Intracellular route and transcriptional competence of polyethylenimine-DNA complexes.

Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proc Natl Acad Sci U S A (2003) 2.37

Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells. Cancer Cell (2009) 2.28

Breaking up the correlation between efficacy and toxicity for nonviral gene delivery. Proc Natl Acad Sci U S A (2007) 1.58

Cellular uptake of cationic polymer-DNA complexes via caveolae plays a pivotal role in gene transfection in COS-7 cells. Pharm Res (2007) 1.39

Gene delivery by cationic lipid vectors: overcoming cellular barriers. Eur Biophys J (2006) 1.20

Engineered polymers for advanced drug delivery. Eur J Pharm Biopharm (2008) 1.17

The possible "proton sponge " effect of polyethylenimine (PEI) does not include change in lysosomal pH. Mol Ther (2012) 1.16

Missing pieces in understanding the intracellular trafficking of polycation/DNA complexes. J Control Release (2009) 1.12

Polyethyleneimine-lipid conjugate-based pH-sensitive micellar carrier for gene delivery. Biomaterials (2012) 1.09

The role of ganglioside GM1 in cellular internalization mechanisms of poly(amidoamine) dendrimers. Bioconjug Chem (2009) 1.05

Vectors for airway gene delivery. AAPS J (2007) 0.99

Membrane and nuclear permeabilization by polymeric pDNA vehicles: efficient method for gene delivery or mechanism of cytotoxicity? Mol Pharm (2012) 0.97

Innovative strategy for microRNA delivery in human mesenchymal stem cells via magnetic nanoparticles. Int J Mol Sci (2013) 0.95

Cellular binding, motion, and internalization of synthetic gene delivery polymers. Biochim Biophys Acta (2007) 0.93

Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes. J Leukoc Biol (2013) 0.91

Nanopolymers improve delivery of exon skipping oligonucleotides and concomitant dystrophin expression in skeletal muscle of mdx mice. BMC Biotechnol (2008) 0.90

Exploiting endocytosis for nanomedicines. Cold Spring Harb Perspect Biol (2013) 0.89

Uptake and intracellular traffic of siRNA dendriplexes in glioblastoma cells and macrophages. Int J Nanomedicine (2011) 0.86

Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted SiRNA Delivery to HER2+ Breast Cancer. Adv Funct Mater (2015) 0.86

Investigation of Polyethylenimine/DNA Polyplex Transfection to Cultured Cells Using Radiolabeling and Subcellular Fractionation Methods. Mol Pharm (2013) 0.86

Enhanced immune response against HIV-1 induced by a heterologous DNA prime-adenovirus boost vaccination using mannosylated polyethyleneimine as DNA vaccine adjuvant. Int J Nanomedicine (2013) 0.86

Polymeric nucleic acid vehicles exploit active interorganelle trafficking mechanisms. ACS Nano (2012) 0.85

Charge shielding effects on gene delivery of polyethylenimine/DNA complexes: PEGylation and phospholipid coating. J Mater Sci Mater Med (2012) 0.85

Polyethylenimine-mediated gene delivery to the lung and therapeutic applications. Drug Des Devel Ther (2009) 0.84

Real-time gene delivery vector tracking in the endo-lysosomal pathway of live cells. Microsc Res Tech (2011) 0.83

Formulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine)-poly(ethylene glycol) copolymers complexed to oligonucleotides. J Nanobiotechnology (2009) 0.83

DNA nuclear targeting sequences for non-viral gene delivery. Pharm Res (2011) 0.80

Fluid phase endocytosis contributes to transfection of DNA by PEI-25. Mol Ther (2009) 0.80

Polyplex exposure inhibits cell cycle, increases inflammatory response, and can cause protein expression without cell division. Mol Pharm (2013) 0.79

Delivery of antibodies to the cytosol: debunking the myths. MAbs (2014) 0.79

Exogenous mRNA delivery and bioavailability in gene transfer mediated by piggyBac transposition. BMC Biotechnol (2013) 0.79

Magnetic Nanoparticle Based Nonviral MicroRNA Delivery into Freshly Isolated CD105(+) hMSCs. Stem Cells Int (2014) 0.78

Elucidating the role of free polycationic chains in polycation gene carriers by free chains of polyethylenimine or N,N,N-trimethyl chitosan plus a certain polyplex. Int J Nanomedicine (2014) 0.77

Polyion complex (PIC) particles: Preparation and biomedical applications. Eur Polym J (2016) 0.77

A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery. Mol Ther (2017) 0.77

Polyplex Evolution: Understanding Biology, Optimizing Performance. Mol Ther (2017) 0.76

Preparation and characterization of vinculin-targeted polymer-lipid nanoparticle as intracellular delivery vehicle. Int J Nanomedicine (2012) 0.75

Effects of dendritic core-shell glycoarchitectures on primary mesenchymal stem cells and osteoblasts obtained from different human donors. J Nanobiotechnology (2015) 0.75

Temporary Single-Cell Coating for Bioprocessing with a Cationic Polymer. ACS Appl Mater Interfaces (2017) 0.75

Quantitative comparison between poly(L-arginine) and poly(L-lysine) at each step of polyplex-based gene transfection using a microinjection technique. Sci Technol Adv Mater (2012) 0.75

Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J Clin Invest (2009) 4.12

Bone marrow-derived cells do not incorporate into the adult growing vasculature. Circ Res (2003) 3.81

Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation (2003) 3.55

Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res (2008) 2.51

Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice. Cell (2011) 2.51

Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2. Cell Stem Cell (2008) 2.41

Role of extracellular RNA in atherosclerotic plaque formation in mice. Circulation (2013) 2.18

S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes. Cardiovasc Res (2007) 2.15

Bone marrow-derived cells contribute to infarct remodelling. Cardiovasc Res (2006) 2.00

Blood monocyte concentration is critical for enhancement of collateral artery growth. Am J Physiol Heart Circ Physiol (2002) 1.99

Human hibernating myocardium is jeopardized by apoptotic and autophagic cell death. J Am Coll Cardiol (2004) 1.88

Tako-Tsubo cardiomyopathy: intraindividual structural analysis in the acute phase and after functional recovery. Eur Heart J (2007) 1.81

Abnormalities in intracellular Ca2+ regulation contribute to the pathomechanism of Tako-Tsubo cardiomyopathy. Eur Heart J (2009) 1.78

Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling. Cell Stem Cell (2011) 1.72

Gap junctional remodeling by hypoxia in cultured neonatal rat ventricular myocytes. Cardiovasc Res (2005) 1.70

Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4. Am J Hum Genet (2007) 1.50

Schwann cells and the pathogenesis of inherited motor and sensory neuropathies (Charcot-Marie-Tooth disease). Glia (2006) 1.42

Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res (2005) 1.41

Myf5-positive satellite cells contribute to Pax7-dependent long-term maintenance of adult muscle stem cells. Cell Stem Cell (2013) 1.29

Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: correlation of CD163 expression, cytokine levels and early relapse. Int J Cancer (2013) 1.27

Exogenous application of transforming growth factor beta 1 stimulates arteriogenesis in the peripheral circulation. FASEB J (2002) 1.26

Sca1-derived cells are a source of myocardial renewal in the murine adult heart. Stem Cell Reports (2013) 1.25

Fibrosis in endstage human heart failure: severe changes in collagen metabolism and MMP/TIMP profiles. Int J Cardiol (2010) 1.25

Deregulation of tumor angiogenesis and blockade of tumor growth in PPARbeta-deficient mice. EMBO J (2007) 1.24

Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ). PLoS One (2011) 1.23

Circulating vascular progenitor cells do not contribute to compensatory lung growth. Circ Res (2003) 1.21

Endothelial nitric oxide synthase activity is essential for vasodilation during blood flow recovery but not for arteriogenesis. Arterioscler Thromb Vasc Biol (2007) 1.21

Platelet-derived growth factor receptor-β-positive telocytes in skeletal muscle interstitium. J Cell Mol Med (2012) 1.20

Cellular cardiomyoplasty: improvement of left ventricular function correlates with the release of cardioactive cytokines. Stem Cells (2006) 1.13

A common MLP (muscle LIM protein) variant is associated with cardiomyopathy. Circ Res (2009) 1.11

SLC4A11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria. J Biol Chem (2010) 1.10

Matrix metalloproteinases and their tissue inhibitors in pressure-overloaded human myocardium during heart failure progression. J Am Coll Cardiol (2004) 1.10

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res (2011) 1.07

Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor. Blood (2007) 1.07

15-hydroxyeicosatetraenoic acid is a preferential peroxisome proliferator-activated receptor beta/delta agonist. Mol Pharmacol (2009) 1.05

Tissue-engineered cardiac constructs for cardiac repair. Ann Thorac Surg (2011) 1.04

Transcriptional profiling identifies functional interactions of TGF β and PPAR β/δ signaling: synergistic induction of ANGPTL4 transcription. J Biol Chem (2010) 1.04

Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. J Biol Chem (2009) 1.02

Multiple internalization pathways of polyelectrolyte multilayer capsules into mammalian cells. ACS Nano (2013) 0.99

Ligand-mediated regulation of peroxisome proliferator-activated receptor (PPAR) beta/delta: a comparative analysis of PPAR-selective agonists and all-trans retinoic acid. Mol Pharmacol (2008) 0.98

Construction of autologous human heart valves based on an acellular allograft matrix. Circulation (2002) 0.95

Ischemic acidosis causes apoptosis in coronary endothelial cells through activation of caspase-12. Cardiovasc Res (2006) 0.95

Remodeling of the adventitia during coronary arteriogenesis. Am J Physiol Heart Circ Physiol (2002) 0.95

Phenotypical and ultrastructural features of Oct4-positive cells in the adult mouse lung. J Cell Mol Med (2014) 0.94

Expression profiling of cardiac genes in Tako-Tsubo cardiomyopathy: insight into a new cardiac entity. J Mol Cell Cardiol (2007) 0.93

Charcot-Marie-Tooth disease-associated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission. EMBO Rep (2013) 0.92

Sympathoadrenergic overstimulation in Tako-Tsubo cardiomyopathy triggered by physical and emotional stress. Int J Cardiol (2007) 0.91

Ischemia depletes dystrophin and inhibits protein synthesis in the canine heart: mechanisms of myocardial ischemic injury. J Mol Cell Cardiol (2005) 0.90

Ischemia triggers BNP expression in the human myocardium independent from mechanical stress. Int J Cardiol (2009) 0.89

Induction of PPARbeta and prostacyclin (PGI2) synthesis by Raf signaling: failure of PGI2 to activate PPARbeta. FEBS J (2006) 0.88

Enhanced connexin-43 and alpha-sarcomeric actin expression in cultured heart myocytes exposed to triiodo-L-thyronine. J Mol Histol (2004) 0.87

Therapeutic targeting of the oncostatin M receptor-β prevents inflammatory heart failure. Basic Res Cardiol (2013) 0.87

Targeting and function of the mitochondrial fission factor GDAP1 are dependent on its tail-anchor. PLoS One (2009) 0.87

SLC4A7 sodium bicarbonate co-transporter controls mitochondrial apoptosis in ischaemic coronary endothelial cells. Cardiovasc Res (2010) 0.87

Types of cardiomyocyte death and clinical outcomes in patients with heart failure. J Am Coll Cardiol (2011) 0.87

Translocation and cleavage of myocardial dystrophin as a common pathway to advanced heart failure: a scheme for the progression of cardiac dysfunction. Proc Natl Acad Sci U S A (2004) 0.87

Time- and cell type-specific induction of platelet-derived growth factor receptor-beta during cerebral ischemia. Brain Res Mol Brain Res (2003) 0.86

Regression of cardiac hypertrophy by granulocyte colony-stimulating factor-stimulated interleukin-1β synthesis. Eur Heart J (2011) 0.86

Dynamin 2 mutations in Charcot-Marie-Tooth neuropathy highlight the importance of clathrin-mediated endocytosis in myelination. Brain (2012) 0.85

Reverse crosstalk of TGFβ and PPARβ/δ signaling identified by transcriptional profiling. Nucleic Acids Res (2010) 0.85

Importance of bicarbonate transport for ischaemia-induced apoptosis of coronary endothelial cells. J Cell Mol Med (2007) 0.85

Structural remodelling in heart failure. Exp Clin Cardiol (2002) 0.85

Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB", is an essential component of human TFIIIC1 activity. J Biol Chem (2004) 0.85

Acidic preconditioning protects endothelial cells against apoptosis through p38- and Akt-dependent Bcl-xL overexpression. Apoptosis (2009) 0.84

Reduced sarcoplasmic reticulum Ca2+ -ATPase activity and dephosphorylated phospholamban contribute to contractile dysfunction in human hibernating myocardium. Mol Cell Biochem (2006) 0.84

Assessment of human MAPCs for stem cell transplantation and cardiac regeneration after myocardial infarction in SCID mice. Exp Hematol (2010) 0.84

Expression of cytoskeletal, linkage and extracellular proteins in failing dog myocardium. Heart Fail Rev (2005) 0.84

Deposition of nonsarcomeric alpha-actinin in cardiomyocytes from patients with dilated cardiomyopathy or chronic pressure overload. Exp Clin Cardiol (2009) 0.83

Regulation of TAK1/TAB1-mediated IL-1β signaling by cytoplasmic PPARβ/δ. PLoS One (2013) 0.82

Adult rat cardiac myocytes in culture: 'Second-floor' cells and coculture experiments. Exp Clin Cardiol (2006) 0.82

Myostatin induces interstitial fibrosis in the heart via TAK1 and p38. Cell Tissue Res (2015) 0.81

TVP1022 attenuates cardiac remodeling and kidney dysfunction in experimental volume overload-induced congestive heart failure. Circ Heart Fail (2011) 0.80

(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. J Med Chem (2012) 0.80

The rotamase Pin1 is up-regulated, hypophosphorylated and required for cell cycle progression in head and neck squamous cell carcinomas. Oral Oncol (2009) 0.80

Treatment with bone morphogenetic protein 2 limits infarct size after myocardial infarction in mice. Shock (2013) 0.80

Cell death and adenosine triphosphate: the paradox. Circulation (2005) 0.79

A new missense GDAP1 mutation disturbing targeting to the mitochondrial membrane causes a severe form of AR-CMT2C disease. Neurogenetics (2011) 0.79

Expression level and agonist-binding affect the turnover, ubiquitination and complex formation of peroxisome proliferator activated receptor beta. FEBS J (2007) 0.79

mRNA cargo no longer on time. Am J Physiol Heart Circ Physiol (2008) 0.78

Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene. Nucleic Acids Res (2003) 0.77

EGF-dependent induction of BCL-xL and p21CIP1/WAF1 is highly variable in HNSCC cells--implications for EGFR-targeted therapies. Anticancer Res (2010) 0.77

Images in cardiovascular medicine. Natural tissue engineering inside a ventricular septum defect occluder. Circulation (2006) 0.77

Transforming growth factor-beta1 downregulates beating frequency and remodeling of cultured rat adult cardiomyocytes. Cell Tissue Res (2005) 0.77

ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure. Circ Cardiovasc Genet (2015) 0.75

Carvedilol improves myocardial contractility compared with metoprolol in patients with chronic hibernating myocardium after revascularization. J Cardiovasc Pharmacol Ther (2005) 0.75

Late onset neuropathy with spontaneous clinical remission in mice lacking the POZ domain of the transcription factor Myc-interacting zinc finger protein 1 (Miz1) in Schwann cells. J Biol Chem (2015) 0.75

A novel small-animal model for accelerated investigation of tissue-engineered aortic valve conduits. Tissue Eng Part C Methods (2010) 0.75