Published in Br J Anaesth on December 01, 1975
The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects. Br J Clin Pharmacol (1992) 1.40
Policy for controlling pain after surgery: effect of sequential changes in management. BMJ (1992) 1.31
Transcutaneous electrical nerve stimulation following appendicectomy: the placebo effect. Ann R Coll Surg Engl (1986) 1.01
Maternal kinetics and transplacental passage of pethidine during labour. Br J Clin Pharmacol (1982) 0.75
Inhibition of antipyrine metabolism by beta-adrenoceptor antagonists. Br J Clin Pharmacol (1981) 3.07
Postoperative pain. Br Med J (1978) 2.93
Intrathecal and epidural administration of opioids. Anesthesiology (1984) 2.91
Oxidation phenotype--a major determinant of metoprolol metabolism and response. N Engl J Med (1982) 2.72
Determination of debrisoquine and its 4-hydroxy metabolite in biological fluids by gas chromatography with flame-ionization and nitrogen-selective detection. J Chromatogr (1977) 2.43
Amiodarone pharmacokinetics. Am Heart J (1983) 2.42
Metformin kinetics in healthy subjects and in patients with diabetes mellitus. Br J Clin Pharmacol (1981) 2.38
Inhibition of oxidative drug metabolism by beta-adrenoceptor antagonists in related to their lipid solubility. Br J Clin Pharmacol (1981) 2.08
Binding of anilide-type local anesthetics in human plasma. I. Relationships between binding, physicochemical properties, and anesthetic activity. Anesthesiology (1970) 1.71
The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes. Br J Clin Pharmacol (1992) 1.71
Polymorphic hydroxylation of debrisoquine. Lancet (1977) 1.69
Plasma concentrations of local anaesthetics after interscalene brachial plexus block. Br J Anaesth (1977) 1.66
Metoprolol metabolism and debrisoquine oxidation polymorphism--population and family studies. Br J Clin Pharmacol (1985) 1.64
Lack of effect of atenolol on antipyrine clearance. Br J Clin Pharmacol (1982) 1.51
Clinical pharmacokinetics of local anaesthetics. Clin Pharmacokinet (1979) 1.47
The prevention of renal impairment in patients undergoing orthotopic liver grafting by infusion of low dose dopamine. Anaesthesia (1987) 1.47
Clinical pharmacokinetics of fentanyl and its newer derivatives. Clin Pharmacokinet (1983) 1.45
Central nervous system toxicity attributable to epidural ropivacaine hydrochloride. Anaesth Intensive Care (1998) 1.42
Caffeine urinary metabolite ratios as markers of enzyme activity: a theoretical assessment. Pharmacogenetics (1996) 1.41
Gerontokinetics--a reappraisal. Br J Clin Pharmacol (1992) 1.41
The influence of age upon opioid analgesic use in the patient-controlled analgesia (PCA) environment. Anaesthesia (1997) 1.41
Intersubject and dose-related variability after intravenous administration of erythromycin. Br J Clin Pharmacol (1980) 1.39
Meperidine kinetics in man. Intravenous injection in surgical patients and volunteers. Clin Pharmacol Ther (1975) 1.39
Potential dangers of laparoscopic insufflator. Lancet (1992) 1.39
Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes. Biochem Pharmacol (1997) 1.37
Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes. J Pharmacol Exp Ther (1988) 1.37
Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep. Anesth Analg (1998) 1.35
Measurement of the renal clearance of drugs. Br J Clin Pharmacol (1981) 1.35
Metoprolol and debrisoquin metabolism in Nigerians: lack of evidence for polymorphic oxidation. Clin Pharmacol Ther (1986) 1.32
Polymorphic drug oxidation: pharmacokinetic basis and comparison of experimental indices. Br J Clin Pharmacol (1986) 1.29
Organ donation. BMJ (1993) 1.28
Lignocaine and indocyanine green kinetics in patients following myocardial infarction. Br J Clin Pharmacol (1980) 1.28
Anesthesia for hepatic transplantation: cardiovascular and metabolic alterations and their management. Anesth Analg (1985) 1.26
Why hypertensive patients vary in their response to oral debrisoquine. Br Med J (1977) 1.25
Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability. Xenobiotica (2006) 1.24
Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6. Drug Metab Dispos (1997) 1.23
Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers. Clin Pharmacol Ther (1983) 1.22
A pharmacokinetic approach to postoperative pain: continuous infusion of pethidine. Anaesth Intensive Care (1979) 1.22
Population pharmacokinetics of methadone in opiate users: characterization of time-dependent changes. Br J Clin Pharmacol (1999) 1.21
Variables of patient-controlled analgesia. 2. Concurrent infusion. Anaesthesia (1989) 1.21
Morphine pharmacokinetics after pulmonary administration from a novel aerosol delivery system. Clin Pharmacol Ther (1997) 1.21
Mechanism of plasma catecholamine increases during surgical stress in man. J Clin Endocrinol Metab (1977) 1.20
The disposition of debrisoquine in hypertensive patients. Br J Clin Pharmacol (1978) 1.16
Relationship of impaired insulin secretion during surgical stress to anesthesia and catecholamine release. J Clin Endocrinol Metab (1980) 1.16
Physiopathology and control of postoperative pain. Arch Surg (1977) 1.16
Multiple intramuscular injections: a major source of variability in analgesic response to meperidine. Pain (1980) 1.15
Enterocytic CYP3A4 in a paediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis. Br J Clin Pharmacol (2001) 1.15
Arterial plasma epinephrine concentrations and hemodynamic responses after dental injection of local anesthetic with epinephrine. J Am Dent Assoc (1982) 1.13
Selective spinal analgesia. Lancet (1979) 1.12
Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver. Br J Clin Pharmacol (2003) 1.11
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease. J Pharmacol Exp Ther (1996) 1.11
Lactic acidosis during metformin treatment in an elderly diabetic patient with impaired renal function. Acta Med Scand (1981) 1.11
Circadian hydrocortisone infusions in patients with adrenal insufficiency and congenital adrenal hyperplasia. Clin Endocrinol (Oxf) (2006) 1.10
Pharmacokinetic aspects of intravenous regional anesthesia. Anesthesiology (1971) 1.10
Clinical pharmacokinetics of pethidine. Clin Pharmacokinet (1978) 1.10
Mechanism-based inactivation of CYP2D6 by methylenedioxymethamphetamine. Drug Metab Dispos (2004) 1.10
The efficacy of intrathecal morphine and clonidine in the treatment of pain after spinal cord injury. Anesth Analg (2000) 1.09
Altered plasma drug binding in cancer: role of alpha 1-acid glycoprotein and albumin. Clin Pharmacol Ther (1982) 1.08
Polymorphic metabolism of beta-adrenoceptor antagonists. Br J Clin Pharmacol (1984) 1.08
Meperidine and other basic drugs: general method for their determination in plasma. J Pharm Sci (1974) 1.08
Evaluation of an intermittent oxygen flow system. Am Rev Respir Dis (1972) 1.08
Routine detection and identification in urine of stimulants and other drugs, some of which may be used to modify performance in sport. J Pharm Pharmacol (1967) 1.08
Timolol and atenolol: relationships between oxidation phenotype, pharmacokinetics and pharmacodynamics. Br J Clin Pharmacol (1985) 1.07
Studies on absorption of a newly developed enteric-coated erythromycin base. J Clin Pharmacol (1977) 1.06
Systemic absorption of mepivacaine in commonly used regional block procedures. Anesthesiology (1972) 1.06
Relief of postoperative pain: advances awaiting application. Med J Aust (1989) 1.05
Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors. Xenobiotica (2004) 1.05
Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6. J Biol Chem (1995) 1.05
Pharmacokinetics of local anaesthetics. Br J Anaesth (1986) 1.04
Pethidine clearance during continuous intravenous infusions in postoperative patients. Br J Clin Pharmacol (1981) 1.04
Relationship between blood meperidine concentrations and analgesic response: a preliminary report. Anesthesiology (1980) 1.04
Journal impact factors: a 'bioequivalence' issue? Br J Clin Pharmacol (2001) 1.04
Modified-release hydrocortisone for circadian therapy: a proof-of-principle study in dexamethasone-suppressed normal volunteers. Clin Endocrinol (Oxf) (2007) 1.04
Effects of beta-adrenoceptor antagonists on the pharmacokinetics of lignocaine. Br J Clin Pharmacol (1984) 1.03
Amiodarone pharmacokinetics. Br J Clin Pract Suppl (1986) 1.02
The antitussive effect of dextromethorphan in relation to CYP2D6 activity. Br J Clin Pharmacol (1999) 1.01
The polymorphic oxidation of beta-adrenoceptor antagonists. Clinical pharmacokinetic considerations. Clin Pharmacokinet (1986) 1.00
The pharmacokinetics of methadone in healthy subjects and opiate users. Br J Clin Pharmacol (1997) 1.00
Testing for bimodality in frequency distributions of data suggesting polymorphisms of drug metabolism--hypothesis testing. Br J Clin Pharmacol (1989) 0.99
Acebutolol in hypertension: relationships between drug concentration and effects. Eur J Clin Pharmacol (1978) 0.99
Testing for bimodality in frequency distributions of data suggesting polymorphisms of drug metabolism--histograms and probit plots. Br J Clin Pharmacol (1989) 0.99
Lack of effect of high doses of inhaled morphine on exercise endurance in chronic obstructive pulmonary disease. Eur Respir J (1997) 0.99
The effect of duration of dose delivery with patient-controlled analgesia on the incidence of nausea and vomiting after hysterectomy. Br J Clin Pharmacol (1998) 0.98
Absorption and bioavailability of oral erythromycin. Br J Clin Pharmacol (1981) 0.98
Effects of diclofenac in the rat tail ischaemia--reperfusion injury model of acute hyperalgesia. Pain (2001) 0.98
Determination of metformin in biological samples. Br J Clin Pharmacol (1978) 0.98
Arterial-venous differences of plasma catecholamines in man. Metabolism (1980) 0.97
Effect of spinal anesthesia on adrenergic tone and the neuroendocrine responses to surgical stress in humans. Anesthesiology (1981) 0.97
In-vivo indices of enzyme activity: the effect of renal impairment on the assessment of CYP2D6 activity. Pharmacogenetics (1999) 0.96
Pulmonary insulin administration using the AERx system: physiological and physicochemical factors influencing insulin effectiveness in healthy fasting subjects. Diabetes Technol Ther (2000) 0.96
Backtracking booze with Bayes--the retrospective interpretation of blood alcohol data. Br J Clin Pharmacol (1991) 0.95
Towards a quantitative framework for the prediction of DDIs arising from cytochrome P450 induction. Curr Drug Metab (2009) 0.95
Lidocaine and bupivacaine mixtures for epidural blockade. Anesthesiology (1982) 0.95
The development and clinical use of patient-controlled analgesia. Anaesth Intensive Care (1988) 0.95
Rate of formation of norpethidine from pethidine. Br J Anaesth (1981) 0.95