Published in Biochem Pharmacol on September 01, 2002
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci U S A (2004) 7.51
The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3. J Virol (2003) 4.73
Multiple anti-interferon actions of the influenza A virus NS1 protein. J Virol (2007) 3.53
Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus. J Virol (2005) 2.16
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol (2004) 2.06
Toll-like receptor (TLR) expression and TLR-mediated cytokine/chemokine production by human uterine epithelial cells. Immunology (2004) 1.87
Homo-oligomerization facilitates the interferon-antagonist activity of the ebolavirus VP35 protein. Virology (2005) 1.63
Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling. J Virol (2007) 1.58
ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon. EMBO Rep (2013) 1.54
The protein kinase PKR: a molecular clock that sequentially activates survival and death programs. EMBO J (2004) 1.29
Tissue-specific and inducer-specific differential induction of ISG56 and ISG54 in mice. J Virol (2007) 1.28
Ubiquitination and proteasomal degradation of interferon regulatory factor-3 induced by Npro from a cytopathic bovine viral diarrhea virus. Virology (2007) 1.28
Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3. J Virol (2011) 1.24
Loss of interferon regulatory factor 3 in cells infected with classical swine fever virus involves the N-terminal protease, Npro. J Virol (2005) 1.23
Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression. PLoS Pathog (2010) 1.14
Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection. PLoS Pathog (2010) 1.10
Adenovirus induction of IRF3 occurs through a binary trigger targeting Jun N-terminal kinase and TBK1 kinase cascades and type I interferon autocrine signaling. J Virol (2009) 1.08
Comparative genomics of Toll-like receptor signalling in five species. BMC Genomics (2009) 1.06
Endoplasmic reticulum stress regulates the innate immunity critical transcription factor IRF3. J Immunol (2012) 1.04
Cytomegalovirus induces interferon-stimulated gene expression and is attenuated by interferon in the developing brain. J Virol (2006) 1.04
The amino-terminal domain of bovine viral diarrhea virus Npro protein is necessary for alpha/beta interferon antagonism. J Virol (2006) 1.03
Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases. J Immunol (2008) 1.00
Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3. J Mol Biol (2008) 1.00
Role of Toll-like receptors in adjuvant-augmented immune therapies. Evid Based Complement Alternat Med (2006) 0.97
The interferon inducing pathways and the hepatitis C virus. World J Gastroenterol (2007) 0.95
RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma. Cancer Res (2014) 0.94
Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of mitochondrial antiviral signaling (MAVS). Cell Res (2011) 0.93
Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Mol Cell Biol (2004) 0.93
Interferon regulatory factor 3-independent double-stranded RNA-induced inhibition of hepatitis C virus replicons in human embryonic kidney 293 cells. J Virol (2005) 0.92
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation. PLoS One (2011) 0.92
Protective role of interferon regulatory factor 3-mediated signaling against prion infection. J Virol (2012) 0.91
The varicella-zoster virus ORF47 kinase interferes with host innate immune response by inhibiting the activation of IRF3. PLoS One (2011) 0.89
8-Prenylkaempferol Suppresses Influenza A Virus-Induced RANTES Production in A549 Cells via Blocking PI3K-Mediated Transcriptional Activation of NF-κB and IRF3. Evid Based Complement Alternat Med (2011) 0.87
Characterization of HCV interactions with Toll-like receptors and RIG-I in liver cells. PLoS One (2011) 0.86
IRF3 polymorphisms induce different innate anti-Theiler's virus immune responses in RAW264.7 macrophages. Virology (2011) 0.84
Innate immune responses in NF-kappaB-repressing factor-deficient mice. Mol Cell Biol (2006) 0.83
CD13 restricts TLR4 endocytic signal transduction in inflammation. J Immunol (2015) 0.82
Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1. J Virol (2013) 0.81
Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5. J Innate Immun (2014) 0.79
Membrane Perturbation-Associated Ca2+ Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry. J Virol (2015) 0.77
ArfGAP domain containing protein 2 (ADAP2) integrates upstream and downstream modules of RIG-I signaling, and facilitates Type I interferon production. Mol Cell Biol (2016) 0.75
Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3. Front Immunol (2017) 0.75
Triggering the interferon antiviral response through an IKK-related pathway. Science (2003) 11.62
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents. Cancer Cell (2003) 5.89
Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes. J Virol (2002) 4.31
A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J Exp Med (2005) 3.59
The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways. Nat Immunol (2007) 2.91
Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. J Biol Chem (2003) 2.57
RIG-I-like receptors: sensing and responding to RNA virus infection. Semin Immunol (2009) 2.47
The interferon antiviral response: from viral invasion to evasion. Curr Opin Infect Dis (2002) 2.33
Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20. J Biol Chem (2005) 2.27
Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage. J Virol (2006) 2.15
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol (2004) 2.06
Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation. J Virol (2002) 2.04
Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells. J Virol (2005) 1.97
Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex. Cell Host Microbe (2012) 1.93
Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3. J Biol Chem (2007) 1.81
Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression. J Virol (2006) 1.75
Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis. Proc Natl Acad Sci U S A (2008) 1.73
Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon. J Virol (2005) 1.72
The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation. PLoS Pathog (2009) 1.57
TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB. Oncogene (2003) 1.57
Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon. J Immunol (2006) 1.56
Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis. Ann N Y Acad Sci (2003) 1.55
RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I. J Virol (2010) 1.55
Targeting dendritic cell signaling to regulate the response to immunization. Blood (2008) 1.50
Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter. Mol Cell Biol (2009) 1.49
Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter. Curr Opin Immunol (2011) 1.46
The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity (2012) 1.44
A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers. Mol Ther (2010) 1.38
Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7. J Immunol (2011) 1.31
Distinct roles for IFN regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophages. Cancer Res (2006) 1.25
Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta. J Virol (2010) 1.24
A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells. J Biol Chem (2007) 1.23
Differential regulation of HIV-1 clade-specific B, C, and E long terminal repeats by NF-kappaB and the Tat transactivator. Virology (2002) 1.22
Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines. Microbes Infect (2006) 1.22
Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J Virol (2008) 1.19
Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. J Immunol (2006) 1.19
A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response. Cell Res (2011) 1.18
Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression. J Virol (2007) 1.14
Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression. PLoS Pathog (2010) 1.14
A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization. J Biol Chem (2004) 1.12
Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7. Eur J Immunol (2009) 1.12
Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS. J Biol Chem (2009) 1.11
Effects of the hepatitis C virus core protein on innate cellular defense pathways. J Interferon Cytokine Res (2004) 1.09
Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription. J Mol Biol (2002) 1.09
Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein. J Virol (2007) 1.08
VSV oncolysis in combination with the BCL-2 inhibitor obatoclax overcomes apoptosis resistance in chronic lymphocytic leukemia. Mol Ther (2010) 1.08
Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression. Virol J (2006) 1.08
Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells. J Immunol (2007) 1.07
Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity. PLoS Pathog (2013) 1.07
Acetylated Tat regulates human immunodeficiency virus type 1 splicing through its interaction with the splicing regulator p32. J Virol (2006) 1.06
Dual role of NOX2 in respiratory syncytial virus- and sendai virus-induced activation of NF-kappaB in airway epithelial cells. J Immunol (2008) 1.06
Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages. Eur J Immunol (2007) 1.05
Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells. J Immunol (2002) 1.04
Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis. Cell Host Microbe (2013) 1.03
Inhibition of dengue and chikungunya virus infections by RIG-I-mediated type I interferon-independent stimulation of the innate antiviral response. J Virol (2014) 1.03
Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins. J Virol (2005) 1.03
Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7. Mol Cell Biol (2009) 1.03
Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis. J Virol (2008) 1.02
HTLV-1 evades type I interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1). PLoS Pathog (2010) 1.01
A requirement for NF-kappaB induction in the production of replication-competent HHV-8 virions. Oncogene (2004) 1.01
Ub surprised: viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates. Cell Host Microbe (2007) 0.99
Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. Blood (2007) 0.98
Bax-dependent mitochondrial membrane permeabilization enhances IRF3-mediated innate immune response during VSV infection. Virology (2007) 0.97
On the TRAIL to apoptosis. Cytokine Growth Factor Rev (2002) 0.97
Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages. Biochem Pharmacol (2006) 0.97
Cryptic O2- -generating NADPH oxidase in dendritic cells. J Cell Sci (2004) 0.96
In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors. Cancer Res (2002) 0.96
Histone deacetylase inhibitors potentiate vesicular stomatitis virus oncolysis in prostate cancer cells by modulating NF-κB-dependent autophagy. J Virol (2013) 0.95
Suppression of IRF4 by IRF1, 3, and 7 in Noxa expression is a necessary event for IFN-γ-mediated tumor elimination. Mol Cancer Res (2011) 0.94
Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation. J Virol (2008) 0.93
STING-ing the antiviral pathway. J Mol Cell Biol (2009) 0.93
Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses. PLoS Pathog (2013) 0.90
IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH oxidase-mediated airway antiviral response. Cell Res (2013) 0.90
The interface between the innate interferon response and expression of host retroviral restriction factors. Cytokine (2010) 0.90
Repression of IRF-4 target genes in human T cell leukemia virus-1 infection. Oncogene (2002) 0.89
IRF-4 activities in HTLV-I-induced T cell leukemogenesis. J Interferon Cytokine Res (2002) 0.89
Gene expression profiling of the host response to HIV-1 B, C, or A/E infection in monocyte-derived dendritic cells. Virology (2006) 0.89
The emergence of combinatorial strategies in the development of RNA oncolytic virus therapies. Cell Microbiol (2009) 0.89
Functional analysis of a dominant negative mutation of interferon regulatory factor 5. PLoS One (2009) 0.88
HCV NS5A and IRF9 compete for CypA binding. J Hepatol (2012) 0.88
SAMHD1 host restriction factor: a link with innate immune sensing of retrovirus infection. J Mol Biol (2013) 0.88
Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients. J Hepatol (2011) 0.88
IFN regulatory factor 4 participates in the human T cell lymphotropic virus type I-mediated activation of the IL-15 receptor alpha promoter. J Immunol (2002) 0.88
Oncolytic viruses and histone deacetylase inhibitors--a multi-pronged strategy to target tumor cells. Cytokine Growth Factor Rev (2010) 0.88
Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes. J Mol Biol (2005) 0.87
Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon. J Biol Chem (2005) 0.87