Pharmacophore model for novel inhibitors of ubiquitin isopeptidases that induce p53-independent cell death.

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🔗 View Article (PMID 12130688)

Published in Mol Pharmacol on August 01, 2002

Authors

J E Mullally1, F A Fitzpatrick

Author Affiliations

1: Huntsman Cancer Institute, Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112-5550, USA.

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Cyclooxygenase-2 and carcinogenesis. Biochim Biophys Acta (2000) 1.95

Anaphylactic release of thromboxane A2, prostaglandin D2, and prostacyclin from human lung parenchyma. Am Rev Respir Dis (1981) 1.86

Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. J Biol Chem (1983) 1.52

Albumin stabilizes leukotriene A4. J Biol Chem (1982) 1.35

Convergence of hormones, inflammation, and energy-related factors: a novel pathway of cancer etiology. Cancer Prev Res (Phila) (2009) 1.32

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The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity. J Biol Chem (1994) 1.27

Inhibition of phospholipase C dependent processes by U-73, 122. Adv Prostaglandin Thromboxane Leukot Res (1989) 1.27

Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes. J Biol Chem (1991) 1.26

Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry. J Biol Chem (1986) 1.23

Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles. Carcinogenesis (2006) 1.20

Prostaglandin E2 and thromboxane B2 in cerebrospinal fluid of afebrile and febrile cat. Am J Physiol (1983) 1.19

Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor. Oncogene (2007) 1.15

Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway. J Biol Chem (2001) 1.15

Redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3 and antagonizes their transcriptional repressor function. J Biol Chem (2010) 1.13

6,9-deepoxy-6,9,-(phenylimino)-delta 6,8-prostaglandin I1, (U-60,257), a new inhibitor of leukotriene C and D synthesis: in vitro studies. Prostaglandins (1982) 1.12

Virus and interferon effects on cellular prostaglandin biosynthesis. J Immunol (1980) 1.12

Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril. J Biol Chem (1991) 1.11

Synthesis and structure of the platelet aggregation factor thromboxane A2. Nature (1985) 1.09

Erythrocyte-neutrophil interactions: formation of leukotriene B4 by transcellular biosynthesis. Proc Natl Acad Sci U S A (1986) 1.08

The stability of 13,14-dihydro-15 keto-PGE2. Prostaglandins (1980) 1.05

Acetyl glyceryl ether phosphorylcholine. Intravascular alterations following intravenous infusion into the baboon. Lab Invest (1981) 1.04

Tyrosine kinase activity modulates catalysis and translocation of cellular 5-lipoxygenase. J Biol Chem (1996) 1.02

9,11-epoxyiminoprosta-5,13-dienoic acid is a thromboxane A2 antagonist in human platelets. Nature (1978) 1.00

Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins. Proc Natl Acad Sci U S A (2000) 0.99

Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein translation. J Biol Chem (2005) 0.99

5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins. J Biol Chem (1994) 0.98

A radioimmunoassay for thromboxane B2. Anal Biochem (1977) 0.98

Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids. J Biol Chem (1992) 0.97

Prostaglandin D2 formation by malignant melanoma cells correlates inversely with cellular metastatic potential. Proc Natl Acad Sci U S A (1979) 0.95

Hapten mimic elicits antibodies recognizing prostaglandin E2. Proc Natl Acad Sci U S A (1978) 0.94

A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid. Two selective thromboxane synthetase inhibitors. Biochim Biophys Acta (1978) 0.94

Taxane-mediated gene induction is independent of microtubule stabilization: induction of transcription regulators and enzymes that modulate inflammation and apoptosis. Proc Natl Acad Sci U S A (1998) 0.94

In vivo suppression of prostaglandin biosynthesis by non-steroidal anti-inflammatory agents. Prostaglandins (1976) 0.93

Mechanism-based inactivation of leukotriene A4 hydrolase during leukotriene B4 formation by human erythrocytes. J Biol Chem (1990) 0.92

Taxanes propagate apoptosis via two cell populations with distinctive cytological and molecular traits. Cell Growth Differ (1998) 0.91

Albumin-eicosanoid interactions. A model system to determine their attributes and inhibition. J Biol Chem (1984) 0.91

Albumins stabilize prostaglandin I2. Prostaglandins (1980) 0.91

Albumin-lipid interactions: prostaglandin stability as a probe for characterizing binding sites on vertebrate albumins. Biochemistry (1981) 0.90

Conditional expression of 15-lipoxygenase-1 inhibits the selenoenzyme thioredoxin reductase: modulation of selenoproteins by lipoxygenase enzymes. J Biol Chem (2004) 0.89

Epoxyeicosatrienoic acids inhibit Ca2+ entry into platelets stimulated by thapsigargin and thrombin. J Biol Chem (1992) 0.89

Irreversible inactivation of 5-lipoxygenase by leukotriene A4. Characterization of product inactivation with purified enzyme and intact leukocytes. J Biol Chem (1994) 0.88

In vivo and in vitro actions of a new selective inhibitor of leukotriene C and D synthesis. Adv Prostaglandin Thromboxane Leukot Res (1983) 0.88

"Suicide" inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets. J Biol Chem (1990) 0.87

Reciprocal regulation of human platelet cAMP levels by thromboxane A2 and prostacyclin. Adv Cyclic Nucleotide Res (1978) 0.87

A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E1 and E2: an indirect index of their in vivo disposition and pharmacokinetics. J Pharmacol Exp Ther (1982) 0.87

Modification of leukotriene A(4) hydrolase/aminopeptidase by sulfhydryl-blocking reagents: differential effects on dual enzyme activities by methyl-methane thiosulfonate. Arch Biochem Biophys (1999) 0.87

Inhibition of human platelet thromboxane synthetase by 9,11-azoprosta-5,13-dienoic acid. Proc Natl Acad Sci U S A (1977) 0.87

Mechanism-based inactivation of leukotriene A4 hydrolase/aminopeptidase by leukotriene A4. Mass spectrometric and kinetic characterization. J Biol Chem (1992) 0.86

Human neutrophil activation with interleukin-1. A role for intracellular calcium and arachidonic acid lipoxygenation. Biochem Pharmacol (1987) 0.86

Albumins activate peptide hydrolysis by the bifunctional enzyme LTA4 hydrolase/aminopeptidase. Biochemistry (1992) 0.85

Leukotriene A4-hydrolase activity in guinea pig and human liver. Biochim Biophys Acta (1985) 0.85

"Suicide" inactivation of prostaglandin I2 synthase: characterization of mechanism-based inactivation with isolated enzyme and endothelial cells. Arch Biochem Biophys (1995) 0.85

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Platelet rich plasma transforms exogenous prostaglandin endoperoxide H2 into thromboxane A2. Prostaglandins (1977) 0.85

Opioid peptides are substrates for the bifunctional enzyme LTA4 hydrolase/aminopeptidase. Prostaglandins (1992) 0.84

Effect of taxol and taxotere on gene expression in macrophages: induction of the prostaglandin H synthase-2 isoenzyme. J Immunol (1999) 0.84

A radioimmunoassay for thromboxane B2. Methods Enzymol (1982) 0.83

Nitric oxide modulates the activity of the hemoproteins prostaglandin I2 synthase and thromboxane A2 synthase. Arch Biochem Biophys (1997) 0.83

Cyclooxygenase-2 induction by paclitaxel, docetaxel, and taxane analogues in human monocytes and murine macrophages: structure-activity relationships and their implications. Clin Cancer Res (2002) 0.83

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5-Lipoxygenase compartmentalization in granulocytic cells is modulated by an internal bipartite nuclear localizing sequence and nuclear factor kappa B complex formation. Arch Biochem Biophys (1998) 0.82

Regulatory role of cyclic adenosine 3',5'-monophosphate on the platelet cyclooxygenase and platelet function. Biochim Biophys Acta (1979) 0.82

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A comparison of absorption-inhibition and absorption-elution methods in the detection of ABO(H) antigens found in vaginal samples submitted in sexual offense cases. J Forensic Sci (1978) 0.82

Arachidonic acid metabolites do not mediate modulation of neurotransmitter release by adenosine in rat hippocampus or striatum. Brain Res (1990) 0.82

A rapid, solid phase radioimmunoassay for prostaglandin F2alpha and its main circulating metabolite. Anal Biochem (1976) 0.82

Comparison between circulating interferon and drug levels following administration of 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP) to different animal species. J Interferon Res (1982) 0.81

Prostaglandin D2 controls pulmonary metastasis of malignant melanoma cells. Nature (1979) 0.81

Leukotriene-induced contraction and thromboxane production in guinea-pig lung parenchymal strips. Eur J Pharmacol (1984) 0.81

High-performance liquid chromatographic assay for prostacyclin. J Chromatogr (1979) 0.81

Thromboxane B2 (TxB2) release following acetyl glyceryl ether phosphorylcholine (AGEPC) infusion in the rabbit. Immunopharmacology (1983) 0.81

Pharmacology of synthetic thromboxane A2. Adv Prostaglandin Thromboxane Leukot Res (1987) 0.81

Phase I study of 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP), an oral interferon inducer, in cancer patients. J Biol Response Mod (1986) 0.80

Glass capillary gas chromatography with electron-capture detection. Separation of prostaglandins. J Chromatogr (1979) 0.79

Inhibition of mitogen-activated protein kinase kinase blocks activation and redistribution of 5-lipoxygenase in HL-60 cells. Arch Biochem Biophys (1996) 0.79

Arachidonic acid and 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid modulate human polymorphonuclear neutrophil activation by monocyte derived neutrophil activating factor. Biochem Biophys Res Commun (1987) 0.79

Electron capture gas chromatographic detection of thromboxane B2. Prostaglandins (1977) 0.79

Modulation of pulmonary leukotriene formation and perfusion pressure by bestatin, an inhibitor of leukotriene A4 hydrolase. Biochem Pharmacol (1994) 0.79

Cardiovascular and renal actions of cytochrome P-450 metabolites of arachidonic acid. Blood Vessels (1989) 0.78

Oximes for high performance liquid and electron capture gas chromatography of prostaglandins and thromboxanes. Anal Chem (1977) 0.78

A selective thromboxane synthetase inhibitor blocks the cAMP lowering activity of PGH2. Biochem Biophys Res Commun (1977) 0.78

14, 15-cis-episulfide-eicosatrienoic acid, an 'epoxygenase' eicosanoid analog, inhibits ionophore- but not thrombin-induced platelet aggregation. Mol Pharmacol (1991) 0.77

Radioimmunologic determination of 15-keto-13,14-dihydro-PGE2: a method for its stable degradation product, 11-deoxy-15-keto-13,14-dihydro-11 beta, 16 xi-cyclo-PGE2. Methods Enzymol (1982) 0.77

Sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate (U-63557A), a new, selective thromboxane synthase inhibitor: intravenous and oral pharmacokinetics in dogs and correlations with ex situ thromboxane B2 production. Prostaglandins (1983) 0.77

Prostacyclin biosynthesis in activated, stimulated and normal mouse peritoneal cell populations. Prostaglandins (1978) 0.77

Transcellular biosynthesis of eicosanoids. Pharmacol Res (1989) 0.77

Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding protein 2. Anal Biochem (1995) 0.77

Thromboxane A2 synthase. Modification during "suicide" inactivation. J Biol Chem (1991) 0.77

Determination of leukotriene C4 by radioimmunoassay with a specific antiserum generated from a synthetic hapten mimic. Anal Chem (1984) 0.77

An antiserum against 9,11-azo-15-hydroxyprosta-5,13-dienoic acid recognises and binds prostaglandin endoperoxides. Nature (1978) 0.75

Gas chromatography of the prostaglandins. Adv Prostaglandin Thromboxane Res (1978) 0.75

An antiserum against 9-deoxy-6,9-epoxy-PGF1alpha recognizes and binds PGI2 (prostacyclin). Prostaglandins (1978) 0.75

Stream Sediment Sources in Midwest Agricultural Basins with Land Retirement along Channel. J Environ Qual (2014) 0.75

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Thromboxane A2 synthesis in human erythroleukemia cells. Biochem Biophys Res Commun (1991) 0.75

Some observations on vaginal phosphoglucomutase. J Forensic Sci (1978) 0.75

Leukotriene B4 biosynthesis by erythrocyte-neutrophil interactions. Methods Enzymol (1990) 0.75