Gary K Smith

Author PubWeight™ 17.92^‹?›

Top papers

Rank	Title	Journal	Year	PubWeight™‹?›
1	Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase.	J Biol Chem	2002	1.74
2	Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.	J Med Chem	2008	1.74
3	Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper.	Mol Biol Cell	2003	1.32
4	Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.	J Med Chem	2007	1.18
5	Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.	J Pharmacol Exp Ther	2006	1.17
6	Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis.	Cancer Res	2009	1.13
7	Pro-cathepsin D interacts with the extracellular domain of the beta chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth.	J Cell Sci	2010	1.02
8	Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases.	J Med Chem	2008	0.90
9	Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity.	J Med Chem	2007	0.89
10	Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease.	Bioorg Med Chem Lett	2010	0.85
11	Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.	Bioorg Med Chem Lett	2010	0.81
12	Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties.	Bioorg Med Chem Lett	2011	0.80
13	Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor.	Biochem Pharmacol	2009	0.79
14	Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.	J Med Chem	2013	0.78
15	Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease.	Bioorg Med Chem Lett	2010	0.78
16	Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.	J Med Chem	2012	0.76
17	Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells.	Protein Pept Lett	2006	0.76
18	Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates.	Bioorg Med Chem Lett	2010	0.76
19	Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups.	Bioorg Med Chem Lett	2012	0.75