Published in Nat Immunol on July 29, 2002
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A (2003) 4.89
AID mediates hypermutation by deaminating single stranded DNA. J Exp Med (2003) 3.24
The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell (2009) 2.42
Proteasomal degradation restricts the nuclear lifespan of AID. J Exp Med (2008) 1.80
Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled. Proc Natl Acad Sci U S A (2004) 1.79
A coming-of-age story: activation-induced cytidine deaminase turns 10. Nat Immunol (2009) 1.68
DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination. J Exp Med (2004) 1.59
Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate. PLoS Biol (2004) 1.56
Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a). Proc Natl Acad Sci U S A (2003) 1.55
Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation. J Exp Med (2007) 1.46
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination. EMBO J (2003) 1.46
Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells. J Virol (2005) 1.40
Complex regulation and function of activation-induced cytidine deaminase. Trends Immunol (2011) 1.36
AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation. Immunity (2003) 1.32
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes. Proc Natl Acad Sci U S A (2012) 1.26
The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1. Proc Natl Acad Sci U S A (2004) 1.24
AIDing antibody diversity by error-prone mismatch repair. Semin Immunol (2012) 1.10
Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate. Nucleic Acids Res (2004) 1.07
Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination. J Clin Invest (2003) 1.06
DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase. Proc Natl Acad Sci U S A (2005) 1.05
Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation. J Exp Med (2006) 1.03
Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines. DNA Repair (Amst) (2006) 1.03
RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells. Proc Natl Acad Sci U S A (2003) 1.02
Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase. J Exp Med (2012) 1.00
Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair. J Clin Immunol (2003) 0.99
Ongoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells. J Immunol (2002) 0.98
Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses. Proc Natl Acad Sci U S A (2004) 0.95
Class-switch recombination: after the dawn of AID. Curr Opin Immunol (2003) 0.95
Involvement of Rad18 in somatic hypermutation. Proc Natl Acad Sci U S A (2006) 0.94
A novel human B cell subpopulation representing the initial germinal center population to express AID. Blood (2006) 0.94
DNA-dependent protein kinase inhibits AID-induced antibody gene conversion. PLoS Biol (2007) 0.94
Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias. Mol Immunol (2007) 0.93
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo. Proc Natl Acad Sci U S A (2009) 0.92
E2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification. J Immunol (2009) 0.92
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase. Proc Natl Acad Sci U S A (2013) 0.92
Does AID need another aid? Nat Immunol (2002) 0.91
The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs. Mol Cell Biol (2009) 0.88
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation. Proc Natl Acad Sci U S A (2011) 0.87
V(H) replacement in rearranged immunoglobulin genes. Immunology (2005) 0.87
Diversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion. Mol Med (2003) 0.87
Overlapping hotspots in CDRs are critical sites for V region diversification. Proc Natl Acad Sci U S A (2015) 0.84
Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. J Biol Chem (2009) 0.84
Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues. Eur J Immunol (2008) 0.83
Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity. Nat Rev Immunol (2016) 0.82
DNA replication to aid somatic hypermutation. Adv Exp Med Biol (2007) 0.82
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase. Proc Natl Acad Sci U S A (2014) 0.82
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability. Nat Commun (2016) 0.81
Complex downstream effects of nuclear export inhibition in B-cell lymphomas: a possible role for activation-induced cytidine deaminase (AID). Haematologica (2013) 0.81
TGF-β suppression of HBV RNA through AID-dependent recruitment of an RNA exosome complex. PLoS Pathog (2015) 0.80
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination. Proc Natl Acad Sci U S A (2014) 0.80
DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations. DNA Repair (Amst) (2013) 0.80
Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases. DNA Repair (Amst) (2015) 0.80
Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinoma. PLoS One (2013) 0.79
The cell cycle restricts activation-induced cytidine deaminase activity to early G1. J Exp Med (2016) 0.78
Refining the Neuberger model: Uracil processing by activated B cells. Eur J Immunol (2014) 0.78
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase. Proc Natl Acad Sci U S A (2015) 0.78
A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation. PLoS One (2008) 0.78
The chick chorioallantoic membrane as an in vivo xenograft model for Burkitt lymphoma. BMC Cancer (2014) 0.77
Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas. Cell Commun Signal (2012) 0.77
The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated. Mol Immunol (2010) 0.76
Novel antibody switching defects in human patients. J Clin Invest (2003) 0.75
Mutagenesis by AID: Being in the Right Place at the Right Time. PLoS Genet (2015) 0.75
Activation-Induced Cytidine Deaminase Does Not Impact Murine Meiotic Recombination. G3 (Bethesda) (2013) 0.75
Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood (2004) 5.10
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J (2002) 4.17
Multiple layers of B cell memory with different effector functions. Nat Immunol (2009) 3.33
Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo. Immunity (2006) 2.50
Human marginal zone B cells. Annu Rev Immunol (2009) 2.48
8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins. Nature (2007) 2.32
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse. J Exp Med (2005) 2.13
Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota. Nature (2002) 2.04
Proteasomal degradation restricts the nuclear lifespan of AID. J Exp Med (2008) 1.80
Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants. J Exp Med (2008) 1.75
DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse. J Exp Med (2006) 1.74
Expression of the AID protein in normal and neoplastic B cells. Blood (2004) 1.73
IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients. Blood (2012) 1.65
DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination. J Exp Med (2004) 1.59
Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. Mol Cell Biol (2009) 1.54
Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu. Immunity (2003) 1.53
The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells. Blood (2008) 1.48
Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line. DNA Repair (Amst) (2008) 1.40
Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation. J Immunol (2002) 1.38
Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency. J Clin Invest (2012) 1.35
A human equivalent of mouse B-1 cells? J Exp Med (2011) 1.30
DNA polymerases in adaptive immunity. Nat Rev Immunol (2008) 1.22
B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells. J Clin Invest (2012) 1.17
What role for AID: mutator, or assembler of the immunoglobulin mutasome? Nat Immunol (2003) 1.11
Hypermutation in human B cells in vivo and in vitro. Ann N Y Acad Sci (2003) 1.05
DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts. PLoS One (2010) 1.03
IgM memory B cells: a mouse/human paradox. Cell Mol Life Sci (2012) 1.03
AID and partners: for better and (not) for worse. Curr Opin Immunol (2011) 1.02
Vaccination against encapsulated bacteria in humans: paradoxes. Trends Immunol (2005) 1.02
A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta. J Immunol (2009) 0.99
PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance. DNA Repair (Amst) (2011) 0.91
Gene profiling of CD11b⁺ and CD11b⁻ B1 cell subsets reveals potential cell sorting artifacts. J Exp Med (2012) 0.88
A bird's eye view on human B cells. Semin Immunol (2004) 0.88
Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. Mol Immunol (2003) 0.87
Do developing B cells need antigen? J Exp Med (2005) 0.87
Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties. J Exp Med (2014) 0.86
ATM localization and gene expression in the adult mouse eye. Mol Vis (2009) 0.85
Ionizing radiation sensitivity of DNA polymerase lambda-deficient cells. Radiat Res (2007) 0.85
Splenic marginal zone B cells in humans: where do they mutate their Ig receptor? Eur J Immunol (2005) 0.84
Competitive repair pathways in immunoglobulin gene hypermutation. Philos Trans R Soc Lond B Biol Sci (2009) 0.83
Normal immune system development in mice lacking the Deltex-1 RING finger domain. Mol Cell Biol (2005) 0.83
DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations. DNA Repair (Amst) (2013) 0.80
Allelic exclusion: lesson from GALT species. Semin Immunol (2002) 0.76
IL-12 secreting dendritic cells are required for optimum activation of human secondary lymphoid tissue T cells. J Immunother (2002) 0.76
Multiple players in mouse B cell memory. Curr Opin Immunol (2013) 0.76
The ups and downs of negative (and positive) selection of B cells. J Clin Invest (2015) 0.75
[A nursery in the setting of a home for the aged]. Soins Pediatr Pueric (2008) 0.75
RPA tightens AID to DNA...editing. Nat Immunol (2004) 0.75
Ig gene hypermutation: a mechanism is due. Adv Immunol (2002) 0.75
[Immunoglobulin gene hypermutation: when error becomes a quality]. Med Sci (Paris) (2007) 0.75