Published in Blood on August 15, 2002
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Retinaldehyde represses adipogenesis and diet-induced obesity. Nat Med (2007) 3.18
CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med (2004) 3.03
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von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models. Blood (2010) 2.82
CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism. Nat Med (2002) 2.77
Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol (2012) 2.75
Histones induce rapid and profound thrombocytopenia in mice. Blood (2011) 2.66
Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. J Am Soc Nephrol (2012) 2.58
Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood (2004) 2.53
Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. J Clin Invest (2005) 2.50
Inflammation induces hemorrhage in thrombocytopenia. Blood (2008) 2.28
The clearance mechanism of chilled blood platelets. Cell (2003) 2.25
Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc Natl Acad Sci U S A (2012) 2.23
Systemic antithrombotic effects of ADAMTS13. J Exp Med (2006) 2.21
Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Nat Med (2003) 2.18
BET bromodomains mediate transcriptional pause release in heart failure. Cell (2013) 2.17
Reciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytes. Arterioscler Thromb Vasc Biol (2006) 2.13
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. Proc Natl Acad Sci U S A (2006) 2.09
Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III. J Clin Invest (2007) 2.05
Platelet P-selectin facilitates atherosclerotic lesion development. Blood (2002) 2.04
Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation (2007) 2.04
Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo. Blood (2005) 2.03
Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice. Proc Natl Acad Sci U S A (2013) 1.98
The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation. Blood (2008) 1.93
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Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies. Blood (2012) 1.87
Thrombosis: tangled up in NETs. Blood (2013) 1.85
Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles. Arterioscler Thromb Vasc Biol (2006) 1.84
Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proc Natl Acad Sci U S A (2007) 1.83
Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice. Blood (2011) 1.83
The peroxisome proliferator-activated receptor-gamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice. J Am Coll Cardiol (2008) 1.81
A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy. Blood (2009) 1.80
Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression. Blood (2009) 1.79
Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin. Blood (2005) 1.78
Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proc Natl Acad Sci U S A (2003) 1.74
ADAMTS13: a new link between thrombosis and inflammation. J Exp Med (2008) 1.72
p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo. Blood (2009) 1.71
The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood (2011) 1.71
von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke. Blood (2009) 1.71
The pathologic continuum of diabetic vascular disease. J Am Coll Cardiol (2009) 1.70
The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med (2011) 1.70
A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature (2013) 1.69
PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice. J Clin Invest (2008) 1.68
Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy. Blood (2010) 1.67
Prothrombotic effects of fibronectin isoforms containing the EDA domain. Arterioscler Thromb Vasc Biol (2007) 1.66
PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis. Circ Res (2002) 1.66
Platelet adhesion receptors and their ligands in mouse models of thrombosis. Arterioscler Thromb Vasc Biol (2007) 1.65
Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proc Natl Acad Sci U S A (2003) 1.65
Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK/ERK activation. J Biol Chem (2003) 1.64
P-selectin and leukocyte microparticles are associated with venous thrombogenesis. J Vasc Surg (2003) 1.64
The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proc Natl Acad Sci U S A (2006) 1.62
Platelet granule secretion continuously prevents intratumor hemorrhage. Cancer Res (2008) 1.59
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nat Med (2012) 1.57
Neutrophil extracellular trap (NET) impact on deep vein thrombosis. Arterioscler Thromb Vasc Biol (2012) 1.56
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo. Circ Res (2004) 1.54
Immunoregulatory role of TNFalpha in inflammatory kidney diseases. Kidney Int (2009) 1.50
Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets. Blood (2003) 1.49
p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. Blood (2008) 1.48
Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice. Blood (2012) 1.48
Human neutrophil Fcgamma receptors initiate and play specialized nonredundant roles in antibody-mediated inflammatory diseases. Immunity (2008) 1.47
Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR-RXR complex. FEBS Lett (2007) 1.46
The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease). Circulation (2006) 1.46
A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med (2010) 1.45
von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins. Blood (2006) 1.44
Mechanisms and implications of platelet discoid shape. Blood (2003) 1.42
Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice. Blood (2012) 1.42
CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets. Blood (2008) 1.41
Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion. Blood (2007) 1.41
Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. Nat Med (2013) 1.36
Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity. Diabetes (2010) 1.36
Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. Mol Biol Cell (2008) 1.34
von Willebrand factor: an emerging target in stroke therapy. Stroke (2011) 1.34
N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice. J Clin Invest (2011) 1.32
Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis. Immunity (2012) 1.30
Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J Clin Invest (2005) 1.29
Diabetic macrovascular disease: the glucose paradox? Circulation (2002) 1.29
PPARalpha in atherosclerosis and inflammation. Biochim Biophys Acta (2007) 1.28
Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Blood (2005) 1.28
ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage. Am J Physiol Cell Physiol (2006) 1.28
The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patient. Diab Vasc Dis Res (2008) 1.27
Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. J Biol Chem (2008) 1.25
Antithrombotic activity of TNF-alpha. J Clin Invest (2003) 1.25
VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice. Blood (2013) 1.24
Inflammation in diabetes mellitus: role of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma agonists. Am J Cardiol (2006) 1.23
Glycoprotein Ibalpha and von Willebrand factor in primary platelet adhesion and thrombus formation: lessons from mutant mice. Thromb Haemost (2008) 1.22