Published in J Med Chem on September 12, 2002
Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents. J Med Chem (2009) 1.26
Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents. J Med Chem (2006) 1.25
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. J Nat Prod (2010) 1.20
New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1. J Med Chem (2013) 1.16
Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action. Antimicrob Agents Chemother (2004) 1.13
Activation and inhibition of the proteasome by betulinic acid and its derivatives. FEBS Lett (2007) 1.12
HIV entry inhibitors and their potential in HIV therapy. Med Res Rev (2009) 1.04
Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents. Nat Prod Rep (2009) 0.91
Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity. BMC Complement Altern Med (2011) 0.88
New betulinic acid derivatives as potent proteasome inhibitors. Bioorg Med Chem Lett (2011) 0.84
Molecular cloning and promoter analysis of squalene synthase and squalene epoxidase genes from Betula platyphylla. Protoplasma (2015) 0.83
Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity. Bioorg Med Chem Lett (2015) 0.75
Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation. J Virol (2004) 2.65
New developments in the chemistry and biology of the bioactive constituents of Tanshen. Med Res Rev (2007) 2.15
Rational selection of training and test sets for the development of validated QSAR models. J Comput Aided Mol Des (2003) 2.01
Recent progress in the development of coumarin derivatives as potent anti-HIV agents. Med Res Rev (2003) 1.90
Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids. Bioorg Med Chem (2005) 1.71
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza. J Med Chem (2004) 1.64
Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents. J Med Chem (2002) 1.57
Anti-AIDS agents. 60. Substituted 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents. J Med Chem (2004) 1.49
Anti-HBV and cytotoxic activities of pyranocoumarin derivatives. Bioorg Med Chem (2008) 1.47
Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs. Bioorg Med Chem (2004) 1.47
New developments in natural products-based anti-AIDS research. Med Res Rev (2007) 1.45
A new anti-HIV alkaloid, drymaritin, and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra. J Nat Prod (2004) 1.42
Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents. J Med Chem (2006) 1.42
Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos. Bioorg Med Chem Lett (2003) 1.33
Anti-HIV agents. Part 55: 3'R,4'R-Di-(O)-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP), a novel anti-HIV agent. Bioorg Med Chem Lett (2003) 1.29
Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents. J Med Chem (2006) 1.29
Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents. J Med Chem (2010) 1.28
Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents. J Med Chem (2009) 1.26
Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents. J Med Chem (2006) 1.25
Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives. Bioorg Med Chem (2005) 1.24
Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents. Nat Prod Rep (2011) 1.21
Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod (2003) 1.21
Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates. J Med Chem (2012) 1.18
In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms. MBio (2013) 1.18
Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Bioorg Med Chem (2004) 1.17
Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert. J Nat Prod (2003) 1.17
Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues. J Med Chem (2010) 1.16
New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1. J Med Chem (2013) 1.16
Plant-derived natural product research aimed at new drug discovery. J Nat Med (2008) 1.15
The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV. Expert Opin Investig Drugs (2005) 1.15
Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring. J Med Chem (2015) 1.14
Anti-AIDS agents. 52. Synthesis and anti-HIV activity of hydroxymethyl (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone derivatives. J Med Chem (2004) 1.14
Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents. Bioorg Med Chem (2005) 1.13
Prenylated benzophenones and xanthones from Hypericum scabrum. J Nat Prod (2004) 1.13
Activation and inhibition of the proteasome by betulinic acid and its derivatives. FEBS Lett (2007) 1.12
Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors. J Med Chem (2009) 1.12
Recent discovery of plant-derived anti-diabetic natural products. Nat Prod Rep (2012) 1.11
Structural analogs of tylophora alkaloids may not be functional analogs. Bioorg Med Chem Lett (2007) 1.11
Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents. J Med Chem (2009) 1.11
A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity. PLoS Negl Trop Dis (2010) 1.10
Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents. J Nat Prod (2006) 1.08
Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2',2'-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents. Bioorg Med Chem (2010) 1.08
Biyouyanagin A, an anti-HIV agent from Hypericum chinense L. var. salicifolium. Org Lett (2005) 1.08
Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. J Med Chem (2007) 1.08
Anti-AIDS agents. Part 62: anti-HIV activity of 2'-substituted 4-methyl-3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (4-methyl DCK) analogs. Bioorg Med Chem Lett (2004) 1.08
Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii. J Nat Prod (2003) 1.07
Antitumor agents 251: synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents. Bioorg Med Chem (2006) 1.07
Anticancer drugs designed by mother nature: ancient drugs but modern targets. Curr Pharm Des (2007) 1.06
Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors. J Med Chem (2010) 1.06
Willingness to pay per quality-adjusted life year: is one threshold enough for decision-making?: results from a study in patients with chronic prostatitis. Med Care (2011) 1.06
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line. J Med Chem (2003) 1.05
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1. Antimicrob Agents Chemother (2007) 1.05
Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides. Bioorg Med Chem (2005) 1.04
Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents. Bioorg Med Chem Lett (2009) 1.04
Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors. J Med Chem (2010) 1.04
HIV entry inhibitors and their potential in HIV therapy. Med Res Rev (2009) 1.04
Coptidis Rhizoma: protective effects against peroxynitrite-induced oxidative damage and elucidation of its active components. J Pharm Pharmacol (2004) 1.04
Antitumor agents 247. New 4-ethoxycarbonylethyl curcumin analogs as potential antiandrogenic agents. Bioorg Med Chem (2006) 1.03
Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents. Bioorg Med Chem (2002) 1.02
CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol Cancer Ther (2008) 1.02
Picomolar dichotomous activity of gnidimacrin against HIV-1. PLoS One (2011) 1.01
Antitumor agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents. J Comput Aided Mol Des (2007) 1.01
Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity. J Med Chem (2008) 1.00
Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus. J Nat Prod (2010) 1.00
Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors. J Med Chem (2012) 1.00
Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense. J Nat Prod (2009) 1.00
The cytotoxic properties of natural coumarins isolated from roots of Ferulago campestris (Apiaceae) and of synthetic ester derivatives of aegelinol. Nat Prod Commun (2009) 0.99
Antitumor agents. 280. Multidrug resistance-selective desmosdumotin B analogues. J Med Chem (2010) 0.99
Anti-AIDS agents. Part 58: synthesis and anti-HIV activity of 1-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (1-thia-DCK) analogues. Bioorg Med Chem Lett (2004) 0.99
Recent advances in the investigation of curcuminoids. Chin Med (2008) 0.98
Intercedensides D-I, cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert. J Nat Prod (2005) 0.98
Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorg Med Chem Lett (2012) 0.98
A novel strategy to rapidly explore potential chemical markers for the discrimination between raw and processed Radix Rehmanniae by UHPLC-TOFMS with multivariate statistical analysis. J Pharm Biomed Anal (2009) 0.98
Bioactive constituents of Clausena lansium and a method for discrimination of aldose enantiomers. Phytochemistry (2012) 0.97
5-Hydroxymethyl-2-furfural, a clinical trials agent for sickle cell anemia, and its mono/di-glucosides from classically processed steamed Rehmanniae Radix. J Nat Med (2007) 0.97
Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs. Bioorg Med Chem Lett (2005) 0.97
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents. Bioorg Med Chem (2009) 0.97
Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents. Bioorg Med Chem Lett (2010) 0.96
First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. J Med Chem (2007) 0.96
Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity. Bioorg Med Chem (2008) 0.96
Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L. Org Lett (2011) 0.96