecular tomography (FMT). Mol Imaging Biol (2009) 1.21
Neonatal development of the rat visual cortex: synaptic function of GABAA receptor alpha subunits. J Physiol (2002) 1.20
Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane. J Neurosci (2004) 1.18
Normative data for pH of exhaled breath condensate. Chest (2006) 1.17
Reducing abuse liability of GABAA/benzodiazepine ligands via selective partial agonist efficacy at alpha1 and alpha2/3 subtypes. J Pharmacol Exp Ther (2009) 1.16
Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin. J Pharmacol Exp Ther (2002) 1.16
The complexity of the GABAA receptor shapes unique pharmacological profiles. Drug Discov Today (2009) 1.16
The neuropathological basis of clinical progression in multiple sclerosis. Acta Neuropathol (2011) 1.14
Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves. Science (2007) 1.14
Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones. J Physiol (2007) 1.10
Impact of indoor residual spraying with lambda-cyhalothrin on malaria parasitemia and anemia prevalence among children less than five years of age in an area of intense, year-round transmission in Malawi. Am J Trop Med Hyg (2012) 1.10
Discrete forms of amylose are synthesized by isoforms of GBSSI in pea. Plant Cell (2002) 1.09
A transglucosidase necessary for starch degradation and maltose metabolism in leaves at night acts on cytosolic heteroglycans (SHG). Plant J (2006) 1.05
Up-beat UK: a programme of research into the relationship between coronary heart disease and depression in primary care patients. BMC Fam Pract (2011) 1.05
Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS. Eur J Neurosci (2007) 1.04
Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors. Br J Pharmacol (2005) 1.03
Identification of acid reflux cough using serial assays of exhaled breath condensate pH. Cough (2006) 1.03
Repair of incisional hernias with biological prosthesis: a systematic review of current evidence. Am J Surg (2012) 1.03
Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers. J Med Chem (2004) 1.02
An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. J Med Chem (2004) 1.01
HIV risk behaviors of male and female jail inmates prior to incarceration and one year post-release. AIDS Behav (2013) 1.00
Oxytocin regulates neurosteroid modulation of GABA(A) receptors in supraoptic nucleus around parturition. J Neurosci (2003) 1.00
Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1. Proc Natl Acad Sci U S A (2005) 0.99
Changes in cardiovascular function after venlafaxine but not pregabalin in healthy volunteers: a double-blind, placebo-controlled study of orthostatic challenge, blood pressure and heart rate. Hum Psychopharmacol (2013) 0.98
Increased nuclear factor-erythroid 2 p45-related factor 2 activity protects SH-SY5Y cells against oxidative damage. J Neurochem (2005) 0.97
The synthesis and preclinical evaluation in rhesus monkey of [¹⁸F]MK-6577 and [¹¹C]CMPyPB glycine transporter 1 positron emission tomography radiotracers. Synapse (2011) 0.96
Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors. Mol Pharmacol (2002) 0.96
Concordance of CCR5 genotypes that influence cell-mediated immunity and HIV-1 disease progression rates. J Infect Dis (2011) 0.96
6-Sulphated chondroitins have a positive influence on axonal regeneration. PLoS One (2011) 0.95
Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. J Psychopharmacol (2006) 0.94
A quantitative volumetric micro-computed tomography method to analyze lung tumors in genetically engineered mouse models. Neoplasia (2009) 0.94
Recent progress in the discovery of non-sarcosine based GlyT1 inhibitors. Curr Top Med Chem (2010) 0.93
Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders. J Med Chem (2006) 0.93
Discrete expression of TRPV2 within the hypothalamo-neurohypophysial system: Implications for regulatory activity within the hypothalamic-pituitary-adrenal axis. J Comp Neurol (2004) 0.92
Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther (2010) 0.92
Role of GABAA alpha5-containing receptors in ethanol reward: the effects of targeted gene deletion, and a selective inverse agonist. Eur J Pharmacol (2005) 0.92
Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides. ChemMedChem (2006) 0.91
The role of GABAbeta2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole. Eur J Neurosci (2006) 0.90
A pilot randomised controlled trial of personalised care for depressed patients with symptomatic coronary heart disease in South London general practices: the UPBEAT-UK RCT protocol and recruitment. BMC Psychiatry (2012) 0.90
In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. Psychopharmacology (Berl) (2009) 0.90
Characterization and localization of a human serine racemase. Brain Res Mol Brain Res (2004) 0.90
Assaying all of the nitrogen oxides in breath modifies the interpretation of exhaled nitric oxide. Vascul Pharmacol (2005) 0.90
In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232. J Pharmacol Exp Ther (2013) 0.90
Ex vivo imaging of pancreatic beta cells using a radiolabeled GLP-1 receptor agonist. Mol Imaging Biol (2012) 0.90
Effects of ginsenosides on GABA(A) receptor channels expressed in Xenopus oocytes. Arch Pharm Res (2003) 0.89
The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells. J Physiol (2003) 0.89
Development of subtype selective GABAA modulators. CNS Spectr (2005) 0.89
A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety. J Med Chem (2006) 0.89