Published in Am J Epidemiol on September 01, 2002
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke (2011) 10.11
Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry (2006) 4.74
Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med (2010) 3.57
Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ (2003) 2.74
Physical activity and functional limitations in older adults: a systematic review related to Canada's Physical Activity Guidelines. Int J Behav Nutr Phys Act (2010) 2.69
Dementia risk after traumatic brain injury vs nonbrain trauma: the role of age and severity. JAMA Neurol (2014) 2.58
Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Front Aging Neurosci (2010) 2.43
Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med (2012) 2.36
Depression and risk of developing dementia. Nat Rev Neurol (2011) 2.31
Pathways linking late-life depression to persistent cognitive impairment and dementia. Dialogues Clin Neurosci (2008) 2.30
Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies. Br J Psychiatry (2013) 2.23
AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem (2010) 2.21
Boosting power for clinical trials using classifiers based on multiple biomarkers. Neurobiol Aging (2010) 2.13
The association between blood pressure and incident Alzheimer disease: a systematic review and meta-analysis. Epidemiology (2011) 2.01
Neuropsychological and neuroimaging changes in preclinical Alzheimer's disease. J Int Neuropsychol Soc (2006) 1.90
NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type. Neurology (2007) 1.88
Nontraditional risk factors combine to predict Alzheimer disease and dementia. Neurology (2011) 1.81
Bridging animal and human models of exercise-induced brain plasticity. Trends Cogn Sci (2013) 1.79
Epidemiology of Alzheimer disease. Cold Spring Harb Perspect Med (2012) 1.78
Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons. Neurology (2009) 1.78
Exercise, brain, and cognition across the life span. J Appl Physiol (1985) (2011) 1.76
Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and qualitative analyses. PLoS One (2012) 1.76
Adenosine receptors as drug targets--what are the challenges? Nat Rev Drug Discov (2013) 1.74
Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease. CMAJ (2008) 1.70
Impairment of paravascular clearance pathways in the aging brain. Ann Neurol (2014) 1.66
The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Hum Brain Mapp (2012) 1.66
Polyphenols and human health: prevention of disease and mechanisms of action. Nutrients (2010) 1.66
Cigarette smoking is a risk factor for Alzheimer's Disease: an analysis controlling for tobacco industry affiliation. J Alzheimers Dis (2010) 1.65
Cardiovascular risk factors and incident Alzheimer disease: a systematic review of the literature. Alzheimer Dis Assoc Disord (2009) 1.64
Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia. Cardiovasc Psychiatry Neurol (2012) 1.57
Depressed mood is not a risk factor for incident dementia in a community-based cohort. Am J Geriatr Psychiatry (2009) 1.54
Apolipoprotein E epsilon4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian Study of Health and Aging. CMAJ (2004) 1.52
Fruit and vegetable juices and Alzheimer's disease: the Kame Project. Am J Med (2006) 1.52
Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition. Arch Neurol (2012) 1.52
Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study. BMJ (2004) 1.51
Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. J Toxicol Environ Health B Crit Rev (2007) 1.49
Smoking, dementia and cognitive decline in the elderly, a systematic review. BMC Geriatr (2008) 1.49
Very early detection of Alzheimer neuropathology and the role of brain reserve in modifying its clinical expression. J Geriatr Psychiatry Neurol (2005) 1.48
No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology (2008) 1.45
Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia. Arch Gen Psychiatry (2009) 1.44
Smoking is associated with an increased risk of dementia: a meta-analysis of prospective cohort studies with investigation of potential effect modifiers. PLoS One (2015) 1.43
Relationship between education and dementia: an updated systematic review. Alzheimer Dis Assoc Disord (2011) 1.42
Dietary approaches that delay age-related diseases. Clin Interv Aging (2006) 1.37
Dysthymia and depression increase risk of dementia and mortality among older veterans. Am J Geriatr Psychiatry (2012) 1.33
Dementia and its implications for public health. Prev Chronic Dis (2006) 1.30
Neurodegenerative diseases: an overview of environmental risk factors. Environ Health Perspect (2005) 1.30
Alzheimer's disease: analyzing the missing heritability. PLoS One (2013) 1.28
Moderate alcohol consumption and cognitive risk. Neuropsychiatr Dis Treat (2011) 1.26
Physical activity and cognitive health. Alzheimers Dement (2007) 1.22
Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. J Neuroinflammation (2008) 1.22
The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study. Ann Intern Med (2013) 1.21
Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study. J Cell Mol Med (2008) 1.20
Promoting successful cognitive aging: a comprehensive review. J Alzheimers Dis (2010) 1.19
Therapeutic potential of resveratrol in Alzheimer's disease. BMC Neurosci (2008) 1.19
Interactive effects of physical activity and APOE-ε4 on BOLD semantic memory activation in healthy elders. Neuroimage (2010) 1.14
Pacific Northwest Udall Center of excellence clinical consortium: study design and baseline cohort characteristics. J Parkinsons Dis (2013) 1.12
Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade. J Neurochem (2011) 1.10
Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia. Curr Psychiatry Rev (2009) 1.09
Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population-based study of elders. Mov Disord (2010) 1.09
Drug development for Alzheimer's disease: where are we now and where are we headed? Am J Geriatr Pharmacother (2009) 1.07
Physical activity and risk of Parkinson's disease: a prospective cohort study. J Neurol Neurosurg Psychiatry (2006) 1.06
Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum. J Neurochem (2008) 1.04
Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study. BMC Geriatr (2005) 1.03
Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease. FASEB J (2012) 1.01
Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases. J Alzheimers Dis (2010) 1.01
Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease. Front Aging Neurosci (2014) 1.01
Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans. Longev Healthspan (2012) 1.00
Changes in brain volume and cognition in a randomized trial of exercise and social interaction in a community-based sample of non-demented Chinese elders. J Alzheimers Dis (2012) 0.98
Interaction of neuritic plaques and education predicts dementia. Alzheimer Dis Assoc Disord (2008) 0.97
Development of a new method for assessing global risk of Alzheimer's disease for use in population health approaches to prevention. Prev Sci (2013) 0.97
The association between physical activity and dementia in an elderly population: the Rotterdam Study. Eur J Epidemiol (2013) 0.97
Neuronutrition and Alzheimer's disease. J Alzheimers Dis (2010) 0.97
Blood pressure and dementia - a comprehensive review. Ther Adv Neurol Disord (2009) 0.95
Caffeine, cognitive functioning, and white matter lesions in the elderly: establishing causality from epidemiological evidence. J Alzheimers Dis (2010) 0.95
Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline. PLoS One (2014) 0.93
Physical activity for the prevention of cognitive decline: current evidence from observational and controlled studies. Z Gerontol Geriatr (2012) 0.93
Bone density and brain atrophy in early Alzheimer's disease. J Alzheimers Dis (2009) 0.93
Stem-cell-associated structural and functional plasticity in the aging hippocampus. Psychol Aging (2008) 0.93
"Studying injured minds" - the Vietnam head injury study and 40 years of brain injury research. Front Neurol (2011) 0.92
Effectiveness of topical caffeine in cataract prevention: studies with galactose cataract. Mol Vis (2010) 0.92
Apolipoprotein E genotype modifies the association between midlife lung function and cognitive function in old age. Dement Geriatr Cogn Disord (2009) 0.91
Characterization of Japanese-American men with a single neocortical AD lesion type. Neurobiol Aging (2007) 0.91
Apolipoprotein E-polymorphism, frailty and mortality in older adults. J Cell Mol Med (2008) 0.90
Genetics of Alzheimer's disease. Biomed Res Int (2013) 0.90
Effect of Apolipoprotein E epsilon4 on the association between health behaviors and cognitive function in late midlife. Mol Neurodegener (2010) 0.90
Smoking exacerbates amyloid pathology in a mouse model of Alzheimer's disease. Nat Commun (2013) 0.90
Exercise and cognition: results from the National Long Term Care Survey. Alzheimers Dement (2010) 0.90
Atrophy and dysfunction of parahippocampal white matter in mild Alzheimer's disease. Neurobiol Aging (2010) 0.89
Effects of diet on brain plasticity in animal and human studies: mind the gap. Neural Plast (2014) 0.89
Alcohol and cognition in the elderly: a review. Psychiatry Investig (2012) 0.89
Physical activity and cognitive trajectories in cognitively normal adults: the adult children study. Alzheimer Dis Assoc Disord (2014) 0.89
Exercise, APOE genotype, and the evolution of the human lifespan. Trends Neurosci (2014) 0.89
Harm avoidance and risk of Alzheimer's disease. Psychosom Med (2011) 0.88
Physical activity and brain function in older adults at increased risk for Alzheimer's disease. Brain Sci (2013) 0.88
Hypertension and cognitive function. Clin Geriatr Med (2009) 0.88
Apolipoprotein e4 genotype and depressive symptoms as risk factors for dementia in an older korean population. Psychiatry Investig (2010) 0.88
Predicting dementia: role of dementia risk indices. Future Neurol (2009) 0.88
Epidemiologic evidence of a relationship between tea, coffee, or caffeine consumption and cognitive decline. Adv Nutr (2013) 0.88
Influence of social support on cognitive change and mortality in old age: results from the prospective multicentre cohort study AgeCoDe. BMC Geriatr (2012) 0.87
Mitochondrial dysfunction leads to deconjugation of quercetin glucuronides in inflammatory macrophages. PLoS One (2013) 0.87
A global clinical measure of fitness and frailty in elderly people. CMAJ (2005) 8.99
Prevalence, attributes, and outcomes of fitness and frailty in community-dwelling older adults: report from the Canadian study of health and aging. J Gerontol A Biol Sci Med Sci (2004) 2.67
Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study. Eur Heart J (2008) 2.50
Neuropsychological tests accurately predict incident Alzheimer disease after 5 and 10 years. Neurology (2005) 2.45
Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people. Arch Neurol (2002) 2.18
Diabetes mellitus and the risk of dementia, Alzheimer's disease and vascular cognitive impairment in the Canadian Study of Health and Aging. Dement Geriatr Cogn Disord (2002) 1.95
Hypnotic analgesia intervention during first-trimester pregnancy termination: an open randomized trial. Am J Obstet Gynecol (2008) 1.91
Intrasession reliability of center of pressure measures of postural steadiness in healthy elderly people. Arch Phys Med Rehabil (2004) 1.68
Predictors of driving cessation in mild-to-moderate dementia. CMAJ (2006) 1.68
Increased risk of depression in COPD patients with higher education and income. Chron Respir Dis (2005) 1.56
Optimal duration of antibiotic therapy for uncomplicated urinary tract infection in older women: a double-blind randomized controlled trial. CMAJ (2004) 1.54
The effect of social engagement on incident dementia: the Honolulu-Asia Aging Study. Am J Epidemiol (2006) 1.51
Conceptualizing the healthscape: contributions of time geography, location technologies and spatial ecology to place and health research. Soc Sci Med (2009) 1.51
The feasibility of establishing correction factors to adjust self-reported estimates of obesity. Health Rep (2008) 1.41
Statins and micronutrients: unanswered questions. J R Soc Med (2004) 1.38
Five-year follow-up of cognitive impairment with no dementia. Arch Neurol (2003) 1.32
Recurrence after varicose vein surgery: a prospective long-term clinical study with duplex ultrasound scanning and air plethysmography. J Vasc Surg (2003) 1.29
The contribution of neuropsychiatric symptoms to the cost of dementia care. Int J Geriatr Psychiatry (2006) 1.24
Application of a case-mix classification based on the functional autonomy of the residents for funding long-term care facilities. Age Ageing (2003) 1.20
Development of a wearable global positioning system for place and health research. Int J Health Geogr (2008) 1.18
Prevalence of physical and verbal aggressive behaviours and associated factors among older adults in long-term care facilities. BMC Geriatr (2005) 1.13
Family physician involvement in cancer care follow-up: the experience of a cohort of patients with lung cancer. Ann Fam Med (2010) 1.12
Omega-3 fatty acids and risk of cognitive impairment and dementia. J Alzheimers Dis (2003) 1.11
Disability-based classification system for older people in integrated long-term care services: the Iso-SMAF profiles. Arch Gerontol Geriatr (2005) 1.10
Neovascularization and recurrent varicose veins: more histologic and ultrasound evidence. J Vasc Surg (2004) 1.08
Evaluation of postural stability in the elderly with stroke. Arch Phys Med Rehabil (2004) 1.08
Is complexity of work associated with risk of dementia? The Canadian Study of Health And Aging. Am J Epidemiol (2008) 1.08
Quasi-experimental study of the effectiveness of an integrated service delivery network for the frail elderly. Can J Aging (2004) 1.07
PRISMA-7: a case-finding tool to identify older adults with moderate to severe disabilities. Arch Gerontol Geriatr (2007) 1.05
Potentially inappropriate prescriptions for older patients in long-term care. BMC Geriatr (2004) 1.04
Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging. Am J Clin Nutr (2009) 1.02
Nonsteroidal anti-inflammatory drug use and the risk of cognitive impairment and Alzheimer's disease. Alzheimers Dement (2012) 1.02
Patient, primary care physician and specialist expectations of primary care physician involvement in cancer care. J Gen Intern Med (2011) 1.02
Cognitive scores, even within the normal range, predict death and institutionalization. Age Ageing (2002) 1.01
Prevalence and predictors of depression in elderly Canadians: The Canadian Study of Health and Aging. Chronic Dis Can (2005) 1.01
Prevalence of insomnia and its associated factors in elderly long-term care residents. Arch Gerontol Geriatr (2005) 1.00
Measuring chronic patients' feelings of being a burden to their caregivers: development and preliminary validation of a scale. Med Care (2003) 0.99
Canadian Outcomes Study in Dementia: study methods and patient characteristics. Can J Psychiatry (2004) 0.98
Assisted self-report of health-services use showed excellent reliability in a longitudinal study of older adults. J Clin Epidemiol (2007) 0.97
The detection and management of abdominal aortic aneurysm: a cost-effectiveness analysis. Clin Invest Med (2002) 0.97
Performance of the international physical activity questionnaire (short form) in subgroups of the Hong Kong chinese population. Int J Behav Nutr Phys Act (2011) 0.97
Physical health and mental disorder in elderly suicide: a case-control study. Aging Ment Health (2005) 0.96
Cognitive-impairment-free life expectancy for Canadian seniors. Dement Geriatr Cogn Disord (2006) 0.96
The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency. Haematologica (2006) 0.95
Culturally Safe Epidemiology: Oxymoron or Scientific Imperative. Pimatisiwin (2010) 0.95
Interventions to improve continuity of care in the follow-up of patients with cancer. Cochrane Database Syst Rev (2012) 0.94
Postural stability in the elderly: empirical confirmation of a theoretical model. Arch Gerontol Geriatr (2004) 0.94
Neyman's bias re-visited. J Clin Epidemiol (2003) 0.93
More than the epidemiology of Alzheimer's disease: contributions of the Canadian Study of Health and Aging. Can J Psychiatry (2004) 0.93
Initial emergency department trauma scores from the OPALS study: the case for the motor score in blunt trauma. Acad Emerg Med (2004) 0.91
Comparison of two functional independence scales with a participation measure in post-stroke rehabilitation. Arch Gerontol Geriatr (2003) 0.90
Meeting the home-care needs of disabled older persons living in the community: does integrated services delivery make a difference? BMC Geriatr (2011) 0.90
Prediction of all-cause dementia using neuropsychological tests within 10 and 5 years of diagnosis in a community-based sample. J Alzheimers Dis (2010) 0.90
Development and validation of the Health Care Satisfaction Questionnaire (HCSQ) in elders. J Nurs Meas (2006) 0.88
Lipid-lowering agents and the risk of cognitive impairment that does not meet criteria for dementia, in relation to apolipoprotein E status. Neuroepidemiology (2007) 0.87
Depressive symptoms in people with chronic physical conditions: prevalence and risk factors in a Hong Kong community sample. BMC Psychiatry (2012) 0.87
The individualized service plan as a clinical integration tool: qualitative analysis in the Quebec PRISMA experiment. Int J Integr Care (2007) 0.87
Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia. Metabolism (2005) 0.85
Assessing pain in dementia patients with comorbid delirium and/or depression. Pain Manag Nurs (2008) 0.85
A prospective evaluation of the Charlson Comorbidity Index for use in long-term care patients. J Am Geriatr Soc (2002) 0.85
Efficacy of supervised Tai Chi exercises versus conventional physical therapy exercises in fall prevention for frail older adults: a randomized controlled trial. Disabil Rehabil (2012) 0.85
Vitamin E and C supplements and risk of dementia. JAMA (2002) 0.84
The effect of supervised Tai Chi intervention compared to a physiotherapy program on fall-related clinical outcomes: a randomized clinical trial. Disabil Rehabil (2012) 0.84
Is there agreement between Canadian older adults and their primary informal caregivers on behaviour towards institutionalisation? Health Soc Care Community (2009) 0.83
Vascular risk factors and cognitive functions in nondemented elderly individuals. J Geriatr Psychiatry Neurol (2009) 0.83
Physical restraint use among nursing home residents: A comparison of two data collection methods. BMC Nurs (2004) 0.83
[Validity 'and Utilities' clinic of a grid observation (PACSLAC-F) to evaluate the pain in seniors with dementia's living in the Long-Term Care ]. Can J Aging (2008) 0.83
A cluster analysis of patterns of objectively measured physical activity in Hong Kong. Public Health Nutr (2012) 0.83
[The systematic evaluation of instruments designed to assess pain in persons with limited ability to communicate]. Pain Res Manag (2007) 0.83
Correlates of the perceived need for institutionalisation among older adults without cognitive impairment. Gerontology (2008) 0.83
The use of hypnosis to improve pain management during voluntary interruption of pregnancy: an open randomized preliminary study. Contraception (2006) 0.83
Managing disruptive behaviors with neuroleptics: treatment options for older adults in nursing homes. J Gerontol Nurs (2005) 0.83
For non-exercising people, the number of steps walked is more strongly associated with health than time spent walking. J Sci Med Sport (2012) 0.82
The role of activity restriction in poststroke depressive symptoms. Rehabil Psychol (2009) 0.82
Residual flow after cerebral aneurysm coil occlusion: diagnostic accuracy of MR angiography. Stroke (2012) 0.82
Relationship between regulatory status, quality of care, and three-year mortality in Canadian residential care facilities: a longitudinal study. Health Serv Res (2002) 0.82
Thyroid function and cognition in the euthyroid elderly: a case-control study embedded in Quebec longitudinal study - NuAge. Psychoneuroendocrinology (2013) 0.82
Intracerebral aneurysms: a review with special attention to geriatric aspects. J Gerontol A Biol Sci Med Sci (2003) 0.81
Income inequality and health in Ontario: a multilevel analysis. Can J Public Health (2005) 0.81
Psychometric evaluation of the Chinese version of the Subjective Happiness Scale: evidence from the Hong Kong FAMILY Cohort. Int J Behav Med (2014) 0.81
Living long and keeping well: elderly Canadians account for success in aging. Can J Aging (2007) 0.81
Factors associated with long-term benzodiazepine use among elderly women and men in Quebec. J Women Aging (2007) 0.81
Yearly transitions of disability profiles in older people living at home. Arch Gerontol Geriatr (2012) 0.81
Reducing verbal agitation in people with dementia: evaluation of an intervention based on the satisfaction of basic needs. Aging Ment Health (2011) 0.80
Family physician involvement in cancer care and lung cancer patient emotional distress and quality of life. Support Care Cancer (2010) 0.80
Outcomes during and after inpatient rehabilitation: comparison between adults and older adults. J Rehabil Med (2008) 0.80
The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture. J Am Geriatr Soc (2004) 0.80
Folate improves endothelial function in patients with coronary heart disease. Clin Chem Lab Med (2003) 0.79